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Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis

Cellular & Molecular Immunology 2018年第10期15卷 898-906页

作者： Marta Consuegra-Fernández Marc Julià Mario Martínez-Florensa Fernando Aranda Cristina Català Noelia Armiger-Borràs María-Teresa Arias Francisca Santiago Antonio Guilabert Anna Esteve carlos Muñoz carlos ferrándiz José-Manuel Carrascosa Edurne Pedrosa Jorge Romaní MercèAlsina José-Manuel Mascaró-Galy Francisco Lozano Immunoreceptores del Sistema Innat i Adaptatiu Institut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036Spain Servicio de Dermatologia Hospital Universitario de BasurtoBilbao 48013Spain Servei d’Immunologia Centre de Diagnòstic BiomèdicHospital Clínic de BarcelonaBarcelona 08036Spain Servei de Dermatologia Hospital General de GranollersBarcelona 08402Spain Centre d’Estudis Epidemiològics sobre les ITS i Sida de Catalunya(CEEISCAT) ASPCCIBER Epidemiologia y Salud PúblicaBadalona 08916Spain Servei de Dermatologia Hospital Universitari Germans Trias i PujolBadalona 08916Spain Laboratori d’Immunobiologia per Investigaciói Aplicacions al Diagnòstic Banc de Sang i Teixits(BST)Institut d’Investigacióen Ciències de la Salut Germans Trias i PujolDepartament de Biologia Cel·lularFisiologia i ImmunologiaUniversitat Autònoma de BarcelonaBellaterra 08193Spain Servei de Dermatologia Consorci Sanitari Parc Taulí08208 Sabadell.Universitat Autónoma de BarcelonaBellaterra 08193Spain Servei de Dermatologia Hospital Clínic de BarcelonaBarcelona 08036Spain Departament de Biomedicina Universitat de BarcelonaBarcelona 08036Spain

Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental *** evidence supports CD6,a lymphocyte surface receptor mostly expressed by T cells,as a putative target in ***,a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders,including ***,we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis ***,an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice,as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines,namely,***,isolated CD4+CD62L+T cells from CD6-deficient mice displayed decreased in vitro T-helper type 17 ***,a statistically significant association between CD6 single-nucleotide polymorphisms(rs17824933,rs11230563 and rs12360861)and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of *** together,these results provide new supportive evidence of the contribution of the CD6 lymphocyte receptor in psoriasis at both experimental and clinical levels.

关键词： ALCAM CD5 CD6 lymphocyte psoriasis

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Energy Meteorology for the Evaluation of Solar Farm Thermal Impacts on Desert Habitats

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Advances in Atmospheric Sciences 2025年第2期42卷 313-326页

作者： carlos F.M.COIMBRA Department of Mechanical and Aerospace Engineering Jacobs School of EngineeringCenter of Excellence in Renewable Resource Integration and Center for Energy ResearchUniversity of California San DiegoLa JollaCA 92093USA

This work addresses challenges and opportunities in the evaluation of solar power plant impacts,with a particular focus on thermal effects of solar plants on the environment and ***-scale solar power plants are often sited in arid or desert habitats,which tend to include fauna and flora that are highly sensitive to changes in temperature and *** understanding of both shortwave(solar)and longwave(terrestrial)radiation processes in solar power plants is complete enough to render the modeling of radiation fluxes with high confidence for most *** contrast to radiation,the convective environment in large-scale solar power plants is much more difficult to *** direction,wind speed,turbulence intensity,dust concentration,ground condition,panel configuration density,orientation and distribution throughout the solar field,all affect the local environment,the balance between radiation and convection,and in turn,the performance and thermal impact of solar power *** the temperatures of the two sides of photovoltaic(PV)panels depend on detailed convection-radiation balances,the uncertainty associated with convection affects the heat and mass transfer balances as *** balances are critically important in estimating the thermal impact of large-scale solar farms on local *** we discuss outstanding issues related with these transfer processes for utility-scale solar generation and highlight potential pathways to gain useful knowledge about the convective environment directly from solar farms under operating conditions.

