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Journal of Computer Science & Technology 2018年第2期33卷 249-262页

作者： Seilendria A. Hadiwardoyo Subhadeep Patra carlos T. Calafate Juan-carlos Cano Pietro Manzoni deptartment of Computer Engineering Universitat Politecnica de Valencia Valencia 46022 Spain

Alerting drivers about incoming emergency vehicles and their routes can greatly improve their travel time in congested cities, while reducing the risk of accidents due to distractions. This paper contributes to this goal by proposing Messiah, an Android application capable of informing regular vehicles about incoming emergency vehicles like ambulances, police cars and fire brigades. This is made possible by creating a network of vehicles capable of directly communicating between them. The user can, therefore, take driving decisions in a timely manner by considering incoming alerts. Using the support of our GRCBox hardware, the application can rely on vehicular ad-hoc network communications in the 5 GHz band, being V2V （vehicle-to-vehicle） communication provided through a combination of Android-based smartphone and our GRCBox device. The application was tested in three different scenarios with different levels of obstruction, showing that it is capable of providing alerts up to 300 meters, and notifying vehicles within less than one second.

关键词： intelligent transportation systems (ITS) vehicular ad-hoc network (VANET) mobile application Android,navigation ad-hoc network

Pathogenesis of occult chronic hepatitis B virus infection

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World Journal of Gastroenterology 2011年第12期17卷 1543-1548页

作者： Rocio Aller de la Fuente María L Gutiérrez Javier Garcia-Samaniego Conrado Fernández-Rodriguez Jose Luis Lledó Gregorio Castellano Gastroenterology Hospital Clinico Universitario Valladolid Institute of endocrinology and Nutrition Medical SchoolUniversity of Valladolid47003 ValladolidSpain Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadridSpain Gastroenterology department Hospital Carlos IIIc/Sinesio Delgado28029 MadridSpain Hospital Universitario 12 de Octubre Av de Andalucia 2804128039 MadridSpain

Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological *** HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene *** is an entity with world-wide *** failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this"occult"HBV infection;although the mechanisms responsible for suppression of HBV are not well *** majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV *** evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma.

关键词： Occult hepatitis B virus infection Hepatitis B virus-DNA Anti-HBc alone Hepatitis B virus Hepadnaviral hepatitis Occult viral persistence Primary occult infection Secondary occult infection Virus reactivation

A LoRa-based protocol for connecting IoT edge computing nodes to provide small-data-based services

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Digital Communications and Networks 2022年第3期8卷 257-266页

作者： Kiyoshy Nakamura Pietro Manzoni Alessandro Redondi Edoardo Longo Marco Zennaro Juan-carlos Cano carlos T.Calafate Universitat Politécnica de Valéncia ValenciaSpain Abdus Salam International Centre for Theoretical Physics(ICTP) TriesteItaly Politecnico di Milano MilanItaly

Data is becoming increasingly *** regularly interact with a variety of structured data,ranging from SQLite databases on the phone to personal sensors and open government ***“digital traces left by individuals through these interactions”are sometimes referred to as“small data”.Examples of“small data”include driving records,biometric measurements,search histories,weather forecasts and usage *** this paper,we present a flexible protocol called LoRaCTP,which is based on LoRa technology that allows data“chunks”to be transferred over large distances with very low energy *** provides all the mechanisms necessary to make LoRa transfer reliable by introducing a lightweight connection setup and allowing the ideal sending of an as-long-as necessary data *** designed this protocol as communication support for small-data edge-based IoT solutions,given its stability,low power usage,and the possibility to cover long *** evaluated our protocol using various data content sizes and communication distances to demonstrate its performance and reliability.

关键词： Small data Edge computing LoRa IoT

Frontal penetrating arrow injury:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4117-4122页

作者： Alejandra Rodríguez-Ramos carlos A Zapata-Castilleja José L Treviño-González Gerardo C Palacios-Saucedo Ramón G Sánchez-Cortés Leonor G Hinojosa-Amaya Adriana Nieto-Sanjuanero Manuel de la O-Cavazos department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMexico

BACKGROUND Penetrating arrow injuries of the head and neck are exceedingly rare in pediatric *** pathology has high morbidity and mortality because of the presence of vital organs,the airway,and large ***,the treatment and removal of an arrow is a challenge that requires multidisciplinary *** SUMMARY A 13-year-old boy was brought to the emergency room after an arrow injury to the frontal *** arrowhead was lodged in the *** studies showed a lesion of the paranasal sinuses without compromising vital *** arrow was successfully removed by retrograde nasoendoscopy without complications,and the patient was *** Although rare,maxillofacial arrow injuries have high morbidity and mortality and require multidisciplinary management to preserve function and aesthetics.

