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Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： Yani Xu Lan Yang Min Li Haozhou Shu na Jia Yunzhen Gao Rongying Shi Xiaojia Yang Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resistant to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(BSA)to form 5-FU@Ni Fe-LDH/Ti3C2/BSA nanoplatforms(5NiTiB).Both in vitro and in vivo data demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate fromnanotherapeutic platform achieved higher therapeutic efficacy with a lower agent dose,thereby minimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil nanocomposite

Classical Electromagnetic Field Theory in the Presence of Magnetic Sources

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Chinese Physics Letters 2003年第3期20卷 321-324页

作者： Li Kang Chen Wen-Jun carlos M. naón Department of Physics Hangzhou Teacher's College Hangzhou 310036 Department of Physics Zhejiang University Hangzhou 310027 Instituto de Física La Plata Departamento de Física Facultad de Ciencias Exactas Universidad Nacional de La Plata CC 67 1900 La Plata Argentina

Using two new well-defined four-dimensional potential vectors, we formulate the classical Maxwell field theory in a form which has manifest Lorentz covariance and SO(2) duality symmetry in the presence of magnetic sources. We set up a consistent Lagrangian for the theory. Then from the action principle we obtain both Maxwell's equation and the equation of motion of a dyon moving in the electromagnetic field.

关键词： Maxwell equations

Transcranial Direct Current Stimulation: Effects on Motor and Non-Motor Symptoms of Parkinson’s Disease

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Journal of Behavioral and Brain Science 2024年第5期14卷 135-160页

作者： Fayda Protásio carlos Alberto Bezerra Tomaz Joaquim Brasil-Neto Pedro Brandão nasser Allam Maria Clotilde Henriques Tavares Laboratory of Neuroscience and Behavior Department of Physiological Sciences Institute of Biology University of Braslia Braslia Brazil Master Program in Environment University CEUMA So Lus MA and Faculty of Medicine Euro-American University Center-UNIEURO Braslia Brazil Faculty of medicine Euro-American University Center-UNIEURO Braslia Brazil na Neurologistas Associados Braslia Brazil

Introduction: In the last thirty years, brain neuromodulation techniques have been used as an alternative to pharmacological treatment of neurological disorders. Parkinson’s disease (PD) is a neurodegenerative disorder leading to bradykinesia, rest tremor, postural changes, and non-motor symptoms such as depression, anxiety, sleep disorders, pain, and cognitive decline that compromises executive functions (EFs), responsible for the orderly execution of behaviors and tasks of daily life and intentional and directed actions. To this date, a few studies with transcranial direct current stimulation (tDCS) have shown beneficial effects in PD patients concerning specific motor and non-motor symptoms, targeting the motor cortex and/or prefrontal regions. Objective: The main objective of this study was to evaluate the effects of left prefrontal tDCS across a broad spectrum of motor and non-motor symptoms of PD using established validated scales. Method: Single-blind randomized clinical trial with 18 volunteers with PD, aged between 45 and 80 years (66.1 ± 9.65), who met inclusion and exclusion criteria. Participants were submitted to assessments of motor and non-motor functions employing psychometric scales and tests to evaluate EFs and were randomly divided into two groups: control (sham stimulation) and experimental (active stimulation). All participants were involved in three separate tDCS sessions. The anode was positioned over the left dorsolateral prefrontal cortex and the cathode over the right supraorbital region, with a direct current intensity of 2 mA, lasting 20 minutes. At the end of the three sessions, all participants were reassessed. Results: Significant effects of tDCS on non-motor functions were observed for cognition (verbal fluency of actions, clock copy test, appointment by visual confrontation, and verbal memory with immediate free recall) and subjective assessment of sleep quality (overall restlessness and discomfort in the arms and legs at night, leg

关键词： Parkinson’s Disease Neuromodulation Transcranial Direct Current Stimulation—tDCS Movement Disorders Mood Sleep Cognition

借助新媒体提高临床实践指南传播力:《协和医学杂志》的探索与实践

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中国科技期刊研究 2024年第5期35卷 658-663页