关键词： environmental impact solar farms thermal balances shortwave and longwave radiation convection

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Metallogenic model of sandstone-hosted copper deposits:a case study from the Paleogene in Jiashi area,northwestern China

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Journal of Palaeogeography 2025年第01期14卷 105-125页

作者： Long-Qing Shi Xing-Yue Qu carlos Zavala Yang Li College of Earth Science and Engineering Shandong University of Science and Technology Geology Department Universidad Nacional del Sur Geología de Cuencas Sedimentarias (GCS) Argentina Institute of Energy Peking University Ordos Research Institute of Energy Peking University Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and Technology

Sandstone-hosted copper deposits,a type of Sediment-Hosted Stratiform Copper (SSC) deposits,are widely distributed *** economically viable deposits of SSC are relatively scarce,they account for approximately 30%of the world's total discovered copper ***,there is still a lack of comprehensive and in-depth research into the depositional and metallogenic models of these *** Jiashi area of the Tarim Basin in northwestern China,known for its economically significant Paleogene SSC deposit,lacks in-depth studies on metallogenic *** address this,field profile observations were conducted to analyze the sedimentary evolution,sequence stratigraphy,and tectonism of the Paleogene strata in the Jiashi *** with elemental geochemical analysis of samples,the provenance of sediment,and the source of metallogenic materials,a robust metallogenic model was *** results reveal the influence of provenance for the origin of Paleogene copper-rich *** evolution played a crucial role in controlling the distribution of copper and sulfur elements,as well as the spatial arrangement of metallogenic ***,nappe movement potentially generated faults,allowing upward movement of basin fluids,which played a crucial role in the formation of copper deposits within sandstone-hosted ***,this study offers a comprehensive analysis of the metallogenic processes involved in sandstone-hosted copper deposits,thereby contributing significant insights to the broader research on SSC deposits worldwide.

关键词： Tarim Basin Paleogene Sandstone-hosted copper deposits Metallogenic material source Metallogenic model

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Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients:A systematic review of clinical trials

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World Journal of Transplantation 2025年第1期15卷 156-164页

作者： carlos M Ardila Pradeep K Yadalam Jaime Ramírez-Arbelaez Department of Basic Sciences Faculty of Dentistry Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia Department of Postdoctoral Program CIFE University CenterCuernavaca 62330MorelosMexico Department of Periodontics Saveetha Dental CollegeSaveetha Institute of Medical and HealthSIMATSSaveetha UniversityChennai 600077Tamil NaduIndia Department of Transplantation Hospital San Vicente FundaciónRionegro 054047Colombia

BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ *** To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant *** A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and *** review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial *** search strategy involved analyzing multiple databases,including PubMed/MEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until May 2024,with no language *** After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were *** most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also *** antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and *** concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;P<0.05).The total reported deaths in three clinical trials were 75,and there were 24 graft rejections in two *** All clinical trials reported significant proportions of antimicrobial-resistant microor

关键词： Antimicrobial resistance Antimicrobials Antivirals Solid organ transplant recipients Infections Microorganisms Cytomegalovirus

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Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： carlos M Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors

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Updating the distribution of Nothofagus alessandrii: Impact of deforestation, fragmentation and connectivity

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FOREST ECOSYSTEMS 2025年第01期12卷 136-145页

作者： Cabrera-Ariza, Antonio M. Rivas, carlos A. Aguilera-Peralta, Miguel Navarro-Cerrillo, Rafael M. Santelices-Moya, Romulo Univ Catolica Maule Ctr Invest Estudios Avanzados Maule Ave San Miguel 3605 Talca 3460000 Chile Univ Catol Maule Fac Ciencias Agr & Forestales Ctr Desarrollo Secano Interior Talca 3460000 Chile Univ Cordoba Lab Dendrochronol Silviculture & Global Change DendrodatLab ERSAF Dept Forest Engn Cordoba Spain

