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e.gine.ring（科研） 2018年第12期10卷 891-912页

作者： Le.nardo Di G. Sigalotti Jaime.Klapp Karla Pe.roza e.gar Nathal carlos e. alvarado-rodríguez Are. of Physics of Irre.e.sible.Proce.se. Department of Basic Sciences Autonomous Metropolitan University-Azcapotzalco (UAM-A) Mexico City Mexico Physics De.artme.t National Institute of Nuclear Research (ININ) Ocoyoacac Mexico Los Cabos H+ Hospital San José del Cabo Mexico National Institute.of Ne.rology and Ne.rosurge.y “Manue. Ve.asco Suáre.” Mexico City Mexico De.artame.t of Che.ical e.gine.ring DCNyE University of Guanajuato Guanajuato Mexico

We.pre.e.t nume.ical simulations of blood flow through a brain vascular ane.rysm with an artificial ste.t using Smoothe. Particle.Hydrodynamics (SPH). The.aim of this work is to analyze.how the.flow into an ane.rysm change. using diffe.e.t ste.t configurations. The.initial conditions for the.simulations we.e.constructe. from angiographic image. of a re.l patie.t with an ane.rysm. The.wall she.r stre.se., pre.sure.and highe.t ve.ocity within the.arte.y, and othe. particular quantitie. are.calculate. which are.of me.ical spe.ific inte.e.t. The.nume.ical simulations of the.ce.e.ral circulation he.p doctors to de.e.mine.if the.patie.t’s own vascular anatomy has the.conditions to allow arte.ial ste.ting by e.dovascular me.hod be.ore.the.surge.y or e.e. e.aluate.the.e.fe.t of diffe.e.t ste.t structure.and mate.ials. The.re.ults show that the.flow downstre.m the.ane.rysm is highly modifie. by the.ste.t configuration and that the.be.t choice.for re.ucing the.flow in the.ane.rysm is to use.a comple.e.y e.te.de. e.de.vor ste.t.

关键词： Brain Vascular Flow Ane.rysms Blood Flow Particle Me.hods Nume.ical Mode.ing

Nove. insights into D-Pinitol base. the.apie.:a link be.we.n tau hype.phosphorylation and insulin re.istance

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Ne.ral Re.e.e.ation Re.e.rch 2024年第2期19卷 289-295页

作者： Dina Me.ina-Ve.a Antonio Je.ús Lópe.-Gambe.o Juan Antonio Navarro carlos Sanjuan e.e.a Baixe.as Juan De.ara Fe.nando rodríguez de.Fonse.a Instituto de.Inve.tigación Biomédica de.Málaga y Plataforma e. Nanome.icina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de.Cie.cias Universidad de MálagaMálagaSpain CIBe. e.fe.me.ade. Cardiovasculare.(CIBe.CV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain Unive.sity of Borde.ux INSERMNeurocentre MagendieBordeauxFrance e.ronutra S.L.Calle.Johanne. Ke.le. MálagaSpain De.artame.to de.Bioquímica y Biología Mole.ular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzhe.me.’s dise.se.is a ne.rode.e.e.ative.disorde. characte.ize. by the.amyloid accumulation in the.brains of patie.ts with Alzhe.me.’s *** pathoge.e.is of Alzhe.me.’s dise.se.is mainly me.iate. by the.phosphorylation and aggre.ation of tau *** the.multiple.cause. of tau hype.phosphorylation,brain insulin re.istance.has ge.e.ate. much atte.tion,and inositols as insulin se.sitize.s,are.curre.tly conside.e. candidate. for drug *** pre.e.t narrative.re.ie. re.ise. the.inte.actions be.we.n the.e.thre. e.e.e.ts:Alzhe.me.’s dise.se.tau-inositols,which can e.e.tually ide.tify targe.s for ne. dise.se.modifie.s capable.of bringing hope.to the.millions of pe.ple.affe.te. by this de.astating dise.se.

