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Gastric mucosa-associated lymphoid tissue lymphomas and Helicobacter pylori infection:A Colombian perspective

World Journal of Gastroenterology 2012年第7期18卷 685-691页

作者： Sally Yepes Maria Mercedes Torres carlos saavedra Rafael Andrade Institute of Genetics Universidad Nacional de Colombia14490 Bogotá DCColombia Department of Pathology Fundación Santa Fe de Bogotá220246 Bogotá DCColombia Human Genetics Laboratory Universidad de los Andes4976 Bogotá DCColombia Faculty of Medicine Universidad Nacional de Colombia14490 Bogotá DCColombia

AIM:To assess the significance of chromosome translocation t(11;18)(q21;q21),B-cell lymphoma 10 (BCL-10) protein and Helicobacter pylori (H.pylori) infection in gastric mucosa-associated lymphoid tissue (MALT) lymphoma in Colombia.METHODS:Fifty cases of gastric MALT lymphoma and their respective post-treatment follow-up biopsies were examined to assess the presence of the translocation t(11;18)(q21;q21) as identified by fluorescence in situ hybridization;to detect protein expression patterns of BCL10 using immunohistochemistry;and for evaluation of tumor histology to determine the correlation of these factors and resistance to H.pylori eradication.RESULTS:Infection with H.pylori was confirmed in all cases of gastric MALT lymphoma in association with chronic gastritis.Bacterial eradication led to tumor regression in 66% of cases.The translocation t(11;18)(q21;q21) was not present in any of these cases,nor was there evidence of tumor transformation to diffuse large B-cell lymphoma.Thirty-four percent of the patients showed resistance to tumor regression,and within this group,7 cases,representing 14% of all those analyzed,were considered to be t(11;18)(q21;q21)-positive gastric MALT lymphomas.Protein expression of BCL10 in the nucleus was associated with the presence of translocation and treatment resistance.Cases that were considered unresponsive to therapy were histologically characterized by the presence of homogeneous tumor cells and a lack of plasmacytic differentiation.Responder cases exhibited higher cellular heterogeneity and a greater frequency of plasma cells.CONCLUSION:Both t(11;18)(q21;q21)-positive MALT lymphoma cases and those with nuclear BCL10 expression are considered resistant to H.pylori eradication.It is suggested that chronic antigenic stimulation is not a dominant event in resistant cases.

关键词： B细胞淋巴瘤哥伦比亚淋巴组织胃黏膜幽门螺杆菌感染胃癌染色体易位

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A CMOS wideband front-end chip using direct RF sampling mixer with embedded discrete-time filtering

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Journal of Semiconductors 2011年第8期32卷 111-117页

作者：许江涛 carlos E.saavedra 陈贵灿 Institute of Microelectronics Xi'an Jiaotong University Queen's University

A CMOS wideband front-end IC is demonstrated in this paper.It consists of a low noise transconductance amplifier（LNTA） and a direct RF sampling mixer（DSM） with embedded programmable discrete-time filtering.The LNTA has the features of 0.5-6 GHz wideband,wideband input matching and low noise.The embedded filter following the DSM operates in discrete-time charge domain,filtering the aliasing signals and interferences while controlling the IF bandwidth according to the clock frequency.The measured NF of the front-end was below 7 dB throughout the whole band from 0.5 to 6 GHz.It shows a conversion gain of 12.6 dB and IP_（1dB） of-7.5 dBm at 2.4 GHz.It occupies a chip area of 0.23 mm^2 and consumes 14 mA DC current.

关键词： wideband front-end LNTA DSM discrete time FIR filtering IIR windowed integration

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Autoimmune hepatitis in human immunodeficiency virus infection: Case report and literature review

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World Journal of Clinical Infectious Diseases 2017年第4期7卷 50-57页

作者： Ivan Nore?a Jairo A Morantes-Caballero Andrés Garcés Brian José Gómez Gabriel Rodríguez carlos saavedra William Otero Infectious Diseases Section Department of Internal Medicine Universidad Nacional de Colombia and Hospital Universitario Nacional de Colombia Department of Internal Medicine Universidad Nacional de Colombia and Hospital Universitario Nacional de Colombia Gastroenterology Section Department of Internal Medicine Universidad Nacional de Colombia and Hospital Universitario Nacional de Colombia

