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Insulin resistance is associated with subclinical vascular disease in humans

World Journal of Diabetes 2019年第2期10卷 63-77页

作者： María M Adeva-Andany Eva Ameneiros-Rodríguez carlos fernández-fernández Alberto Domínguez-Montero Raquel Funcasta-Calderón Internal Medicine Department Hospital General Juan Cardona

Insulin resistance is associated with subclinical vascular disease that is not justified by conventional cardiovascular risk factors,such as smoking or *** injury associated to insulin resistance involves functional and structural damage to the arterial wall that includes impaired vasodilation in response to chemical mediators,reduced distensibility of the arterial wall(arterial stiffness),vascular calcification,and increased thickness of the arterial *** dysfunction associated to insulin resistance is present in asymptomatic subjects and predisposes to cardiovascular diseases,such as heart failure,ischemic heart disease,stroke,and peripheral vascular *** and functional vascular disease associated to insulin resistance is highly predictive of cardiovascular morbidity and *** pathogenic mechanisms remain *** studies have demonstrated that animal protein consumption increases the risk of developing cardiovascular disease and predisposes to type 2 diabetes(T2D)whereas vegetable protein intake has the opposite *** disease linked to insulin resistance begins to occur early in *** and adolescents with insulin resistance show an injured arterial system compared with youth free of insulin resistance,suggesting that insulin resistance plays a crucial role in the development of initial vascular *** of the vascular dysfunction related to insulin resistance should begin early in *** the clinical onset of T2D,asymptomatic subjects endure a long period of time characterized by insulin *** vascular dysfunction begins to develop during this phase,so that patients with T2D are at increased cardiovascular risk long before the diagnosis of the disease.

关键词： Diabetes Cardiovascular risk Arterial stiffness Arterial elasticity Intimamedia thickness Vascular calcification Insulin resistance Animal protein Vegetable protein

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A demand side management approach to increase self-consumption in buildings

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Building Simulation 2023年第2期16卷 317-335页

作者： carlos fernández Bandera Gabriela Bastos Porsani María fernández-Vigil Iglesias School of Architecture University of Navarra31009 PamplonaSpain

There is a growing interest in increasing the presence of renewable energy in the electric *** production from grid-connected systems is leading this growth in terms of *** this development,concern about network security has emerged,because excesses of intermittent renewable energy on the grid could exceed voltage ***-consumption,understood as the capacity of the producer to consume his or her own production,can partially solve these *** controllable loads,such as heating and cooling,represent 50%of the total amount of energy consumed by buildings;the proper allocation of these loads could be a driving force for *** this study,a demand side management strategy is proposed based on a building energy model equipped with an inverter heat pump coupled with a photovoltaic *** goal is to maximize the use of local energy from the photovoltaic plant(self-consumption),reducing the export and import of energy to and from the *** goal is achieved by optimizing the set-points in each *** array of optimal set-points over six years is *** results show the capacity of the methodology to match similar values of self-consumption(70%in winter and 50%in summer)obtained by strategies based on chemical *** findings are shown in an energy matching chart at different levels of detail(yearly and monthly).Color bubbles are added to the matching chart to help visualize the unmatched energy of the system *** comparison with actual model predictive control technologies,this study’s strategy offers great simplicity and a large saving in computational time.

关键词： sensor data internal thermal mass energy simulation EnergyPlus inverse model

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A building energy models calibration methodology based on inverse modelling approach

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Building Simulation 2022年第11期15卷 1883-1898页

作者： Vicente Gutiérrez González carlos fernández Bandera Installations construction and structuresSchool of ArchitectureUniversity of NavarraCampus UniversitarioPamplona31009NavarraSpain

