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The 8th International Congress on SLE

作者： Luiz Fernando Goulart Clara Pereira Ana monica Gabriel Barbara Leal maria Francisca Fontes carlos Vasconcelos carlos m.ferreira Jorge martins Joo matos-Costa Berta martins António marinho margarida Lima Jocelyne Demengeot Constantin Fesel Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPort

＜正＞Purpose:Intavenous immunoglobulin（ivIg）,which has well-demonstrated beneficial effects in various autoimmune diseases,is used as a therapeutic option for Systemic Lupus Erythematosus（SLE）patients,particularly for those with poor responses to standard *** studied immune homeostasis and regulation in patients undergoing this

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A Chopper Negative-R Delta-Sigma ADC for Audio mEmS Sensors

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Computer modeling in Engineering & Sciences 2022年第2期130卷 607-631页

作者： Jamel Nebhen Pietro m.ferreira College of Computer Engineering and Sciences Prince Sattam bin Abdulaziz UniversityAlkharj11942Saudi Arabia Universit´e Paris-Saclay Centrale SupelecCNRSLaboratory de G´enie Electrique et Electronique de ParisGif-sur-Yvette91192France Sorbonne Universite CNRSLab.de Genie Electrique et Electronique de ParisParis75252France

This paper presents a proposed low-noise and high-sensitivity Internet of Thing(IoT)system based on an m&NEmS *** IoT device consists of an m&NEmS resistive accelerometer associated with an electronic readout circuit,which is a silicon nanowire and a Continuous-Time(CT)△∑*** first integrator of the△∑ADC is based on a positive feedback DC-gain enhancement two-stage amplifier due to its high linearity and low-noise *** mitigate both the offset and 1/f noise,a suggested delay-time chopper negative-R stabilization technique is applied around the first integrator.A 65-nm CmOS process implements the CT△∑*** supply voltage of the CmOS circuit is 1.2-V while 0.96-mW is the power consumption and 0.1-mm^(2) is the silicon *** m&NEmS microphone and△∑ADC complete circuit are fabricated and *** a working frequency bandwidth of 20-kHz,the measurement results of the proposed IoT system reach a signal to noise ratio(SNR)of ***,it has a measured dynamic range(DR)of 108-dB and a measured signal to noise and distortion ratio(SNDR)of 101.3-dB.

关键词： m&NEmS sensor △∑ ADC chopper negative-R IoT 1/f noise SNR

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Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： carlos m Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip microorganism identification Diagnostics Point-ofcare testing Biosensors

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Incorporation of phenolic extracts from different by-products in yoghurts to create fortified and sustainable foods

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Food Bioscience 2023年第1期51卷 816-826页

作者： Sara m.ferreira Lúcia Santos LEPABE-Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465PortoPortugal ALiCE-Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465PortoPortugal

This work aimed to study and compare the effect of the incorporation of agro-industrial by-products(chestnut shell,grapeseed,and pomegranate peel)into yoghurts to fortify them while assessing their potential to replace synthetic *** each by-product,phenolic extracts were obtained and *** extracts demonstrated antioxidant and antibacterial properties,and the capacity to inhibitα-*** shell extract stood out regarding antioxidant capacity,displaying values of 1128 and 972 mgT_(rolox•gextract)^(-1),for the assays with DPPH and ABTS,*** yoghurts were produced(negative control,positive control with 0.1%of sorbic acid,two for each extract with 0.1%and 0.2%of extract,a mixture of extracts and a mixture of extracts with sorbic acid),and stored at 4℃.The incorporation of the extracts into the yoghurts maintained their physical-chemical properties and microbiological *** samples inhibited the growth of Escherichia coli and Staphylococcus *** analysis proved that higher concentrations of extract had similar results to synthetic *** results showed the viability to fortify yoghurts with the incorporation of by-product extracts,developing a value-added ***,revealed the possibility of these extracts replacing synthetic preservatives and antioxidants.

关键词： Antioxidants By-products Sustainability Circular economy Fortified foods Yoghurts Preservatives

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Droplet-based bioprinting enables the fabrication of cell–hydrogel–microfibre composite tissue precursors

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Bio-Design and manufacturing 2022年第3期5卷 512-528页

作者： marcin Kotlarz Ana m.ferreira Piergiorgio Gentile Stephen J.Russell Kenneth Dalgarno School of Engineering Newcastle UniversityNewcastle upon Tyne NE17RUUK School of Design University of LeedsLeeds LS29JTUK

Composites offer the option of coupling the individual benefits of their constituents to achieve unique material properties,which can be of extra value in many tissue engineering *** combining hydrogelswith fibre-based scaffolds can create tissue constructs with enhanced biological and structural ***,developing efficient and scalable approaches to manufacture such composites is ***,we use a droplet-based bioprinting system called reactive jet impingement(ReJI)to integrate a cell-laden hydrogel with a microfibrous *** system uses microvalves connected to different bioink reservoirs and directed to continuously jet bioink droplets at one another in mid-air,where the droplets react and form a hydrogel that lands on a microfibrous ***–hydrogel–fibre composites are produced by embedding human dermal fibroblasts at two different concentrations(5×10^(6) and 30×10^(6) cells/mL)in a collagen–alginate–fibrin hydrogel matrix and bioprinted onto a fibre-based *** results show that both types of cell–hydrogel–microfibre composite maintain high cell viability and promote cell–cell and cell–biomaterial *** lower fibroblast density triggers cell proliferation,whereas the higher fibroblast density facilitates faster cellular organisation and infiltration into the ***,the fibrous component of the composite is characterised by high swelling properties and the quick release of calcium *** data indicate that the created composite constructs offer an efficient way to create highly functional tissue precursors for laminar tissue engineering,particularly for wound healing and skin tissue engineering applications.