The infection due to human immunodeficiency virus(HIV) is characterized by the progressive reduction of CD4+ T lymphocytes and the compromise of other cell lines of the immune system, resulting in immunosuppression. In this context, autoimmune diseases could be considered contradictory, however, cases of autoimmune diseases during this infection have been described, including autoimmune hepatitis(AIH), which is uncommon and has few case reports within medical literature, none of them from Latin America. In this case report where a patient with an HIV infection on combined antiretroviral treatment developed acute elevation of transaminases, hyperbilirubinemia, and deterioration in hepatic synthetic function. Although initially an antiretroviral drug-induced liver injury was suspected, during the study a diagnosis of autoimmune hepatitis was proven, which required treatment with corticosteroid and azathioprine, obtaining a satisfactory response and managing to continue the antiretroviral therapy. Autoimmune diseases in HIV infection must be taken into account. In the case of hepatitis in patients with HIV on antiretroviral treatment, the differentiation between viral hepatitis caused by autoimmune diseases or medications is essential to establish an adequate treatment, and avoid the suspension of the antiretroviral therapy.

关键词： Autoimmunity Autoimmune hepatitis Human immunodeficiency virus Anti-human immunodeficiency virus agents Drug-induced liver injury

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基于电流矢量和的多模QAM直接数字调制器

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电子学报 2012年第1期40卷 40-46页

作者：许江涛 carlos E saavedra 陈贵灿西安交通大学微电子学系陕西西安710049 加拿大女皇大学电气与计算机工程系

本文提出了一种新型直接数字正交幅度调制器(QAM),可用于4-QAM,16-QAM或更高阶调制方式.其基于电流矢量相加的原理,首次采用一对跨导可调的高速运算跨导放大器产生幅值可控的基本电流矢量,开关网络在电流域中选择矢量相加,减小了非线性... 详细信息

本文提出了一种新型直接数字正交幅度调制器(QAM),可用于4-QAM,16-QAM或更高阶调制方式.其基于电流矢量相加的原理,首次采用一对跨导可调的高速运算跨导放大器产生幅值可控的基本电流矢量,开关网络在电流域中选择矢量相加,减小了非线性失真.该芯片采用0.13μmCMOS工艺进行流片.在5.4GHz载波频率、16Mbps数据率时的测试结果显示,16-QAM调制的EVM为6.2%,芯片面积0.09mm2,在1.2V电源电压下总直流功耗为20mA.

关键词： QAM调制器多模直接数字调制运算跨导放大器跨阻放大器

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Diversity and host assemblage of avian haemosporidians in different terrestrial ecoregions of Peru

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Current Zoology 2022年第1期68卷 27-40页

作者： Luz GARCIA-LONGORIA Jaime MURIEL Sergio MAGALLANES Zaira Hellen VILLA-GALARCE Leonila RICOPA Wilson Giancarlo INGA-DIAZ Esteban FONG Daniel VECCO Cesar GUERRA-SALDANA Teresa SALAS-RENGIFO Wendy FLORES-saavedra Kathya ESPINOZA carlos MENDOZA Blanca SALDANA Manuel GONZALEZ-BLAZQUEZ Henry GONZALES-PINEDO Charlene LUJAN-VEGA carlos Alberto Del AGUILA Yessica VILCA-HERRERA carlos Alberto PINEDA Carmen REATEGUI Jorge Manuel CARDENAS-CALLIRGOS JoseAlberto IANNACONE Jorge Luis MENDOZA Ravinder NMSEHGAL Alfonso MARZAL Departamento de Anatomia Biologia Celular y ZoologiaUniversidad de ExtremaduraBadajoz E-506071Spain Molecular Ecology and Evolution Lab Department of BiologyLund UniversitySolvegatan 37SE-22362 LundSweden Instituto Pirenaico de Ecologıa-IPE(CSIC) Avda.Nuestra Senora de la Victoria 16Jaca 22700Spain DIRESA Direccion Regional de SaludLoreto 16001Peru Departamento Academico de Microbiologia y Parasitologia.Facultad de Ciencias Biologicas Universidad Nacional de la Amazonia PeruanaIquitos 16001Peru Facultad de Ciencias Agropecuarias Universidad Alas PeruanasLima 15823Peru EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Peru Observatorio de Aves Loreto(LBO) Distrito de San JuanLoreto 16008Peru Centro Urku de Estudios Amazonicos Tarapoto 22200Peru Servicio Nacional de Areas Naturales Protegidas por el Estado 15036Peru Sanidad Animal-Facultad de Zootecnia Universidad Nacional Agraria La MolinaLima 15012Peru Laboratorio de Microbiologia Facultad de Medicina Veterinaria y ZootecniaUniversidad CientUfica del SurLima 15067Peru Laboratorio de Analisis Clinico Moraleslab SAC MoralesSan Martin 22201Peru Asociacion Ecosistemas Andinos(ECOAN) Cuzco 08002Peru Pharmacology and Toxicology Graduate Group University of CaliforniaDavisDA 95616USA Global Health Initiative Wabash CollegeCrawfordsvilleIN 47933USA Facultad de Ciencias Biologicas Universidad Nacional Mayor de San MarcosLima 15081Peru Facultad de Medicina Veterinaria Universidad Nacional Hermilio ValdizanHuanuco10160Peru Asociacion Peruana de Helmintologia e Invertebrados Afines Lima 15054Peru Laboratorio de Ecologia y Biodiversidad Animal Universidad Nacional Federico VillarrealEl AgustinoLima 15007Peru Laboratorio de Invertebrados Universidad Ricardo Palma-Santiago de SurcoLima 15537Peru Department of Biology San Francisco State UniversitySan FranciscoCA 94132USA

