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Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid dynamics: mathematical and modelling aspects of porous media

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 399-409,F0004页

作者： Fernando F.Rivera Berenice Miranda-Alcantara German Orozco carlos ponce de leon Luis F.Arenas National Council of Science and Technology(CONACYT) Mexico City 03940Mexico Center of Research and Technological development in Electrochemistry(CIdeTEQ) Queretaro 76703Mexico Electrochemical Engineering Laboratory Energy Technology Research GroupFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

description of electrolyte fluid dynamics in the electrode compartments by mathematical models can be a powerful tool in the development of redox flow batteries(RFBs)and other electrochemical *** order to determine their predictive capability,turbulent Reynolds-averaged Navier-Stokes(RANS)and free flow plus porous media(Brinkman)models were applied to compute local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive half-cell of a cerium-based RFB for laboratory *** different platinized titanium electrodes were considered,a plate plus a turbulence promoter and an expanded metal *** pressure drop was validated against experimental data obtained with typical cerium *** was found that the pressure drop values were better described by the RANS approach,whereas the validity of Brinkman equations was strongly dependent on porosity and permeability values of the porous media.

关键词： CFD simulation porous media porous electrode pressure drop redox flow battery

Dysregulation of the PD-1/PD-L1 pathway contributes to the pathogenesis of celiac disease

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Cellular & Molecular Immunology 2019年第9期16卷 777-779页

作者： Candelaria ponce de leon Miguel Angel Lopez-Casado Pedro Lorite Teresa Palomeque Maria Isabel Torres department of Experimental Biology University of JaenJaenSpain department of Pediatrics Gastroenterology Hospital Virgen de las NievesGranadaSpain

In this study,we focus on the alteration of the programmed cell death 1(PD-1)/PD-L1 pathway in celiac *** discuss the diverse roles of the PD-1 pathway in regulating immune responses and how this knowledge can improve celiac disease(CD)*** PD-1 and PD-L1 levels in the serum and in intestinal biopsies of CD patients may be relevant to the determination of a possible correlation between markers of the autoimmune response,inflammation,and disease activity.

关键词： celiac pathogenesis inflammation

RANS simulations of the U and V grooves effect in the subcritical flow over four rotated circular cylinders

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Journal of Hydrodynamics 2015年第4期27卷 569-578页

作者： ALONZO-GARCIA A. GUTIERREZ-TORRES C.del C. JIMENEZ BERNAL J.A. MOLLINEDO-ponce de leon H.R. MARTINEZ-deLGADILLO S.A. BARBOSA-SALDANA J.G. Instituto Politécnico Nacional SEPI ESIME ZacatencoLABINTHAP U.P.Adolfo López Mateos Edif.5 3er.PisoMéxicoD.F.México Instituto Politécnico Nacional UPIITAAv.IPN 2580C.P.07340MéxicoD.F.México Universidad Autónoma Metropolitana-Azcapotzalco Depto.Ciencias BásicasAv.San Pablo 180Azcapotzalco C.P 07740MéxicoD.F.México

This paper presents a CFD study about the effect of the V and U grooves in the flow over four cylinders in diamond shape configuration at subcritical flow conditions（Re= 41 000）. The k- ε Realizable turbulence model was implemented to fully structured hexahedral grids with near-wall refinements. Results showed that the numerical model was able to reproduce the impinging flow pattern and the repulsive forces present in the lateral cylinders of the smooth cylinder array. As a consequence of the flow alignment induced by the grooves, a jet-flow is formed between the lateral cylinders, which could cause an important vortex induced vibration effect especially in the rear cylinder. The magnitudes of the shear stresses at the valleys and peaks for the V grooved cylinders were lower than those of the U grooved cylinders, but the separation points were delayed due the U grooves presence. It is discussed the presence of a blowing effect caused by counter-rotating eddies located near the grooves peaks that cause a decrease of the shear stresses in the valleys, and promote them at the peaks.

关键词： RANS model grooved cylinder four cylinders subcritical flow impinging flow

Two novel mutations in theGAN gene causing giant axonal neuropathy

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World Journal of Pediatrics 2018年第3期14卷 298-304页

作者： Monica Irad Normendez-Martínez Lucero Monterde-Cruz Roberto Martínez Magdalena Marquez-Harper Nayelli Esquitin-Garduno Margarita Valdes-Flores leonora Casas-Avila Valeria ponce de leon-Suarez Viktor Javier Romero-Díaz Alberto Hidalgo-Bravo Medical Specialties Hospital Boulevard Milenio 130San Carlos la Roncha37660 LeonGuanajuatoMexico department of Gene tics National Institute of R ehabilitationAvenue Mexico-Xochimilco 28914389 Me xico CityMexico department ofHis tology School ofMedicineAutonomous University oft heS tate ofN uevo LeonMonterreyMexico