关键词： Arrow Penetrating trauma Maxillofacial injuries Pediatrics Pediatric emergency medicine Case report

Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain

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World Journal of Gastroenterology 2005年第37期11卷 5770-5776页

作者： Ana Sánchez de Abajo Miguel de la Hoya Alicia Tosar Javier Godino Juan Manuel Fernández Jose Lopez Asenjo Beatriz Perez Villamil Pedro Perez Segura Eduardo Diaz-Rubio Trinidad Caldes laboratorio de Oncología Molecular Hospital Clinico San carlos Madrid Spain Servicio de Anatomía Patológica Hospital Clinico San carlos Madrid Spain Servicio de Oncología Médica Hospital Clinico San carlos Madrid Spain

AIM: To investigate the prevalence and penetrance of hMSH6 mutations in Spanish HNPCC families that was negative for mutation in hMLH1 or ***: We used PCR-based DGGE assay and direct Sequencing to screen for hMSH6 gene in 91 HNPCC ***: we have identified 10 families with germ-line mutations in the DNA sequence. These mutations included two intronic variation, three missense mutation, one nonsense mutation, and four silent mutations. Among the 10 germ-line mutations identified in the Spanish cohort,8 were novel, perhaps, suggesting different mutational spectra in the Spanish population. detailed pedigrees were constructed for the three families with a possible pathogenic hMSH6 mutation. The two silent mutations H388H and L758L, detected in a person affected of colorectal cancer at age 29, produce loss of the wild-type allele in the tumor sample. Immunohistochemical analysis showed that expression of MSH6 protein was lost only in the tumors from the carriers of V878A and Q263X ***: Altogether, our results indicate that disease-causing germ-line mutations of hMSH6 are very less frequent in Spanish HNPCC families.

关键词： HNPCC MMR hMSH6 MSI IHC SPANISH

Endoscopic anti-reflux therapy for gastroesophageal reflux disease

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World Journal of Gastroenterology 2021年第39期27卷 6601-6614页

作者： Enrique Rodríguez de Santiago Eduardo Albéniz Fermin Estremera-Arevalo carlos Teruel Sanchez-Vegazo Vicente Lorenzo-Zúñiga department of Gastroenterology and Hepatology Hospital Universitario Ramón y CajalInstituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid 28034Spain Endoscopy Unit Gastroenterology DepartmentHospital Universitario de Navarra.Gastrointestinal Endoscopy Research UnitNavarrabiomed Biomedical Research Center.PamplonaSpain Endoscopy Unit Gastroenterology DepartmentHospital Universitari i Politècnic La FeInstituto de Investigación Sanitaria La Fe(IIS La Fe)Valencia 46026Spain

Gastroesophageal reflux disease has an increasing incidence and prevalence worldwide.A significant proportion of patients have a suboptimal response to proton pump inhibitors or are unwilling to take lifelong medication due to concerns about long-term adverse *** anti-reflux therapies offer a minimally invasive option for patients unwilling to undergo surgical treatment or take lifelong *** best candidates are those with a good response to proton pump inhibitors and without a significant sliding hiatal *** incisionless fundoplication and nonablative radiofrequency are the techniques with the largest body of evidence and that have been tested in several randomized clinical ***-assisted ligation techniques,anti-reflux mucosectomy,antireflux mucosal ablation,and new plication devices have yielded promising results in recent noncontrolled ***,the role of endoscopic procedures remains controversial due to limited long-term and comparative data,and no consensus exists in current clinical *** review provides an updated summary focused on the patient selection,technical details,clinical success,and safety of current and future endoscopic anti-reflux techniques.

关键词： Treatment Gastroesophageal reflux Transoral incisionless fundoplication Anti-reflux mucosectomy Anti-reflux mucosal ablation Stretta

Factors affecting populations of the endemic Iberian hare(Lepus granatensis)after the first myxomatosis outbreaks in Central Spain

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Integrative Zoology 2023年第6期18卷 981-993页

作者： carlos LÁZARO JoséLuis GUZMÁN Fabián CASAS carlos SÁNCHEZ-GARCÍA department of Research Fundación ArtemisanCiudad RealSpain department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain

The Iberian hare(Lepus granatensis)is an endemic species distributed in Spain and *** outbreaks affecting this species were detected in 2018 in Central and Southern Spain,spreading *** to evaluate factors affecting the status of hare population after the arrival of myxomatosis,we conducted 108 nocturnal hare counts in Central Spain during two study periods(winter/spring and summer/autumn)in 54 different hunting grounds,covering 1071 km and observing 884 *** mean density in winter/spring was 7.66 hares/100 ha,(range 6.14-9.54/100 ha),while in summer/autumn,it was 3.4 hares/100 ha(range 2.6-4.4/100 ha).densities of hares were not affected by the dominant habitat and the presence/absence of myxomatosis *** were more abundant at hunting grounds at a higher altitude and in those conducting targeted management,while detection of myxomatosis was related to lower altitude and higher levels of game management.A MaxEnt model used to generate a risk map for myxomatosis occurrence showed that the temperature annual range was the most important predictor,which suggests that environmental factors affecting myxomatosis vectors(mosquitoes,fleas,and ticks)could play a key role in disease *** myxomatosis in hares is becoming endemic,hare densities may be improved by game management and the monitoring and surveillance of this emerging *** surveillance programs could be the basis of effective collaborations between hunters,researchers,and environmental managers.

