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BIOCELL 2019年第1期43卷 29-35页

作者： Odin ramirez-FERNANDEZ Ludovika CACOPARDO Benjamin LEON-MANCILLA Joana COSTA Research Centre“E.Piaggio”Department of Information Engineering University of PisaItaly Departamento de Cirugia Facultad de MedicinaUniversidad nacional Autonoma de Mexico Departamento de Ciencias Basicas Instituto Tecnologico de TlalnepantlaTecnologicos de MexicoMexico

We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic *** custom-designed presents a semipermeable membrane bioreactor,with peristaltic flow and compression variation that allows adjustment of luminal flow *** addition,this system is also capable of achieving the drug distribution in the small intestine model from the apical compartment to the basal compartment by the semipermeable *** dynamic bioreactor can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy with the previously described in vitro small intestinal models,providing a more representative model of the small intestine.

关键词： Bioreactor Flow Simulation Permeability 3D Print Small Intestine

Re-evaluating the importance of carbohydrates as regenerative biomaterials

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Regenerative Biomaterials 2019年第1期6卷 1-12页

作者： Heidi F.Oldenkamp Julia E.Vela ramirez Nicholas A.Peppas Institute for Biomaterials Drug Deliveryand Regenerative Medicine McKetta Department of Chemical Engineering Department of Biomedical Engineering Department of Pediatrics Dell Medical School Department of Surgery and Perioperative Care Dell Medical School Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA

Introduction Carbohydrates are the most abundant natural biomaterials in the *** interacting with cells of a variety of levels,they take part in essential functions of organisms including cellular communication,inflammation,infection development and *** carbohydrate–cell interactions occur on a variety of levels through glycoconjugates such as glycolipids,glycosaminoglycans(GAGs),glycoproteins and proteoglycans[1–4].The roles of carbohydrates in biological systems pose them as some of the most sought-after *** use of these multifaceted molecules provides the opportunity to tailor desired responses depending on the target application[1–5].

关键词： carbohydrate regenerative biomaterials polysaccharide tissue engineering

Effect of the thin cell layer technique in the induction of somatic embryos in Pinus patula Schl. et Cham

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Journal of Forestry Research 2019年第4期30卷 1535-1539页

作者： Marco A.ramirez-Mosqueda Lourdes G.Iglesias-Andreu Arturo A.Armas-Silva Esmeralda J.Cruz-Gutierrez Jose F.de la Torre-Sanchez Otto R.Leyva-Ovalle carlos M.Galan-Paez Instituto de Biotecnologfa y Ecologfa Aplicada(INBIOTECA) Universidad Veracruzana.Av.de las Culturas Veracruzanas No.101Campus para la Culturalas Artes y el DeporteCol.Emiliano ZapataC.P.91090 XalapaVeracruzMexico Centro Nacional de Recursos Geneticos-INIFAP Boulevard de la Biodiversidad No.400 Rancho las CrucesC.P.47600 Tepatitlan de MorelosJaliscoMexico Facultad de Ciencias Bioldgicas y Agropecuarias Region Cordoba-Orizaba Universidad VeracruzanaC.P.94945 Amatlan de los ReyesVeracruzMexico

Pinus patula is a species commonly used for reforestation in ***,efficient methods for the mass production seedlings are *** particularly by somatic embryogenesis provides an option for the rapid multiplication of high-quality,genetically improved *** study induces somatic embryogenesis in this species using the thin cell layer(TCL)*** sources of explants(complete immature embryos;lTCL segments from immature embryos)were *** efficiency of TCL from longitudinal sections[lTCL]and transverse[tTCL]was *** results show using thin cell layers from immature embryos cultivated in 16 light/8 dark hours achieves induction of somatic embryos.A higher percentage of embryogenic callus was obtained when tTCL segments were used as an explant *** results produced somatic embryos from tTCL segments of an immature embryo without germinating the seed,making the process more time *** addition,this technique can be used to generate somatic embryogenesis in forest species that have low germination rates.

关键词： Pinus patula Somatic embryos Micropropagation Thin cell layer Maturation

The effects of plyometric jump training on lower-limb stiffness in healthy individuals:A meta-analytical comparison

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Journal of Sport and Health Science 2023年第2期12卷 236-245页

作者： Jason Moran Bernard Liew Rodrigo ramirez-Campillo Urs Granacher Yassine Negra Helmi Chaabene School of Sport Rehabilitation and Exercise SciencesUniversity of EssexColchesterEssex CO43SQUK Department of Physical Activity Sciences Universidad de Los LagosOsorno 5290000Chile Division of Training and Movement Science University of PotsdamPotsdam 14469Germany Higher Institute of Sport and Physical Education of Ksar Saı¨d University of Manouba Tunis 2037Tunisia High Institute of Sports and Physical Education of Kef University of JendoubaJendouba 8189Tunisia