Nothofagus alessandrii forests in the Mediterranean region of Chile face significant threats from deforestation, fragmentation, wildfires, and climate change. This study investigated the temporal and spatial dynamics of N. alessandrii populations and their implications for habitat fragmentation and connectivity. Using remote sensing data and geographic information system analysis, we assessed deforestation patterns, fragmentation metrics, and connectivity indices for different scenarios between 2009 and 2022. A reduction in the N. alessandrii forest area, extensive fragmentation, and decreased connectivity were observed over time, with wildfires exacerbating these trends. Reforestation simulations showed the potential of targeted restoration efforts to improve connectivity, especially when focusing on proximate patches. However, careful consideration of seed dispersal distances and wildfire risk is essential for effective reforestation planning. Overall, our findings underscore the urgent need for conservation interventions to preserve N. alessandrii forests and their biodiversity in Chile's coastal mountain ecosystems. A proactive and collaborative approach is essential to ensure the survival of these forests for future generations.

关键词： Ruil Endangered species Red list IUCN Conservation biology

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Some artificial intelligence tools may currently be useful in orthopedic surgery and traumatology

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World Journal of Orthopedics 2025年第2期16卷 88-91页

作者： Emerito carlos Rodriguez-Merchan Department of Orthopedic Surgery Hospital Universitario La Paz-IdiPazMadrid 28046Spain

Artificial intelligence(AI)can help in diagnosing fractures and demonstrating effusions,dislocations,and focal bone lesions in both adult and pediatric aged individuals and also aid in early tumor discovery(bone osteosarcoma)and in robot-assisted surgery.A recent AI model[Mask R-CNN(region-based convolutional neural network)]has shown to be dependable for detecting surgical target zones in pediatric hip and periarticular infections,offering a more convenient and quicker alternative to conventional *** can help inexperienced physicians in pre-treatment evaluations,diminishing the risk of missed diagnosis and *** has some very interesting applications in orthopedic surgery,which orthopedic surgeons should be aware of and if possible *** some interesting advances have been made recently on AI in orthopedic surgery,its usefulness in clinical practice is still very *** concerns,such as transparency in AI decision-making,data privacy,and the potential loss of human intuition cannot be ***,it is paramount to explore how to gain trust from both healthcare professionals and patients in the utilization of AI.

关键词： Artificial intelligence Orthopedic surgery Pediatric orthopedics Clinical applications

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The Locust (Tropidacris spp) within the Ejido “El Cuayo”

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Advances in Entomology 2025年第1期13卷 200-224页

作者： Compeán-Guzmán Francisco Javier carlos Ricardo Menéndez Gámiz Institute of Social Sciences and Faculty of Forestry Sciences Jurez University of the State of Durango Durango Mexico Agricultural Development Planning UNAM FES Aragn Nezahualcyotl Mexico

Tropidacris spp. represent the largest known group among acridoids. Their presence ranges from southeastern Mexico and has so far been confirmed only in tropical habitats. This publication seeks to highlight the current and potential challenges associated with their presence. For decades, the use of chemical insecticides has been the primary method for controlling locust populations, though these substances pose significant risks to human health and the environment. Recent research efforts are directed toward developing control methods that are less detrimental to both ecological and human health, such as biopesticides derived from pathogenic fungi, plant extracts, and strategically prescribed burns. Satellite surveillance enables the monitoring of the origination and progression of outbreaks to inform control strategy selection.

关键词： Ejido “El Cuayo” Locust Infestation Tropidacris Collaris

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FANET and MANET, a Support and Composition Relationship

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Computers, Materials & Continua 2025年第2期82卷 1699-1732页

作者： carlos Andrés Tavera Romero Jesús Hamilton Ortiz Luis carlos Rodríguez Timaná Fernando Vélez Varela Andrés Hernando Aristizábal Montufar Javier Gamboa-Cruzado COMBA R&D Laboratory Faculty of EngineeringUniversidad Santiago de CaliCali76001Colombia Development Department Closemobile R&D Telecommunications LSMadrid28070Spain GIEIAM Research Group Faculty of EngineeringUniversidad Santiago de CaliCali76001Colombia Faculty of Engineering Universidad LibreCali760031Colombia Faculty of Systems and Informatics Engineering Universidad Nacional Mayor de San MarcosLima15001Perú

