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Case study for investigating groundwater and the future of mountain spring discharges in Southern Italy

Journal of Mountain Science 2017年第9期14卷 1791-1800页

作者： Nazzareno DIODATO Gianni BELLOCCHI Francesco FIORILLO gerardo VENTAFRIDDA Science and Technology Department University of Sannio 82100 Benevento Italy Met European Research Observatory 82100 Beneuento Italy UMR Ecosysteme Frairial INRA VetAgro Sup 63000 Clermont-Ferrand France Acquedotto Pugliese S.p.A. 70121 Bari Italy

Groundwater extraction is used to alleviate drought in many habitats. However, widespread drought decreases spring discharge and there is a need to integrate climate change research into resource management and action. Accurate estimates of groundwater discharge may be valuable in improving decision support systems of hydrogeological resource exploitation. The present study performs a forecast for groundwater discharge in Aquifer?s Cervialto Mountains(southern Italy). A time series starting in 1883 was the basis for longterm predictions. An Ensemble Discharge Prediction(EDis P) was applied, and the progress of the discharge ensemble forecast was inferred with the aid of an Exponential Smoothing(ES) model initialized at different annual times. EDisP-ES hindcast model experiments were tested, and discharge plume-patterns forecast was assessed with horizon placed in the year 2044. A 46-year cycle pattern was identified by comparing simulations and observations, which is essential for the forecasting purpose. ED is P-ES performed an ensemble mean path for the coming decades that indicates a discharge regime within ± 1 standard deviation around the mean value of 4.1 m^3 s^(-1). These fluctuations are comparable with those observed in the period 1961-1980 and further back, with changepoints detectable around the years 2025 and 2035. Temporary drought conditions are expected after the year 2030.

关键词： Caposele(Italy) Ground water Drought Ensemble forecast Exponential smoothing Spring discharge

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Insecticidal Effect of Green Bimetallic Nanoparticles from Crotalaria longirostrata on Cotton Mealybug,Phenacoccus solenopsis

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Journal of Renewable Materials 2022年第10期10卷 2543-2552页

作者： Vianey Mendez-Trujillo Benjamín Valdez-Salas Mario Curiel-Alvarez Ernesto Beltran-Partida Arnoldo Alfaro-Corres EsaúRuiz-Sanchez gerardo Bautista-Trujillo Olivia Tzintzun Camacho Onecimo Grimaldo-Juarez carlos Ceceña-Duran carlos Ail-Catzin Daniel González-Mendoza Facultad de Medicina de la Universidad Autónoma de Baja California Dr.Humberto Torres Sanginés S/NCentro CívicoMexicaliBaja CaliforniaMéxico Instituto de Ingeniería de la Universidad Autónoma de Baja California Calle de la Normal S/N y Boulevard Benito JuárezMexicaliBaja CaliforniaMéxico Instituto Tecnológico de Conkal División de Estudios de Posgrado e InvestigaciónAntigua Carretera Mérida-MotulConkalYucatánMéxico Facultad de Medicina Veterinaria y Zootecnia de la Universidad Autónoma de Chiapas ChiapasMéxico Universidad Autónoma de Baja California Instituto de Ciencias AgrícolasBaja CaliforniaMéxico

The present study was conducted to evaluate the impact of bimetallic nanoparticles(NPs)of copper(Cu)and zinc(Zn)from Crotalaria longirostrata on the insect mortality and cell viability of Phenacoccus *** biosynthesis of bimetallic nanoparticles(Cu/Zn-NPs)from *** was confirmed by the presence of a single peak around 378 *** hydrodynamic diameter of the Cu/Zn nanoparticles varied from 59 to 119 nm and their zeta potential was found to be−30.90 *** EDX analysis showed a strong signal for Cu and Zn(8 and 8.6 keV,respectively).The Cu/Zn-NPs showed an effective insecticide activity against *** with 63%of insect mortality after 96 h ***,further studies about nanotoxicity of Cu/Zn-NPs from *** are needed to reveal the exact mechanism of nanoparticles toxicity in insects.

