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Prevalence of gastroesophageal reflux disease:a population-based cross-sectional study in southern Chile

Gastroenterology Report 2020年第4期8卷 286-292,I0001,I0002页

作者： carlos manterola Luis Grande Luis Bustos Tamara Otzen Center of Morphological and Surgical Studies Universidad de La FronteraTemucoChile Department of Surgery Universidad de La FronteraTemucoChile Department of Surgery Hospital del MarUniversitat Auto`noma de BarcelonaBarcelonaSpain Department of Public Health Universidad de La FronteraTemucoChile

Background This study assessed the prevalence of gastroesophageal reflux disease(GERD)in a general adult population from Temuco in southern *** association of GERD with demographic variables was also *** A cross-sectional study among the general population of Temuco in southern Chile was conducted in 2017,using a validated and reliable questionnaire for detecting *** urban area of Temuco,with a population of 245,317 inhabitants(2002 census),was divided into four zones,which were representative of the socioeconomic sectors of the *** sample size was estimated assuming a prevalence of 52.8%,an accuracy of 3.0%,a confidence level of 95.0%,and a design effect of *** sampling was used to build *** prevalence of GERD was determined and associated factors were studied by means of bivariate and multivariate *** A total of 1,069 subjects(47.9%women,median age 40 years)from the selected subareas were *** prevalence of GERD was 44.8%.The most frequently reported symptom was regurgitation(54.8%).One-third of subjects took medication to control symptoms and was considered‘sick’by the instrument,although>68%of them had never sought medical *** was a significant association between GERD and age(P<0.001)and female gender(P=0.001).Conclusions In this population-based study,the prevalence of GERD was high(44.8%).GERD was associated with age and female gender.

关键词： gastroesophageal reflux disease prevalence cross-sectional studies evidence-based medicine clinical epidemiology

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Differences in standing balance between patients with diplegic and hemiplegic cerebral palsy

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Neural Regeneration Research 2013年第26期8卷 2478-2483页

作者： Valeska Gatica Rojas Guillermo Méndez Rebolledo Eduardo Guzman Muoz Natalia Ibarra Cortés Caterine Berrios Gaete carlos manterola Delgado Laboratory of Human Motor Control Faculty of Health Sciences University of Talca Laboratory of Human Motor Control School of Kinesiology Faculty of Health Sciences University of Talca School of Kinesiology University Santo Tomas Student School of Kinesiology Faculty of Health Sciences University of Talca Program in Medical Sciences University of the Frontera

Maintaining standing postural balance is important for walking and handling abilities in patients with cerebral palsy. This study included 23 patients with cerebral palsy （seven with spastic diplegia and 16 with spastic hemiplegia）, aged from 7 to 16 years of age. Standing posture balance measurements were performed using an AMTI model OR6-7 force platform with the eyes open and closed. Patients with diplegic cerebral palsy exhibited greater center of pressure displacement areas with the eyes open and greater center of pressure sway in the medial-lateral direction with the eyes open and closed compared with hemiplegic patients, Thus, diplegic patients exhibited weaker postural balance control ability and less standing stability compared with hemiplegic cerebral palsy patients.

关键词： neural regeneration cerebral palsy postural balance postural control center of pressure children diplegia hemiplegia grants-supported paper neuroregeneration

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Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： carlos M Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors

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Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients:A systematic review of clinical trials

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World Journal of Transplantation 2025年第1期15卷 156-164页

作者： carlos M Ardila Pradeep K Yadalam Jaime Ramírez-Arbelaez Department of Basic Sciences Faculty of Dentistry Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia Department of Postdoctoral Program CIFE University CenterCuernavaca 62330MorelosMexico Department of Periodontics Saveetha Dental CollegeSaveetha Institute of Medical and HealthSIMATSSaveetha UniversityChennai 600077Tamil NaduIndia Department of Transplantation Hospital San Vicente FundaciónRionegro 054047Colombia

BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ *** To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant *** A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and *** review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial *** search strategy involved analyzing multiple databases,including PubMed/MEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until May 2024,with no language *** After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were *** most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also *** antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and *** concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;P<0.05).The total reported deaths in three clinical trials were 75,and there were 24 graft rejections in two *** All clinical trials reported significant proportions of antimicrobial-resistant microor