作者：李娜刘洋李玉乐董哲赵娜李慧文李洁北京协和医院《协和医学杂志》编辑部北京100730 中国医学科学院《中国医学科学杂志(英文)》编辑部北京100005

【目的】探索医学期刊借助新媒体平台提高临床实践指南(简称“指南”)传播力的新途径。【方法】通过文献检索并结合期刊实践经验,分析我国指南传播现状、传统指南传播策略中存在的问题,明确医学期刊在指南传播中的角色定位,并在《协和... 详细信息

【目的】探索医学期刊借助新媒体平台提高临床实践指南(简称“指南”)传播力的新途径。【方法】通过文献检索并结合期刊实践经验,分析我国指南传播现状、传统指南传播策略中存在的问题,明确医学期刊在指南传播中的角色定位,并在《协和医学杂志》日常工作中借助新媒体平台开展探索性实践,展示其提高指南传播力的典型案例及效果。【结果】我国重指南制订而轻指南传播的现象较为普遍,传统指南传播策略具有一定局限性。《协和医学杂志》的实践证明,借助新媒体可弥补传统指南传播策略中的不足,有效提高指南传播力。【结论】医学期刊作为指南发布的重要载体,新媒体时代充分利用新媒体技术及平台优势,可在提高指南传播力中发挥重要作用。

关键词：临床实践指南传播医学期刊高质量发展

Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells

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Protein & Cell 2012年第11期3卷 855-863页

作者： Fei Yi Jing Qu Mo Li Keiichiro Suzuki na Young Kim Guang-Hui Liu Juan carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA national Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Center for Regenerative medicine in Barcelona Dr.Aiguader 8808003 BarcelonaSpain

The combination of disease-specific human induced pluripotent stem cells(iPSC)and directed cell differentiation offers an ideal platform for modeling and studying many inherited human ***’s disease(WD)is a monogenic disorder of toxic copper accumulation caused by pathologic mutations of the ATP7B *** affects multiple organs with primary manifestations in the liver and central nervous system(CNS).In order to better investigate the cellular pathogenesis of WD and to develop novel therapies against various WD syndromes,we sought to establish a comprehensive platform to differentiate WD patient iPSC into both hepatic and neural *** we report the generation of patient iPSC bearing a Caucasian population hotspot mutation of *** with directed cell differentiation strategies,we successfully differentiated WD iPSC into hepatocyte-like cells,neural stem cells and *** expression analysis and cDna sequencing confirmed the expression of the mutant ATP7B gene in all differentiated *** we established a platform for studying both hepatic and neural abnormalities of WD,which may provide a new tool for tissue-specific disease modeling and drug screening in the future.

关键词： induced pluripotent stem cell Wilson’s disease hepatocyte neural stem cell neuron

基于CNKI-CiteSpace探讨大蒜素在医学领域中的应用现状与趋势

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河西学院学报 2024年第2期40卷 28-35页

作者：岳娜娜曹玉青李萍河西学院医学院甘肃张掖734000

目的:对大蒜素在医学领域中的研究现状、热点和趋势进行可视化分析,为后续相关研究提供参考。方法:系统检索中国知网数据库关于大蒜素在医学领域相关研究文献,基于CiteSpace 6.1.R6软件运用文献计量学方法对发文量、发文期刊、作者、关... 详细信息

目的:对大蒜素在医学领域中的研究现状、热点和趋势进行可视化分析,为后续相关研究提供参考。方法:系统检索中国知网数据库关于大蒜素在医学领域相关研究文献,基于CiteSpace 6.1.R6软件运用文献计量学方法对发文量、发文期刊、作者、关键词等进行可视化分析。结果:共纳入有效文献333篇,发文量随年份变化波动较大,《中国中西医结合杂志》是发文量最多的期刊,史载祥教授团队就大蒜素对心血管疾病的中西医结合治疗开展了大量研究。关键词共现和聚类分析显示,大蒜素在医学领域的研究主要集中在慢病防治和抗菌2个方面,大蒜素可有效抑制肿瘤细胞侵袭、转移并增加其凋亡。目前大蒜素的研究热点主要聚焦于抗炎、抗氧化、抗癌的机制研究。结论:大蒜素在医学领域的研究仍处于活跃的发展阶段,各团队间的合作交流有待加强。大蒜素的抗炎、抗氧化、抗癌及抑菌活性的相关基础研究证据翔实,随着其作用机制的逐步揭示,大蒜素的临床应用将更值得期待。

