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Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy

World Journal of Gastroenterology 2014年第43期20卷 15992-16013页

作者： Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki carlos vazquez-chacon Armando Martinez-Guarneros Juan carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera Laboratorio de Biología Molecular División PatologíaHospital de Ni?os "Ricardo Gutiérrez"Buenos Aires C1425EFDArgentina Instituto de Diagnóstico y Referencia Epidemiológicos Mexico 01480Mexico Department of Biology Institute of BioscienceLanguage and Exact ScienceS?o Paulo State UniversityS?o José do Rio PretoSP 13560-970Brazil Laboratorio de Inmunobiología de Enfermedades Infecciosas Unidad de Investigación MultidisciplinariaFacultad de Estudios Superiores CuautitlánUniversidad Nacional Autónoma de MéxicoCuautitlán IzcalliEstado de México 54714Mexico Departmento de Microbiología y Parasitología Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico City 04510Mexico

Hepatitis C virus(HCV)infection represents an important public health problem *** of HCV morbidity and mortality is a current challenge owned to several viral and host *** molecular evolution plays an important role in HCV transmission,disease progression and therapy *** high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and *** evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging *** advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against *** a result,superior sustained viral responses have been *** rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era.

关键词： Hepatitis C virus Evolution Phylogenetics Drug resistance Clinical outcome

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Effects of Yerba Mate Consumption (Ilex paraguariensis) on Cardiac Remodeling in Rats

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Food and Nutrition Sciences 2024年第8期15卷 827-845页

作者： carlos Eduardo Brochini de Paiva Thaíssa Baptista Brochini de Paiva Isabelle Tiburcio Pecin Ferreira Sandra Cristina Genaro Danilo Silva Martins Santos Thaoan Bruno Mariano Robson chacon Castoldi Rafael Stuani Floriano Julia Amanda Rodrigues Fracasso Lucas Pires Guarnier Marina Politi Okoshi Francis Lopes Pacagnelli Postgraduate Program in Health Sciences Unoeste Presidente Prudente Brazil Faculty of Medicine Unoeste Presidente Prudente Brazil Department of Physiotherapy Unoeste Presidente Prudente Brazil Department of Nutrition Unoeste Presidente Prudente Brazil Postgraduate Program in Science and Movement Unesp Rio Claro Brazil Postgraduate Program in Health Promotion University of Northern Paran (UNOPAR) Londrina Brazil School of Dentistry So Paulo State University (UNESP) Araatuba Brazil Department of Genetics Ribeiro Preto Medical School University of So Paulo USP Ribeiro Preto Brazil Internal Medicine Department Botucatu Medical School So Paulo State University (UNESP) Botucatu Brazil

This study investigated the effects of yerba mate consumption, a South American beverage, on cardiac remodeling in rats. For this purpose, 24 male Wistar rats were divided into Control Group (CG) which received filtered water and a standard diet, and Yerba Mate Group (YM), 6 g of Ilex paraguariensis in 100 ml water and the same diet, for 30 days. The YM group showed a reduction in final body weight and food consumption without altering weight gain. Regarding cardiac remodeling, the YM group exhibited a decrease in the right ventricle weight/final body weight ratio, suggesting cardiac atrophy, without affecting the atria and left ventricle. There was no change in cardiomyocyte area or nuclear fractal dimension in both groups. However, animals that consumed yerba mate showed increased collagen deposition and a smaller fractal dimension in the left ventricle. The consumption of yerba mate at room temperature for 30 days induced changes in cardiac remodeling, as evidenced by increased collagen deposition and alterations in fractal dimension in the left ventricle.

关键词： Tereré Ilex paraguariensis Yerba Mate Cardiac Remodeling Fractal Dimension Hypertrophy

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Review and update on the molecular basis of Leber congenital amaurosis

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World Journal of Clinical Cases 2015年第2期3卷 112-124页

作者： Oscar Francisco chacon-Camacho Juan carlos Zenteno Genetics Department-Research Unit Institute of Ophthalmology"Conde de Valenciana" Biochemistry Department Faculty of MedicineNational Autonomous University of Mexico

Inherited retinal diseases are uncommon pathologies and one of the most harmful causes of childhood and adult blindness. Leber congenital amaurosis(LCA) is the most severe kind of these diseases accounting for approximately 5% of the whole retinal dystrophies and 20% of the children that study on blind schools. Clinical ophthalmologic findings including severe vision loss, nystagmus and ERG abnormalities should be suspected through the first year of life in this group of patients. Phenotypic variability is found when LCA patients have a full ophthalmologic examination. However, a correct diagnosis may be carried out; the determination of ophthalmologic clues as light sensibility, night blindness, fundus pigmentation, among other, join with electroretinographics findings, optical coherence tomography, and new technologies as molecular gene testing may help to reach to a precise diagnosis. Several retinal clinical features in LCA may suggest a genetic or gene particular defect; thus genetic-molecular tools could directly corroborate the clinical diagnosis. Currently, approximately 20 genes have been associated to LCA. In this review, historical perspective, clinical ophthalmological findings, new molecular-genetics technologies, possible phenotype-genotypes correlations, and gene therapy for some LCA genes are described.