关键词： Antimicrobial resistance Antimicrobials Antivirals Solid organ transplant recipients Infections Microorganisms Cytomegalovirus

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Hyperpycnal (over density) flows and deposits

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Journal of Palaeogeography 2020年第3期9卷 267-287页

作者： carlos Zavala Departamento de Geologia Universidad Nacional del SurSan Juan 6708000 Bahia BlancaArgentina GCS Argentina 5RL Molina Campos 1508000 Bahia BlancaArgentina

A hyperpycnal flow forms when a relatively dense land-derived gravity flow enters into a marine or lacustrine water reservoir. As a consequence of its excess of density, the incoming flow plunges in coastal areas, generating a highly dynamic and often long-lived dense underflow. Depending on the characteristics of the parent flow(flow duration and flow rheology) and basin salinity, the resulting deposits(hyperpycnites) can be very *** to flow duration, land-derived gravity flows can be classified into short-lived or long-lived flows. Shortlived gravity flows last for minutes or hours, and are mostly related to small mountainous river discharges, alluvial fans, collapse of natural dams, landslides, volcanic eruptions, j?kulhlaups, etc. Long-lived gravity flows last for days,weeks or even months, and are mostly associated with medium-to large-size river *** the rheology of the incoming flow, hyperpycnal flows can be initiated by non-Newtonian(cohesive debris flows), Newtonian supercritical(lahars, hyperconcentrated flows, and concentrated flows) or Newtonian subcritical flows(pebbly, sandy or muddy sediment-laden turbulent flows). Once plunged, non-Newtonian and Newtonian supercritical flows require steep slopes to accelerate, allow the incorporation of ambient water and develop flow transformations in order to evolve into a turbidity current and travel further basinward. Their resulting deposits are difficult to differentiate from those related to intrabasinal turbidites. On the contrary, long-lived Newtonian subcritical flows are capable of transferring huge volumes of sediment, freshwater and organic matter far from the coast even along gentle or flat slopes. In marine settings, the buoyant effect of interstitial freshwater in pebbly and sandy hyperpycnal flows can result in lofting due to flow density reversal. Since the excess of density in muddy hyperpycnal flows is provided by silt-clay sediments in turbulent suspension, lofting

关键词： Hyperpycnal flows Hyperpycnites Turbidites Sediment gravity flows

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MULTIGRID METHOD FOR A MODIFIED CURVATURE DRIVEN DIFFUSION MODEL FOR IMAGE INPAINTING

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Journal of Computational Mathematics 2008年第6期26卷 856-875页

作者： carlos Brito-Loeza Department of Mathematical Sciences University of Liverpool

Digital inpainting is a fundamental problem in image processing and many variational models for this problem have appeared recently in the literature. Among them are the very successfully Total Variation （TV） model [11] designed for local inpainting and its improved version for large scale inpainting： the Curvature-Driven Diffusion （CDD） model [10]. For the above two models, their associated Euler Lagrange equations are highly nonlinear partial differential equations. For the TV model there exists a relatively fast and easy to implement fixed point method, so adapting the multigrid method of [24] to here is immediate. For the CDD model however, so far only the well known but usually very slow explicit time marching method has been reported and we explain why the implementation of a fixed point method for the CDD model is not straightforward. Consequently the multigrid method as in [Savage and Chen, Int. J. Comput. Math., 82 （2005）, pp. 1001-1015] will not work here. This fact represents a strong limitation to the range of applications of this model since usually fast solutions are expected. In this paper, we introduce a modification designed to enable a fixed point method to work and to preserve the features of the original CDD model. As a result, a fast and efficient multigrid method is developed for the modified model. Numerical experiments are presented to show the very good performance of the fast algorithm.

关键词： Image inpainting Variational models Regularization Multilevel methods.

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QUANTUM FINANCIAL ECONOMICS——RISK AND RETURNS

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Journal of Systems Science & Complexity 2013年第2期26卷 187-200页

作者： GONCALVES carlos Pedro Instituto Superior de Ciencias Socials e Politicas-Technical University of Lisbon

Financial volatility risk and its relation to a business cycle-related intrinsic time is addressed through a multiple round evolutionary quantum game equilibrium leading to turbulence and multifractal signatures in the financial returns and in the risk *** model is simulated and the results are compared with actual financial volatility data.