Nowadays,building energy models(BEMs)are widely used,particularly in the assessment of energy consumption in buildings to address the potential savings that can be *** realisation of a dynamic energy model based on high-fidelity physics(white-box models)requires a tuning process to fit the model to reality,due to many uncertainties *** some research trends try to reduce this performance gap by modulating different types of experimental parameters such as:capacitances or *** EnergyPlus simulation software,in its latest versions,has implemented an object:HybridModel:Zone that calculates the infiltration and internal mass of buildings using an inverse modelling approach that employs only the measured indoor temperature data to invert the heat balance equation for the zone under *** main objective of this paper is to reduce the execution time and uncertainties in the development of quality energy models by generating a new calibration methodology that implements this *** uses,as a starting point,a research created by the authors of this study,which was empirically and comparatively validated against the energy models developed by the participants in Annex *** is also worth highlighting the empirical validation of the HybridModel:Zone object,since it was activated in all scenarios where its execution is possible:periods of seven days or more of free oscillation and periods in which the building is under *** findings are *** data generated with the new methodology,if compared with those produced by the baseline model,improve their resemblance to the real ones by 22.9%.While those of its predecessor did it by 15.6%.For this study,the two dwellings foreseen in Annex 58 of the IEA ECB project have been modelled and their real monitoring data have been used.

关键词： internal thermal mass energy simulation EnergyPlus inverse model Annex 58 infiltration

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The versatility of Fe(Ⅱ) in the synthesis of uniform citrate-stabilized plasmonic nanoparticles with tunable size at room temperature

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Nano Research 2020年第9期13卷 2351-2355页

作者： carlos fernández-Lodeiro Javier fernández-Lodeiro Enrique Carbó-Argibay carlos Lodeiro Jorge Pérez-Juste Isabel Pastoriza-Santos CINBIO Universidade de VigoCampus universitario LagoasMarcosende36310 VigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS-UVIGO36312 VigoSpain BIOSCOPE Group LAQV@REQUIMTEChemistry DepartmentNOVA School of Science and TechnologyNOVA University LisbonCaparica Campus2829-516 CaparicaPortugal PROTEOMASS Scientific Society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/n4715-330 BragaPortugal

A highly versatile seed-mediated approach for the synthesis of citrate-stabilized gold,silver and palladium nanoparticles(NPs)with size control is *** use of iron(Ⅱ)as a reducing agent enables the fabrication of monodisperse NPs in a wide range of sizes(from 15 nm to at least 120 nm(90 nm for Pd))at room *** citrate as capping ligand on the NPs surface facilitates its further surface modification with proteins and thiolated molecules.

关键词： plasmonic nanoparticles gold silver palladium citrate-stabilized Fe(Ⅱ)

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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： carlos González-fernández Pau González Francisco Javier Rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

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Olfactory proteotyping: towards the enlightenment of the neurodegeneration

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Neural Regeneration Research 2019年第6期14卷 979-981页

作者： Joaquín fernández-Irigoyen Enrique Santamaría Proteored-Institute of Health carlos Ⅲ (ISCⅢ) Clinical Neuroproteomics UnitNavarrabiomedNavarra Health DepartmentPublic University of NavarraNavarra Institute for Health Research (IdiSNA)

Although phylogenetically ancient,the olfactory system has received less attention than other sensorial ***,olfactory dysfunction is considered an early prodromal event in neurodegenerative diseases(NDs)(Doty,2012;Attems et al.,2014),which may vary from severe smell loss(e.g.,Alzheimer’s and Parkinson’s diseases)to relatively moderate loss(e.g.,progressive supranuclear palsy)(Doty,2017).Recently,a cluster of neuropathological and functional discoveries has evidenced the relevant role of the olfactory bulb(OB)during the neurodegenerative process(Attems et al.,2014;Rey et al.,2018).For instance,the double-transgenic APP/PS1 mouse model of Alzheimer’s disease(AD)develops early proteomic disturbances accompanied by a specific modulation of the focal adhesion kinase(FAK)and mitogen-activated protein kinase(MAPK)dynamics at the level of the OB,demonstrating that olfactory molecular alterations occur prior toβ-amyloid plaque appearance and memory impairments in APP/PS1 transgenic mice(Lachen-Montes et al.,2016).