Background Giant axonal neuropathy (GAN) is a rare neurodegenerative disease transmitted in an autosomal recessive mode. This disorder presents motor and sensitive symptoms with an onset in early childhood. Progressive neurodegeneration makes the patients wheelchair dependent by the end of the second decade of life. Affected individuals do not survive beyond the third decade of life. Molecular analysis has identified mutations in the gene GAN in patients with this disorder. This gene produces a protein called gigaxonin which is presumably involved in protein degradation via the ubiquitin-proteasome system. However, the underlying molecular mechanism is not clearly understood yet. Methods Here we present the fi rst patient from Mexico with clinical data suggesting GAN. Sequencing of the GAN gene was carried out. Changes in the nucleotide sequence were investigated for their possible impact on protein function and structure using the publicly available prediction tools PolyPhen-2 and PANTHER. Results The patient is a compound heterozygous carrying two novel mutations in the GAN gene. The sequence analy-sis revealed two missense mutations in the Kelch repeats domain. In one allele, a C>T transition was found in exon 9 at the nucleotide position 55393 (g.55393C>T). In the other allele, a transversion G>T in exon 11 at the nucleotide position 67471 (g.67471G>T) was observed. Both of the bioinformatic tools predicted that these amino acid substitutions would have a negative impact on gigaxonin's function. Conclusion This work provides useful information for health professionals and expands the spectrum of disease-causing mutations in the GAN gene and it is the first documented case in Mexican population.

关键词： GAN Genetics Giant axonal neuropathy Incapacity Neurodegenerative

Does parity worsen diabetes-related chronic complications in women with type 1 diabetes?

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World Journal of Diabetes 2016年第12期7卷 252-259页

作者： Marilia Brito Gomes carlos Antonio Negrato Ana Almeida Antonio ponce de leon department of Internal Medicine Diabetes Unit State University of Rio de Janeiro Rio de Janeiro 20550-900 Brazil Bauru’s Diabetics Association Bauru SPaulo 17012-433 Brazil department of Epidemiology State University of Rio de Janeiro Rio de Janeiro 20550-900 Brazil

AIM: To determine the relationship between parity, glycemic control, cardiovascular risk factors and diabetesrelated chronic complications in women with type 1 ***: This was a multicenter cross-sectional study conducted between december 2008 and december 2010 in 28 public clinics in 20 cities from the 4 Brazilian geographic regions. Data were obtained from 1532 female patients, 59.2% Caucasians, and aged 25.2 ± 10.6 years. Diabetes duration was of 11.5 ± 8.2 years. Patient's information was obtained through a questionnaire and a chart review. Parity was stratified in five groups: Group 0(nulliparous), group 1(1 pregnancy), group 2(2 pregnancies), group 3(3 pregnancies), group 4(≥ 4 pregnancies). Test for trend and multivariate random intercept logistic and linear regression models were used to evaluate the effect of parity upon glycemic control, cardiovascular risk factors and diabetes-related complications. RESULTS: Parity was not related with glycemic control and nephropathy. Moreover, the effect of parity upon hypertension, retinopathy and macrovascular disease did not persist after adjustments for demographic and clinical variables in multivariate analysis. For retinopathy, the duration of diabetes and hypertension were the most important independent variables and for macrovascular disease, these variables were age and hypertension. Overweight or obesity was noted in a total of 538 patients(35.1%). A linear association was found between the frequency of overweight or obesity and parity(P = 0.004). Using a random intercept multivariate linear regression model with body mass index(BMI) as dependent variable a borderline effect for parity(P = 0.06) was noted after adjustment for clinical and demographic data. The observed variability of BMI was not attributable to differences between ***: Our results suggest that parity has a borderline effect on body mass index but does not have an important effect upon hypertension and micro or macrova

关键词： Type 1 diabetes Parity Glycemic control Cardiovascular risk factors Diabetes-related chronic complications

First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico

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Insect Science 2016年第6期23卷 829-834页

作者： Gustavo ponce Iram P. Sanchez Selene M. Garcia Jose M. Torrado Saul Lozano-Fuentes Beatriz Lopez-Monroy Adriana E. Flores Facultad de Ciencias Biologicas Universidad Autonoma de Nuevo Leon A v. Universidad sin Cd. Universitaria San Nicolas de los GarzaN.L. 66455 Mexico department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO USA

The L1014F mutation in the voltage-sodium channel gene has been associated with resistance to DDT and pyrethroids in various arthropod species including mosquitoes. We determined the frequency of the L1014F kdr mutation in 16 field populations of Culex quinquefasciatus from Northeastern Mexico collected between 2008 and 2013. The L1014F was present in all populations analyzed with the lowest frequency （3.33%） corresponding to the population from Monclova collected in 2012, and the highest frequency （63.63%） from the Monterrey population collected in 2012. The presence of a kdr mutation in populations of Cx. quinquefasciatus from northeastern Mexico provides evidence ofpyrethroid resistance. This requires a special attention, considering that pyrethroid-based insecticides are commonly used in vector-control campaigns, especially against Aedes aegypti （L.）.

