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Quick Review and Technical Approach for Regenerative Peripheral Nerve Interface Surgery

Modern Plastic Surgery 2023年第4期13卷 126-131页

作者： Obed H Grajeda Chávez Andres Gallardo Castillo Samantha Colchado Mariscal Xunaxi Guadalupe Vázquez Orozco Dulce Sánchez Dauth carlos javier mata quintero Jorge Montalvo Hernández Ricardo Palacios Merino Minerva Irene Hernandez Cristian Diaz Solleiro Department of Surgery Pemex Hospital Central Norte Mexico City Mexico

Regenerative peripheral nerve interface RPNI’s surgery was originally designed for prosthetic control. RPNI’s has demonstrated to be an effective tool to prevent neuroma formation by providing free muscle grafts as physiological targets for peripheral nerve ingrowth. Nerve transection injuries can result in painful neuromas that adversely affect patient recovery. This is especially significant following amputation surgeries, but they can also be used in surgeries in which the nerves can be visualized with a noticeable lesion. The first series of patients undergoing RPNI implantation for treatment of symptomatic postamputation neuromas was published in 2016. The series included a report of 46 patients undergoing RPNI. The clinical outcomes of RPNI have been optimistic with a reduction in neuroma pain up to 73% and phantom pain reduction of 53% along the uniformly high patient satisfaction. Since then, studies have been expanded, and knowledge regarding physiology has increased, providing us with new tools for a better understanding and giving these procedures more benefits and applications.

关键词： Component Formatting Style Styling Insert

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New environmental factors related to diabetes risk in humans:Emerging bisphenols used in synthesis of plastics

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World Journal of Diabetes 2023年第8期14卷 1301-1313页

作者： Rafael Moreno-Gómez-Toledano María Delgado-Marín Alberto Cook-Calvete Claudia González-Cucharero Nunzio Alcharani Beatriz Jiménez-Guirado Ignacio Hernandez Rafael Ramirez-Carracedo Laura Tesoro Laura Botana Sandra Sánchez-Esteban javier Diez-mata Jose Luis Zamorano Ricardo J.Bosch carlos Zaragoza Marta Saura Universidad de Alcalá Department of Biological Systems/PhysiologyAlcaláde Henares 28871Spain Cardiology Department University Hospital Ramón y CajalMadrid 28034Spain Laboratory of Cardiovascular Pathophysiology Joint Translational Research UnitUniversity Francisco de Vitoria School of MedicineMadrid 28034Spain Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS Madrid 28034Spain

BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st *** recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPS,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the ***,a meta-analysis was performed to unify the existing quantitative *** Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of ***,three authors analyzed the set of ***,a meta-analysis was performed for each BP,using RevMan *** addition,funnel plots were developed to study publication *** The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study *** qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPS,BPF and ***,the meta-analysis determined a positive relationship with BPS,BPF and BPAF,which was only statistically significant with *** There is a need to apply the precautionary principle,regulating the use of new ***,replacing BPA with BPS,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.

关键词： Bisphenol S Bisphenol F Bisphenol AF Diabetes mellitus Systematic review Meta-analysis

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Current treatment landscape for oligometastatic non-small cell lung cancer

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World Journal of Clinical Oncology 2022年第6期13卷 485-495页

作者： javier Garde-Noguera Margarita Martín-Martín Andres Obeso Miriam López-mata Inigo Royo Crespo Lira Pelari-Mici O Juan Vidal Xabier Mielgo-Rubio Juan carlos Trujillo-Reyes Felipe Couñago Department of Medical Oncology Hospital Arnau de VilanovaValencia 46015Spain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Thoracic Surgery Hospital Clínico Universitario de Santiago de CompostelaVigo 15706Spain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009Spain Department of Thoracic Surgery Hospital Universitari Vall d’HebronBarcelona 08035Spain Department of Medical Oncology Hospital Universitario y Politécnico La FeValencia 46026Spain Department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The management of patients with advanced non-small cell lung carcinoma(NSCLC)has undergone major changes in recent *** the one hand,improved sensitivity of diagnostic tests,both radiological and endoscopic,has altered the way patients are *** the other hand,the arrival of new drugs with antitumoral activity,such as targeted therapies or immunotherapy,has changed the prognosis of patients,improving disease control and prolonging ***,the development of radiotherapy and surgical and interventional radiology techniques means that radical ablative treatments can be performed on metastases in any location in the *** of these advances have impacted the treatment of patients with advanced lung cancer,especially in a subgroup of these patients in which all of these treatment modalities *** poses a challenge for physicians who must decide upon the best treatment strategy for each patient,without solid evidence for one optimal mode of treatment in this patient *** aim of this article is to review,from a practical and multidisciplinary perspective,published evidence on the management of oligometastatic NSCLC *** evaluate the different alternatives for radical ablative treatments,the role of primary tumor resection or radiation,the impact of systemic treatments,and the therapeutic *** short,the present document aims to provide clinicians with a practical guide for the treatment of oligometastatic patients in routine clinical practice.

关键词： Oligometastatic Non-small cell lung carcinoma Non-small cell lung cancer Oligometastasis

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