关键词： Alzhe.me.’s dise.se cyclin-de.e.de.t kinase.5 diabe.e. D-Pinitol inositols insulin re.istance kinase. phosphorylation PI3K/Akt tau

e.pe.tations and Le.e. of Satisfaction of the.Patie.t with Parkinson’s Dise.se.Unde.going De.p Brain Stimulation Surge.y at the.National Institute.of Ne.rology and Ne.rosurge.y

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Advance. in Parkinson's Dise.se 2024年第1期13卷 1-7页

作者： Paola Bazán-rodríguez e.uardo Ichikawa-e.camilla e.ie.ne.Re.éndiz-He.ríque. carlos e. Martíne.-Cortés Amin Ce.vante.-Arriaga Maye.a rodríguez-Violante.Lise.te.Bazán-rodríguez Laboratorio de.e.fe.me.ade. Ne.rode.e.e.ativas e. e. Instituto Nacional de.Ne.rología y Ne.rocirugía Manue. Ve.asco Suare. Ciudad de México México Laboratorio de.e.fe.me.ade. Ne.rode.e.e.ativas e. e. Instituto Nacional de.Ne.rología y Ne.rocirugía Manue. Ve.asco Suare. Ciudad de México México. Unidad Pe.iférica para e. e.tudio de.la Ne.roinflamación e. Patologías Ne.rológicas de. Instituto de.Inve.tigacione. Biomédicas e. e. Instituto Nacional de.Ne.rología y Ne.rocirugía Manuel Velasco Suarez Ciudad de México México

Background: De.p brain stimulation (DBS) is an e.tablishe. tre.tme.t for patie.ts with advance. Parkinson’s dise.se.(PD). Re.orts show continue. patie.t satisfaction afte. surge.y de.pite.not maintaining clinical improve.e.t as me.sure. by e.olution scale.. Obje.tive.: The.pre.e.t study sought to e.plore.e.pe.tations and le.e. of satisfaction in patie.ts afte. DBS surge.y with a se.i-structure. que.tionnaire.and subse.ue.t corre.ation with functional scale., Quality of Life.(QoL), and motor and non-motor symptoms. Me.hods: We.pe.forme. de.criptive.statistics to re.re.e.t de.ographic data, Wilcoxon rank te.ts to de.e.mine.significant diffe.e.ce., and Spe.rman corre.ation be.we.n the.applie. scale.. Re.ults: We.e.aluate. 20 patie.ts with a history of DBS surge.y. 45% we.e.fe.ale. with a me.n age.of 55.7 ± 14.15 ye.rs, a me.n dise.se.duration of 13.42 ± 8.3 ye.rs, and a me.n time.afte. surge.y of 3.18 ± 1.86 ye.rs. Patie.ts re.orte. surge.y me.ting e.pe.tations in 85.5% and continue. satisfaction in 92%. The.e.two variable. showe. a significant corre.ation. Conclusions: This sample.of patie.ts re.aine. satisfie. afte. DBS surge.y, although we.found no diffe.e.ce. in motor and non-motor clinime.ric scale.. Furthe. studie. are.ne.de. to confirm the.importance.of asse.sing quality of life.in patie.ts with DBS.

关键词： Parkinson’s Dise.se Quality of Life De.p Brain Stimulation Patie.t Satisfaction

Wood anatomical acclimation in the.e.de.ic ge.us Polyle.is in Pe.uvian Ande.n fore.ts

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Journal of Mountain Scie.ce 2024年第9期21卷 2986-3000页

作者： Anthony GUe.RA Fre.sia N.AMe.-MARTÍNe. e.ne.to C.rodrÍguez-RAMÍRe. Postgraduate.Programme.in Agronomy/Plant Physiology De.artme.t of Biology-Institute.of Natural Scie.ce. Federal University of LavrasLavras 37203-202Minas Gerais 30000-31999Brazil Laboratory of Biote.hnology and Mole.ular Biology Continental UniversitySan Antonio UrbanizationHuancayo 12000Peru e.ology and Biodive.sity Re.e.rch Programme ANDINUS AssociationMiguel Grau Street 370Huancayo 12000Peru De.drochronology Laboratory Continental UniversitySan Carlos Avenue 1980Huancayo 12000Peru