Purpose:This study aimed to examine the effects of plyometric jump training(PJT)on lower-limb ***:Systematic searches were conducted in PubMed,Web of Science,and *** participants included healthy males and females who undertook a PJT programme isolated from any other training ***:There was a small effect size(ES)of PJT on lower-limb stiffness(ES=0.33,95%confidence interval(95%CI):0.07-0.60,z=2.47,p=0.01).Untrained individuals exhibited a larger ES(ES=0.46,95%CI:0.08-0.84,p=0.02)than trained individuals(ES=0.15,95%CI:-0.23 to 0.53,p=0.45).Interventions lasting a greater number of weeks(>7 weeks)had a larger ES(ES=0.47,95%CI:0.06-0.88,p=0.03)than those lasting fewer weeks(ES=0.22,95%CI:-0.12 to 0.55,p=0.20).Programmes with2 sessions per week(ES=0.20,95%CI:-0.10 to 0.50,p=0.18).Programmes with500 jumps per week had negative effects(ES=-0.22,95%CI:-1.10 to 0.67,p=0.63).Programmes with>7.5 jumps per set showed larger effect sizes(ES=0.55,95%CI:0.02-1.08,p=0.04)than those with7 weeks).

关键词： Jumps Stretch shortening cycle Tendon

Data driven discovery of conjugated polyelectrolytes for optoelectronic and photocatalytic applications

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npj Computational Materials 2021年第1期7卷 641-649页

作者： Yangyang Wan Fernando ramirez Xu Zhang Thuc-Quyen Nguyen Guillermo C.Bazan Gang Lu Department of Physics and Astronomy California State University NorthridgeNorthridgeCaliforniaUSA Department of Chemistry and Biochemistry University of CaliforniaSanta BarbaraCaliforniaUSA

Conjugated polyelectrolytes(CPEs),comprised of conjugated backbones and pendant ionic functionalities,are versatile organic materials with diverse ***,the myriad of possible molecular structures of CPEs render traditional,trial-and-error materials discovery strategy ***,we tackle this problem using a data-centric approach by incorporating machine learning with high-throughput first-principles *** systematically examine how key materials properties depend on individual structural components of CPEs and from which the structure–property relationships are *** means of machine learning,we uncover structural features crucial to the CPE properties,and these features are then used as descriptors in the machine learning to predict the properties of unknown ***,we discover promising CPEs as hole transport materials in halide perovskite-based optoelectronic devices and as photocatalysts for water *** work could accelerate the discovery of CPEs for optoelectronic and photocatalytic applications.

关键词： conjugated backbone photocatalytic

Trans-epithelial accelerated corneal cross-linking for keratoconus in children

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1919-1921页

作者： Andrew Olivo-Payne Juan carlos Serna-Ojeda Erick Hernandez-Bogantes Alexandra Abdala-Figuerola Lucero Pedro-Aguilar Alejandro Lichtinger Arturo ramirez-Miranda Alejandro Navas Enrique O.Graue-Hernandez Department of Cornea and Refractive Surgery Institute of Ophthalmology ＂Conde de Valenciana＂ department of cornea and refractive surgery institute of ophthalmology"conde de valenciana"Cuauhtemoc 06800Mexico CityMexico

The aim of the study is to evaluate the safety and effi cacy of trans-epithelial accelerated corneal cross-linking（TE-ACXL） in children with progressive ***,case-series of 23 eyes of 14 children who underwent *** were performed at baseline and 1,3,6,12 and 18 mo *** follow-up time of 23.82±3.15 mo and mean age was 13.7±1.4 y（range 11 to 16 y）.Mean preoperative uncorrected distance visual acuity changed from 0.92±0.45 log MAR（20/160） to 0.71±0.40 log MAR（20/100）（P=0.001）.Mean keratometry（Km） changed from 53.87± 6.03 to 53.00±5.81（P=0.001）.Pachymetry did not have significant changes at last follow-up（P=0.30）.The mean preoperative sphere was-5.58±2.48 and-4.89±4.66 D（P=0.11） at last follow-up;refractive cylinder from-5.58±2.48 to-5.02±2.23（P=0.046）.In conclusion,tomographic and refractive stability are shown in over 91% of eyes with pediatric progressive keratoconus who underwent TE-ACXL.

关键词： corneal cross-linking keratoconus acceleratedcross-linking pediatric keratoconus

Antibacterial activities of mangrove leaf endophytic fungi from Luzon Island,Philippines

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Studies in Fungi 2020年第1期5卷 320-331页

作者： ramirez CSP Notarte KIR dela Cruz TEE The Graduate School University of Santo TomasEspaña Blvd.1008 ManilaPhilippines Fungal Biodiversity Ecogenomics and Systematics GroupResearch Center for the Natural and Applied SciencesUniversity of Santo TomasEspaña Blvd.1008 ManilaPhilippines Department of Biological Sciences College of ScienceUniversity of Santo TomasEspaña Blvd.1008 ManilaPhilippines

Fungi associated with mangroves are untapped sources of bioactive secondary *** this study,628 mangrove leaf endophytic fungi(MLEF)were recorded from 19 mangrove hosts collected from the provinces of Zambales,Batangas,Cavite,and Quezon in Luzon Island,*** MLEF morphospecies were identified as belonging to the genera Aspergillus,Cladosporium,Colletotrichum,Fusarium,Nigrospora,Penicillium,Pestalotiopsis,Phialophora,and *** revealed that the MLEF crude culture extracts were promisingly potent against the gram-positive bacteria Staphylococcus aureus and Micrococcus luteus(ZOI>19 mm)with no or partial activity against the gram-negative bacteria Klebsiella oxytoca and Pseudomonas *** findings showed that mangrove leaf endophytic fungi are potential sources of bioactive compounds.