Characterizing the diversity and structure of host–parasite communities is crucial to understandingtheir eco-evolutionary dynamics.Malaria and related haemosporidian parasites are responsible forfitness loss and mortality in bird species worldwide.However,despite exhibiting the greatest ornithologicalbiodiversity,avian haemosporidians from Neotropical regions are quite unexplored.Here,we analyze the genetic diversity of bird haemosporidian parasites(Plasmodium andHaemoproteus)in 1,336 individuals belonging to 206 bird species to explore for differences in diversityof parasite lineages and bird species across 5 well-differentiated Peruvian ecoregions.Wedetected 70 different haemosporidian lineages infecting 74 bird species.We showed that 25 out ofthe 70 haplotypes had not been previously recorded.Moreover,we also identified 81 new host–parasite interactions representing new host records for these haemosporidian parasites.Our outcomesrevealed that the effective diversity(as well as the richness,abundance,and Shannon–Weaver index)for both birds and parasite lineages was higher in Amazon basin ecoregions.Furthermore,we also showed that ecoregions with greater diversity of bird species also had highparasite richness,hence suggesting that host community is crucial in explaining parasite richness.Generalist parasites were found in ecoregions with lower bird diversity,implying that the abundanceand richness of hosts may shape the exploitation strategy followed by haemosporidian parasites.These outcomes reveal that Neotropical region is a major reservoir of unidentified haemosporidianlineages.Further studies analyzing host distribution and specificity of these parasites inthe tropics will provide important knowledge about phylogenetic relationships,phylogeography,and patterns of evolution and distribution of haemosporidian parasites.

关键词： Amazonia avian malaria generalist parasite habitat specificity Haemoproteus Plasmodium specialist parasite

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Risk Factors and Gender Differences for Depression in Chilean Older Adults:A Cross-Sectional Analysis from the National Health Survey 2016–2017

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International Journal of Mental Health Promotion 2022年第5期24卷 679-697页

作者： Gabriela Nazar carlos-María Alcover Yeny Concha-Cisternas Igor Cigarroa Ximena Díaz-Martínez Mariela Gatica-saavedra Fabián Lanuza Ana María Leiva-Ordónez María Adela Martínez-Sanguinetti Miquel Martorell Fanny Petermann-Rocha Claudia Troncoso-Pantoja carlos Celis-Morales Departamento de Psicología Facultad de Ciencias SocialesUniversidad de ConcepciónConcepciónChile Centro de Vida Saludable Universidad de ConcepciónConcepciónChile Departamento de Psicología Facultad de Ciencias de la SaludUniversidad Rey Juan CarlosMadridEspaña Pedagogía en Educación Física Facultad de EducaciónUniversidad AutónomaTalcaChile Escuela de Kinesiología Facultad de SaludUniversidad Santo TomásLosÁngelesChile Grupo de Investigación Calidad de Vida Departamento de Ciencias de la EducaciónUniversidad del BiobíoChillánChile Depto de Psiquiatría y Salud Mental Facultad de MedicinaUniversidad de ConcepciónConcepciónChile Centro de Epidemiología Cardiovascular y Nutricional(EPICYN) Facultad de MedicinaUniversidad de La FronteraTemucoChile Biomarkers and Nutrimetabolomics Laboratory Department of NutritionFood Sciences and GastronomyFood Technology Reference Net(XIA)Nutrition and Food Safety Research Institute(INSA)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelona08028Spain Instituto de Anatomía Histología y PatologíaFacultad de MedicinaUniversidad Austral de ChileValdiviaChile Instituto de Farmacia Facultad de CienciasUniversidad Austral de ChileValdiviaChile Departamento de Nutrición y Dietética Facultad de Farmacia.Universidad de ConcepciónConcepciónChile Facultad de Medicina Universidad Diego PortalesSantiagoChile BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK Centro de Investigación en Educación y Desarrollo(CIEDE-UCSC).Departamento de Salud Pública Facultad de MedicinaUniversidad Católica de la Santísima ConcepciónConcepciónChile Laboratorio de Rendimiento Humano Grupo de Estudio en EducaciónActividad Física y Salud(GEEAFyS)Universidad Católica del MauleTalcaChile