关键词： Although phylogenetically olfactory system considered

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Variation in SARS-CoV-2 seroprevalence in children in the region of Asturias,Northern Spain

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World Journal of Pediatrics 2022年第12期18卷 835-844页

作者： Elisa García-García Mercedes Rodríguez-Pérez David Pérez-Solís carlos Pérez-Méndez Cristina Molinos-Norniella Ángeles Cobo-Ruisánchez Eva María fernández fernández Noelia García González Laura Calle-Miguel Pediatrics Department Centro de Salud LaviadaCalle Juanín de Mieres833207GijónSpain Microbiology Department Hospital Universitario Central de AsturiasOviedoSpain Pediatrics Department Hospital Universitario San AgustínAvilésSpain Pediatrics Department Hospital Universitario de CabueñesGijónSpain Pediatrics Department Hospital Carmen y Severo Ochoa.Cangas del NarceaSpain Pediatrics Department Centro de Salud TeatinosOviedoSpain Pediatrics Department Hospital Universitario Central de AsturiasOviedoSpain

Background Updated seroprevalence estimates are important to describe the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)landscape and to guide public health *** aims are to describe longitudinal changes in seroprevalence in children in a region in Northern Spain and to analyze factors associated with SARS-CoV-2 *** Prospective multicenter longitudinal study with subjects recruited from July to September ***(up to 14 years old)were included and followed up until September *** blood samples were collected every six months during three testing rounds and were analyzed for SARS-CoV-2 *** data regarding epidemiological features,contact tracing,symptoms,and virological tests were *** evolution of SARS-CoV-2 seroprevalence during the study and the differences between children with positive and negative SARS-CoV-2 antibody tests were *** Two hundred children were recruited(50.5%girls,median age 9.7 years).The overall seroprevalence increased from round 1[1.5%,95%confidence interval(CI)0.3%–4.3%]to round 2(9.1%,95%CI 4.6%–12.7%)and round 3(16.6%,95%CI 9.5%–19.6%)(P<0.001).Main changes occurred in children aged zero to four years(P=0.001)who lived in urban areas(P<0.001).None of the children who were previously positive became *** multivariable analysis,three variables independently associated with SARS-CoV-2 seropositivity were identified:close contact with coronavirus disease 2019(COVID-19)confirmed or suspected cases[odds ratio(OR)=3.9,95%CI 1.2–12.5],previous positive virological test(OR=17.1,95%CI 3.7–78.3)and fatigue(OR=18.1,95%CI 1.7–193.4).Conclusions SARS-CoV-2 seroprevalence in children has remarkably increased during the time of our *** was the only COVID-19-compatible symptom that was more frequent in seropositive than in seronegative children.

关键词： Antibodies Child COVID-19 Seroepidemiologic studies

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Effect of Noisy Fitness in Real-Time Strategy Games Player Behaviour Optimisation Using Evolutionary Algorithms

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Journal of Computer Science & Technology 2012年第5期27卷 1007-1023页

作者： Antonio M. Mora Antonio fernndez-Ares Juan J. Merelo Pablo García-Snchez carlos M. fernandes Computer Architecture and Technology Department University of Granada Institute for Systems and Robotics Technical University of Lisbon

This paper investigates the performance and the results of an evolutionary algorithm （EA） specifically designed for evolving the decision engine of a program （which, in this context, is called bot） that plays Planet Wars. This game, which was chosen for the Google Artificial Intelligence Challenge in 2010, requires the bot to deal with multiple target planets, while achieving a certain degree of adaptability in order to defeat different opponents in different scenarios. The decision engine of the bot is initially based on a set of rules that have been defined after an empirical study, and a genetic algorithm （GA） is used for tuning the set of constants, weights and probabilities that those rules include, and therefore, the general behaviour of the bot. Then, the bot is supplied with the evolved decision engine and the results obtained when competing with other bots （a bot offered by Google as a sparring partner, and a scripted bot with a pre-established behaviour） are thoroughly analysed. The evaluation of the candidate solutions is based on the result of non-deterministic battles （and environmental interactions） against other bots, whose outcome depends on random draws as well as on the opponents＇ actions. Therefore, the proposed GA is dealing with a noisy fitness function. After analysing the effects of the noisy fitness, we conclude that tackling randomness via repeated combats and reevaluations reduces this effect and makes the GA a highly valuable approach for solving this problem.

