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Mid and late Holocene forest fires and deforestation in the subalpine belt of the Iberian range,northern Spain

Journal of Mountain Science 2016年第10期13卷 1760-1772页

作者： Jose M.GARCIA-ruiz Yasmina SANJUAN Graciela GIL-ROMERA Penelope GONZALEZ-SAMPERIZ Santiago BEGUERIA Jose ARNAEZ Paz COBA-PEREZ Amelia GOMEZ-VILLAR javier ALVAREZ-MARTINEZ Noemi LANA-RENAULT Estela PEREZ-CARDIEL carlos LOPEZ DE CALLE Instituto Pirenaico de Ecologfa Consejo Superior de Investigaciones Cientificas(IPE-CSIC)Campus de Aula DeiP.O.Box 13.03450.080-ZaragozaSpain Estacion Experimental de Aula Dei Consejo Superior de Investigaciones Cientificas(EEAD-CSIC)Campus de Aula DeiP.O.Box 13.03450.080-ZaragozaSpain Area of Physical Geography University ofLa Rioja26.004-LogronoSpain Centro de Investigaciones en Geografia Ambiental Universidad Nacional Autonoma de MexicoUnidad MoreliaAntigua Carretera a Patzcuaro 870158190-MoreliaMichoacanMexico Departamento de Geografia y Geologia Faeultad de Filosofia y LetrasUniversidad de LeonCampus de Vegazana24.071-LeonSpain Departamento de Ingenieria Agricola y Forestal Universidad de ValladolidCampus La Yutera34.071-PalenciaSpain Department of Geography and Land Management University of Zaragoza50.009-ZaragozaSpain Freelance archaeologist Auda.Colon426003-LogronoSpain

The conversion of subalpine forests into grasslands for pastoral use is a well-knownphenomenon, although for most mountain areas the timing of deforestation has not been determined. The presence of charcoal fragments in soil profiles affected by shallow landsliding enabled us to date the occurrence of fires and the periods of conversion ofsubalpine forest into grasslands in the Urbión Mountains, Iberian Range, Spain. We found that the treeline in the highest parts of the northwestern massifs of the Iberian Range(the Urbión, Demanda, Neila, and Cebollera massifs) is currently between 1500 and 1600 m a.s.l., probably because of pastoral use of the subalpine belt, whereas in the past it would have reached almost the highest divides(at approximately 2100–2200 m a.s.l.). The radiocarbon dates obtained indicate that the transformation of the subalpine belt occurred during the Late Neolithic, Chalcolithic, Bronze Age, Iron Age, and Middle Ages. Forest clearing was probably moderate during fires prior to the Middle Ages, as the small size of the sheep herds and the local character of the markets only required small clearings, and therefore more limited fires. Thus, it is likely that the forest recovered burnt areas in a few decades; this suggests the management of the forest and grasslands following a slash-andburn system. During the Middle and Modern Ages deforestation and grassland expansion affected most of the subalpine belt and coincided with the increasing prevalence of transhumance, as occurred in other mountains in the Iberian Peninsula(particularly the Pyrenees). Although the occurrence of shallow landslides following deforestation between the Neolithic and the Roman Period cannot be ruled out, the most extensive shallow landsliding processes would have occurred from the Middle Ages until recent times.

关键词：福雷斯特开火 Holocene 亚高山带的草地浅山崩美化变化伊比利亚人范围

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Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

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Sexual behavior and male volatile compounds in wild and mass-reared strains of the Mexican fruit fly Anastrepha ludens （Diptera： Tephritidae） held under different colony management regimes

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Insect Science 2016年第1期23卷 105-116页

作者： carlos Felipe Bosa Leopoldo Cruz-Lopez Cristina Silvia Zepeda-Cisneros javier Valle-Mora Karina Guillen-Navarro Pablo Liedo El Colegio de la Frontera Sur Carretera Antiguo Aeropuerto km 2.5 Chiapas 30700 Mexico Campana Nacional Moscas de laFruta Programa Moscafrut SAGARPA-IICA Metapa de Dominguez Chiapas Mexico

