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A case of systemic amyloidosis beginning with purpura

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Chinese medical Journal 2012年第3期125卷 555-557页

作者： Zhao Jun-ying Zhang Rui-na Duan Xiao-han Xu Zhi-li Li Hong-wei Gu Fu-sheng Capital med Univ Beijing Friendship Hosp Dept Cardiol Beijing 100050 Peoples R China Capital med Univ Beijing Friendship Hosp Dept Dermatol Beijing 100050 Peoples R China

Primary systemic amyloidosis is a relatively rare disease, caused when abnormal extracellular deposition of fibrillary protein builds up in a variety of target organs, such as heart, kidneys, lungs liver, and so forth. The symptoms of the disease are usually vague, while many kinds of auxiliary or laboratory examinations especially pathologic biopsy can provide a clue for the diagnosis. Here we described a case who had purpura-like lesions in the initial stage, followed by progressive malfunctions in the kidneys, the heart, the lungs, as wel~ as the liver. The final diagnosis was primary systemic amyloidosis determined by skin pathologic biopsy. And the disease led to a fatal outcome within three months after the diagnosis.

关键词： primary systemic amyloidosis Congo red stain purpura

Voltage property analysis of piezoelectric floating mass actuator used in middle ear implant

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Journal of Southeast University(English Edition) 2009年第4期25卷 496-500页

作者：刘后广塔娜饶柱石上海交通大学机械系统与振动国家重点实验室上海200240

Aiming at a kind of middle ear implant（MEI）, the driving voltage of a piezoelectric floating mass actuator is analyzed using a 0. 7Pb （Mg1/3Nb2/3） O3-0. 3PbTiO3 （ PMN- 30% PT）stack as a new type of vibrator. For the purpose of facilitating the analysis, a simplified coupling model of the ossicular chain and the piezoelectric actuator is constructed. First, a finite element model of a human middle ear is constructed by reverse engineering technology, and the validity of this model is confirmed by comparing the simulated motion of the stapes footplate obtained by this model with experimental measurements. Then the displacement impedance of the incus long process is analyzed, and a single mass-spring-damper equivalent model of the ossicular chain attached with the clamp is derived. Finally, a simplified coupling model of the ossicular chain and the piezoelectric actuator is established and used to analyze the driving voltage property of the actuator. The results show that the required driving voltage decreases with the increase in the frequency, and the maximum required driving voltage is 20. 9 V in the voice frequencies. However, in the mid-high frequencies where most sensorineural hearing loss occurs, the maximum required driving voltage is 3.8 V, which meets the low-voltage and low-power requirements of the MEI.

关键词： middle ear implant piezoelectric actuator floating mass driving voltage

《协和医学杂志》新媒体开展知识类视频内容传播的实践与思考

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中国科技期刊研究 2022年第6期33卷 719-728页

作者：刘洋李娜赵娜李玉乐董哲孙静中国医学科学院北京协和医学院北京协和医院《协和医学杂志》编辑部北京市100730 中华医学会杂志社《智慧医学(英文)》编辑部北京市100052

【目的】视频化时代下,通过《协和医学杂志》开展知识类视频内容传播的具体实践,总结医学期刊知识类视频内容传播的有效运营方法及现存问题,为期刊同仁提供思路及借鉴。【方法】介绍《协和医学杂志》新媒体开展知识类视频内容传播的优... 详细信息

【目的】视频化时代下,通过《协和医学杂志》开展知识类视频内容传播的具体实践,总结医学期刊知识类视频内容传播的有效运营方法及现存问题,为期刊同仁提供思路及借鉴。【方法】介绍《协和医学杂志》新媒体开展知识类视频内容传播的优势及效果,并从视频选题、内容制定、类型把控、视觉表现和传播渠道5个方面分享运营策略及典型案例。【结果】《协和医学杂志》新媒体在知识类视频内容传播发展中通过锚定黄金栏目开展高起点系列选题策划,基于不同用户需求差异化制定视频内容,打破藩篱实施短中长视频全线发展,并创新探索MG动画与AI语音融合的视听表现,结合多平台分发、多渠道引流等综合运营措施,增强期刊内容传播力和品牌影响力,成效显著。【结论】医学期刊应抓住视频发展机遇,以多维度综合运营开创知识类视频新干线,为医学期刊视频内容传播拓新局。同时在实践中应注意发布规律、编辑素养、资金投入及长效发展布局等问题,从而坚实期刊市场竞争力,提升中国学术期刊知识内容传播影响力。

关键词：医学期刊新媒体知识类视频视频传播运营策略

最优最小熵反褶积与包络-导数能量算子在轴承故障提取中的应用

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电子测量与仪器学报 2020年第4期32卷 134-141页