关键词：大蒜素医学 CiteSpace 可视化分析

响应面法优化新型磷脂酶PLC_med_(193)大豆油脱胶工艺的研究

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粮食与油脂 2024年第2期37卷 43-48页

作者：孙永威李科娜段乃心魏涛郑州轻工业大学食品与生物工程学院河南郑州450002

利用大肠杆菌工程菌制备大量重磷脂PLC_med_(193),将其应用于大豆毛油的脱胶过程中,在单因素试验的基础上采用响应面试验,得出磷脂酶用于大豆毛油脱胶的最佳工艺条件,即脱胶温度60℃、加酶量300 U/kg、脱胶pH 5.6、加水量3.0 mL、脱胶时... 详细信息

利用大肠杆菌工程菌制备大量重磷脂PLC_med_(193),将其应用于大豆毛油的脱胶过程中,在单因素试验的基础上采用响应面试验,得出磷脂酶用于大豆毛油脱胶的最佳工艺条件,即脱胶温度60℃、加酶量300 U/kg、脱胶pH 5.6、加水量3.0 mL、脱胶时间6 h,在此条件下,脱胶后大豆油的磷含量从36.75 mg/kg降低至(5.25±0.03)mg/kg,磷脂酰胆碱PC和磷脂酰乙醇胺PE含量降低至23 mg/g和20 mg/g,满足后续油脂精炼要求。

关键词：磷脂酶C 脱胶磷含量得率

Patterns of host cell inheritance in the bacterial symbiosis of whiteflies

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Insect Science 2020年第5期27卷 938-946页

作者： Xiao-Rui Xu na-na Li Xi-Yu Bao Angela E.Douglas Jun-Bo Luan Liaoning Key Laboratory of Economic and Applied Entomology College of Plant ProtectionShenyang Agricutural UniversityShenyangChina Department of Entomology Cornell UniversitIthacaNYUSA Department of Molecular Biology and Genetics Cormell UniversitylthacaNYUSA

Whiteflies possess bacterial symbionts Candidatus Portiera aleyrodidium that are housed in specialized cells called bacteriocytes and are faithfully transmitted via the ovary to insect *** one whitefly species studied previously,Bemisia tabaci MEAMI,transmission is mediated by somatic inheritance of bacteriocytes,with a single bacteriocyte transferred to each oocyte and persisting through embryogenesis to the next ***,we investigate the mode of bacteriocyte transmission in two whiefly species,*** med,the sister species of MEAM1,and the phylogenetically distant species Trialeurodes *** analysis supported by microscopical studies demonstrates that *** med bacteriocytes are genetically different from other somatic cells and persist through embryogenesis,as for MEAMI,but *** bacteriocytes are genetically identical to other somatic cells of the insect,likely mediated by the degradation of maternal bacteriocytes in the *** two alternative modes of transmission provide a first demonstration among insect symbioses that the cellular processes underlying vertical transmission of bacterial symbionts can diversify among related host species associated with a single lineage of symbiotic bacteria.

关键词： bacteriocyte inheritance somatic cells symbiont transmission whitefly

Effect of Exogenous Melatonin on Seed Germination and Seedling Growth in Melon(Cucumis melo L.) Under Salt Stress

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Horticultural Plant Journal 2019年第2期5卷 79-87页

作者： José Luis Casta?ares carlos Alberto Bouzo Plant Physiology Laboratory Department of Basic Sciences Universidad Nacional de Luján Laboratory of Research in Physiology and Plant Molecular Biology Facultad de Ciencias Agrarias Universidad Nacional del Litoral

An investigation was carried out to evaluate the effect of different application forms and concentrations of melatonin on germination and initial growth of melon plants in several different salinity conditions. We evaluated germination percentage and growth of seedlings and measured total chlorophyll content, relative electrolyte leakage, peroxidase activity, root viability, proline concentration, relative water content,na^+/K^+ratio in green parts and K^+leakage from roots. Seed germination percentage under salt stress increased with treatments of 10 and50 μmol·L^(-1) melatonin. Seed treatment and plant watering with melatonin at 50 μmol·L^(-1) improved growth parameters and plants showed higher chlorophyll content as well as better biochemical parameters than non-treated plants. Results suggest that melatonin can alleviate the effect of salt stress during seed germination and first stages of plant development.

关键词： melon melatonin salt stress germination antioxidation