关键词： Bioprinting Hydrogel–fibre composites High-cell-density hydrogels Composite manufacturing

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An Approach with a Queue System to the Pandemic Period Study

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Journal of modern Accounting and Auditing 2018年第5期14卷 288-290页

作者： manuel Alberto m.ferreira Instituto Universitário de Lisboa(ISCTE-IUL) LisboaPortugal

Epidemics still happen,being the annual influenza outbreaks examples of such *** estimate the epidemic period length is imperative because,in this period,it is necessary to strengthen the health care,through extra availability in human and material ***,a huge increase of expenses *** a pandemic is an epidemic with a great population and geographical dissemination,more appropriately this happens with the pandemic *** using results on the m|G|∞queue busy period,it is presented an application of this queue system to the pandemic period’s parameters and distribution function study.

关键词： m|G|∞ busy period pandemic cost

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Changes in the redox status of the brain in an experimental glaucoma model

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BIOCELL 2016年第1期40卷 51-53页

作者： CLAUDIA G.REIDES ROmINA m.LASAGNI VITAR AGUSTINA PEVERINI NATASHA S.JANEZIC AILEN G.HVOZDA ARANA SANDRA m.ferreira SUSANA F.LLESUY Química General e Inorgánica Facultad de Farmacia y Bioquímica.Universidad de Buenos AiresBuenos Aires Argentina Instituto de Bioquímica y medicina molecular(IBImOL) Universidad de Buenos Aires-CONICETBuenos AiresArgentina

The purpose of this study was to evaluate the redox status changes of primary visual targets in the rat brain of a high pressure-induced glaucoma *** animal model consisted of inducing ocular hypertension by cauterizing two episcleral veins on the left *** markers of oxidative damage and the oxidative balance evaluated in the brain seven days postoperative were:nitrites concentration,levels of non-enzymatic antioxidants and antiox-idant enzymes *** increase in the nitrite content,which could be the result of the enhancement in the production of nitrogen species,and in the activity of NADPH oxidase in the glaucoma group could lead to an increase on lipid and protein *** decrease on the non-enzymatic antioxidants and the compensatory increase of the superoxide dismutase and glutathione peroxidase activities could be a consequence of the increase of oxidative *** decrease in the activity of glutathione reductase leads to a decrease in the recycling of thiol *** suggest that oxidative stress can possibly acts as a risk factor for neurodegeneration in the ***-tic strategies to stop the progression of the disease in glaucoma should also be considered the central neuronal degeneration beyond the retina and the optic nerve.

关键词： oxidative damage antioxidants central nervous system neurodegenerative diseases

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A Selection Process as a Game

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management Studies 2018年第6期6卷 531-535页

作者： manuel Alberto m.ferreira maria Cristina Peixoto de matos Instituto Universitário de Lisboa(ISCTE-IUL) LisbonPortugal Instituto Politecnico de Viseu(IPV)-Escola Superior deTecnologia e Gestao de Viseu(ESTGV) ViseuPortugal

The aim of this paper is to exemplify how to solve the problem of selecting a candidate up to his/her acceptance trough game *** originality this paper proposes is how this problem will be approached:It will be treated as a single game which is made up of two parts,going as far as to state that the payoffs in the first part of the game will be the mediators of the second part of the game.

关键词： selection process game theory two-part game code form

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ENERGY ESTImATES FOR DELAY DIFFUSION-REACTION EQUATIONS

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Journal of Computational mathematics 2008年第4期26卷 536-553页

作者： J.A.ferreira P.m.daSilva CmUC-Departamento Departamento

In this paper we consider nonlinear delay diffusion-reaction equations with initial and Dirichlet boundary conditions. The behaviour and the stability of the solution of such initial boundary value problems （IBVPs） are studied using the energy method. Simple numerical methods are considered for the computation of numerical approximations to the solution of the nonlinear IBVPs. Using the discrete energy method we study the stability and convergence of the numerical approximations. Numerical experiments are carried out to illustrate our theoretical results.

关键词： Delay diffusion reaction equation Energy method Stability Convergence.

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-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

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World Journal of Gastroenterology 2006年第34期12卷 5473-5478页

作者： Carina Pereira Hugo Sousa Paula ferreira maria Fragoso Luís moreira-Dias carlos Lopes Rui medeiros mário Dinis-Ribeiro molecular Oncology Group Portuguese Institute of Oncology of Porto Portugal and ICBAS Abel Salazar Institute for the Biomedical Sciences Porto Portugal Oncology Department Portuguese Institute of Oncology of Porto Portugal Gastroenterology Department Portuguese Institute of Oncology of Porto Portugal and Cintesis / Faculty of medicine University of Porto Porto Portugal

AIm： To investigate the relationship between the -765G 〉 C COX-2 polymorphism and the development of different gastric lesions： atrophy or intestinal metaplasia and gastric adenocarcinoma. mETHODS： A cross-sectional study was performed involving 320 Portuguese individuals （210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia） using a PCR-RFLP method.RESULTS： -765C allele was overrepresented in the patients with gastric adenocarcinoma （51%） when compared either with the control group （38%） or patients with atrophy or intestinal metaplasia （27%）. Callele was found to be very common in our population （0.22）, and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele （OR = 2.67, 95% CI = 1.03-6.93; P = 0.04）.CONCLUSION： -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.

关键词： Gastric adenocarcinoma Atrophy Intestinal metaplasia COX-2 Polymorphism PCR-RFLP Pharmacogenomic

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