关键词： Phytonanoparticles chipilin biocontrol agronanotechnology

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New perspectives in the treatment of advanced or metastatic gastric cancer

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World Journal of Gastroenterology 2009年第22期15卷 2689-2692页

作者： gerardo Rosati Domenica Ferrara Luigi Manzione Medical Oncology Unit S.Carlo Hospital

Metastatic gastric cancer remains an incurable disease,with a relative 5-year survival rate of 7%-27%.Chemotherapy,which improves overall survival(OS) and quality of life,is the main treatment *** has demonstrated that the best survival results obtained in earlier randomized studies were achieved with three-drug regimens containing a fluoropyrimidine,an anthracycline,and cisplatin(ECF).Although there has been little progress in improving median OS times beyond the 9-mo plateau achievable with the standard regimens,the availability of newer agents has provided some measure of optimism.A number of new combinations incorporating docetaxel,oxaliplatin,capecitabine,and S-1 have been explored in randomized *** combinations,such as epirubicin-oxaliplatin-capecitabine,have been shown to be as effective as(or perhaps more effective than) ECF,and promising early data have been derived for S-1 in combination with *** factor that might contribute to extending median OS is the advancement whenever possible to second-line cytotoxic ***,the biggest hope for signif icant survival advances in the near future would be the combination of new targeted biological agents with existing chemotherapy f irst-line regimens.

关键词： Advanced gastric cancer Biological agents Chemotherapy

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Milestones in the discovery of hepatitis C

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World Journal of Gastroenterology 2022年第37期28卷 5395-5402页

作者： Octavio Campollo gerardo Amaya P Aiden McCormick Center of Studies on Alcohol and Addictions Antiguo Hospital Civil de GuadalajaraDepartment of Medical ClinicsUniversidad de GuadalajaraGuadalajara 44280JaliscoMexico Medical Clinics CUCSUniversidad de GuadalajaraGuadalajara 44280JaliscoMexico Department of Hepatology Saint Vincent’s University HospitalNational Liver Transplant UnitDublin D04Ireland

The discovery of hepatitis C has been a landmark in public health as it brought the opportunity to save millions of lives through the diagnosis,prevention and cure of the *** combined work of three researchers,Alter H,Houghton M and Rice C,which set the basis for the diagnosis,treatment and prevention of hepatitis C apart from laying the ground work for a new approach to study infections in general and developing new antiviral *** is a story of a transfusion-associated infection.A series of clinical studies demonstrated the existence of an infectious agent associated with *** was followed by the identification of what was later known to be the hepatitis C virus(HCV)and the development of diagnostic *** all preceded the full molecular identification and demonstration of a causal *** it ended up with the development and discovery of a new class of therapeutic drugs,the direct acting antivirals,which are now used not only to cure the disease but most probably,to eliminate the *** work started with Dr Alter H who demonstrated that a new virus was responsible for the majority of post-transfusion hepatitis followed by Houghton M who cloned the virus and developed the blood test to identify those cases that carried the ***,the work of Rice C demonstrated that a cloned HCV produced after applying molecular biology techniques could cause long-standing infection and cause the same disease as the one observed in humans.

关键词： Hepatitis C Nobel prize Discovery Diagnosis Treatment Elimination World Health Organization initiative

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Association of TCF7L2 mutation and atypical diabetes in a Uruguayan population

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World Journal of Diabetes 2018年第9期9卷 157-164页

作者： Carolina Beloso Jorge Souto Matias Fábregat gerardo Romanelli gerardo Javiel Adriana Mimbacas Biodiversity and Genetics Department Instituto de Investigaciones Biológicas Clemente Estable Cytogenetics Laboratory Hematology and Transplant Service of Hematopoietic Progenitors Maciel Hospital ASSE Department of Genetics Faculty of Medicine UDELAR Human Molecular Genetics Laboratory Institut Pasteur de Montevideo Cell Signaling and Nanobiology Laboratory Instituto de Investigaciones Biológicas Clemente Estable Unit of Diabetes Hospital Pasteur ASSE-Ministry of Public Health Diabetologyc Service of Private Health Center Centro de Asistencia del Sindicato Médico del Uruguay

