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Typical and atypical COVID-19 computed tomography findings

World Journal of Clinical Cases 2020年第15期8卷 3177-3187页

作者： Damiano Caruso Tiziano Polidori Gisella Guido Matteo Nicolai Benedetta Bracci Antonio Cremona MartaZerunian Michela Polici Francesco Pucciarelli carlotta rucci Chiara De Dominicis Marco Di Girolamo Giuseppe Argento Daniela Sergi Andrea Laghi Department of Surgical and Medical Sciences and Translational Medicine “Sapienza”-University of RomeSant'Andrea University HospitalAOU Sant’AndreaRome 00189Italy

In December 2019 a novel coronavirus,named severe acute respiratory syndrome coronavirus 2 was identified and the disease associated was named coronavirus disease 2019(COVID-19).Fever,cough,myalgia,fatigue associated to dyspnea represent most common clinical symptoms of the *** reference standard for diagnosis of severe acute respiratory syndrome coronavirus 2 infection is real time reverse-transcription polymerase chain reaction test applied on respiratory tract *** of lower specificity,chest computed tomography(CT),as reported in manifold scientific studies,showed high sensitivity,therefore it may help in the early detection,management and follow-up of COVID-19 *** affected by COVID-19 pneumonia usually showed on chest CT some typical features,such as:Bilateral ground glass opacities characterized by multilobe involvement with posterior and peripheral distribution;parenchymal consolidations with or without air bronchogram;interlobular septal thickening;crazy paving pattern,represented by interlobular and intralobular septal thickening surrounded by ground-glass opacities;subsegmental pulmonary vessels enlargement(>3 mm).Halo sign,reversed halo sign,cavitation and pleural or pericardial effusion represent some of atypical findings of COVID-19 *** the other hand lymphadenopathy’s and bronchiectasis’frequency is unclear,indeed conflicting data emerged in *** play a key role in recognition of high suspicious findings of COVID-19 on chest CT,both typical and atypical ***,the aim of this review is to illustrate typical and atypical CT findings of COVID-19.

关键词： SARS-CoV-2 COVID-19 Chest computed tomography Interstitial pneumonia Ground-glass opacities

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Acute symptomatic seizures in newborns:a narrative review

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Acta Epileptologica 2024年第1期7卷 1-13页

作者： carlotta Spagnoli Francesco Pisani Child Neurology Unit Pediatric DepartmentAzienda USL-IRCCS Di Reggio EmiliaReggio Emilia42123Italy Child Neurology and Psychiatry Unit Department of Human NeurosciencesSapienza University of RomeRome00185Italy Azienda Ospedaliero Universitaria Policlinico Umberto I Rome00185Italy

Acute symptomatic seizures are the main sign of neurological dysfunction in *** is linked to the unique characteristics of the neonatal brain,making it hyperexcitable compared to older ages,and to the common occurrence of some forms of acquired brain injury,namely hypoxic-ischemic *** this narrative review we will provide an overview of neonatal seizures definition,their main underlying etiologies,diagnostic work-up and differential diagnoses,and will discuss about therapeutic options and prognostic *** latest publications from the ILAE Task Force on Neonatal Seizures will be presented and *** note,they highlight the current lack of robust evidence in this field of clinical *** will also report on specificities pertaining to low-and-middle income countries in terms of incidence,main etiologies and *** possibilities offered by telemedicine and automated seizures detection will also be summarized in order to provide a framework for future directions in seizures diagnosis and management with a global *** challenges and opportunities for improving identification,monitoring and treatment of acute symptomatic seizures in newborns *** current caveats potentially represent different lines of research with the aim to provide better care and reach a deeper understanding of this important topic of neonatal neurology.