We compared the calling and mating behavior and volatile release of wild males Anastrepha ludens （Loew） with males from 4 mass-reared strains：（i） a stan- dard mass-reared colony （control）, （ii） a genetic sexing strain （Tap-7）, （iii） a colony started from males selected on their survival and mating competitiveness abilities （selected）, and （iv） a hybrid colony started by crossing wild males with control females. Selected and wild males were more competitive, achieving more matings under field cage conditions. Mass-reared strains showed higher percentages of pheromone calling males under field conditions except for Tap-7 males, which showed the highest percentages of pheromone calling males under laboratory cage conditions. For mature males of all strains, field-cage calling behavior increased during the last hour before sunset, with almost a 2 fold increase exhibited by wild males during the last half hour. The highest peak mating activity of the 4 mass-reared strains occurred 30 rain earlier than for wild males. By means of solid phase microextraction （SPME） plus gas chromatography-mass spectrometry （GC- MS）, the composition of volatiles released by males was analyzed and quantified, Wild males emitted significantly less amounts of （E,E）-α-farnesene but emitted significantly more amounts of （E,E）-suspensolide as they aged than mass-reared males. Within the 4 mass-reared strains, Tap-7 released significantly more amounts of （E,E）-α-farnesene and hybrid more of （E,E）-suspensolide. Differences in chemical composition could be ex- plained by the intrinsic characteristics of the strains and the colony management regimes. Characterization of calling behavior and age changes of volatile composition between wild and mass-reared strains could explain the differences in mating competitiveness and may be useful for optimizing the sterile insect technique in A. ludens.

关键词： age-dependent changes fruit fly mating pheromone

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Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients:A systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2023年第2期12卷 147-157页

作者： Antonio García-Hermoso Robinson Ramírez-Vélez javier Díez Arantxa González Mikel Izquierdo Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)University Hospital of NavarraPamplona 310008Spain CIBER of Frailty and Healthy Aging(CIBERFES) Carlos Ⅲ Institute of HealthMadrid 28029Spain Institute for Health Research of Navarra(IDISNA) Pamplona 31008Spain Program of Cardiovascular Diseases Center for Applied Medical ResearchUniversity of NavarraPamplona 31008Spain Centre for Biomedical Research in Cardiovascular Disease Network Carlos Ⅲ Institute of HealthMadrid 28029Spain Departments of Nephrology and Cardiology University of Navarra ClinicPamplona 31008Spain

Background:This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise ***:A systematic search for relevant studies was performed in 3 *** controlled trials investigating the effects of exercise training on at least one of the following exerkines were included:adiponectin,apelin,brain-derived neurotrophic factor,fetuin-A,fibroblast growth factor-21,follistatin,ghrelin,interleukin(IL)-6,IL-8,IL-10,IL-15,IL-18,leptin,myostatin,omentin,resistin,retinol-binding protein 4,tumor necrosis factor-α,and ***:Forty randomized controlled trials were selected for data extraction(n=2160).Exercise training induces changes in adiponectin,fetuin-A,fibroblast growth factor-21,IL-6,IL-10,leptin,resistin,and tumor necrosis factor-a levels but has no significant effects on apelin,IL-18,and ghrelin compared to *** exercise training favored large and positive changes in pooled exerkines(i.e.,an overall effect size calculated from several exerkine s)(Hedge’s g=1.02,95%confidence interval(95%CI):0.76-1.28),which in turn were related to changes in glycated hemoglobin(mean difference(MD)=-0.81%,95%CI:-0.95%to-0.67%),fasting glucose(MD=-23.43 mg/dL,95%CI:-30.07 mg/dL to-16.80 mg/dL),waist circumference(MD=-3.04 cm,95%CI:-4.02 cm to-2.07 cm),and body mass(MD=-1.93 kg,95%CI:-2.00 kg to-1.86 kg).Slightly stronger effects were observed with aerobic,resistance,or high-intensity interval protocols at moderate-to vigorous-intensity and with programs longer than 24 weeks that comprise at least 3 sessions per week and more than 60 min per ***:Exercise training represents an anti-inflammatory therapy and metabolism-improving strategy with minimal side effects for patients with type 2 diabetes mellitus.

