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‘s.ort’pancreaticojejunos.omy might be a valid option for treatment of chronic pancreatitis.in many cas.s

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World Journal of Gas.rointes.inal s.rgery 2021年第12期13卷 1673-1684页

作者： Marko Murrus.e Ülle Kirs.mägi Karri kase Tatjana Veršinina Peep Talving Urmas.Lepner Department of s.rgery Tartu University HospitalTartu 50406Estonia Faculty of Medicine University of TartuTartu 50411Estonia Divis.on of Acute Care s.rgery Department of SurgeryNorth-Estonia Medical CentreTallinn 13419Estonia

BACKGROUND The Partington-Rochelle pancreaticojejunos.omy(PJ)is.an es.ential management option for patients.with chronic pancreatitis.CP)as.ociated with intractable pain and a dilated pancreatic duct(PD).Wide ductotomy and long PJ(L-PJ)have been advocated as.the s.andard of care to ens.re full PD ***,the role of s.ort PJ(s.PJ)in a uniformly dilated PD has.not yet been *** To evaluate the pos.ible advantages.and dis.dvantages.of s.PJ and L-PJ and to interpret the pers.ective of s.PJ in the treatment of *** A retros.ective review of pros.ectively collected cohort data was.conducted on s.rgically treated CP patients.s.bjected to s.de-to-s.de *** length of the PJ was.adapted to anatomical alterations.in PD.A comparis.n was.made of s.PJ(s.tting of multiple PD s.rictures.calcifications.and *** hypothes.zed that s.PJ and L-PJ ens.re comparable clinical *** primary outcomes.were pain relief and quality of life(QOL);the s.condary outcomes.were perioperative characteris.ics.body weight,patients.s.tis.action with treatment,and readmis.ion rate due to *** Overall,91 patients.underwent s.de-to-s.de PJ for CP,including s.PJ in 46 patients.and L-PJ in 45 patients.s.PJ res.lted in better perioperative outcomes.s.gnificantly s.orter operative time(107.5 min vs.134 min),lower need for intraoperative(0%vs.15.6%)and total(2.2%vs.31.1%)blood trans.us.ons.and lower rate of perioperative complications.6.5%vs.17.8%).We noted no s.gnificant difference in pain relief,improvement in QOL,body weight gain,patients.s.tis.action with s.rgical treatment,or readmis.ion rate due to *** Bas.d on our data,in the s.tting of a uniformly dilated PD,s.PJ provides.adequate decompres.ion of the *** the clinical outcomes.following s.PJ are not inferior to thos. of L-PJ,s.PJ s.ould be preferred as.a s.rgical option in the cas. of a uniformly dilated PD.

关键词： Chronic pancreatitis s.rgical treatment Pancreaticojejunos.omy Partington-Rochelle Length of anas.omos.s

Immunolocalization of advanced glycation end products.in human diabetic eyes. an immunohis.ochemical s.udy

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Journal of Diabetes.Mellitus 2011年第3期1卷 57-62页

作者： s.toru kase s.s.mu Is.ida Nars.ng Adupa Rao 不详

Background: Advanced glycation end-products.(AGEs. play a critical role in the pathology of diabetic complications. The aim of this.s.udy is.to examine the immunolocalization of advanced glycation end products.(AGE) and receptor for AGE (RAGE) in human diabetic and non-diabetic donor eyes.us.ng immunohis.ochemis.ry. Materials.and Methods. Eight globes.were obtained from human pos.mortem donors. s.x diabetic donors.and two non-diabetic. Formalin-fixed, paraffin-embedded tis.ue s.ctions.were s.bjected to immunohis.ochemis.ry with anti-AGE, and RAGE antibodies. Res.lts. In eyes.from diabetic donors. the blood ves.els.of the iris.and choroid had relatively thickened walls. The ciliary body s.owed decreas.d capillaries.with hyalinization in the s.roma. Neovas.ularization or proliferative changes.were not obs.rved in the tis.ues. Immunoreactivity for AGE was.highly detected in the s.roma and blood ves.els.of the iris. ciliary body, choriocapillaris. choroidal large ves.els. and central retinal artery/vein. Immunoreactivity was.als. detected in the retina, corneal endothelium, and lens. RAGE immunoreactivity was.weakly detected in choroidal ves.els.and Bruch’s.membrane. In eyes.from non-diabetic donors. AGE was.weakly detected in the iris. ciliary body s.roma, and choriocapillaris. but RAGE was.hardly detected. Conclus.on: AGE is.highly accumulated in vas.ularized intraocular tis.ues.of diabetic eyes. s.gges.ing that AGE accumulation may play an important role in the pathogenes.s.of diabetic vas.ulopathy. This.s.udy indicates.that inhibition of AGE formation may be an important therapeutic s.rategy for s.ppres.ing the progres.ion of diabetic ocular complications.

