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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci carlos Rocha Oliveira gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUV-LED EBL simulation

Training birdsong recognition using virtual reality

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Virtual Reality & Intelligent Hardware 2021年第5期3卷 397-406页

作者： carlos ARCE-LOPERA María JoséARIAS gustavo CORRALES Department of Technology and Information Universidad IcesiCali 760046Colombia

Background In mega-biodiverse environments,where different species are more likely to be heard than seen,species monitoring is generally performed using bioacoustics ***,since bird vocalizations are reasonable estimators of biodiversity,their monitoring is of great importance in the formulation of conservation ***,birdsong recognition is an arduous task that requires dedicated training in order to achieve mastery,which is costly in terms of time and money due to the lack of accessibility of relevant information in field trips or even specialized *** technology based on virtual reality(VR)and spatial audio may improve species monitoring by enhancing information accessibility,interaction,and user *** This study used spatial audio,a Bluetooth controller,and a head-mounted display(HMD)to conduct an immersive training experience in *** moved inside a virtual world using a Bluetooth controller,while their task was to recognize targeted *** measured the accuracy of recognition and user engagement according to the User Engagement *** The experimental results revealed significantly higher engagement and accuracy for participants in the VR-based training system than in a traditional computer-based training *** four dimensions of the user engagement scale received high ratings from the participants,suggesting that VR-based training provides a motivating and attractive environment for learning demanding tasks through appropriate design,exploiting the sensory system,and virtual reality *** The accuracy and engagement of the VR-based training system were significantly high when tested against traditional *** research will focus on developing a variety of realistic ecosystems and their associated birds to increase the information on newer bird species within the training ***,the proposed VR-based training system must be tested with ad

关键词： Human computer interaction Virtual environment Birdsong Audio training User engagement

Fast preparation route to high-performances textured Sr-doped Ca_3Co_4O_9 thermoelectric materials through precursor powder modification

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Science China Materials 2019年第3期62卷 399-406页

作者： Miguel Angel Torres gustavo Garcia Idoia Urrutibeascoa Maria Antonieta Madre Juan carlos Diez Andres Sotelo ICMA (CSIC-Universidad de Zaragoza) Centro Stirling S. Coop. Mondragon Unibertsitatea

This work presents a short and very efficient method to produce high performance textured Ca_3Co_4O_9 thermoelectric materials through initial powders modification. Microstructure has shown good grain orientation, and low porosity while slightly lower grain sizes were obtained in samples prepared from attrition milled powders. All samples show the high density of around 96% of the theoretical *** similar characteristics are reflected in, approximately,the same electrical resistivity and Seebeck coefficient values for both types of samples. However, in spite of similar power factor(PF) at low temperatures, it is slightly higher at high temperature for the attrition milled samples. On the other hand, the processing time reduction(from 38 to 2 h) when using attrition milled precursors, leads to lower mechanical properties in these samples. All these data clearly point out to the similar characteristics of both kinds of samples, with a drastic processing time decrease when using attrition milled precursors, which is of the main economic importance when considering their industrial production.

关键词： ceramics oxides hot-pressing electrical properties power factor

Smart Contract to Traceability of Food Social Selling

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Computers, Materials & Continua 2023年第3期74卷 4703-4728页

作者： Cristian Valencia-Payan JoséFernando Grass-Ramírez gustavo Ramirez-Gonzalez Juan carlos Corrales University of Cauca Calle 5#4-70190003Popayan-CaucaColombia

Traditionally,food sustainability has been considered solely in the stage of agricultural ***,globalization,the expansion of the food production industry,and the emergence of supermarket chains that control the retail food market require specific significant changes in supply chains in the food sector and,therefore,we need to address the economic,social,and environmental impacts of these *** the other hand,social selling has increased rapidly in recent years,with a further boom,following current events related to the coronavirus disease(COVID-19).This explosion of social sales,where there are usually no control and regulation entities,can bring problems associated with mishandling *** this paper,we expose how Blockchain technology supports the traceability of social sales by validating the data provided by the chain participants such as digital health passports,production and transport data in the sale process;the proposed solution generates recommendations on productmanagement considering the agreements previously made by the network *** evaluate the proposed smart contracts,we useHyperledger Caliper,obtaining an average throughput of 12.6 transactions per second and an average latency of 0.3 s for the asset update *** also use a study case to evaluate the proposed project platform’s selling-transport stage using Internet of Things(IoT)sensors.