AIM To investigate if mutations in TCF7 L2 are associated with "atypical diabetes" in the Uruguayan *** Healthy, nondiabetic controls(n = 133) and patients with type 2 diabetes(n = 177) were selected from among the presenting population at level-3 referral healthcare centers in Uruguay. Patients with type 2 diabetes were subgrouped according to "atypical diabetes"(n = 92) and "classical diabetes"(n = 85). Genotyping for the rs12255372 and rs7903146 single nucleotide polymorphisms(SNPs) in the TCFTL2 gene was carried out with Taq Man? probes. Random samples were sequenced by Macrogen Ltd.(South Korea). Statistical analysis of the SNP data was carried out with the SNPStats online tool(http://***/SNPstats). The best inheritance model was chosen according to the lowest values of Akaike's information criterion and Bayesian information criterion. Differences between groups were determined by unpaired t-tests after checking the normal distribution or were converted to normalize the data. The association of SNPs was tested for matched case-control samples by using χ2 analysis and calculation of odds ratios(ORs) with 95% confidence intervals(CIs). All statistical tests were performed using SPSS v10.0 and EpiI nfo7 statistical packages. Significant statistical differences were assumed in all cases showing adjusted P < *** We genotyped two TCF7 L2 SNPs(rs7903146 and rs12255372) in a population-based sample of 310 Uruguayan subjects, including 133 healthy control subjects and 177 clinical diagnosed with type 2 diabetes. For both SNPs analyzed, the best model was the dominant type: rs12255372 = G/G vs G/T+T/T, OR = 0.63, 95%CI: 0.40-0.98, P < 0.05 and rs7903146 = C/C vs C/T+T/T, OR = 0.79, 95%CI: 0.41-1.55, P = 0.3. The rs12255372 SNP showed high association with the type 2 diabetes cases(OR = 1.60, 95%CI: 1.20-2.51, P < 0.05). However, when the type 2 diabetics group was analyzed according to the atypical and classical subgroupings, t

关键词： TCF7L2 Atypical diabetes Type 2 diabetes Latin America TaqMan

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Cheap and secure metatransactions on the blockchain using hash-based authorisation and preferred batchers

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Blockchain(Research and Applications) 2023年第2期4卷 41-66页

作者： William Hughes Tobias Magnusson Alejandro Russo gerardo Schneider Dept.of Computer Science and Engineering University of Gothenburg41296GothenburgSweden Dept.of Computer Science and Engineering Chalmers University41296GothenburgSweden

Smart contracts are self-executing programs running in the blockchain allowing for decentralised storage and execution without a ***-chain execution is expensive,with miners charging fees for distributed execution according to a cost model defined in the *** particular,transactions have a high fixed *** present MultiCall,a transaction-batching interpreter for Ethereum that reduces the cost of smart contract executions by gathering multiple users’transactions into a *** current implementation of MultiCall includes the following features:the ability to emulate Ethereum calls and create transactions,both from MultiCall itself and using an identity unique to the user;the ability to cheaply pay Ether to other MultiCall users;and the ability to authorise emulated transactions on behalf of multiple users in a single transaction using hash-based authorisation rather than more expensive *** improves upon a previous version of *** experiments show that MultiCall provides a saving between 57%and 99%of the fixed transaction cost compared with the standard approach of sending Ethereum transactions directly.

关键词： Ethereum Domain-specific language Interpreter Gas optimisation

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Safety and Efficacy of Oral Mirodenafil in Mexican with Erectile Dysfunction

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International Journal of Clinical Medicine 2016年第9期7卷 628-638页

作者： Juan gerardo Reyes-garcía Noemí Santos-Caballero Francisco Javier Flores-Murrieta Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional Ciudad de México Mexico Landsteiner Scientific S.A. de C.V. Ciudad de México Mexico Unidad de Investigación en Farmacología Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas” Ciudad de México Mexico

Erectile dysfunction is treated with 5-phospodiesterase inhibitors as Mirodenafil, which has shown its efficacy and safety in Koreans, however;no information in other populations is available. An open clinical trial study was designed to evaluate the efficacy and safety in real life of a fixed-dose of Mirodenafil in Mexican patients with erectile dysfunction. Forty-seven male patients received a 100 mg tablet of Mirodenafil, during 12 weeks. Primary outcome efficacy measure was the percentage of male patients with successful intercourse. Secondary outcomes measures included patient satisfaction, mood and self-esteem level. Safety assessments included laboratory tests, vital signs, physical examination, 12-lead electrocardiogram recordings, and incidence of adverse events by patients. Oral administration of Mirodenafil improved in an 80% - 90% the number of successful intercourses from 7 to 84 days of treatment. Moreover, patients reported a significant increment in their sexual satisfaction, mood and self-esteem. Mirodenafil treatment did not modify vital signs nor anthropometric parameters during 84 days. Mild headache was the most frequent adverse event (17.0%) and there were no severe adverse events during pharmacological treatment. Data suggest that oral Mirodenafil is safety, well tolerated and effective in the Mexican population with erectile dysfunction.