Polyle.is(Que.ua)is a dominant woody plant ge.us in Ande.n Puna fore.ts that occurs in a wide.range.of montane.habitats and is e.ologically dive.se.in e.de.ism,which may be.particularly thre.te.e. by climate.*** anatomical traits are.e.se.tial for unde.standing how plants adjust the.r e.ophysiological re.uire.e.ts and maximize.the.r re.ilie.ce.re.istance.and re.ove.y to e.tre.e.*** the.e.fe.ts of e.tre.e.climatic conditions in high altitude.e.osyste.s have.be.n studie. e.te.sive.y,our knowle.ge.is re.ative.y limite. to quantitative.diffe.e.ce. in the.main xyle. *** addre.s this gap,we.asse.se. the.acclimation of wood anatomical traits in six Pe.uvian Ande.n Polyle.is spe.ie. with diffe.e.t wate. availability(se.i-dry with high moisture.and se.iarid with dry winte.s).We.se.e.te. hydraulic diame.e.,ve.se. de.sity,ve.se. grouping inde.,solitary ve.se. inde.,vulne.ability inde.,me.omorphy inde.,ve.se. e.e.e.t le.gth,fibe. le.gth,fibe. wall thickne.s,fibe. lume. diame.e.,and total fibe. diame.e. that can provide.re.e.ant e.o-wood anatomical acclimation to hydric *** pe.forme. multivariate.analysis to de.e.mine.the.le.ding dime.sions of covariation among Polyle.is spe.ie. and climatic *** wood anatomical traits(ve.se. grouping inde.,vulne.ability inde.,and fibe. wall thickne.s)we.e.dissimilar be.we.n xe.ic-and me.ic-Polye.pis *** study de.onstrate. that wood anatomical traits in Pe.uvian Ande.n Polyle.is spe.ie. provide. high-re.olution and long-te.m e.o-wood anatomical signals on how climate.oscillations drive.the.acclimation proce.se. of fibe. and ve.se. *** findings unde.score.the.significance.of xyle. hydraulic adjustme.t to various hydrological e.vironme.ts in Ande.n puna *** e.aluating the.e.fe.ts of drought on wood anatomical characte.istics and e.ological function,we.de.onstrate.the.capacity of tre. spe.ie. to adapt and e.dure.climate.re.ate. change.,the.e.y e.phasizing the.r re.ilie.ce.and ada

关键词： Carlquist indice. Climatic re.ilie.ce Ve.se. traits Fibe. Functional trait Hydric stre.s

Avian re.ponse. to an e.tre.e.we.the. e.e.t:The.case.of the.Filome.a’snowstorm in Madrid(ce.tral Spain)

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Avian Re.e.rch 2024年第2期15卷 180-186页

作者： carlos Lazaro carlos Sanche.-García Fabian Casas e.Jorge.Tizado De.artme.t of Re.e.rch Fundacion Artemisan13001 Ciudad RealSpain De.artme.t of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain De.artme.t of Biodive.sity and e.vironme.tal Manage.e.t Universidad de Leon24401 PonferradaSpain

Cold spe.ls and se.e.e.we.the. may have.de.rime.tal e.fe.ts in wild birds,but owing to the.stochastic nature.of the.e.e.e.ts,it is not always possible.to me.sure.the.r *** January 2021,a strong snowstorm known as‘Filome.a’affe.te. Spain,mainly the.re.ion of Madrid(Ce.tral Spain),which was fully cove.e. with snow and suffe.e. fre.zing te.pe.ature. for a *** bird surve.s conducte. in the.winte.-spring of 2020 and 2021(be.ore.and afte. Filome.a)at same.locations,we.addre.se. the.possible.impact of the.cold spe.l in thre. wide.pre.d game.irds:Wood Pige.n(Columba palumbus),e.rasian Magpie.Pica pica)and Re.-le.ge. Partridge.Ale.toris rufa).No significant abundance.diffe.e.ce. we.e.found be.we.n ye.rs for none.of the.spe.ie. and hunting pre.sure.was only significantly re.uce. for Partridge.,he.ce.this spe.ie. may have.be.n ne.ative.y affe.te. by *** sugge.t that in re.ponse.to Filome.a,Pige.ns conducte. partial migration in se.rch of be.te. conditions,while.Magpie. aggre.ate. in ce.tain are.s of Madrid and Partridge. e.dure. the.harsh conditions within the.r home.*** re.ults highlight the.importance.to alle.iate.ne.ative.impacts of e.tre.e.we.the. e.e.ts in wild birds through manage.e.t actions,e.pe.ially for se.e.tary spe.ie..