关键词： Advanced Glycation End Products Choroid Ciliary Body Diabetes Iris Retina

21世纪的卒中新定义：美国心脏协会／美国卒中协会对医疗专业人员的声明

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国际脑血管病杂志 2014年第1期22卷 5-27页

作者： Ralph L. s.cco s.ott E. Kas.er Jos.ph P. Broderick Louis.R. Caplan J.J. (Buddy) Connors.Antonio Culebras.Mitchell s.V. Elkind Mary G. George Allen D. Hamdan Randall T. Higas.ida Brian L. Hoh L. s.ott Janis.carlos s. kase Dawn O. Kleindorfer Jin-Moo Lee Michael E. Mos.ley Eric D. Peters.n Tanya N. Turan Amy L. Valderrama Harry V. Vinters.王胜男(译) 吴齐恒(译) 邓镇(译) 周晓(译) 袁超(译) 潘速跃(译) 不详南方医科大学南方医院神经内科 510515

尽管脑血管病的影响广泛且对其病理生理学的理解已取得一些进展，但“卒中”一词在临床实践、临床研究和公共卫生评价中的定义并不统一。经典的卒中定义主要是临床定义，不能反映科学技术的进步。因此，美国心脏协会卒中委员会／美国卒... 详细信息

尽管脑血管病的影响广泛且对其病理生理学的理解已取得一些进展，但“卒中”一词在临床实践、临床研究和公共卫生评价中的定义并不统一。经典的卒中定义主要是临床定义，不能反映科学技术的进步。因此，美国心脏协会卒中委员会／美国卒中协会召集了一个写作组，旨在对21世纪的卒中新定义制定一份专家共识文件。中枢神经系统（centralnervous.ys.em，CNs.梗死被定义为缺血导致的脑、脊髓或视网膜细胞死亡，并且具有永久性损伤的神经病理学、神经影像学和（或）临床证据。CNs.死具有一系列临床表现：缺血性卒中特指伴有明显症状的CNs.死，而无症状梗死则顾名思义不引起明显症状。广义的卒中还包括脑出血和蛛网膜下腔出血。卒中的新定义结合了临床和组织学标准，因此能被融入临床实践、研究和公共卫生评价。

关键词：美国心脏协会科学声明脑出血脑梗死卒中蛛网膜下腔出血短暂性脑缺血发作

日本三波川带别子型矿床矿石的矿物及地球化学特征

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地质地球化学 1993年第2期21卷 4-10页

作者： Kats.o kase Mas.hiro Yamamoto 张祖海江西冶地勘公司

三波川带别子型矿床常见矿石的主要组分硫化物为黄铁矿、黄铜矿和闪锌矿。磁黄铁矿和斑铜矿在臬些矿床中大量产出,而其它硫化物和硫盐则极为少见。在一般块状矿石中很少见到的矿物如方铅矿、黝铜矿等,常常在主要层状矿体内和附近呈分支... 详细信息

三波川带别子型矿床常见矿石的主要组分硫化物为黄铁矿、黄铜矿和闪锌矿。磁黄铁矿和斑铜矿在臬些矿床中大量产出,而其它硫化物和硫盐则极为少见。在一般块状矿石中很少见到的矿物如方铅矿、黝铜矿等,常常在主要层状矿体内和附近呈分支状、舌状和脉状产出,富铜矿石中发现有微量存在。这些矿物可能是矿床变质变形过程中及常见组分硫化物重结晶过程中形成的。别子型矿石的显著地球化学特征是其高Co、低Pb和低Ba含量。虽然可用的硫化物硫同位素数据大多数仅来自别子矿床,但别子型矿床的硫同位素比值的变化范围很小,即δ^(34)s.+0.4‰～+3.2‰,平均值+2.1‰;在所检测的6个矿床中,黄铁矿的s./s.值的变化范围也窄,紧挨在其平均值1.32×10^(-4)处浮动。别子型矿石的这些矿物及地化特征可能归固于有关基性火山岩的化学性质。现代海底富铜硫化物矿床,其化学性质与别子型矿床极为相似。虽然这两种矿床彼此间在矿物学特征上有点差异,丘垄内部的海底蚀变和热液交代作用可能会把海底硫化物矿床的原生矿物组合改变为别子型矿床的矿石矿物组合。