关键词： Culex quinquefasciatus insecticide resistance kdr L 1014F mutation

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赫利俄斯加油站美国洛杉矶

世界建筑导报 2018年第2期33卷 78-80页

作者： Nader Tehrani Monica ponce de leon Dan Gallagher Christian Ervin Lisa Huang Ji-Young Park Brandon Clifford Cathlyn Newell Office dA AIA 不详

赫利俄斯加油站的设计包含了创建绿色加油站的悖论。作为一个“学习实验室”，该加油站的设计旨在鼓励对话，促进教育，并培育关于环境管理问题的讨论。赫利俄斯加油站的供水、供热、能源、照明和材料等这些系统的建造均需最大限度地提... 详细信息

赫利俄斯加油站的设计包含了创建绿色加油站的悖论。作为一个“学习实验室”，该加油站的设计旨在鼓励对话，促进教育，并培育关于环境管理问题的讨论。赫利俄斯加油站的供水、供热、能源、照明和材料等这些系统的建造均需最大限度地提高可持续性和能源效率。该加油站重新发现了极具设计潜力的结构，这种结构在二十世纪的大部分时间一直主导美国景观角落地段的建设。顶篷的设计是该工程最具代表性的特点。以结构开间为起点，包覆系统将柱基、轴、主体与顶篷融为一体。在参数方面，

关键词：加油站美国洛杉矶能源效率管理问题可持续性设计实验室

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通州门楼中国北京

世界建筑导报 2018年第2期33卷 94-95页

作者： Nader Tehrani Monica ponce de leon Kristen Giannattasio Tali Buchler Hansy Luz Better Christine Mueller Achille Rossini Jeff Asanza Julian Palacio 不详

在距北京三十英里的地方，一个由200多名具有国际知名度的中国艺术家组成的社区，缺乏一个互动吸引点、艺术展示区或接待场所。一个由艺术家、评论家和代理人组成的财团收购了一处地产，准备为通州的艺术组织建设一个这样的项目。这是... 详细信息

在距北京三十英里的地方，一个由200多名具有国际知名度的中国艺术家组成的社区，缺乏一个互动吸引点、艺术展示区或接待场所。一个由艺术家、评论家和代理人组成的财团收购了一处地产，准备为通州的艺术组织建设一个这样的项目。这是一个分期项目，已完工的首期是门楼，包括定居在此的艺术家们的住房和工作室。项目场址被一堵现有的砖墙隔开，一边是一片树林，另一边是一片贫瘠的工业场地。虽然艺术中心位于工业场地一侧，但该方案将主要公共庭院面向树林，在砖墙上拆除部分墒体，以便形成框景。

关键词：门楼通州北京中国工业场地艺术家组织建设艺术中心

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BANQ餐厅美国波士顿

世界建筑导报 2018年第2期33卷 96-99页

作者： Nader Tehrani Dan Gallagher Monica ponce de leon Harry Lowd Richard Lee Lisa Huang Remon Alberts Janghwan Cheon Jumanah Jamal Aishah Al Sager

Banq餐厅位是一家新型餐厅．位于便士储蓄银行（Penny Savings Bank）旧大楼以前用来经营银行业务的大厅内。餐厅分成两个部分，前面区域面向华盛顿大街．设计成酒吧，后面的大厅则作为用餐区。然而，这个空间在z轴上以天花板和地面之... 详细信息

Banq餐厅位是一家新型餐厅．位于便士储蓄银行（Penny Savings Bank）旧大楼以前用来经营银行业务的大厅内。餐厅分成两个部分，前面区域面向华盛顿大街．设计成酒吧，后面的大厅则作为用餐区。然而，这个空间在z轴上以天花板和地面之间的另一个分区为中心进行设计。如果由于餐厅空间活动的多变性而需要保持灵活性——包括两个座位、四个座位和六个座位，以及与聚会和其他活动有关的座位配置--那么天花板就包合了一部分的固定的建筑物基础设施．

关键词：餐厅波士顿美国空间活动储蓄银行银行业务基础设施天花板