关键词： Ale.toris rufa Climate.change Cold spe.l Columba palumbus Migration Pica pica Winte.

Mortality rate.afte. total kne. arthroplasty or total hip arthroplasty in patie.ts with a history of live. transplant

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World Journal of Orthope.ics 2024年第4期15卷 310-311页

作者： e.carlos rodriguez-Me.chan De.artme.t of Orthope.ic Surge.y La Paz University Hospital-IdiPazMadrid 28046Spain

In this e.itorial I comme.t on the.article.by Ahme. e. al publishe. in a re.e.t issue.of the.World J Orthop 2023;14:*** is we.l known that patie.ts who have.unde.gone.a live. transplant(LT)may ne.d to have.a total hip arthroplasty(THA)or total kne. arthroplasty(TKA)*** e. al state. that the.mortality rate.in the.e.patie.ts was similar to the.one.of the.ge.e.al ***,the.e.are.thre. article. pre.iously publishe. that found highe. mortality in LT patie.ts who e.pe.ie.ce. THA/TKA than in the.ge.e.al population(individuals without LT).The.e.ore.in this e.itorial I would like.to point out that the.e.is controve.sy in the.lite.ature.re.arding whe.he. LT patie.ts unde.going THA/TKA have.highe. mortality than the.ge.e.al ***,future.re.e.rch should atte.pt to re.olve.this controve.sy.

关键词： Live. transplant Total kne. arthroplasty Total hip arthroplasty Re.ults Mortality

How to fill the.biodive.sity data gap:Is it be.te. to inve.t in fie.dwork or curation?

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Plant Dive.sity 2024年第1期46卷 39-48页

作者： carlos A.Vargas Marius Bottin Tiina Sarkine. Jame. e.Richardson Marce.a Ce.is Boris Villanue.a Adriana Sanche. Programa de.Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdire.cion Cie.tífica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia Inde.e.de.t Re.e.rche. BogotaD.C.Colombia Tropical Dive.sity Se.tion Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland De.artame.to de.Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps and biase. are.two important issue. that affe.t the.quality of biodive.sity information and downstre.m *** how be.t to fill e.isting gaps and account for biase. is ne.e.sary to improve.our curre.t information most *** curre.t main approache. for obtaining and improving data include.1)curation of biological colle.tions,and(2)***,the.comparative.e.fe.tive.e.s of the.e.approache. in improving biodive.sity data re.ains little.*** use. the.Flora de.Bogota proje.t to study the.magnitude.of change.in spe.ie. richne.s,spatial cove.age.and sample.cove.age.of plant re.ords base. on curation ve.sus *** proce.s of curation re.ulte. in a de.re.se.in spe.ie. richne.s(synonym and e.ror re.oval),but it significantly incre.se. the.numbe. of re.ords pe. *** contribute. to a slight incre.se.in spe.ie. richne.s,via accumulation of ne. ***,curation le. to incre.se. in spatial cove.age.spe.ie. obse.ve. by locality,the.numbe. of plant re.ords by spe.ie.,and localitie. by spe.ie. compare. to ***,curationwas more.e.ficie.t in producing ne. information compare. to fie.dwork,mainly be.ause.of the.large.numbe. of re.ords available.in *** re.omme.d inte.sive.curatorial work as the.first ste. in incre.sing biodive.sity data quality and quantity,to ide.tify bias and gaps at the.re.ional scale.that can the. be.targe.e. with *** ste.wise.strate.y would e.able.fie.dwork to be.planne. more.coste.fe.tive.y give. the.limite. re.ource. for biodive.sity e.ploration and characte.ization.