关键词： game management habitat Iberian hare MaxEnt monitoring myxomatosis

An unsupervised pattern recognition methodology based on factor analysis and a genetic-DBSCAN algorithm to infer operational conditions from strain measurements in structural applications

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Chinese Journal of Aeronautics 2021年第2期34卷 165-181页

作者： Juan carlos PERAFAN-LOPEZ Julian SIERRA-PEREZ Grupo de Investigacion en Ingenieria Aeroespacial Universidad Pontificia BolivarianaCircular 170-01Medellin 050031Colombia

Structural Health Monitoring(SHM) suggests the use of machine learning algorithms with the aim of understanding specific behaviors in a structural system. This work introduces a pattern recognition methodology for operational condition clustering in a structure sample using the well known density Based Spatial Clustering of Applications with Noise(DBSCAN) *** methodology was validated using a data set from an experiment with 32 Fiber Bragg Gratings bonded to an aluminum beam placed in cantilever and submitted to cyclic bending loads under 13 different operational conditions(pitch angles). Further, the computational cost and precision of the machine learning pipeline called FA + GA-DBSCAN(which employs a combination of machine learning techniques including factor analysis for dimensionality reduction and a genetic algorithm for the automatic selection of initial parameters of DBSCAN) was measured. The obtained results have shown a good performance, detecting 12 of 13 operational conditions, with an overall precision over 90%.

关键词： Clustering DBSCAN Factor analysis FBGs Pattern recognition Strain field

Pannexin 1-based channels activity as a novel regulator of multiple sclerosis progression

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Neural Regeneration Research 2020年第1期15卷 65-66页

作者： Fernando C.Ortiz carlos Puebla Mechanisms on Myelin Formation and Repair laboratory Instituto de Ciencias BiomedicasFacultad de Ciencias de la SaludUniversidad Autonoma de ChileSantiagoChile Cellular Physiology laboratory Instituto de Ciencias BiomedicasFacultad de Ciencias de la SaludUniversidad Autonoma de ChileSantiagoChile

Multiple sclerosis(MS):MS is a neurodegenerative disease affecting around 2.5 million people worldwide,representing the second cause of disabilities in the young adult *** is a demyelinating pathology which originates in the autoimmune attack of T and B lymphocytes against *** lack of myelin leads,in turn,to axonal degeneration,neuronal death and the consequent neurological disabilities(Franklin and Ffrench-Constant,2017).A main hallmark of MS is a preserved local neuroinflammatory *** is now acknowledged that this persistent inflammatory scenario is a central and common condition in almost all neurodegenerative pathologies(as in Parkinson’s and Alzheimer’s diseases,among others)controlling and modulating the regulatory responses of the system to the triggering *** the case of MS,this original insult corresponds to the loss of myelin(Chitnis and Weiner,2017;Franklin and Ffrench-Constant,2017).

关键词： Franklin representing degeneration

Finite One-Dimensional Photonic Crystal with Gaussian Modulation: Transmission and Escape

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Optics and Photonics Journal 2017年第10期7卷 170-180页

作者： María de la Luz Silba-Vélez David-Armando Contreras-Solorio Rolando Pérez-álvarez carlos Iván Cabrera Academic Unit of Physics Autonomous University of Zacatecas Zacatecas Mexico Center of Science Research Institute of Basic and Applied Sciences Autonomous University of the State of Morelos Cuernavaca Mexico

This paper studied the transmission coefficient and escape frequencies in a system of planar dielectric layers where the refractive index changes from one layer to another through a Gaussian function. The wave equation with normal incidence is analyzed. For the calculations, the transfer matrix formalism is used. In a previous work, the transmission and escape problem for Gaussian electronic superlattices is investigated. Now it studied the electromagnetic modes for a system formed by layers where the refractive index of the structure is modulated by a Gaussian function. The system presents transparency bands of transmission and gaps without transmission. The escape frequencies are situated near these transparency bands but they do not coincide with them. is the frequency (mode) and Γdescribes the width of the states. For these systems, the escape states are very wide. A non Gaussian system presents resonance peaks in the transmission and the escape states are narrow. The formation of transparency bands in the transmission for a Gaussian system is attributed to the widening of the escape states.

关键词： Transmission Coefficient Escape Frequencies Photonic Crystal