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Semantic and Phonemic Verbal Fluency Performance in Patients with General Anxiety Disorders and Allostatic Load under Alprazolam Treatment

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Open Journal of Psychiatry 2019年第2期9卷 138-152页

作者： carlos A. soria Carolina Remedi Luciana D’Alessio Emilio J. A. Roldán Institute of Biosciences Henri Laborit Córdoba Argentina Buenos Aires University CONICET Buenos Aires Argentina Scientific Direction Gador SA Buenos Aires Argentina

Purpose: Anxiety disorders are frequently associated with chronic stress with possible cognitive consequences. The aim of this study was to determine the verbal fluency performance in a cohort of patients with anxiety disorders and allostatic load, treated with alprazolam during 12 weeks. Methods: Patients with GAD (general anxiety disorders, DSM IV), with >6 in Hamilton Anxiety Rating Scale (HAM-A), neuroticism > 18 (NEO-FFI inventory), and normal Mini-Mental State Examination were included. Clinical and Psychiatric examination, Allostatic Load Index and cognitive assessment were analyzed before and after 12 weeks of treatment. The phonemic and semantic verbal fluency tests were determined in all patients. The scoring for each fluency task was determined by counting the number of correct words. The total score from each semantic and phonemic verbal task was analyzed comparing the individual score with normal data controlled by age and sex. Patients with scores > ?2 standard deviation (SD) from normative data were considered impaired. Results: Fifty-four patients completed the semantic verbal fluency test before treatment and fifty patients completed after treatment. According to the z-scores before treatment 7 patients of 54 (12.9%) had verbal fluency impairments. After treatment none patients showed semantic verbal fluency deficits but 3 patients of 50 (6%) showed phonemic impairments. Impaired group was significantly associated with an older age before treatment (p = 0.033) and with a similar tendency but not significant (p = 0.09) after treatment (Student t test). Conclusion: In this study older age factor was associated with verbal fluency impairment in GAD patients. Stratified treatments analyzing age and sex factors, including allostatic load measurements and cognitive assessments may be useful tools to determine the effectiveness and the safety of psychopharmacological treatments.

关键词： Verbal Fluency Test Chronic Stress Allostatic Load Sex Age

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Open Journal of Psychiatry 2018年第3期8卷 212-232页

作者： carlos A. soria Carolina Remedi Luciana D’Alessio Emilio J. A. Roldán Institute of Biosciences Henri Laborit Córdoba Argentina Buenos Aires University ENyS-CONICET Buenos Aires Argentina Scientific Direction Department Gador SA Buenos Aires Argentina

Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been described for the general population. In this observational study we describe the effects of sex and age on AL variables, in a cohort of patients with general anxiety disorders and neuroticism treated with alprazolam during 12 weeks, before and after treatment. Methods: Patients with general (DSM IV) anxiety disorders with >6 in Hamilton scale, AL (>1 Crimmins and Seeman AL modified criteria) and neuroticism >18 (NEO-FFI inventory), were included. All patients completed psychiatric assessment, AL index determination before (−1 week) and after 12 weeks of treatment with alprazolam (0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular, metabolic and inflammatory variables. Univariate analysis (two-way ANOVA), Student’s t-test (related variables) and Pearson correlations were determined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19 males (44.2 ± 12.8 years) with general anxiety disorder were included;28 patients with Conclusions: In this preliminary analysis we described sex and age differences in psychiatry aspects and AL indexes in patients with general anxiety disorders in the short-term treatment with alprazolam. These considerations remark the need of pondering sex and age differences during the use of drugs for protracted periods.

关键词： Chronic Stress Neuroticism Alprazolam Anxiety Allostatic Load

Integrating Levels of Hierarchical Organization in Porous Organic Molecular Materials

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Nano-Micro Letters 2024年第5期16卷 134-153页

作者： Jesus Ferrando‑soria Antonio Fernandez Instituto de Ciencia Molecular(ICMol) Universidad de Valencia46980 ValenciaSpain School of Science Loughborough UniversityLoughborough LE113TUUK

Porous organic molecular materials(POMMs)are an emergent class of molecular-based materials characterized by the formation of extended porous frameworks,mainly held by non-covalent *** represent a variety of chemical families,such as hydrogen-bonded organic frameworks,porous organic salts,porous organic cages,C-H···πmicroporous crystals,supramolecular organic frameworks,π-organic frameworks,halogen-bonded organic framework,and intrinsically porous molecular *** some porous materials such as zeolites and metal organic frameworks,the integration of multiscale has been adopted to build materials with multifunctionality and optimized ***,considering the significant role of hierarchy in porous materials and the growing importance of POMMs in the realm of synthetic porous materials,we consider it appropriate to dedicate for the first time a critical review covering both ***,we will provide a summary of literature examples showcasing hierarchical POMMs,with a focus on their main synthetic approaches,applications,and the advantages brought forth by introducing hierarchy.