关键词： bioactivities fungal endophytes mangrove forests secondary metabolites

Molecular and in vitro Characterization of Field Isolates of Bovine Herpesvirus-1

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Virologica Sinica 2012年第1期27卷 26-37页

作者： Julian Ruiz-Saenz Jairo Jaime Gloria ramirez Victor Vera Faculty of Veterinary Medicine and Animal Science National University of Colombia

Bovine Herpesvirus-1 (BoHV-1) is distributed worldwide and is a major pathogen in cattle, being the causal agent of a variety of clinical syndromes. The aim of this study was to isolate and to characterize (molecular and biological characterization) BoHV-1 from 29 immunosuppressed animals. It was possible to obtain 18 isolates, each from a different animal, such as from the respiratory and reproductive tracts. In some cases the cytopathic effect was visible 12 hours post-inoculation, and became characteristic after 36-48 hours. Biological characteristics were evaluated and compared with Iowa and Colorado-1 reference strains, and differences were found in plaque size, virus titer measured by TCID50 and PFU/mL, and one step virus curves. These results showed that some isolates had a highly virulent-like behavior in vitro, compared to the reference strains, with shorter eclipse periods, faster release of virus into the supernatants, and higher burst size and viral titer. There were no differences in glycoprotein expression of BoHV-1 isolates, measured by Western blot on monolayers. Moreover, using restriction endonucleases analysis, most of the viruses were confirmed as BoHV-1.1 and just one of them was confirmed as BoHV-1.2a subtype. These findings suggest that some wild-type BoHV-1 isolates could be useful as seeds to develop new monovalent vaccines.

关键词： Bovine herpesvirus 1 Genital infection Respiratory infection Latent infection

Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure

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Neural Regeneration Research 2022年第2期17卷 237-245页

作者： Jessica D.Panes Aline Wendt Oscar ramirez-Molina Patricio A.Castro Jorge Fuentealba Laboratorio de Screening de Compuestos Neuroactivos(LSCN) Departamento de FisiologiaFacultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile Centro de Investigaciones Avanzadas en Biomedicina(CIAB-UdeC) Facultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile Departamento de Fisiologia Facultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile

The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The main features of neurodegenerative diseases have been related with cellular and molecular events like neuronal loss, mitochondrial dysfunction and aberrant accumulation of misfolded proteins or peptides in specific areas of the brain. The most prevalent neurodegenerative diseases belonging to age-related pathologies are Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis. Interestingly, mitochondrial dysfunction has been observed to occur during the early onset of several neuropathological events associated to neurodegenerative diseases. The master regulator of mitochondrial quality control and energetic metabolism is the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α). Additionally, it has been observed that PGC-1α appears to be a key factor in maintaining neuronal survival and synaptic transmission. In fact, PGC-1α downregulation in different brain areas(hippocampus, substantia nigra, cortex, striatum and spinal cord) that occurs in function of neurological damage including oxidative stress, neuronal loss, and motor disorders has been seen in several animal and cellular models of neurodegenerative diseases. Current evidence indicates that PGC-1α upregulation may serve as a potent therapeutic approach against development and progression of neuronal damage. Remarkably, increasing evidence shows that PGC-1α deficient mice have neurodegenerative diseases-like features, as well as neurological abnormalities. Finally, we discuss recent studies showing novel specific PGC-1α isoforms in the central nervous system that appear to exert a key role in the age of onset of neurodegenerative diseases and have a neuroprotective function in the central nervous system, thus opening a new molecular strategy for treatment of neurodegenerative diseases. The purpose of this review is to provide an up-t

关键词： Alzheimer's disease amyotrophic lateral sclerosis Huntington's disease mitochondrial dysfunction Parkinson's disease PGC-1α synaptic function vascular dementia

An Inexact Proximal Method with Proximal Distances for Quasimonotone Equilibrium Problems

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Journal of the Operations Research Society of China 2017年第4期5卷 545-561页

作者： Lennin Mallma ramirez Erik Alex Papa Quiroz P.R.Oliveira Coordenação dos Programas de Pós-gaduação em Engenharia-Programa de Engenharia de Sistemas e Computação Federal University of Rio de JaneiroRio of JaneiroBrazil Mayor de San Marcos National University LimaPeru

In this paper,we propose an inexact proximal point method to solve equilibrium problems using proximal distances and the diagonal *** some natural assumptions on the problem and the quasimonotonicity condition on the... 详细信息

关键词： Equilibrium problems Quasimonotonicity Proximal distance Proximal method