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multicenter,randomized study to optimize bowel for colon capsule endoscopy

World Journal of Gastroenterology 2017年第48期23卷 8615-8625页

作者： David Kastenberg Wilmot C Burch Jr David P Romeo Pankaj K Kashyap David C Pound Neophytos Papageorgiou Ignacio Fernández-Urien Sainz carly E Sokach Douglas K Rex Division of Gastroenterology Thomas Jefferson University Franklin Gastroenterology PLLC Dayton Gastroenterology Inc. Pinnacle Research Group LLC Indianapolis Gastroenterology and hepatology Department of Gastroenterology American Medical Center Department of Gastroenterology Servicio de Digestivohospital de Navarra Sidney Kimmel medical College at Thomas Jefferson University Indiana University hospital

AIm To assess the cleansing efficacy and safety of a new Colon capsule endoscopy(CCE) bowel preparation *** This was a multicenter,prospective,randomized,controlled study comparing two CCE regimens. Subjects were asymptomatic and average risk for colorectal cancer. The second generation CCE system(Pill Cam? COLON 2;medtronic,Yoqneam,Israel) was utilized. Preparation regimens differed in the 1 st and 2 nd boosts with the Study regimen using oral sulfate solution(89 m L) with diatrizoate meglumine and diatrizoate sodium solution("diatrizoate solution")(boost 1 = 60 m L,boost 2 = 30 m L) and the Control regimen oral sulfate solution(89 m L) alone. The primary outcome was overall and segmental colon cleansing. Secondary outcomes included safety,polyp detection,colonic transit,CCE completion and capsule excretion ≤ 12 h. RESULTS Both regimens had similar cleansing efficacy for the whole colon(Adequate: Study = 75.9%,Control = 77.3%;P = 0.88) and individual segments. In the Study group,CCE completion was superior(Study = 90.9%,Control = 76.9%;P = 0.048) and colonic transit was more often min(Study = 21.8%,Control = 4%;P = 0.0073). more Study regimen subjects experienced adverse events(Study = 19.4%,Control = 3.4%;P = 0.0061),and this difference did not appear related to diatrizoate solution. Adverse events were primarily gastrointestinal in nature and no serious adverse events related either to the bowel preparation regimen or the capsule were observed. There was a trend toward higher polyp detection with the Study regimen,but this did not achieve statistical significance for any size category. mean transit time through the entire gastrointestinal tract,from ingestion to excretion,was shorter with the Study regimen while mean colonic transit times were similar for both study *** A CCE bowel preparation regimen using oral sulfate solution and diatrizoate solution as a boost agent is effective,safe,and achieved superior CCE completion.

关键词： Bowel preparation Purgative Capsule endoscopy Endoscopy Capsule colonoscopy Large intestine

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magnetic Field Configurations Corresponding to Electric Field Patterns That Evoke Long-Term Potentiation Shift Power Spectra of Light Emissions from microtubules from Non-Neural Cells

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Open Journal of Biophysics 2014年第4期4卷 112-118页

作者： Blake T. Dotta David A.E. Vares carly A. Buckner Robert m. Lafrenie michael A. Persinger Biomolecular Sciences and Behavioural Neuroscience Programs Laurentian University Sudbury Canada

Photon counts were measured every 15 ms for 75 s from microtubule-enriched preparations (and nuclei) from mouse melanoma cells during baseline and after 2 min exposures to 1 μT magnetic fields. The magnetic fields were generated from a circular array of solenoids and presented with accelerating or decelerating rotation velocities. The range of photon radiant flux density was in the order of 10-12 W·m-2. microtubules preparations that had been exposed for only 2 min to a magnetic field configuration corresponding to the electric field pattern that induced long-term potentiation in neural tissue when applied as electric current displayed peaks of spectral power densities within 7 - 8 Hz, 9.5 Hz, 14 - 15 Hz, and 22 Hz bands. The major peak (9.4 Hz) bandwidth was approximately 0.1 Hz. While microtubule preparations exposed for 2 min to a 7 Hz sine-wave or in the absence of a field emitted an overall similar level of spectral power density, the peaks in power density were not present. Treatment with the LTP patterned fields, compared to the baseline or sine-wave fields primarily altered the frequency band in which the amplitude of the photon field was expressed. These results suggest that the photon emissions from microtubule preparations have the capacity to respond to specifically-patterned or geometric shapes of magnetic fields by altering spectral configurations rather than the absolute numbers of photons.