关键词： Blockchain reliability smart contracts social selling traceability artisan sweets

Entanglement,Identical Particles and the Uncertainty Principle

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Communications in Theoretical Physics 2016年第8期65卷 201-206页

作者： gustavo Rigolin Departamento de Fisica Universidade Federal de Sao Carlos 13565-905 Sao Carlos SP Brazil

A new uncertainty relation(UR) is obtained for a system of N identical pure entangled particles if we use symmetrized observables when deriving the inequality. This new expression can be written in a form where we identify a term which explicitly shows the quantum correlations among the particles that constitute the system. For the particular cases of two and three particles, making use of the Schwarz inequality, we obtain new lower bounds for the UR that are different from the standard one.

关键词： quantum mechanics uncertainty relations identical and entangled particles

A Bidimensional Finite Element Study of Crack Propagation in Austempered Ductile Iron

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Computers, Materials & Continua 2023年第11期77卷 1411-1424页

作者： gustavo von Zeska de França Roberto Luís de Assumpção Marco Antonio Luersen carlos Henrique da Silva Department of Mechanical Engineering Federal University of Technology–ParanáCuritiba81280-340Brazil

Austempered ductile iron(ADI)is composed of an ausferritic matrix with graphite nodules and has a wide range of applications because of its high mechanical strength,fatigue resistance,and wear resistance compared to other cast *** amount and size of the nodules can be controlled by the chemical composition and austenitizing *** the nodules have lower stiffness than the matrix and can act as stress concentrators,they influence crack ***,the crack propagation mechanism in ADI is not yet fully *** this study,we describe a numerical investigation of crack propagation in ADIs subjected to cyclic *** numerical model used to calculate the stress intensity factors in the material under the given conditions is built with the aid of Abaqus commercial finite element *** crack propagation routine,which is based on the Paris law,is implemented in *** results of the simulation show that the presence of a nodule generates a shear load on the crack ***,even under uniaxial tensile loading,the presence of the nodule yields a non-zero stress intensity factor in mode II,resulting in a deviation in the crack propagation *** is the primary factor responsible for changing the crack propagation direction towards the *** the parameters,for example,increasing the nodule size or decreasing the distance between the nodule and crack tip,can intensify this *** simulations comparing two different ADIs with the same graphite fraction area,the crack in the material with more nodules reaches another nodule in a shorter propagation time(or shorter number of cycles).This suggests that the high fatigue resistance observed in ADIs may be correlated with the number of nodules intercepted by a crack and the additional energy required to nucleate new *** summary,these findings contribute to a better understanding of crack propagation in ADIs,provide insights into the relationship between the presence

关键词： Austempered ductile iron(ADI) fatigue crack propagation graphite nodule

Management of gallstones and gallbladder disease in patients undergoing gastric bypass

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World Journal of Gastroenterology 2010年第17期16卷 2075-2079页

作者： Bernabé M Quesada gustavo Kohan Hernán E Roff carlos M Canullán Luis T Chiappetta Porras Department of Surgery Cosme Argerich HospitalAlte.Brown 240ZC 1155 Buenos AiresArgentina

The appropriate management of gallstones and gallbladder disease in patients undergoing gastric bypass remains *** therapeutic modalities are used and include performing cholecystectomy on all patients at the time of gastric bypass,performing concomitant cholecystectomy only when patients have gallstones and performing cholecystectomy only in the presence of both symptoms and *** groups administer ursodeoxycholic acid for gallstone prevention in the postoperative *** treatment modalities are analyzed and their results and rationality are discussed.

关键词： Gallbladder Gastric bypass Morbid obesity Gallstones Cholecystectomy

Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy

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World Journal of Gastroenterology 2008年第13期14卷 2126-2127页

作者： Silvia Sookoian gustavo Castao carlos J Pirola Department of Molecular Genetics and Biology of Complex Diseases Institute of Medical Research A. Lanari University of Buenos Aires-CONICET Buenos Aires 1427 Argentina Research Council of GCBA Buenos Aires 1427 Argentina

The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic predisposition. We would like to add some comments on a paper recently published concerning the role of ABCB11 and ABCC2 polymorphisms in both ICP and contraceptive-induced cholestasis, especially in the light of our recently published findings about a positive association between ICP and ABCC2 common variants.

关键词： Intrahepatic cholestasis of pregnancy ABCC2 MRP2 Gene variants