关键词： Acute symptomatic Neonatal seizures EEG Newborn Outcome Diagnosis Etiologies

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专访意大利灯具品牌Artemide总裁carlotta de Bevilacqua:打造“人类之光”

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包装与设计 2024年第4期 6-31页

作者：无 carlotta de Bevilacqua 《包装&设计》意大利灯具品牌Artemide

“在Artemide的产品中,光才是主角,而非灯具本身。”自电灯发明以来,无数品牌携手设计师热忱地构建灯与光的迷人画卷。在2024年iF设计奖的参评作品中,来自意大利知名照明品牌Artemide的IXA LED灯具系列,以其灵动的雕塑感与优雅的建筑感... 详细信息

“在Artemide的产品中,光才是主角,而非灯具本身。”自电灯发明以来,无数品牌携手设计师热忱地构建灯与光的迷人画卷。在2024年iF设计奖的参评作品中,来自意大利知名照明品牌Artemide的IXA LED灯具系列,以其灵动的雕塑感与优雅的建筑感获得了iF国际评审的认可,夺得iF金奖,而这是Artemide获得的第45个iF设计奖!

关键词： LED灯具雕塑感设计奖品牌意大利

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Surgical management of tegmen defects of the temporal bone and meningoencephalic herniation: our experience

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Journal of Otology 2024年第1期19卷 30-34页

作者： Giuseppe De Donato Emanuela Fuccillo Alberto Maria Saibene Elena Ferrari Giorgia carlotta Pipolo Antonia Pisani Liliana Colletti Anastasia Urbanelli Luigi De Donato Giovanni Felisati Otorhinolaryngology Unit Head and Neck DepartmentASST Santi Paolo e Carlo HospitalVia Antonio di Rudinì820142MilanItaly Department of Health Sciences University of MilanVia Festa del Perdono720122MilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanVia Festa del Perdono720122MilanItaly ENT Unit Department of Surgical SciencesUniversity of TurinVia Verdi810124TurinItaly

1. Introduction The tegmental wall of the tympanic cavity is a thin plate of the temporal bone that separates the middle cranial fossa(MCF) from the ear. This anatomical region consists of two areas: an anterior one, comprised of the tegmen tympani(To′th et al., 2007), and a posterior one, formed by the tegmen antri and the tegmen mastoideum(Makki et al., 2011). In some patients, the tegmental region of the temporal bone can be interrupted, causing a tegmen defect(TD). A TD is sometimes associated with a meningoencephalic herniation(MEH), in which brain tissue herniates through a TD.

关键词： al. herniation bone

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Experimental characterization of the 3D linear viscoelastic behavior of cold recycled bitumen emulsion mixtures

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第4期6卷 324-336页

作者： Andrea Graziani carlotta Godenzoni Francesco Canestrari Dipartimento di Ingegneria Civile Edile e Architettura Università Politecnica delle Marche

Cold mixtures with bitumen emulsion are produced at ambient temperature, leading to substantial reductions of energy consumption and atmospheric emissions. In cold recycling applications, cement is normally used to improve the mixture performance. Thus, the rheological behavior of cold recycled mixtures is different from that of conventional hot mixtures because it is due to the interaction of fresh bitumen, aged bitumen and cementitious bonds. In this study, we investigated the three-dimensional(3 D) linear viscoelastic(LVE) behavior of a cement-bitumen treated material(CBTM) mixture fabricated using bitumen emulsion and cement. For comparison, we also investigated the 3 D LVE behavior of hot-mix asphalt containing 25% of reclaimed asphalt and fabricated using polymermodified binder. Sinusoidal axial tests on cylindrical specimens, were carried out at various temperatures(from 0℃ to 50℃) and frequencies(from 0.1 to 12 Hz). The complex Young’s modulus E~*and the complex Poisson’s ratio v~*were determined through the measurement of axial and transverse strain. We show that when considering E*, CBTM mixtures may be considered thermo-rheologically simple and the Huet-Sayegh model can be used to simulate the frequencyetemperature dependence. On the other hand, when considering v*the behavior of CBTM mixtures is very different from that of hot mix asphalt. In particular, its absolute value is almost constant and very close to 0.15.