关键词： Business cycle dynamics intrinsic time quantum chaotic volatility quantum financialeconomics.

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A Zonotopic-Based Watermarking Design to Detect Replay Attacks

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IEEE/CAA Journal of Automatica Sinica 2022年第11期9卷 1924-1938页

作者： carlos Trapiello Vicenc Puig the Supervision Safety and Automatic Control Research Center(CS2AC)of the Universitat Politécnica de Catalunya(UPC)Rambla Sant Nebridi2208222 TerrassaSpain the UMR 5218-IMS Laboratory France the Institut de Robòtica i Informàtica Industrial(CSIC-UPC) Carrer Llorens Artigas4-608028 BarcelonaSpain

This paper suggests the use of zonotopes for the design of watermark *** proposed approach exploits the recent analogy found between stochastic and zonotopic-based estimators to propose a deterministic counterpart to current approaches that study the replay attack in the context of stationary Gaussian *** this regard,the zonotopic analogous case where the control loop is closed based on the estimates of a zonotopic Kalman filter(ZKF)is *** formulation allows to propose a new performance metric that is related to the Frobenius norm of the prediction ***,the steadystate operation of the system can be related with the size of the minimal Robust Positive Invariant set of the estimation ***,analogous expressions concerning the impact that a zonotopic/Gaussian watermark signal has on the system operation are ***,a novel zonotopically bounded watermark signal that ensures the attack detection by causing the residual vector to exit the healthy residual set during the replay phase of the attack is *** proposed approach is illustrated in simulation using a quadruple-tank process.

关键词： Optimal control physical watermarking replay attack zonotopes

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The new knowledge is written on sedimentary rocks——a comment on Shanmugam’s paper “the hyperpycnite problem”

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Journal of Palaeogeography 2019年第3期8卷 306-313页

作者： carlos Zavala Departamento de Geología Universidad Nacional del Sur GCS Argentina SRL

In a recent contribution G. Shanmugam (2018) discusses and neglects the importance of hyperpycnal flows and hyperpycnites for the understanding of some sediment gravity flow deposits. For him, the hyperpycnal flow paradigm is strictly based on experimental and theoretical concepts, without the supporting empirical data from modern depositional systems. In this discussion I will demonstrate that G. Shanmugam overlooks growing evidences that support the importance of hyperpycnal flows in the accumulation of a huge volume of fossil clastic sediments. Sustained hyperpycnal flows also provide a rational explanation for the origin of well sorted fine-grained massive sandstones with floating clasts, a deposit often wrongly related to sandy debris flows.

关键词： Hyperpycnites Turbidites Sediment gravity flows

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L^1→L^q Poincare Inequalities for 0

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Acta Mathematica Sinica,English Series 2002年第1期18卷 1-20页

作者： PEREZ carlos Departamento dr Matematicas. Universidad Autónoma de Madrid. 28049 Madrid. Spain

Civen two doubling measures μ and v in a metric apace (S.p)of homogeneous type. let B_0 S be a given ball. It has been a well-known result bv now (see)[1 4])theat the validity of an L^1→L^1 Poincaré inequality of the following form: f_B|f-f_B|dv≤cr(B)f_Bgdμ. for all metric balls B B_0 S, implies a variant of representation formula of fractonal integral type: |f(x)-f_(B(11))|≤C integral from n=B_(11) g(y)p(x, y)/μ(B(x, p(x, y)))dμ(y)+C(r(B_0))/(μ(B_0))integral from n=B_0 g(y)dμ(y). One of the main results of this paper shows that an L^1 to L^q Poincaré inequality for some 01, i.e.. (f_B|f-f_B|~q dv)^(1/q)≤cr(B) f_B gdμ, for all metric balls B B_0. will suffice to imply the above representation formula. As an immediate corollary, we can show that the weak-type condition. sup_(λ>0)(λv({x ∈ B:|f(x)-f_B|>λ}))/v(B)≤Gr (B)f_B gdμ. also implies the same formula. Analogous theorems related to high-order Poincaréinequalities and Sobolev spaces in metric spaces are also proved.

关键词： Sobolev spaces Representation formulas High-order derivatives Vector fields Metric spaces Polynomials Doubling measures Poincare inequalities

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