关键词： Gene therapy Leber congenital amaurosis Retinal dystrophies Childhood blindness

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The dual role of necrostatin-1 in Parkinson’s disease models

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Neural Regeneration Research 2021年第10期16卷 2019-2020页

作者： Eva Alegre-Cortes Guadalupe Martinez-chacon Jose M.Fuentes Sokhna M.S.Yakhine-Diop Universidad de Extremadura Depto.Bioquimica y Biologia Molecular y GeneticaFacultad de Enfermeria y Terapia OcupacionalAvda de la Universidad s/nCaceresSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED)Madrid Spain Instituto Universitario de Investigacion Biosanitaria de Extremadura(INUBE) CaceresSpain

Neuronal cell death is the main hallmark of Parkinson’s disease(PD).It is an irreversible process promoted by neurotoxins and/or genetic *** types of cell death have been associated with *** mechanisms by which neurons decide to specific type of cell death remain ***,it is well known that cell death can be either programmed or *** is a programmed cell death that involves the release of cytochrome c from damaged mitochondria to cytosol and the activation of caspases leading to nuclear *** is a caspase-independent cell death characterized by a gain in cell volume,rupture of plasma membrane and leak of cell contents,inflammation,and affects neighbouring *** was classified as a nonprogrammed cell death,but there are types of necrotic death triggered by a protein activation cascade,including necroptosis.

关键词： inflammation Necrosis rupture

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用MTT和resazurin对一线抗结核药物进行药物敏感性检测的多中心研究

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结核与肺部疾病杂志 2005年第4期8卷 171-175页

作者： A. Martin N. Morcillo D. Lemus E. Montoro M. A. da Silva Telles N. Simboli M. Pontino T. Porras C. León M. Velasco L. chacon L. Barrera V. Ritacco F. Portaels J. C. Palomino 张宗德 Institute of Tropical Medicine Antwerp Belgium Hospital Dr. A. Centrangolo Vicente Lopez Buenos Aires Argentina Institute de Medicina Tropical 'Pedro Kouri' La Habana Cuba Institute Adolfo Lutz Sao Paulo Brazil Institute carlos G. Malbran Buenos Aires Argentina Grupo de Micobacterias Subdireccion de Investigacion Institute Nacional de Salud Bogota Colombia Institute de Salud Publica de Chile Santiago Chile Centra Nacional de Diagnostico y Referencia Managua Nicaragua

目的:多中心评价两种快速价廉方法,MTT(3-[4.5-二甲基噻唑-2-一价烃基]-2.5-溴化二苯基四唑)和resazurin(刃天青)试验用于一线抗结核药物利福平(RMP)、异烟肼(INH)、乙胺丁醇(EMB)和链霉素(SM)的药敏检测。方法:30株编过号的结核分枝杆... 详细信息

目的:多中心评价两种快速价廉方法,MTT(3-[4.5-二甲基噻唑-2-一价烃基]-2.5-溴化二苯基四唑)和resazurin(刃天青)试验用于一线抗结核药物利福平(RMP)、异烟肼(INH)、乙胺丁醇(EMB)和链霉素(SM)的药敏检测。方法:30株编过号的结核分枝杆菌被送往拉丁美洲6个国家的7个试验室。每个试验室使用盲法,应用MTT和刃天青显色法进行一线药物利福平、异烟肼,乙胺丁醇和链霉素的药敏检测。获得的最低抑菌浓度的结果与传统的罗氏培养基比例法的结果进行对比。结果:确定临界浓度后,RMP,INH和EMB的结果非常好,特异性和敏感性介于96%-99%之间。结论:MTT和刃天青试验是非常有希望的一种方法,为中等资源以及资源贫乏国家进行一线结核药物的快速、价廉药敏试验方法提供了选择。

关键词：结核分枝杆菌 MTT 刃天青一线抗结核药物药物敏感性检测抗结核药物多中心研究刃天青试验药敏检测最低抑菌浓度

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