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High-frequency lacustrine sequence stratigraphy of clastic lakes: lessons from ancient successions

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Journal of Palaeogeography 2024年第4期13卷 621-645页

作者： carlos Zavala Hua-Qing Liu Xiang-Bo Li Valentin Trobbiani Yang Li Mariano Arcuri Agustin Zorzano Departamento de Geología Universidad Nacional del Sur (UNS) GCS Consulting Services.Bahía Blanca Research Institute of Petroleum Exploration&Development-Northwest Consejo Nacional de Investigaciones Científicas y T ecnicas (CONICET) Shandong University of Science and Technology

Sequence stratigraphic concepts and methods provide novel tools for performing stratigraphic analysis, allowing us to improve our understanding of depositional models and basin evolution. Main controls and depositional elements(e.g., surfaces, systems tracts, parasequences, etc.) recognized in conventional sequence stratigraphy are designed for marine-related systems. In contrast, the sequence stratigraphy of lacustrine successions is much more complex and poorly understood, because it is not driven by sea-level changes, but by a complex interaction between tectonics and high-frequency climatic cycles. The comprehensive analysis of the water balance of lacustrine systems allows the recognition of three types of lake conditions: Underfilled, balanced-fill and overfilled lakes. Understanding the lake conditions in ancient successions is fundamental for unraveling lacustrine sequence stratigraphy, since these conditions effectively control water salinity, internal stacking pattern and the characteristics of systems tracts. Underfilled lakes are hydrologically closed lakes, and consequently, the lake-level can highly fluctuate, driven by high-frequency wet-dry climatic cycles. During wet periods, rivers supply water and sediments, resulting in fining-and thinning-upward elementary depositional sequences(EDS's) accumulated during the transgressive systems tract(TST). In contrast, dry periods are characterized by a relative lake-level fall with the subaerial exposure of lake margin areas during the regressive systems tract(RST). Lake water salinity can fluctuate from brackish to hypersaline. Balanced-fill lakes are partially closed lakes, and consequently, they have characteristics of both underfilled and overfilled lakes. During the TST, the lake is in underfilled condition, and consequently, the introduction of water and sediment will accumulate a fining-upward interval until reaching the spill point during the maximum flooding. The RST is accumulated under an overfille

关键词： Lacustrine sequence stratigraphy Underfilled lakes Balanced-fill lakes Overfilled lakes Forced transgression Forced regression

Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2512-2522页

作者： Juan Jose Urquijo-Ponce carlos Alventosa-Mateu Mercedes Latorre-Sánchez Inmaculada Castelló-Miralles Moisés Diago Hepatology Unit Department of Digestive Diseases Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic *** therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at *** the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical *** systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of *** review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative *** also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative ***,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.

关键词： Hepatocellular carcinoma Early stage Intermediate stage Neoadjuvant Adjuvant Systemic therapy

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina Medina-Vera Antonio Jesús López-Gambero Juan Antonio Navarro carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

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Foot and ankle surgery:Tourniquet placement site to cause as little postoperative pain as possible

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World Journal of Orthopedics 2024年第6期15卷 498-500页

作者： Emerito carlos Rodriguez-Merchan Department of Orthopedic Surgery La Paz University Hospital-IdiPazMadrid 28046Spain Osteoarticular Surgery Research Hospital La Paz Institute for Health Research-IdiPAZ(La Paz University Hospital-Autonomous University of Madrid)Madrid 28046Spain

There is controversy in the literature on where to place the tourniquet(thigh,calf,ankle)for foot and ankle *** some authors prefer the ankle tourniquet to the calf tourniquet,others state that the surgeon can decide between using the thigh tourniquet or the ankle tourniquet,since there was no difference in postoperative pain between *** to place the tourniquet during foot and ankle surgery to cause the least possible postoperative pain to the patient as a result of the tourniquet is a common question in clinical *** reality is that,unfortunately,there is no consensus on this *** the only possible way to answer this question would be to conduct a comparative study with sufficient statistical power to reach scientifically sound *** does not seem easy to carry out such a study,but it would be important to be able to answer the question posed in the title of this Editorial once and for all.

关键词： Surgery Foot Ankle Tourniquet Site Postoperative pain

Building Tax Capacity in Developing Countries

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Belt and Road Initiative Tax Journal 2024年第1期 60-69页

作者： Cindy Negus Juan carlos Benitez Revenue Administration 1 Division Fiscal Affairs Department International Monetary Fund Tax Policy 2 Division Fiscal Affairs Department International Monetary Fund

Building tax capacity is central to the role of government in achieving the sustainable development goals,addressing climate change,and ensuring debt *** progress in revenue mobilization,there is still a large unmet tax potential in low-income developing *** tax capacity requires a firm commitment to building institutions that govern the tax system and manage tax reform,and to improving the design of core *** enhance understanding,this article provides a synopsis of why improving tax capacity is important and contains insights on trends in revenue mobilization,how to strengthen tax policy and the role of supporting ***,it explores the importance of a sound legal framework for tax certainty,which plays a crucial role in shaping investment choices and can significantly affect economic growth.