关键词： Porous organic molecular materials Hierarchy Hydrogen-bonded organic frameworks Porous cages Fullerene

On the Maximal Operator Associated with Certain Rotational Invariant Measures

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Acta Mathematica Sinica,English Series 2010年第6期26卷 993-1004页

作者： Adrián INFANTE Fernando soria Department of Mathematics Universidad Simn Bolívar Department of Mathematics Universidad Autnoma de Madrid

The aim of this work is to investigate the integrability properties of the maximal operator Mu,associated with a non-doubling measure μ defined on Rn. We start by establishing for a wide class of radial and increasing measures μ that Mu is bounded on all the spaces Lu^p（R^n）,P〉***,we show that there is a radial and increasing measure p for which Mμ does not map Lμ^p（R^n） into weak Lμ^p（R^n）,1≤p〈∞.

关键词： maximal operator non-doubling measures

Heuristics of node selection criteria to assess robustness of world airport network

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Chinese Journal of Aeronautics 2017年第4期30卷 1473-1480页

作者： Manel soria Oriol LORDAN JosMaría SALLAN Department of Physics Aeronautics Engineering Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain Department of Management Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain

The world airport network（WAN） is one of the networked infrastructures that shape today＇s economic and social activity, so its resilience against incidents affecting the WAN is an important problem. In this paper, the robustness of air route networks is extended by defining and testing several heuristics to define selection criteria to detect the critical nodes of the *** addition to heuristics based on genetic algorithms and simulated annealing, custom heuristics based on node damage and node betweenness are defined. The most effective heuristic is a multiattack heuristic combining both custom heuristics. Results obtained are of importance not only for advance in the understanding of the structure of complex networks, but also for critical node detection.

关键词： Adaptive strategy Air route networks Complex networks Intentional attacks Network robustness

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熊猫的房子

现代装饰 2017年第6期 118-121页

作者： Bjarke Ingels David Zahle Nanna Gyldholm MΦller Ole Elkjr-Larsen Kamilla Heskje Maja Czesnik Pawel Bussold Jinseok Jang Gkce Gnbulut Christian Lopez Luca Senise HΦgni Laks á foss Sofia Sofianou carlos soria Victor Bejenaru Claus Rytter Bruun de Neergaard Gabrielé Ubareviciute Eskild Schack Pedersen Richard Howis Tore Banke Tobias Hjortdal Joos Jerne Hanne Halvorsen Tommy BjΦrnstrup Joanna Plizga 姜敏华

丹麦著名建筑师事务所BIG（Bjarke Ingels Group）最近公布了哥本哈根动物园熊猫馆的设计方案。新的熊猫馆呈环形状分布，像一个巨大的太极符号，由多个交叉的步道和周边现有的设施组成。身处场馆中，人类就像是熊猫请来的客人，并没有... 详细信息

丹麦著名建筑师事务所BIG（Bjarke Ingels Group）最近公布了哥本哈根动物园熊猫馆的设计方案。新的熊猫馆呈环形状分布，像一个巨大的太极符号，由多个交叉的步道和周边现有的设施组成。身处场馆中，人类就像是熊猫请来的客人，并没有与这种珍稀动物产生从遥远国土被邀请而来的疏离感。栖息地为它们提供了最自由和最自然的生活环境，以及理想的交配条件，这也是解决熊猫濒临灭绝问题的最主要的挑战之一。

关键词：熊猫馆房子建筑师事务所哥本哈根珍稀动物生活环境动物园栖息地

Minimizing sperm oxidative stress using nanotechnology for breeding programs in rams

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2395-2410页

作者： Alejandro Jurado‑Campos Pedro Javier soria‑Meneses Maria Arenas‑Moreira carlos Alonso‑Moreno Virginia Rodriguez‑Robledo Ana Josefa Soler Jose Julian Garde Maria del Rocio Fernandez‑Santos SaBio IREC(CSIC-UCLM-JCCM) Campus UniversitarioS/N02071 AlbaceteSpain. Departamento de Quimica Inorganica Organica Y Bioquimica‑Centro de Innovacion en Quimica Avanzada(ORFEO‑CINQA)Facultad de FarmaciaUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Centro Regional de Investigacion Biomedicas Unidad nanoDrugUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Facultad de Farmacia Universidad de Castilla La Mancha02071 AlbaceteSpain.