Depressive disorders are recognized as one of the most common mental health conditions across different age groups.However,the risk factors associated with depression among older people from low-and middle-income countries remains unclear.This study aims to identify socio-demographic,health and psychosocial-related factors associated with depression in Chilean older adults.A cross-sectional study was carried out in a representative sample of 1,765 adults aged≥60 years participants from the Chilean National Health Survey 2016–2017.Depres-sion was assessed with the Composite International Diagnostic Interview(CIDI-SF).Associations between the exposure variables and depression were investigated using Poisson regression analyses.The mainﬁndings indi-cated that women showed higher likelihood of depression than men(Prevalence Ratio(PR)=2.6[95%CI:1.40;4.89]).An increased likelihood of depression was found in older adults with chronic pain,multimorbidity(≥2 diseases),previous diagnose of depression,high perception of stress,ﬁnancial stress,and difﬁculties for social par-ticipation.In women,higher likelihood of depression was found for those with the frailty phenotype(PR:8.53[95%CI:1.68;43.32]),rheumatoid arthritis(PR:2.41[95%CI:1.34;4.34]),insomnia(PR:2.99[95%CI:1.74;5.12])and low self-rated well-being(PR:4.94[95%CI:2.26;10.79]).Men who were divorced(PR:7.10[95%CI:1.44;34.90])or widowed(PR:10.83[95%CI:3.71;31.58]),obese(PR:5.08[95%CI:1.48;17.42])and who had asthma(PR:7.60[95%CI:2.31;24.99])were associated with higher odds of depression.The currentﬁndings may have clinical implications for the early identiﬁcation of older adults more susceptible to depression and also suggest the need to implement cultural and age-sensitive strategies to promote mental health in late life.

关键词： Depression older adults aging late-life depression risk factors

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Testing the hypothesis of subtypes of nonadherence in schizophrenia and schizoaffective disorder:A prospective study

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World Journal of Psychiatry 2020年第11期10卷 260-271页

作者： Dulcinea Vega Francisco J Acosta Pedro saavedra Department of Psychiatry University of Las Palmas de Gran CanariaLas Palmas de Gran Canaria 35016Las PalmasThe Canary IslandsSpain Department of Psychiatry Insular University Hospital Department of Mental Health General Management of Healthcare Programs Canary Islands Health ServiceLas Palmas de Gran Canaria 35004Las PalmasThe Canary IslandsSpain Research Network on Health Services for Chronic Conditions(REDISSEC) Carlos III Health InstituteMadrid 28029Spain Department of Mathematics University of Las Palmas de Gran CanariaLas Palmas de Gran Canaria 35016Las PalmasThe Canary IslandsSpain

BACKGROUND Nonadherence is a major problem in the treatment of psychotic disorders.It has been hypothesized that nonadherent patients with schizophrenia are not a homogeneous population and subtypes of nonadherence might exist,but this hypothesis has not been specifically tested.AIM To test the hypothesis of subtypes of nonadherence in schizophrenia and schizoaffective disorder.METHODS This prospective study included 110 consecutively admitted patients diagnosed with schizophrenia or schizoaffective disorder.Assessments were performed at baseline and at 6 mo follow-up after discharge.Sociodemographic,clinical,psychopathological and treatment-related variables were evaluated.Adherence was defined as the concurrence of adherence to antipsychotic treatment and outpatient follow-up during the six-month period.Adherence to antipsychotic treatment was defined as the concurrence of objective and subjective adherence.Sixty-four patients(58%)fulfilled nonadherence criteria at the end of the followup period and were categorized according to their subtype of nonadherence.RESULTS In nonadherent patients(n=64),32(50%)fulfilled criteria of intentional nonadherence,and 32(50%)of unintentional nonadherence(UNA).Unintentional nonadherent patients,as compared to intentional nonadherent patients,are characterized by older age,lower educational level,worse cognitive and negative symptoms,greater severity,worse knowledge of their treatment regimen,greater prevalence of supervision of the treatment,lower number of prior hospitalizations and greater use of nonpsychiatric treatment,anticholinergics and hypnotics.Low educational level(OR=26.1;95%CI:2.819-241),worse treatment knowledge at six months(OR per unit=0.904;95%CI:0.853-0.957)and nonpsychiatric treatment at six months(OR=15.8;95%CI:1.790-139)were independently associated to UNA.CONCLUSION Differentiated subtypes of nonadherence according to intentionality seem to exist in patients with schizophrenia and schizoaffective disorder.Our findings suggest the need for differentiated app