This study investigates the design and implementation of Flying Ad Hoc Networks(FANETs),a network architec-ture inspired by the Mobile Ad Hoc Network(MANET)model,specifically tailored to support unmanned aerial vehicles(UAVs).As UAVs increasingly contribute to diverse fields,from surveillance to delivery,FANETs have emerged as essential in ensuring stable,dynamic communication channels among drones in *** research adopts a dual approach,combining rigorous theoretical analysis with detailed practical simulations to assess the performance,adaptability,and efficiency of FANETs in varying *** findings emphasize the ability of FANETs to manage network congestion effectively in densely populated areas,a critical feature for maintaining reliable communications in complex ***,FANETs demonstrate high potential to support critical applications,such as emergency response,disaster management,and public safety operations,where quick and coordinated action is *** study also underscores the importance of establishing a hierarchical structure among nodes within the network,which allows for more efficient data exchange and helps optimize the overall network *** this work,significant insights are offered into the design principles that can enhance UAV communication networks,providing a foundation for the development of more resilient,scalable,and efficient technological *** advancements could accelerate the deployment of UAVs across a variety of sectors,including logistics,agriculture,environmental monitoring,and *** such,this study not only contributes to the field of ad hoc networking but also holds potential for transformative impacts across industries where UAVs play an increasingly central role,promoting greater integration and operational success.

关键词： Ad hoc FANET MANET network UAV

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Hidden dangers of pelvic fracture:A meta-analysis on urinary tract injury incidence and risk factors

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World Journal of Orthopedics 2025年第2期16卷 28-39页

作者： Gonzalo Mariscal Ali Dway carlos Barrios Institute for Research on Musculoskeletal Disorders Valencia Catholic UniversityValencia 46700Spain Faculty of Medicine Al-Andalus University for Medical SciencesTartus 000Syria

BACKGROUND Pelvic fractures are often associated with significant morbidity,including injuries to the urinary *** the incidence and risk factors for urinary tract injury in these patients is crucial for prompt diagnosis and *** meta-analysis aims to synthesize existing evidence to determine the overall incidence and identify specific risk factors associated with urinary tract injuries in patients with pelvic *** To determine the incidence and risk factors for urinary tract injuries in patients with pelvic *** A systematic search of PubMed,EMBASE,Scopus,and the Cochrane Library was conducted without date *** examining the incidence and risk factors of urinary tract injuries in patients with pelvic fractures were *** extracted included demographics,injury mechanism,pelvic fracture type,urinary tract injury incidence,mortality,and discharge *** Manager 5.4 was used for data *** Ten studies comprising 22700 patients were *** pooled incidence of urinary tract injury associated with pelvic fracture was 6.88%(95%CI:6.20%-7.55%).Vehicle,motorcycle,and pedestrian accidents were identified as risk factors for urinary tract injury,with relative risks(RR)of 1.08(95%CI:1.06-1.11),1.89(95%CI:1.78-2.00),and 1.53(95%CI:1.20-1.95),*** fracture and pelvic ring disruption were significantly associated with urinary tract injury[odds ratio(OR)1.94,95%CI:1.09-3.44 and OR 5.53,95%CI:4.67-6.54,respectively)].Patients without urinary tract injury were more likely to be discharged home(RR 0.79,95%CI:0.67-0.92).Mortality was higher in patients with urinary tract injury(OR 1.92,95%CI:1.77-2.09).CONCLUSION Urinary tract injury occurs in nearly 7%of patients with pelvic *** accidents,pubic fractures,and pelvic ring disruptions are significant risk *** tract injury following pelvic fracture is associated with increased mortality.

关键词： Urinary tract Urologic Pelvic fracture Pelvic injury Incidence Meta-analysis

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