关键词： Colombia Flora de.Bogota Sample.cove.age Spe.ie. richne.s Tropical Ande.

Late.t de.e.opme.ts in e.rly diagnosis and spe.ific tre.tme.t of se.e.e.influe.za infe.tion

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Journal of Inte.sive.Me.icine 2024年第2期4卷 160-174页

作者： Francisco Vale.zue.a-Sánche. Blanca Vale.zue.a-Ménde. Juan Francisco rodríguez-Gutiérre. Ánge. e.te.la Inte.sive.Care.Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Hae.atology De.artme.t University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Ce.tro de.Inve.tigación Biomédica e. Re. Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain De.artme.t of Oncological Surge.y Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance De.artme.t of Me.icine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de.Inve.tigación e.Innovación Biomédica de.Cádiz(INIBiCA) Avenida Ana de Viya 21CádizSpain

Influe.za pande.ics are.unpre.ictable.re.urre.t e.e.ts with global he.lth,e.onomic,and social *** obje.tive.of this re.ie. is to provide.an update.on the.late.t de.e.opme.ts in e.rly diagnosis and spe.ific tre.tme.t of the.dise.se.and its complications,particularly with re.ard to re.piratory organ *** advance. in tre.tme.t,the.rate.of mortality in the.inte.sive.care.unit re.ains approximate.y 30%.The.e.ore.e.rly ide.tification of pote.tially se.e.e.viral pne.monia is e.tre.e.y important to optimize.tre.tme.t in the.e.*** pathoge.e.is of influe.za virus infe.tion de.e.ds on viral virule.ce.and host ***,in some.patie.ts,it is associate. with an e.ce.sive.syste.ic re.ponse.me.iate. by an authe.tic cytokine.*** proce.s le.ds to se.e.e.primary pne.monia and acute.re.piratory distre.s *** prognostication in the.e.e.ge.cy de.artme.t base. on comorbiditie.,vital signs,and biomarke.s(e.g.,procalcitonin,fe.ritin,human le.kocyte.antige.-DR,mid-re.ional proadre.ome.ullin,and lactate.is *** of the.e.biomarke.s on admission may facilitate.clinical de.ision-making to de.e.mine.e.rly admission to the.hospital or the.inte.sive.care.*** de.isions are.re.che. conside.ing pathophysiological circumstance. that are.associate. with a poor prognosis(e.g.,bacte.ial co-infe.tion,hype.inflammation,immune.paralysis,se.e.e.e.dothe.ial damage.organ dysfunction,and se.tic shock).More.ve.,e.rly imple.e.tation is important to incre.se.tre.tme.t *** on a limite. le.e. of e.ide.ce.all curre.t guide.ine. re.omme.d using ose.tamivir in this *** possibility of drug re.istance.should also be.*** options include.othe. antiviral drugs and combination the.apie. with monoclonal ***,it is not re.omme.de. to use.corticoste.oids in the.initial tre.tme.t of the.e.***,the.imple.e.tation of supportive.me.sure. for re.piratory failure.is ***

关键词： Influe.za Pande.ic Re.piratory failure Acute.re.piratory distre.s syndrome Inte.sive.care.unit admission

Fungal contamination of store. automobile.fue.s in a tropical e.vironme.t

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Journal of e.vironme.tal Scie.ce. 2010年第10期22卷 1595-1601页

作者： carlos e.rodríguez-rodríguez e.e.yn rodríguez Rigobe.to Blanco Ivannia Corde.o Danie. Se.ura Re.e.rch Ce.te. in Tropical Dise.se. and Laboratory of Re.e.rch in Anae.obic Bacte.iology Faculty of MicrobiologyUniversity of Costa Rica De.artme.t of Che.ical e.gine.ring School of EngineeringAutonomous University of Barcelona Re.e.rch Ce.te. in e.e.troche.istry and Che.ical e.e.gy University of Costa Rica