关键词： Bitumen emulsion Cold recycling Complex modulus Complex Poisson’s ratio Huet-Sayegh model

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The application of reinforcement learning to NATM tunnel design

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Underground Space 2022年第6期7卷 990-1002页

作者： Enrico Soranzo carlotta Guardiani Wei Wu University of Natural Resources and Life Sciences Feistmantelstraße 4Vienna 1180Austria

The New Austrian Tunnelling Method(NATM)tunnel design is performed by testing support classes against the geological *** propose to replace this manual process with reinforcement learning,a generic framework within the realm of artificial intelligence that solves control *** studies have demonstrated this possibility,albeit with methodological *** coupled the Finite Difference Method with a Python script,used the output of the first to train the machine learning model implemented in the latter and improved the choice of the support *** benchmark tests,we demonstrated that our method was capable of choosing the optimal support classes for various geological sets and showed the relation between its performance and the number of training episodes.

关键词： Deep Q-Network NATM Reinforcement learning Support classes Tunnelling

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Toward forest ‘‘sprawl'':monitoring and planning a changing landscape for urban sustainability

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Journal of Forestry Research 2016年第1期27卷 175-184页

作者： Luca Salvati carlotta Ferrara Anastasios Mavrakis Andrea Colantoni Consiglio per la Ricerca in Agricoltura e l'analisi dell'Economia Agraria (CREA) Via della Navicella 2-400184 Rome Italy Department of Agriculture Forests Nature and Energy (DAFNE) Viale dell'Agricoltura 02015 Cittaducale (RI)Italy Department of Economic and Regional Development Institute of Urban Environment and Human ResourcesPanteion University 136 Syngrou Avenue 17671 AthensGreece Dipartimento di Science e Tecnologie per l'Agricoltura le Foreste la Natura e l'Energia Universith degli Studi di Viterbo Via S. Camillo de Lellis snc O1100 Viterbo Italy

The present study analyzes the structure and dynamics of the forest landscape in a peri-urban area （Rome, Italy） during the city＇s expansion from 1949 to 2008 using landscape metrics and change detection anal- ysis of digital maps of the area （1500 km2）. While urban settlements increased continuously from 6.5 to 27.5 % of the study area, woodlands changed less clearly, with a moderate increase （from 11.2 to 11.9 % of the total area） and a higher fragmentation as a consequence of Rome＇s expansion. The structure of forest landscape changed along the urban-to-rural gradient with patch size increasing with the distance to the inner city in 1949 and substantial landscape homogeneity in 2008. The indicators proposed in this study inform dedicated measures for conserving forest and maintaining landscape diversity. Measures adopted in Rome＇s forestation plan to counteract woodlandfragmentation were analyzed and discussed. Based on the complex landscape dynamics found for Rome, an inte- grated multiscale planning approach targeting forest con- servation is considered a key contribution to urban sustainability.

关键词： Landscape ecology Urban form Forestationplan Rome Mediterranean region

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Insight into the interaction of inhaled corticosteroids with human serum albumin: A spectroscopic-based study

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Journal of Pharmaceutical Analysis 2018年第1期8卷 37-44页

作者： carlotta Pontremoli Nadia Barbero Guido Viscardi Sonja Visentin Department of Applied Science and Technology (DISAT) Politecnico of Torino Department of Chemistry and NIS Interdepartmental Centre University of Torino Molecular Biotechnology and Health Sciences Department University of Torino

It is well known that the safety and efficacy profile of an inhaled cortocosteroid(ICS) is influenced by the pharmacokinetic properties and associated pharmacodynamic effects of the drug. Freely circulating,protein unbound, and active ICS can cause systemic adverse effects. Therefore, a detailed investigation of drug-protein interaction could be of great interest to understand the pharmacokinetic behaviour of corticosteroids and for the design of new analogues with effective pharmacological properties. In the present work, the interaction between some corticosteroids and human serum albumin(HSA) has been studied by spectroscopic approaches. UV–Vis spectroscopy confirmed that all the investigated corticosteroids can bind to HSA forming a protein-drug complex. The intrinsic fluorescence of HSA was quenched by all the investigated drugs, which was rationalized in terms of a static quenching mechanism. The thermodynamic parameters determined by the Van't Hoff analysis of the binding constants(negative ΔH and ΔS values) clearly indicate thathydrogen bonds and van der Waals forces play a major role in the binding process between albumin and betamethasone, flunisolide and prednisolone, while hydrophobic forces may play a major role in stabilizing albumin-triamcinolone complexes.