Background Artificial insemination(AI)is a routine breeding technology in animal ***,the temperature-sensitive nature and short fertile lifespan of ram sperm samples hamper its use in *** this sense,nanotechnology is an interesting tool to improve sperm protection due to the development of nanomaterials for AI,which could be used as delivery *** this work,we explored the feasibility of vitamin E nanoemulsion(NE)for improving sperm quality during *** With the aim of evaluating this proposal,ejaculates of 7 mature rams of Manchega breed were collected by artificial vagina and extended to 60×10^(6)spz/mL in *** containing control and NE(12 mmol/L)with and without exogenous oxidative stress(100μmol/L Fe2+/ascorbate)were stored at 22 and 15℃and motility(CASA),viability(YO-PRO/PI),acrosomal integrity(PNA-FITC/PI),mitochondrial membrane potential(Mitotracker Deep Red 633),lipoperoxidation(C11 BODIPY 581/591),intracellular reactive oxygen species(ROS)production and DNA status(SCSAR)monitored during 96 *** results show that NE could be used to maintain ram spermatozoa during transport at 15 and 22℃for up to 96 h,with no appreciable loss of kinematic and physiological characteristics of freshly collected *** The storage of ram spermatozoa in liquid form for 2-5 d with vitamin E nanoemulsions may lead more flexibility to breeders in AI *** view of the potential and high versatility of these nanodevices,further studies are being carried out to assess the proposed sperm preservation medium on fertility after artificial insemination.

关键词： Breeding technology Nanoemulsions Nanotechnology Sperm oxidative stress Vitamin E

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哥本哈根动物园熊猫馆

城市环境设计 2019年第2期 102-113页

作者： Alberto Menegazzo Alex Ritivoi carlos soria Christian Lopez Claus Rytter Bruun De Neergaard Dina Br?ndstrup Eskild Schack Pedersen Fabiana Cortolezzis Federica Longoini Frederik Skou Jensen Gabrielé Ubareviciute G?kce Günbulut Hanne Halvorsen H?gni Laksáfoss Jiajie Wang Jinseok Jang Joanna Plizga Lone Fenger Albrechtsen Luca Senise Maja Czesnik Margarita Nutfulina Maria Stolarikova Martino Hutz Matthieu Brasebi Pawel Bussold Richard Howis Seongil Rasmus Hjortshoj 王婉琳陈思谨

哥本哈根动物园对这两只从中国成都到来的大熊猫十分欢迎,这是中国政府在2014年丹麦女王访问中国后的善意表示。新熊猫馆位于欧洲最古老的动物园之一,它为两只大熊猫创造了一个和谐的、可以自由漫步的室内外空间,并充分考虑大熊猫的理... 详细信息

哥本哈根动物园对这两只从中国成都到来的大熊猫十分欢迎,这是中国政府在2014年丹麦女王访问中国后的善意表示。新熊猫馆位于欧洲最古老的动物园之一,它为两只大熊猫创造了一个和谐的、可以自由漫步的室内外空间,并充分考虑大熊猫的理想交配条件。熊猫馆由BIG、Sch?nherr景观公司及MOE咨询公司共同设计,也是与熊猫专家、动物园工作人员和兽医进行一系列研讨会的成果。

关键词：栖息地哥本哈根动物园阴阳符号

Functional responses of cougars(Puma concolor)in a multiple prey-species system

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Integrative Zoology 2018年第1期13卷 84-93页

作者： Leroy soria-DÍAZ Mike SFOWLER Octavio MONROY-VILCHIS Daniel ORO Institute of Applied Ecology Autonomous University of TamaulipasVictoria city TamaulipasMexico Department of Biosciences Swansea UniversitySwanseaUK Center for Research in Applied Biological Sciences Autonomous University of the State of MexicoCentro TolucaMexico Population Ecology Group Mediterranean Institute for Advanced Studies IMEDEA(CSIC-UIB)EsporlesMallorcaSpain

The study of predator-prey interactions is commonly analyzed using functional responses to gain an understanding of predation patterns and the impact they have on prey *** this,little is known about predator-prey systems with multiple prey species in sites near the *** we studied the functional response of cougars(Puma concolor)in relation to their main prey,armadillo(Dasypus novemcinctus),coati(Nasua narica)and white-tailed deer(Odocoileus virginianus).Between 2004 and 2010,cougar scats were collected along 5 transects to estimate the consumption of different prey species.A relative abundance index(RAI)was calculated for each prey species and cougar using 18 camera *** compared Holling type I,II and III functional response models to determine patterns in prey consumption based on the relative abundance and biomass of each prey species *** 3 main prey species comprised 55%(armadillo),17%(coati)and 8%(white-tailed deer)of the *** I and II functional responses described consumption of the 2 most common prey species armadillos and coati similarly well,while a type I response best characterized consumption of white-tailed deer.A negative correlation between the proportions of armadillo versus coati and white-tailed deer biomass in cougar scats suggests switching to consume alternative prey,confirming high foraging plasticity of this *** work represents one of the few studies to compare functional responses across multiple prey species,combined with evidence for prey-switching at low densities of preferred prey.

关键词： cougar functional responses Holling model comparison multiple prey