关键词： Efficacy Erectile Dysfunction Mexicans Mirodenafil Safety

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Transmission potential of the novel coronavirus (COVID-19) onboard the diamond Princess Cruises Ship, 2020

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Infectious Disease Modelling 2020年第1期5卷 264-270页

作者： Kenji Mizumoto gerardo Chowell Graduate School of Advanced Integrated Studies in Human Survivability Kyoto University Yoshida-Nakaadachi-choSakyo-kuKyotoJapan Hakubi Center for Advanced Research Kyoto UniversityYoshidahonmachiSakyo-kuKyotoJapan Department of Population Health Sciences School of Public HealthGeorgia State UniversityAtlantaGeorgiaUSA Division of International Epidemiology and Population Studies Fogarty International CenterNational Institutes of HealthBethesdaUSA

An outbreak of COVID-19 developed aboard the Princess Cruises Ship during January eFebruary *** mathematical modeling and time-series incidence data describing the trajectory of the outbreak among passengers and crew members,we characterize how the transmission potential varied over the course of the *** estimate of the mean reproduction number in the confined setting reached values as high as^11,which is higher than mean estimates reported from community-level transmission dynamics in China and Singapore(approximate range:1.1e7).Our findings suggest that Rt decreased substantially compared to values during the early phase after the Japanese government implemented an enhanced quarantine *** recent estimates of Rt reached values largely below the epidemic threshold,indicating that a secondary outbreak of the novel coronavirus was unlikely to occur aboard the Diamond Princess Ship.

关键词： Corona Epidemic Confined settings Cruise Next generation matrix

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Is it growing exponentially fast? -Impact of assuming exponential growth for characterizing and forecasting epidemics with initial near-exponential growth dynamics

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Infectious Disease Modelling 2016年第1期1卷 71-78页

作者： gerardo Chowell Cecile Viboud School of Public Health Georgia State UniversityAtlantaGAUSA Division of International Epidemiology and Population Studies Fogarty International CenterNational Institutes of HealthBethesdaMDUSA

The increasing use of mathematical models for epidemic forecasting has highlighted the importance of designing models that capture the baseline transmission characteristics in order to generate reliable epidemic *** models for epidemic forecasting could be achieved by identifying signature features of epidemic growth,which could inform the design of models of disease spread and reveal important characteristics of the transmission *** particular,it is often taken for granted that the early growth phase of different growth processes in nature follow early exponential growth *** the context of infectious disease spread,this assumption is often convenient to describe a transmission process with mass action kinetics using differential equations and generate analytic expressions and estimates of the reproduction *** this article,we carry out a simulation study to illustrate the impact of incorrectly assuming an exponential-growth model to characterize the early phase(e.g.,3e5 disease generation intervals)of an infectious disease outbreak that follows near-exponential growth ***,we assess the impact on:1)goodness of fit,2)bias on the growth parameter,and 3)the impact on short-term epidemic *** findings indicate that devising transmission models and statistical approaches that more flexibly capture the profile of epidemic growth could lead to enhanced model fit,improved estimates of key transmission parameters,and more realistic epidemic forecasts.

关键词： dynamics. process. exponential

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A primer on stable parameter estimation and forecasting in epidemiology by a problem-oriented regularized least squares algorithm

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Infectious Disease Modelling 2017年第2期2卷 268-275页

作者： Alexandra Smirnova gerardo Chowell Department of Mathematics and Statistics Georgia State UniversityAtlantaUSA School of Public Health Georgia State UniversityAtlantaUSA Division of International Epidemiology and Population Studies Fogarty International CenterNational Institutes of HealthBethesdaMDUSA

Public health officials are increasingly recognizing the need to develop disease-forecasting systems to respond to epidemic and pandemic *** instance,simple epidemic models relying on a small number of parameters can play an important role in characterizing epidemic growth and generating short-term epidemic *** the absence of reliable information about transmission mechanisms of emerging infectious diseases,phenomenological models are useful to characterize epidemic growth patterns without the need to explicitly model transmission mechanisms and the natural history of the *** this article,our goal is to discuss and illustrate the role of regularization methods for estimating parameters and generating disease forecasts using the generalized Richards model in the context of the 2014e15 Ebola epidemic in West Africa.

关键词： Generalized Richards model Parameter estimation Regularization methods Epidemic forecasting Ebola

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