关键词： Adipokines Exercise training Hepatokines Myokines

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Social Networks and Their Role in Current Medicine: An Indispensable Tool for Doctors

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Journal of Biosciences and Medicines 2020年第8期8卷 15-25页

作者： Israel Espino-Gaucin carlos Eduardo Rodríguez Rodríguez javier ruiz Ávila javier Soto Catalina Ortiz Monasterio Ruge Rogelio Martinez Wagner Department of Plastic Surgery Hospital General Dr. Manuel Gea González Mexico City México Dermato-Oncologist and Medical Director of Dermedica Mexico City México Plastic and Reconstructive Surgeon Cartagena Institute of Plastic and Reconstructive Surgery Cartagena Colombia Mexican Faculty of Medicine La Salle University Mexico City México Cleft Lip and Palate Clinic General Hospital “Dr. Manuel Gea González” Mexico City México

Social networks have had a substantial impact on the current methods of professional development and practice within the health services industry. They have proven to have a wide range of suitable applications that facilitate communication, training, and medical practice. Currently, there are many web systems that allow people to have a public or semi-public profile, allowing the creation of shared connections with a list of users within the same system, which may vary in nature and terminology depending on the site in which it is used, shaping the concept of the social network. The purpose of this review is to highlight the usefulness of social media networks in academic medicine and its impact on health services.

关键词： Social Networks Academic Medicine Health Services

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Endoscopic identification of endoluminal esophageal landmarks for radial and longitudinal orientation and lesion location

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World Journal of Gastroenterology 2019年第4期25卷 498-508页

作者： Fabian Emura Rene Gomez-Esquivel carlos Rodriguez-Reyes Petros Benias javier Preciado Michael Wallace Luis Giraldo-Cadavid Division of Gastroenterology Universidad de La Sabana Advanced Gastrointestinal Endoscopy EmuraCenter LatinoAmerica Emura Foundation for the Promotion of Cancer Research Unidad de Endoscopia Digestiva Clínica Pediátrica Colsanitas Division of Digestive Diseases and Nutrition Morsani College of Medicine University of South Florida Division of Gastroenterology North Shore-Long Island Jewish Medical Center Unidad de Exploraciones Digestivas Clinica Universitaria Colombia Department of Gastroenterology and Hepatology Mayo Clinic Department of Internal Medicine. Universidad de La Sabana Division of Interventional Pulmonology Fundacion Neumologica Colombiana

AIM To characterize esophageal endoluminal landmarks to permit radial and longitudinal esophageal orientation and accurate lesion *** Distance from the incisors and radial orientation were estimated for the main left bronchus and the left atrium landmarks in 207 consecutive patients using white light examination. A sub-study was also performed using white light followed by endoscopic ultrasound(EUS) in 25 consecutive patients to confirm the *** scope orientation throughout the exam was maintained at the natural axis,where the left esophageal quadrant corresponds to the area between 6 and 9 o'clock. When an anatomical landmark was identified, it was recorded with a photograph and its quadrant orientation and distance from the incisors were determined. The reference points to obtain the distances and radial orientation were as follows: the midpoint of the left main bronchus and the most intense pulsatile zone of the left atrium. With the video processor system set to moderate insufflation, measurements were obtained at the end of the patients' air *** The left main bronchus and left atrium esophageal landmarks were identified using white light in 99% and 100% of subjects at a mean distance of 25.8 cm(SD2.3), and 31.4 cm(SD 2.4) from the incisors, respectively. The left main bronchus landmark was found to be a tubular, concave, non-pulsatile, esophageal external compression, occupying approximately 1/4 of the circumference. The left atrium landmark was identified as a round, convex, pulsatile, esophageal external compression, occupying approximately 1/4 of the circumference. Both landmarks were identified using white light on the anterior esophageal quadrant. In the substudy, the left main bronchus was identified in 24(92%) patients at 25.4 cm(SD2.1) and 26.7 cm(SD 1.9) from the incisors, by white light and EUS, *** left atrium was recognized in all patients at 30.5 cm(SD 1.9), and 31.6 cm(SD2.3) from the incisors, by b

关键词： Esophagus Natural landmark Radial orientation Longitudinal orientation Four-quadrants Left main bronchus Left atrium

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Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

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Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： javier Romero Otero Borja Garcia Gomez Jose Medina Polo carlos Pascual Mateoe Silvia Garcia Barreras Eduard Garcia Cruz javier de la Riva de la Vifia Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment

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ZigID:Improving visibility in industrial environments by combining WSN and RFID

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第11期12卷 849-859页

作者： Pablo GARCíA ANSOLA Andrés GARCíA javier de las MORENAS javier GARCíA ESCRIBANO Francisco javier OTAMENDI Autolog Labs School of Industrial EngineeringUniversity of Castilla-La Mancha Applied Economic Department University Rey Juan Carlos

The objective of this work is to provide decision-making processes with an updated/real picture of the mobile resources in industrial environments through a constant feedback of *** combination of identification technologies and wireless sensor networks(WSN) is proposed as a key development to guarantee an accurate and timely supply of online information regarding the localization and tracking of the mobile wireless *** approach uses a cooperative and distributed localization system,called ZigID,which is a WSN based on a Zigbee network with radio frequency identification(RFID) active tags as end *** WSN can recover not only the ID information stored at the tags attached to mobile resources,but also any other useful data captured by specific sensors for acceleration,temperature,humidity and fuel *** paper also shows the development of ZigID,including devices and information flows,as well as its implementation in ground handling operations at the Ciudad Real Central Airport,Spain.