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Critical Review on Improved Electrochemical Impedance Spectroscopy-cuckoo Search-Elman Neural Network Modeling Methods for Whole-life-cycle Health State Estimation of Lithium-ion Battery Energy Storage Systems

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Protection and Control of Modern Power Systems 2024年第2期9卷 75-100页

作者： Ran Xiong Shunli Wang Paul Takyi-Aninakwa Siyu Jin carlos Fernandez Qi Huang Weihao Hu Wei Zhan School of Information Engineering Southwest University of Science and TechnologyMianyangChina School of Information Engineering Southwest University of Science and TechnologyMianyang621010 China Mechanical Engineering from Kwame Nkrumah Uni-versity of Science and Technology Ghana Northeastern University ShenyangChina Robert Gordon University Scotland Southwest University of Science and Technology(SWUST) Mian-yangChina University of Electronic Science and Technology of China ChengduChina Xi’an Jiaotong University Xi’anChina SPIC Southwest Energy Research Institute ChengduChina

Efficient and accurate health state estimation is crucial for lithium-ion battery(LIB)performance monitoring and economic *** estimating the health state of LIBs online is the key but is also the most difficult task for energy storage *** high adaptability and applicability advantages,battery health state estimation based on data-driven techniques has attracted extensive attention from researchers around the *** neural network(ANN)-based methods are often used for state estimations of *** one of the ANN methods,the Elman neural network(ENN)model has been improved to estimate the battery state more efficiently and *** this paper,an improved ENN estimation method based on electrochemical impedance spectroscopy(EIS)and cuckoo search(CS)is established as the EIS-CS-ENN model to estimate the health state of ***,the paper conducts a critical review of various ANN models against the EIS-CS-ENN *** demonstrates that the EIS-CS-ENN model outperforms other *** review also proves that,under the same conditions,selecting appropriate health indicators(HIs)according to the mathematical modeling ability and state requirements are the keys in estimating the health state *** the calculation process,several evaluation indicators are adopted to analyze and compare the modeling accuracy with other existing *** the analysis of the evaluation results and the selection of HIs,conclusions and suggestions are put ***,the robustness of the EIS-CS-ENN model for the health state estimation of LIBs is verified.

关键词： Lithium-ion battery health state esti-mation elman neural network electrochemical imped-ance spectroscopy cuckoo search health indicators

Health Vigilance and Risk Factors for Cervical Cancer: A Study in the State of Maranhão, Brazil

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Open Journal of Epidemiology 2024年第1期14卷 75-89页

作者： José Márcio Soares Leite carlos Tomaz School of Medicine CEUMA University S&#227o Luís Brazil Master’s Program in Environment CEUMA University S&#227o Luís Brazil

The purpose of this cross-sectional study was to investigate the importance of health vigilance in the prevention of cervical cancer. The sample consisted of 536 women. To identify which risk factors were associated with cervical cancer or with an increase in the mortality rate of this kind of cancer, a logistic regression model was used. The Odds Ratios (OR) and their respective 95% confidence intervals were also calculated. Most of them were at the age of highest incidence of cervical cancer (21 - 59 years old), had an unstable conjugal situation, minimal educational level (78.7%), low income (58.3%), consumed alcoholic beverages (56.4%), had a history of smoking (57.0%) and possessed limited knowledge about the prevention. These results are discussed in terms of a predictive model for cervical cancer that considers the importance of public health vigilance in the screening and precocious diagnosis.

关键词： Cancer Cervix Uteri Public Health Surveillance Epidemiology

Parallelization of frequency domain quantum gates:manipulation and distribution of frequency-entangled photon pairs generated by a 21 GHz silicon microresonator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： Antoine Henry Dario A.Fioretto Lorenzo M.Procopio Stéphane Monfray Frédéric Boeuf Laurent Vivien Eric Cassan carlos Alonzo-Ramos Kamel Bencheikh Isabelle Zaquine Nadia Belabas Institut Polytechnique de Paris LTCITélécom ParisPalaiseauFrance Université Paris-Saclay CNRSCentre for Nanosciences and NanotechnologyUMR 9001PalaiseauFrance Weizmann Institute of Science RehovotIsrael STMicroelectronics SAS CrollesFrance

Harnessing the frequency dimension in integrated photonics offers key advantages in terms of scalability,noise resilience,parallelization,and compatibility with telecom multiplexing *** ring resonators have been used to generate frequency-entangled states through spontaneous four-wave ***,state-of-the-art integrated resonators are limited by trade-offs among size,spectral separation,and efficient photon pair *** have developed silicon ring resonators with a footprint below 0.05 mm^(2)providing more than 70 frequency channels separated by 21 *** exploit the narrow frequency separation to parallelize and independently control 34 single qubit-gates with a single set of three off-the-shelf electro-optic *** fully characterize 17 frequency-bin maximally entangled qubit pairs by performing quantum state *** demonstrate for the first time,we believe,a fully connected five-user quantum network in the frequency *** results are a step towards a generation of quantum circuits implemented with scalable silicon photonics technology,for applications in quantum computing and secure communications.

关键词： integrated photonics frequency domain quantum gates quantum networks

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Una nueva imagen

今日中国（西文版） 2024年第2期 24-25页

作者： LÜYAN JUAN carlos AGUILAR 不详