作者：杨娜刘晔武昆西京学院西安710123 西安交通大学电气工程学院西安710049

最小熵反褶积是检测轴承故障或齿轮故障信号等类脉冲信号的一种有效技术,但是该方法仍存在一个不足,即在使用前须设置滤波器的长度,而该参数值的选择一般只能通过技术人员的经验选择。针对这个局限性,提出了一个基于峭度、排列熵与信号... 详细信息

最小熵反褶积是检测轴承故障或齿轮故障信号等类脉冲信号的一种有效技术,但是该方法仍存在一个不足,即在使用前须设置滤波器的长度,而该参数值的选择一般只能通过技术人员的经验选择。针对这个局限性,提出了一个基于峭度、排列熵与信号能量的滤波器长度选择准则。通过该准则,可以有效地挑选出最优的滤波器长度,从而更好地对故障信号进行滤波。随后,一种增强的能量算子,包络-导数能量算子用来对过滤后的故障信号进行故障特征频率的提取。实验结果表明,该方法不仅可以有效地提取出轴承故障特征频率,并且与一些传统方法相比,该方法可以大大突出故障特征频率的幅值。

关键词：轴承故障诊断最优选择准则最小熵反褶积包络-导数能量算子

急性运动成年人血浆胃肠激素肽水平变化的Meta分析

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中国组织工程研究 2015年第15期19卷 2455-2460页

作者：吴娜娜王茹王雪强管延飞上海体育学院运动健身科技省部共建教育部重点实验室上海市200438

背景:有研究认为急性运动可能是通过影响胃肠激素肽的合成和分泌来调节食欲影响摄食行为,但是目前此方面的相关研究样本量较小且结果迥异。目的:运用Meta分析法评估急性运动对成年人胃肠激素肽(酪酪肽)水平的影响。方法:检索Pub med、Go... 详细信息

背景:有研究认为急性运动可能是通过影响胃肠激素肽的合成和分泌来调节食欲影响摄食行为,但是目前此方面的相关研究样本量较小且结果迥异。目的:运用Meta分析法评估急性运动对成年人胃肠激素肽(酪酪肽)水平的影响。方法:检索Pub med、Google Scholar、Sport Discus、Web of Knowledge及CNKI数据库检索截止时间到2014年1月。采用Rev Man5.1软件进行Meta分析,发表性偏倚和异质性检验,数据合并和敏感性分析。结果与结论:1共有11篇符合纳入标准的文献,对18项随机对照试验188名受试者进行Meta分析急性运动对健康人血浆酪酪肽水平影响,结果发现资料有同质性合并效应量标准化均数差(SMD)合并=0.25,95%CI=0.05-0.46,P=0.01,故认为急性运动组与对照组相比酪酪肽水平在统计学上有显著性差异(P<0.05),且敏感性分析并未改变Meta分析的结果。2纳入3篇急性运动对健康成人血浆酪酪肽(3-36)的影响文献,5项随机对照实验,32名受试者进行Meta分析:异质性显著,故采用随机效应模型进行分析。合并标准化均值差标准化均数差(SMD)合并=1.80,95%CI=0.27-3.32,P=0.02,故急性运动上调了酪酪肽(3-36)水平。结果提示,急性运动可以增加成年人血浆胃肠激素肽水平,其水平变化可能会与运动后摄食量变化有关。

关键词：运动医学肽类食欲组织构建组织工程胃肠激素肽急性运动酪酪肽酪酪肽(3-36) 成年人 Meta分析国家自然科学基金

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

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Protein & Cell 2016年第3期7卷 210-221页

作者： Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan carlos Izpisua Belmonte Jing Qu Guang-Hui Liu national Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China FSU-CAS Innovation Institute Foshan University Foshan 528000 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Universidad Cato1ica San Antonio de Murcia (UCAIVI) Campus de los Jer6nimos N° 135 Guadalupe 30107 Murcia Spain Beijing Hospital of the Ministry of Health Beijing 100730 China Department of Gynecology and Obstetrics Peking University Third Hospital Beijing 100191 China Department of Neurology Peking University First Hospital Beijing 100034 China Beijing Institute for Brain Disorders Capital Medical University Beijing 100069 China University of Chinese Academy of Sciences Beijing 100049 China

Xeroderma pigmentosum （XP） is a group of genetic disorders caused by mutations of XP-associated genes, resulting in impairment of Dna repair. XP patients frequently exhibit neurological degeneration, but the underlying mechanism is unknown, in part due to lack of proper disease models. Here, we generated patientspecific induced pluripotent stem cells （iPSCs） harboring mutations in five different XP genes including XPA, XPB, XPC, XPG, and XPV. These iPSCs were further differentiated to neural cells, and their susceptibility to Dna damage stress was investigated. Mutation of XPA in either neural stem cells （NSCs） or neurons resulted in severe Dna damage repair defects, and these neural cells with mutant XPA were hyper-sensitive to Dna damage-induced apoptosis. Thus, XP-mutant neural cells represent valuable tools to clari the molecular mechanisms of neurological abnormalities in the XP patients.