关键词： Adherence Hospitalization Psychosis Hypothesis Unintentional nonadherence Intentional nonadherence

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Endoscopic submucosal dissection in dogs in a World Gastroenterology Organisation training center

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World Journal of Gastroenterology 2010年第14期16卷 1759-1764页

作者： Miguel A Tanimoto Gonzalo Torres-Villalobos Rikiya Fujita Patricio Santillan-Doherty Jorge Albores-saavedra German Gutierrez Luis A Martin-del-Campo carlos Bravo-Reyna Octavio Villanueva Jose J Villalobos Misael Uribe Miguel A Valdovinos Department of Gastroenterology and World Gastroenterology Organisation Training Center National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico Department of Surgery and Experimental Surgery National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico The Cancer Institute Hospital of JFCR Tokyo Tokyo 135-8550 Japan Department of Pathology National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico Department of Experimental Surgery National Institute of Medical Sciences and Nutrition Salvador Zu- biran Mexico City 14000 Mexico Animal lab and Department of Experimental Research National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico

AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on artificial lesions of the esophagus or stomach marked with coagulation points. After ESD, each canine model was euthanized and surgical resection of the esophagus or stomach was carried out according to "The Principles of Humane Experimental Technique, Russel and Burch". The ESD specimens were fixed with needles on cork submerged in a formol solution with the esophagus or stomach, and delivered to the pathology department to be analyzed. RESULTS: ESD was completed without complications using the Hook-knife in five esophageal areas, with a procedural duration of 124 ± 19 min, a length of 27.4 ± 2.6 mm and a width of 21 ± 2.4 mm. ESD was also completed without complications using the IT-knife2 in five gastric areas, with a procedural duration of 92.6 ± 19 min, a length of 32 ± 2.5 mm and a width of 18 ± 3.7 mm. CONCLUSION: ESD is feasible in the normal esopha- gus and stomach of canine models, which are appropriate for teaching this technique.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Stomach neoplasms Training

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Genetic Diversity of Great Dane Breed Using Ten Microsatellites: Impact of Breeding Control over the Breeding Line

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Open Journal of Genetics 2014年第2期4卷 78-86页

作者： Gino Noris Carla Santana Mariana Herrán-Aguirre Marco Antonio Meraz-Ríos Mario Pérez-Martínez carlos Esquivel-Lacroix Leonor C. Acosta-saavedra Eduardo Rodríguez María de la Paz Juaréz Emma S. Calderón-Aranda Rocío Gómez BIMODI (Biología Molecular Diagnóstica) Querétaro Qro. México Departamento de Biomedicina Molecular Cinvestav-IPN México D.F. México Departamento de Morfología Facultad de Medicina Veteri-naria y Zootecnia Universidad Nacional Autónoma de México México D.F. México Departamento de Reproducción Facultad de Medicina Vete-rinaria y Zootecnia Universidad Nacional Autónoma de México México D.F. México Departamento de Toxicología Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508 Col. San Pedro Zacatenco México D.F. México

The American Kennel Club and the Fédération Cynologique Internationale recognize two phenotypic variants of Great Dane breed denominated American and European varieties. Historically, these varieties have been segregated according to morphological characteristics. In an attempt to obtain a better characterization, breeders have been interested in the genetic parameters that could evaluate the within-breed diversity. In this document, we studied the genetic structure of Great Dane breed with 10 STR markers in 88 dogs using capillary electrophoresis. Cluster analysis, population differentiation and phylogenetic analyses revealed that American and European varieties are genetically independent. Nevertheless, within the American variety a genetic stratification was found. Additionally, a high misclassification (28%) was detected, which could be due to wrong registration or false paternity. Our results support the importance to deem genetic markers as useful tools in breeding control. Similarly, these studies serve as an accurate reference to establish standards by dog breeding associations and for choosing among dogs for inter-breeding. Nevertheless, genetic tools are only a complement of morphological methods, since both are reshuffling the control over the breeding line. Notwithstanding, this database provides an overall and scape concerning the impact of genetic diversity within-breed. Unmistakably, more databases are needed to increase the quality of the breeding line as well as the number of STR in order to study, with more detail, the genetic structure in the Great Dane race.

关键词： Genetic Structure Great Dane Varieties Microsatellites Population Genetics Population Stratification

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