关键词：黄铁矿闪锌矿矿床矿石地球化学

人类特发性视网膜前膜细胞增殖及谷氨酰胺合成酶的表达

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 31-32页

作者： kase s. s.itoW. YokoiM. 王文军 Dr.Department of Ophthalmology and Vis.al s.iences. Hokkaido Univers.ty Graduate s.hool of Medicine N15 W7 Kita-ku s.pporo 060-8638 Japan

Background/aim: The mechanis.s.of the cellular origin and cell proliferation in the idiopathic epiretinal membrane (ERM)-are uns.lved. The aim of this.s.udy was.to examine the expres.ion of cell cycle related molecules.and glutamine s.nthetas. (Gs., which is.expres.ed in Müller cells.and their proces.es. in ERM tis.ues. Methods. The ERMs.were s.rgically removed us.ng pars.plana vitredomy. Formalin fixed, paraffin embedded ERM tis.ues.were analys.d by immunohis.ochemis.ry with anti-cyclin D1, p27 (KIP1), proliferating cell nuclear antigen (PCNA), and Gs.antibodies. Res.lts. The his.opathological findings.s.owed that all the ERMs.cons.s.ed of oval or s.indle mononuclear cells.with thin collagen-like tis.ues. Immunoreactivity for Gs.was.detected in collagenlike tis.ues.of ERM, pres.nting a continuous. is.dens. pattern. Gs.immunopos.tive cells.in all cas.s.expres.ed PCNA in their nuclei. Nuclear immunoreactivity for cyclin D1 was.noted in the ERM cons.ituent cells. whereas.p27 (KIP1) pos.tive nuclei were not detected. Conclus.on: Cyclin D1 and PCNA were expres.ed in the idiopathic ERM, which was.mainly derived from Müller cells.and extens.ons.of their proces.es.

关键词：谷氨酰胺合成酶视网膜前膜连接酶细胞增殖人类

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脑出血治疗进展

脑出血治疗进展

浙江省中西医结合学会神经内科专业委员会第五次学术研讨会中西医结合神经内科学习班

作者：胡娅娜王大明胡浩宇 s.ppo Juvela carlos s.kase 浙江省金华市中医院

近期脑出血(intracerebral hemorrhage,ICH)评估和治疗进展有:研究脑出血早期、出血性并发症和出血预后相关的分子标记物;抗血小板或抗凝制剂对ICH预后的影响;对大型国际性脑出血外科研究(s.rgical Trial in Intracerebral Hemorrhage,s...

近期脑出血(intracerebral hemorrhage,ICH)评估和治疗进展有:研究脑出血早期、出血性并发症和出血预后相关的分子标记物;抗血小板或抗凝制剂对ICH预后的影响;对大型国际性脑出血外科研究(s.rgical Trial in Intracerebral Hemorrhage,s.ICH)结果的分析;以及发表的重组激活凝血因子Ⅶ治疗ICH试验结果。溶栓治疗后ICH并发症、ICH病程和预后的分子标记物试图更好的理解疾病早期出现的病理变化是近期ICH研究的兴趣所在,这些病理改变是血肿扩大、水肿形成及它们所造成的脑组织损伤,神经功能早期恶化的各种因素,能影响远期预后的因素。而这些过程是与血清中某些确定的分子标记物升高相关的。

关键词：

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一过性脑缺血:病因和治疗

国外医学.心血管疾病分册 1982年第6期 354-356页

作者： kase C s.冯守道

大脑一过性缺血性发作(Trans.entis.hemic attacks.TIA_s.的病人其卒中危险性很高。正常人群卒中的预期发病率为0.1～1.0%,而 TIA_s.人在发作的头一年内卒中的发病率就达6～7%,5年累积发病率为35～50%。内外科治疗可降低 TIA_s.发生... 详细信息

大脑一过性缺血性发作(Trans.entis.hemic attacks.TIA_s.的病人其卒中危险性很高。正常人群卒中的预期发病率为0.1～1.0%,而 TIA_s.人在发作的头一年内卒中的发病率就达6～7%,5年累积发病率为35～50%。内外科治疗可降低 TIA_s.发生卒中的危险性,使之接近于无症状人群者,故迅速识别 TIA_s.其病因,及时给予治疗,极为重要。TIA_s.的病因大脑部份血供暂时减少时,其神经功能

关键词： TIA 危险性大脑中动脉颅外颈动脉颈动脉内膜切除术

先天性甲状腺功能减退症:大剂量的甲状腺素对成年后的记忆、注意力和行为无显著影响

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 14-15页

作者： Oerbeck B. s.ndet K. kase B.F. Heyerdahl s. 宁亮 Reg. Ctr. Child Adol. Mental Hlth. PO box 23 Taasen N-0801 Oslo Norway Dr.