关键词： Human serum albumin Inhaled corticosteroids Fluorescence spectroscopy Fluorescence resonance energy transfer(FRET)

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Effect of the rearing diet on gene expression of antimicrobial peptides in Hermetia illucens(Diptera:Stratiomyidae)

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Insect Science 2023年第4期30卷 933-946页

作者： Valentina Candian carlotta Savio Marco Meneguz Laura Gasco Rosemarie Tedeschi Dipartimento di Scienze Agrarie Forestali eAlimentari(DISAFA)University of TorinoGrugliascoItaly NRAE MicalisGMEUniversity of Paris SaclayJouy-en-JosasFrance Laboratory of Entomology Wageningen UniversityWageningenThe Netherlands BEF Biosystems TorinoItaly

Insect proteins have been proposed for human and animal food *** the health status of insects in mass rearing allows to obtain high-quality products and to avoid severe economic losses due to ***,new strategies for preserving insect health must be *** of the insect im-mune system through the diet is one such *** evaluated gene expression of two antimicrobial peptides(one defensin and one cecropin)in Hermetia illucens(L.)(Diptera:Stratiomyidae)reared on different *** were performed on prepupae and 10-day-old larvae reared on cereal-and municipal organic waste-based diets and on only prepupae reared on a cereal-based diet supplemented with sunflower,corn,or soybean *** inclusion of sunflower oil at different points in the cereal-based diet was also ***,diet-driven differences in the inhibitory activity of the hemolymph were tested against Escherichia coli DH5αand Micrococcus yunnanensis HI55 using diffusion assays in solid *** showed that a municipal organic waste-based diet produced a significant overexpression of antimicrobial peptides only in *** of veg-etable oils caused an upregulation of at least one peptide,except for the corn *** expression of both genes was observed when sunflower oil was added 5 days before *** hemolymph samples showed an inhibitory activity against bacteria *** results suggest that municipal organic waste-based diet and vegetable oil-added diet may successfully impact the immune system of *** alternatives may also exist forotherspeciesofeconomic interest.

关键词： cecropin cereal defensin hemolymph organic municipal solid waste vegetable oil

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Role of omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes on intestinal barrier integrity and immunity in animals

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1240-1261页

作者： Tamil Selvi Sundaram carlotta Giromini Raffaella Rebucci Juraj Pistl Mangesh Bhide Antonella Baldi Department of Veterinary Science for Health Animal Production and Food SafetyUniversity of MilanVia Trentacoste 220134 MilanItaly University of Veterinary Medicine and Pharmacy in Kosice Komenskeho 68/7304181 KosiceSlovakia

The gastrointestinal tract of livestock and poultry is prone to challenge by feedborne antigens,pathogens,and other stress factors in the farm *** physiological inflammation and oxidative stress that arises firstly disrupts the intestinal epithelial barrier followed by other components of the gastrointestinal *** the present review,the interrelationship between intestinal barrier inflammation and oxidative stress that contributes to the pathogenesis of inflammatory bowel disease was ***,the role of naturally existing immunomodulatory nutrients such as the omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes in preventing intestinal barrier inflammation was *** on the existing evidence,the possible molecular mechanism of these bioactive nutrients in the intestinal barrier was outlined for application in animal diets.

关键词： Citrus pectin Immunomodulatory nutrients Inflammation Intestinal epithelial barrier Milk-derived exosomes Omega-3 polyunsaturated fatty acids Oxidative stress

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