关键词： microtubules Photon Emissions Spectral Density Shifts Physiologically-Patterned magnetic Fields

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Past Century Fossil Fuel Burning Recorded by Tree-Ring δ13C and δ34S from Chaling,South China

Past Century Fossil Fuel Burning Recorded by Tree-Ring δ13C...

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中国矿物岩石地球化学学会第15届学术年会

作者： Luhua Xie Peter m.Wynn carly J.Stevens Baruch.Spiro Gangjian Wei Gan Zhang State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of Sciences Key Laboratory of marginal Sea Geology Guangzhou Institute of GeochemistryChinese Academy of Sciences Lancaster Environment Centre University of LancasterLancaster

工业革命以来由人类活动带来的大量化石燃料燃烧导致严重的环境污染,并引起气候变化。我国自1970年代开始大量排放人类活动产生的CO2和SO2,而且现在我国已经成为世界最大的CO2和SO2排放国。树轮碳-硫同位素及硫含量能很好地记录长时间...

工业革命以来由人类活动带来的大量化石燃料燃烧导致严重的环境污染,并引起气候变化。我国自1970年代开始大量排放人类活动产生的CO2和SO2,而且现在我国已经成为世界最大的CO2和SO2排放国。树轮碳-硫同位素及硫含量能很好地记录长时间尺度的气候变化,水利用效率,及化石燃料燃烧。本摘要报道了来自南方森林115年全树树轮碳-硫同位素及硫含量,目的在于记录人类活动产生的CO2和SO2历排放历史,及试图探讨人类活动产生的CO2和SO2对树碳同位素及水利用效率的影响。结果显示树轮碳同位素自1940年代后期至2000年代后期持续下降,是由持续增加的化石燃料产生的CO2导致的;大气CO2校正后的树轮碳同位素反映了全年降雨量。此外,树轮细胞内CO2浓度及水利用效率自1940年代后期持续升高,其原因是大气CO2浓度增加。另一方面,树轮硫含量没有明显的变化,表明硫是树的基本元素,而硫同位素自1890年代后期以来持续下降,记录了化石燃料(北方煤)使用历史。与之前发表的数据,显示最近几年或几十年来树轮碳同位素的增加(1.2‰.5‰),但不能证明是由大气污染(SO2增加)引起的,因其被气候变化所掩盖。

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华盛顿州2011-2013年汽车和卡车清洗所致的职业性氢氟酸伤害

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上海预防医学 2016年第7期28卷 515-517页

作者： Carolyn K.Reeb-Whitaker carly m.Eckert Naomi J.Anderson David K.Bonauto 汪源(翻译) 周惠嘉(审校) Safety and Health Assessment and Research for Prevention Program Washington State Department of Labor and Industries Department of Environmental and Occupational Health Sciences University of Washington 不详

氢氟酸（hydrofluoric acid,HF）暴露能够引起腐蚀性化学烧伤,并可能产生致命的系统性毒性。汽车和卡车清洁产品、除锈剂及铝材光亮剂中含有HF,因为HF能有效分解道路污垢。本文概述了华盛顿州2001—2013年1例卡车清洗工因摄入含HF清洁... 详细信息

氢氟酸（hydrofluoric acid,HF）暴露能够引起腐蚀性化学烧伤,并可能产生致命的系统性毒性。汽车和卡车清洁产品、除锈剂及铝材光亮剂中含有HF,因为HF能有效分解道路污垢。本文概述了华盛顿州2001—2013年1例卡车清洗工因摄入含HF清洁产品而致死的死亡病例和48例汽车和卡车清洗相关的职业性HF烧伤病例。

关键词：华盛顿州氢氟酸烧伤化学烧伤光亮剂人外组织损伤急救过程病例报告疼痛感右手指

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