关键词： real-time strategy game genetic algorithm noisy fitness player behaviour optimisation parameter adaptation

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The significance of U-Pb zircon ages in zoned plutons:the case of the Flamenco pluton, Coastal Range batholith, northern Chile

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Geoscience Frontiers 2019年第3期10卷 1073-1099页

作者： Natalia Rodríguez Juan Díaz-Alvarado carlos fernández Paulina Fuentes Christoph Breitkreuz Colombo Celso Gaeta Tassinari Departamento de Geología Universidad de Atacama Departamento de Ciencias de la Tierra Universidad de Huelva Institut für Geologie TU Bergakademie Freiberg High Resolution Geochronological Laboratory University of S?o Paulo

Compositionally zoned plutons, both layered and concentrically arranged, provide granitic exposures where the mechanisms and timing of the magmatic emplacement processes can be studied. The importance of in-situ geochemical differentiation and the magma replenishment rates are revealed by geochemistry and field relations, together with the increasingly accurate U-Pb geochronology, which has promoted the knowledge about the pluton incremental assembly *** Flamenco pluton, located in the Coastal Range of northern Chile, is part of the Upper Triassic to Early Cretaceous Andean intrusives formed in the western active margin of South America, and present a normal zoned structure with mafic magmatic facies(mostly gabbros and Qtz-diorites) close to the contacts with the host metasediments, and tonalites, granodiorites and granites in the inner areas. A combined study of the field relations, geochemistry and zircon geochronology of the magmatic facies was applied to determine the emplacement sequence of the Flamenco pluton, revealing three distinguishable domains separated by metasedimentary septa. The SW area is constituted by mostly homogeneous leucocratic granodiorites that yielded an age of 213 Ma as the best estimation for their emplacement age. Distinctive geochemical characteristics, such as the absence of an Eu anomaly, the depletion in HREE, or the highest Sr, Sr/Y and Ce/Yb values among the granodioritic facies of the pluton,involve lower T and/or higher P conditions at the magmatic source according to experimental *** conditions were established during an early stage of the Andean magmatic arc building that is firstly defined here as Upper Triassic. The NW and E domains of the pluton were sequentially emplaced between 194 Ma and 186 Ma and both the field relations and the detailed geochronological results suggest that the mafic facies intruded latter in the emplacement sequence. To the NW, Qtz-dioritic and gabbroic externally emplaced pulses ga

关键词： Zircon U-Pb geochronology Zoned plutons Andean magmatic arc Sequential emplacement Individual and statistical zircon ages

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Towards an integrated risk analysis security framework according to a systematic analysis of existing proposals

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Frontiers of Computer Science 2024年第3期18卷 199-216页

作者： Antonio SANTOS-OLMO Luis Enrique SÁNCHEZ David G.ROSADO Manuel A.SERRANO carlos BLANCO Haralambos MOURATIDIS Eduardo fernÁndez-MEDINA GSyA Research Group University of Castilla-La ManchaCiudad Real 13071Spain Institute for Analytics and Data Science University of EssexColchester CO43SQUK Alarcos Research Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Research group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The information society depends increasingly on risk assessment and management systems as means to adequately protect its key information *** availability of these systems is now vital for the protection and evolution of ***,several factors have led to an increasing need for more accurate risk analysis *** are:the speed at which technologies evolve,their global impact and the growing requirement for companies to *** analysis processes must consequently adapt to these new circumstances and new technological *** objective of this paper is,therefore,to present the results of an exhaustive analysis of the techniques and methods offered by the scientific community with the aim of identifying their main weaknesses and providing a new risk assessment and management *** analysis was carried out using the systematic review protocol and found that these proposals do not fully meet these new *** paper also presents a summary of MARISMA,the risk analysis and management framework designed by our research *** basis of our framework is the main existing risk standards and proposals,and it seeks to address the weaknesses found in these *** is in a process of continuous improvement,as is being applied by customers in several European and American *** consists of a risk data management module,a methodology for its systematic application and a tool that automates the process.

关键词： information security management security system security risk assessment and management

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