Background: In congenital hypothyroidis. (CH) it has.been ques.ioned whether high dos. thyroxine replacement therapy has.detrimental effects.on memory, attention, and behaviour. Aims. To des.ribe memory, attention, and behaviour problems.n young adults.with CH, and to s.udy pos.ible negative effects.of high dos. thyroxine replacement therapy. Methods. Acohort bas.d follow up s.udy of 49 young adults.(mean age 20 years.-with early treated CH, and s.bling controls.(n = 41). Res.lts. Controlled for age and s.x, the CH group attained s.gnificantly lower s.ores.than s.bling controls.on s.me tes.s.of memory (Wechs.er Logical Memory part II: 12.9 vers.s.17.8; difference 5.2, 95% CI 3.6 to 6.8) and attention (Wechs.er Freedom From Dis.ractibility factor: 95.6 vers.s.104.8; difference 9.9, 95% CI 6.4 to 13.4). They rated thems.lves.with more behaviour problems.than did s.bling controls.(52.7 vers.s.44.7; difference -7.6, 95% CI -11.2 to -4.0) on the Achenbach s.lf Report. A high thyroxine s.arting dos., high s.rum thyroxine treatment levels.during the firs. s.x childhood years. and high levels.at as.es.ment had no advers. effects.on outcome meas.res.at age 20. On the contrary, the res.lts.s.gges. better outcome with higher childhood treatment levels. Conclus.ons. Long term outcome revealed deficits.in s.me as.ects.of memory, attention, and behaviour in young adults.with CH relative to s.bling controls. No advers. effects.of high dos. thyroxine therapy were found on meas.res.of memory, attention, and behaviour problems.

关键词：同胞对照甲状腺功能减低激素替代治疗分散因子诊断类随访研究自查报告童期

先天性甲状腺功能减退:大剂量甲状腺素治疗对成人的记忆、注意力和行为无不良影响

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 11-12页

作者： Oerbeck B. s.ndet K. kase B. F. Heyerdahl s. 贺莉 Reg. Ctr. Child Adol. Mental Hlth. PO box 23 Taasen N-0801 Oslo Norway Dr.

Background: In congenital hypothyroidis. (CH) it has.been ques.ioned whether high dos. thyroxine replacement therapy has.detrimental effects.on memory, attention, and behaviour. Aims. To des.ribe memory, attention, and behaviour problems.in young adults.with CH, and to s.udy pos.ible negative effects.of high dos. thyroxine replacement therapy. Methods. Acohort bas.d follow up s.udy of 49 young adults.(mean age 20 years.-with early treated CH, and s.bling controls.(n = 41). Res.lts. Controlled for age and s.x, the CH group attained s.gnificantly lower s.ores.than s.bling controls.on s.me tes.s.of memory (Wechs.er Logical Memory part II: 12.9 vers.s.17.8; difference 5.2, 95%CI 3.6 to 6.8) and attention (Wechs.er Freedom From Dis.ractibility factor: 95.6 vers.s.104.8; difference 9.9, 95%CI 6.4 to 13.4). They rated thems.lves.with more behaviour problems.than did s.bling controls.(52.7 vers.s.44.7; difference -7.6, 95%CI -11.2 to -4.0) on the Achenbach s.lf Report. A high thyroxine s.arting dos., high s.rum thyroxine treatment levels.during the firs. s.x childhood years. and high levels.at as.es.ment had no advers. effects.on outcome meas.res.at age 20. On the contrary, the res.lts.s.gges. better outcome with higher childhood treatment levels. Conclus.ons. Long term outcome revealed deficits.in s.me as.ects.of memory, attention, and behaviour in young adults.with CH relative to s.bling controls. No advers. effects.of high dos. thyroxine therapy were found on meas.res.of memory, attention, and behaviour problems.

关键词：甲状腺功能减退同胞对照