关键词： xeroderma pigmentosum iPSC disease model neural stem cell. neuron

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本土意识:架起威廉斯与艾青诗歌的桥梁

四川外语学院学报 2006年第4期22卷 30-34页

作者：李嘉娜福建师范大学外国语学院英语系福建福州350007

威廉斯与艾青分别是20世纪美国与中国诗坛上最具本土意识的杰出诗人,由于东西方文化差异,同是具有相同本土意识的诗人,但表现形态上有所不同:艾青的写实体现了形而上的自觉;威廉斯写实则重形而下的实践价值,在诗艺的追求上,艾青的“艾... 详细信息

威廉斯与艾青分别是20世纪美国与中国诗坛上最具本土意识的杰出诗人,由于东西方文化差异,同是具有相同本土意识的诗人,但表现形态上有所不同:艾青的写实体现了形而上的自觉;威廉斯写实则重形而下的实践价值,在诗艺的追求上,艾青的“艾青体”与威廉斯的美国习语和可变音步,虽前者是中式的整体把握,后者是西式的具体做法,但都体现了诗人的创新精神以及把对土地和人民的爱作为创作的根本依托。

关键词：本土意识形而上自觉形而下价值 “艾青体” 可变音步

Growth and development of komatsuna (<i>Brassica rapa</i>L. Nothovar) in NFT (nutrient film technique) system, as influenced by natural mineral

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Agricultural Sciences 2013年第7期4卷 1-7页

作者： Abul Kalam Azad Katsumi Ishikawa Juan carlos Diaz-Perez Touria El-Jaoual Eaton Noriko Takeda Department of Horticulture University of Georgia Tifton USA Department of Plant Soil and Insect Sciences University of Massachusetts Amherst USA Laboratory of Biological and Environmental Systems Kochi University Nankoku-shi Japan

The cultivation of komatsuna (Brassica rapa L. Nothovar) was carried out hydroponically using a nutrient film technique (NFT) system inside a greenhouse, applying a quartz porphyry (QP) treated nutrient solution. Quartz porphyry is a natural mineral containing many substances that easily ionize with water to improve water quality. Different growth attributes of komatsuna such as leaf length, leaf width and plant fresh weight increased in plants that received QP treated nutrient solution. The coefficient of variation was smaller for QP treated nutrient solution plants when compared to the control. High light intensity, long duration of solar radiation and higher temperatures in the summer (July-Aug.) promoted plant growth compare to winter (Dec.-Feb.). In contrast, plants grown in the winter accumulated more fresh weight compare to plants grown in the summer. Results also showed that the rapid exchange of ion in the nutrient solution due to the QP treatment enabled the solution to maintain the ion balance, and thus plants grew uniformly and vigorously. The cations na+ and Ca2+ and the anions Cl- and were dominant and made the media saline. There was a decrease of na+ ion concentration in the recirculating nutrient solution (NFT) due to ion exchange by QP. Results suggest that water treatment with QP could be used for production of high quality vegetables.

关键词： Water Treatment Cations Anions Ion Balance Komatsuna Cultivation

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多奈哌齐致不良反应文献分析

中国新药杂志 2017年第2期26卷 230-235页

作者：汪龙程军朱玲娜安徽省蚌埠市第三人民医院药学部蚌埠233000

目的:分析多奈哌齐致不良反应(ADRs)的发生情况及特点,为临床安全用药提供参考。方法:通过检索Pub med数据库、中国学术期刊全文数据库(CNKI)和维普中文科技期刊数据库(VIP),收集多奈哌齐ADRs的个案报道,并进行统计分析。结果:60例ADRs... 详细信息

目的:分析多奈哌齐致不良反应(ADRs)的发生情况及特点,为临床安全用药提供参考。方法:通过检索Pub med数据库、中国学术期刊全文数据库(CNKI)和维普中文科技期刊数据库(VIP),收集多奈哌齐ADRs的个案报道,并进行统计分析。结果:60例ADRs中,男性27例,女性33例,年龄71岁及以上患者42例(70%)。用药半年内发生52例(86.7%)。累及的系统-器官主要有中枢及外周神经系统损害、肌肉骨骼系统损害及神经紊乱,临床表现有神经抑制药恶性综合征、锥体外系症状、比萨综合征及躁狂等。结论:临床使用多奈哌齐应加强监测,警惕其ADRs和药物相互作用,以实现临床用药安全有效。

关键词：多奈哌齐药物不良反应文献分析