关键词： Radio frequency identification(RFID) Tracking Wireless sensor networks(WSNs)

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Long-term data from a small mammal community reveal loss of diversity and potential effects of local climate change

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Current Zoology 2017年第5期63卷 515-523页

作者： Simone SANTORO Cristina SANCHEZ-SUAREZ carlos Rouco L. javier PALOMO M. Carmen FERNANDEZ Maura B. KUFNER Sacramento MORENO Ethology and Biodiversity Conservation Department DoSana Biological Station-CSIC Americo Vespucio s/n Seville 41092 Spain Departamento de Zoologfa Campus de Rabanales Universidad de Cordoba Cordoba 14071 Spain Wildlife Ecology and Management Team Private Bag 1930 Dunedin 9054 New Zealand Departamento de Biologia Animal Universidad de Malaga Malaga 29071 Spain Diego de 0norato 67 Barrio Uritorco Cordoba 5003 Argentina

Climate change affects distribution and persistence of species. However, forecasting species＇ re-sponses to these changes requires long-term data series that are often lacking in ecological *** used 15 years of small mammal trapping data collected between 1978 and 2015 in 3 areas atDoSana National Park （southwest Spain） to （i） describe changes in species composition and （ii） test theassociation between local climate conditions and size of small mammal populations. Overall, 5 specieswere captured： wood mouse Apodemus sylvaticus, algerian mouse Mus spretus, greater white-toothed shrew Crocidura russula, garden dormouse Eliomys quercinus, and black rat Rattus rattus. Thetemporal pattern in the proportion of captures of each species suggests that the small mammal diver-sity declined with time. Although the larger species （e.g., E. quercinus）, better adapted to colder cli-mate, have disappeared from our trapping records, M. spretus, a small species inhabiting southwestEurope and the Mediterranean coast of Africa, currently is almost the only trapped species. We used 2-level hierarchical models to separate changes in abundance from changes in probability of captureusing records of A. sylvaticus in all 3 areas and of Mo spretus in 1. We found that heavy rainfall and lowtemperatures were positively related to abundance of A. sylvaticus, and that the number of extremelyhot days was negatively related to abundance of M. spretus. Despite other mechanisms are likely to beinvolved, our findings support the importance of climate for the distribution and persistence of thesespecies and raise conservation concerns about potential cascading effects in the Donana ecosystem.

关键词： climate change, count data, N-mixture models, rodents, spain.

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Glutaminolysis-ammonia-urea Cycle Axis,Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 356-362页

作者： Ángela Rojas María Rosario García-Lozano Antonio Gil-Gómez Manuel Romero-Gómez javier Ampuero Department of Unit of Digestive Diseases Virgen del Rocío University HospitalSevilleSpain SeLiver group at the Insti-tute of Biomedicine of Seville(IBIS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Center for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Institute of HealthMadridSpain De-partment of Organic and Medicinal Chemistry Faculty of PharmacyUniversity of SevilleE-41071SevilleSpain

The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic *** is characterized by the accumulation of fat in the liver,and is known to be a cause of *** many pathways have been proposed,the cause of NAFLD-linked fibrosis progression is still unclear,which posed challenges for the development of new therapies to prevent NASH-related cirrhosis and hepatocellular *** is associated with activation of hepatic stellate cells(HSC)and accumulation of excess extracellular matrix proteins,and inhibiting the activation of HSCs would be expected to slow the progression of *** molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HSC *** mechanisms are plausible antifibrotic targets in NASH,as the activation of HSCs the proliferation of myofibroblasts depend on those *** review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression,and shows how the axis could be a novel therapeutic target.

关键词： Non-alcoholic fatty liver disease Cirrhosis Fibrosis Glutaminoly-sis Ammonia Urea

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