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The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： juan Enrique Barranco-García Carolina Caicedo Enrique Javier jim.nez-Regalado carlos Espinoza-González Graciela Morales Rocio Yaneli Aguirre-Loredo Abril Fonseca-García Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Investigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Investigadoras por México CONAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer Starch Chitosan Pluronic®F127 Microparticles Spray drying

Advancing towards accurate phenotyping based on metabolic and fibrosis risk in metabolic-dysfunction associated steatotic liver disease:one step closer to personalized care

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 128-131页

作者： Sergio Muñoz-Martínez Alba jim.nez-Masip juan M.Pericàs Liver Unit Vall d’Hebron Hospital UniversitariVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelonaSpain Universitat de Barcelona BarcelonaSpain Universitat Autònoma de Barcelona BellaterraBarcelonaSpain Centros de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas(CIBERehd)MadridSpain

Relevance of liver fibrosis amongst diabetic patients with metabolic-dysfunction associated steatotic liver disease(MASLD)and knowledge gaps Insulin resistance is paramount in the crosstalk between intrahepatic and extrahepatic pathophysiological mechanisms leading to MASLD(1),hence gaining special relevance in patients diagnosed with type 2 diabetes(T2D).MASLD is the term that was recently endorsed by an international multidisciplinary consensus panel to replace non-alcoholic fatty liver disease[as non-alcoholic steatohepatitis(NASH)was replaced by metabolic dysfunction-associated steatohepatitis(MASH)](2).

关键词： Metabolic-dysfunction associated steatotic liver disease(MASLD) advanced fibrosis type 2 diabetes(T2D) non-invasive tests(NITs)

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia jim.nez-Díaz juan D.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

High Amounts of Halogenated Natural Products in Sperm Whales(Physeter macrocephalus)from Two Italian Regions in the Mediterranean Sea

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Environment & Health 2024年第4期2卷 233-242页

作者： Sina Schweizer Kristin Halder Annika Schafer Jakob Hauns Letizia Marsili Sandro Mazzariol Maria Cristina Fossi juan Muñoz-Arnanz Begoña jim.nez Walter Vetter Institute of Food Chemistry Department of Food Chemistry(170b)University of Hohenheim70599 StuttgartGermany European Union Reference Laboratory(EURL)for Halogenated POPs in Feed and Food 79114 FreiburgGermany Department of Environmental Earth and Physical SciencesUniversity of Siena53100 SienaItaly Department of Public Health Comparative Pathology and Veterinary HygieneUniversity of Padova35020 LegnaroItaly Department of Instrumental Analysis and Environmental Chemistry Institute of Organic Chemistry(IQOG-CSIC)28006 MadridSpain

Halogenated natural products(HNPs)are considered to be emerging contaminants whose environmental distribution and fate are only incompletely ***,several persistent and bioaccumulative HNP groups,together with manmade polychlorinated biphenyls(PCBs)and polybrominated diphenyl ethers(PBDEs),were quantified in the blubber of nine sperm whales(Physeter macrocephalus)stranded on the coast of the Mediterranean Sea in *** naturally occurring polybrominated hexahydroxanthene derivatives(PBHDs;sum of TetraBHD and TriBHD)were the most prominent substance class with up to 77,000 ng/g *** mean PBHD content(35,800 ng/g blubber)even exceeded the one of PCBs(28,400 ng/g blubber),although the region is known to be highly contaminated with manmade *** on mean values,Q1∼PBDEs>MeO-BDEs∼2,2′-diMeO-BB 80 and several other HNPs followed with decreasing *** blubber samples contained an abundant compound whose molecular formula(C_(16)H_(19)Br_(3)O_(2))was verified using high-resolution mass *** only plausible matching isomer was(2S,4′S,9R,9′S)-2,7-dibromo-4′-bromomethyl-1,1-dimethyl-2,3,4,4′,9,9′-9,9′-hexahydro-1H-xanthen-9-ol(OH-TriBHD),a hydroxylated secondary metabolite previously detected together with TriBHD and TetraBHD in a sponge known to be a natural producer of *** estimated mean amount of the presumed OH-TriBHD was 3000 ng/g blubber,which is unexpectedly high for hydroxylated compounds in the lipids of marine mammals.

关键词： Halogenated natural product naturally occurring polyhalogenated compound persistent organic pollutant sperm whale Italy polar metabolite

Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： juan carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés Javier González Ramos Luis Antonio González Gómez Rubén Alberto Bayardo González Sarah Monserrat Lomelí Martínez Periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researcher Guadalajara 44340Mexico Department of Integral Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGROUND Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic *** therapeutic mana gement of radicular cysts is *** is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTR)technique in the same surgical *** present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTR technique,use of a resorbable membrane of type I bovine collagen,and bovine *** SUMMARY A 68-year-old patient presented with a radicular cyst from an upper lateral *** microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTR technique using a resorbable collagen membrane and bovine *** diagnosis of radicular cyst was confirmed using histopathological *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone *** These results suggest that microsurgical management using the GTR technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst Dental root end cyst Case report

Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

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World Journal of Diabetes 2024年第4期15卷 758-768页

作者： Enriqueta Muñoz-Islas Edgar David Santiago-SanMartin Eduardo Mendoza-Sánchez Héctor Fabián Torres-Rodríguez Laura Yanneth Ramírez-Quintanilla Christopher Michael Peters juan Miguel jim.nez-Andrade Unidad Académica Multidisciplinaria Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Department of Anesthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood,adolescence,and adulthood;however,the mechanisms by which gestational diabetes mellitus(GDM)predisposes offspring to metabolic disorders remain *** To quantify the nerve axons,macrophages,and vasculature in the pancreas from adult offspring born from mouse dams with *** GDM was induced by *** of streptozotocin(STZ)in ICR mouse *** 12 wk old,fasting blood glucose levels were determined in *** 15 wk old,female offspring born from dams with and without GDM were sacrificed and pancreata were processed for *** quantified the density of sensory[calcitonin gene-related peptide(CGRP)]and tyrosine hydroxylase(TH)axons,blood vessels(endomucin),and macro-phages(CD68)in the splenic pancreas using confocal *** Offspring mice born from STZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated ***,the density of CGRP+and TH+axons,endomucin+blood vessels,and CD68+macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDM vs control ***,the microvasculature in the islets was significantly greater,but not the number of macrophages within the islets of offspring born from dams with GDM compared to control *** GDM induces neuronal,vascular,and inflammatory changes in the pancreas of adult progeny,which may partially explain the higher propensity for offspring of mothers with GDM to develop metabolic diseases.

关键词： Gestational diabetes mellitus Immunohistochemistry Confocal microscopy Pancreas Offspring

A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria Luzón Nuria Rodríguez-Barroso Alberto Argente-Garrido Daniel jim.nez-López Jose M.Moyano Javier Del Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(ML)models in a distributed and decentralized *** allows ML models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different ML approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

Diagnostic and therapeutic challenges of myeloid sarcoma in the oral cavity

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World Journal of Clinical Cases 2024年第32期12卷 6526-6533页

作者： Melissa Martínez Nieto Luis Antonio González Gómez juan carlos Gómez Mireles Sarah Monserrat LomelíMartínez Department of Integrated Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Department of Well-being and Sustainable Development Centro Universitario del NorteUniversidad de GuadalajaraColotlan 46200JaliscoMexico

Myeloid sarcoma(MS)is a rare neoplasm characterized by the proliferation of immature myeloid precursor cells outside the bone *** pathogenesis of MS is complex and not completely ***,it develops in any extramedullary site of the *** this editorial,we discuss the article published by Li et al,which presents a clinical case involving a 32-year-old man who exhibited gingival inflammation in the maxillary *** was initially diagnosed as periodontal ***,clinical evaluation revealed a firm,grayishwhite mass which underscored the need for comprehensive diagnostics to distinguish MS from other oral *** article emphasizes the different clinical presentations of similar case studies in the literature,and highlights the difficulty in diagnosing oral MS due to its rarity and variability in clinical *** treatment of MS depends on the clinical presentation,tumor location,and the patient's response to conventional *** various therapeutic options currently available are analyzed and *** intervention and multidisciplinary management are crucial for improving treatment *** awareness and education about the various clinical presentations of MS lead to earlier diagnosis and timely treatment,thereby enhancing patients'survival and quality of *** research is essential for optimizing therapeutic strategies and addressing the challenges presented by this rare neoplasm.

关键词： Myeloid sarcoma Acute myeloid leukemia Chloroma Granulocytic sarcoma Oropharyngeal neoplasms Gingiva

Lifestyles of Older Adults in Castilla-La Mancha(Spain):Influence of Sex,Age,and Habitat

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 313-335页

作者： Esther Portal Martínez juan Lirio Castro David Alonso González JoséLuis Gómez Ramos University of Castilla-La Mancha Talavera de la ReinaSpain Complutense University MadridSpain

This paper presents the quantitative research results of a comprehensive study titled“Current Profle of Older Adults in Castilla-La Mancha(Spain).”The study aims to understand and describe the characteristics of individuals aged 65 and above within this autonomous region,with a focus on the variables of sex,age,and habitat.A cross-sectional approach was employed,utilizing quantitative methods to collect *** gather information,a customized questionnaire was developed to address the study objectives,covering various aspects such as sociodemographic factors,living conditions,leisure activities,social participation,and cultural *** survey was conducted via telephone,ensuring representation by employing gender quotas,age-group stratifcation,and considerations for habitat size.A representative sample of 1,065 participants was included in the *** fndings reveal a degree of homogeneity in the lifestyles of older adults,with discernible variations infuenced by factors such as sex,habitat,and *** results shed light on the diverse habits and experiences of older adults,emphasizing the signifcance of habitat conditions,social participation,and the aging process.

关键词： Lifestyle habits Older adults Habitat conditions Social participation Aging experience