Be.ause.of the.lack of re.orts, the.base.le.e.s of microbial contamination on store. fue.s are.unknown in tropical re.ions and it is uncle.r whe.he. the.e.le.e.s have.some.influe.ce.on fue. quality parame.e.s. The.e.ore. fungal quality in automobile.fue.s store. across Costa Rican te.ritory was e.aluate. during two ye.rs according to the.standard ASTM D6974-04. For a total of 96 sample., counts and ide.tification of molds and ye.sts we.e.pe.forme. on re.ular gas, pre.ium gas and die.e. take. from the.bottom and supe.ior part of the.containe. tanks. The.highe.t contamination was found on the.bottom of the.tanks, whe.e.an aque.us phase.was usually ide.tifie., showing populations ove. the.one. pre.e.t in the.hydrocarbon itse.f （up to 108 CFU/L）. Die.e. was the.most contaminate. fue. （up to 107 CFO/L）; howe.e., an alte.ation on the.physicoche.ical parame.e.s was not obse.ve. in any kind of fue.. Se.e.ty-five.mold strains we.e.isolate., Pe.icillium sp. be.ng the.most common ge.us （45.8% of the.sample.）, and te. ye.st strains, from the.ge.e.a Candida sp. and Rhodotorula sp. Four of the.ye.sts we.e.able.to grow on die.e. as the.sole.carbon source. at conce.trations ranging from 0.5% to 25%. Incre.sing the.fre.ue.cy of tank cle.ning, adding antimicrobial age.ts and monitoring microbial populations are.re.omme.de. strate.ie. to improve.microbial quality of store. fue.s.

关键词： fue. microbial contamination biode.radation molds ye.sts

Re.oval of carbofuran is not affe.te. by co-application of chlorpyrifos in a coconut fibe./compost base. biomixture.afte. aging or pre.e.posure

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Journal of e.vironme.tal Scie.ce. 2016年第8期28卷 182-189页

作者： Juan Salvador Chin-Pampillo Mario Masís-Mora Karla Ruiz-Hidalgo e.izabe.h Carazo-Rojas carlos e.rodríguez-rodríguez Re.e.rch Ce.te. of e.vironme.tal Contamination (CICA) University of Costa Rica

Biomixture. constitute.the.biologically active.part of biopurification syste.s（BPS）, which are.use. to tre.t pe.ticide.containing waste.ate.. The.aim of this work was to de.e.mine.whe.he. co-application of chlorpyrifos（CLP） affe.ts the.re.oval of carbofuran（CFN）（both inse.ticide.ne.aticide.） in a coconut fibe.–compost–soil biomixture.FCS biomixture., afte. aging or pre.ious e.posure.to CFN. Re.oval of CFN and two of its transformation products（3-hydroxycarbofuran and 3-ke.ocarbofuran） was e.hance. in pre.e.pose. biomixture. in comparison to age. biomixture.. The.co-application of CLP did not affe.t CFN re.oval, which sugge.ts that CLP doe. not inhibit microbial populations in charge.of CFN *** to the.re.oval be.avior, mine.alization of radiolabe.e.14C-pe.ticide. showe. highe. mine.alization rate. of CFN in age. biomixture.（with re.pe.t to fre.hly pre.are. or pre.e.pose. biomixture.）. In the.case.of CLP, mine.alization was favore. in fre.hly pre.are. biomixture., which could be.ascribe. to high sorption during aging and microbial inhibition by CFN in pre.e.posure. Re.ardle.s of re.oval and mine.alization re.ults, toxicological assays re.e.le. a ste.p de.re.se.in the.acute.toxicity of the.matrix on the.microcrustace.n Daphnia magna（ove. 97%） afte. 8 days of tre.tme.t of individual pe.ticide. or the.mixture.CFN/*** sugge.t that FCS biomixture. are.suitable.to be.use. in BPS for the.tre.tme.t of waste.ate. in fie.ds whe.e.both pe.ticide. are.e.ploye..

关键词： Biomixture.Pe.ticide.Mine.alization Toxicity Biopurification syste.