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Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

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对组合梁有效板宽的评估

钢结构(中英文) 2008年第3期 85-85页

作者： J.M.castro A.Y.Elghazouli B.A.Izzuddin

主要分析组合梁的性能,特别是板的有效宽度,可用于简化结构分析和设计。现行设计规范提出的计算有效宽度的公式中,只考虑梁跨长而忽略了其他重要参数的影响。为了说明这些参数的影响,本文对多个三维模型进行数值模拟分析,并且由此提出... 详细信息

主要分析组合梁的性能,特别是板的有效宽度,可用于简化结构分析和设计。现行设计规范提出的计算有效宽度的公式中,只考虑梁跨长而忽略了其他重要参数的影响。为了说明这些参数的影响,本文对多个三维模型进行数值模拟分析,并且由此提出计算有效宽度的新方法。相比其他基于综合压力的分析方法,此方法更容易应用,并且在简化方法中,它提供的有效宽度数值能更真实地反映梁的实际状态。新方法的应用表明有效宽度主要与实际板宽有关,在大多数情况下,这个数值与规范提议的数值有明显的差别。新方法的有效性通过对比简化的二维模型和最近试验研究的结果以及更复杂的三维数值模拟而得到验证。

关键词：有效宽度剪力滞组合梁

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发展融资体系概览

国际展望 2012年第5期4卷 85-97,145页

作者：阿克塞尔.冯.托森伯格罗西奥.卡斯特罗叶玉世界银行世界银行优惠融资与全球伙伴关系副行长办公室

过去二三十年来,发展融资体系发生了巨大的变化,反映了世界经济的重大调整。二战后呈现的一些最为引人注目的大趋势包括:发展中国家在全球经济增长中的地位上升;贫困率急剧下降;流入发展中国家的私人资本大幅增加;以及中等收入国家成为... 详细信息

过去二三十年来,发展融资体系发生了巨大的变化,反映了世界经济的重大调整。二战后呈现的一些最为引人注目的大趋势包括:发展中国家在全球经济增长中的地位上升;贫困率急剧下降;流入发展中国家的私人资本大幅增加;以及中等收入国家成为低收入国家发展融资的提供者。发展融资体系历史上由经合组织(OECD)国家主宰,如今新兴经济体进入其中,为其带来新的资源、革新和知识。但是,发展合作体系正日益碎片化。为确保其有效性,有必要支持由国家引导的以增进所有伙伴国协调的活动。世界银行成员国遍布全球,以国家需求为驱动开展工作,作为全球知识的一个生产者和连接者(包括南南交流),世界银行能够在该议程中发挥积极作用。

关键词：发展融资发展合作世界银行

A novel mortality risk score for emphysematous pyelonephritis:A multicenter study of the Global Research in the Emphysematous Pyelonephritis group

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Current Urology 2024年第1期18卷 55-60页

作者： Hegel Trujillo-Santamaría José Iván Robles-Torres Jeremy Yuen-Chun Teoh Yiloren Tanidir José Gadú Campos-Salcedo Edgar Iván Bravo-castro Marcelo Langer Wroclawski W.S.Yeoh Santosh Kumar Juan Eduardo Sanchez-Nuñez José Enrique Espinoza-Aznar Deepak Ragoori Saeed Bin Hamri Ong Teng Aik Cecil Paul Tarot-Chocooj Anil Shrestha Mohamed Amine Lakmichi Mateus Cosentino-Bellote Luis Gabriel Vázquez-Lavista Boukary Kabre Ho Yee Tiong José Gustavo Arrambide-Herrera Lauro Salvador Gómez-Guerra Umut Kutukoglu Joao Arthur Brunhara Alves-Barbosa Jorge Jaspersen Christian Acevedo Francisco Virgen-Gutiérrez Sumit Agrawal Hugo Octaviano Duarte-Santos Chai Chu Ann Daniele Castellani Vineet Gahuar Department of Urology Hospital CovadongaCórdobaMéxico Department of Urology Hospital Universitario"Dr.José Eleuterio Gonzalez"MonterreyMéxico Department of Surgery S.H.Ho Urology CentrePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Urology Marmara University School of MedicineIstanbulTurkey Department of Urology Hospital Central MilitarMéxico CityMéxico Department of Urology Hospital Israelita Albert EinsteinBP-a Beneficência Portuguesa de Sao PauloSao PauloBrazil Faculdade de Medicina do ABC Santo AndréBrazil Department of Urology University Surgical ClusterNational University HospitalSingaporeSingapore Department Urology Christian Medical CollegeVelloreTamilnadIndia Department Urology Hospital General de México"Dr.Eduardo Liceaga"México CityMéxico Department of Urology Hospital Regional de Alta Especialidad de la Peninsula de YucatánMéridaMéxico Department Urology Asian Institute of Nephrology and UrologyHyderabadIndia Department Urology King Abdulaziz National Guard HospitalRiyadhSaudi Arabia Division of Urology Department of SurgeryUniversity of MalayaKuala LumpurMalaysia Department of Urology Central Military HospitalMexico CityMexico National Academy of Medical Sciences Bir Hospital and B&B HospitalGwarko LalitpurNepal Department of Urology University Hospital Mohammed theⅥ^(th)of MarrakeshMarrakeshMorocco Department of Urology Federal University of ParanáSchool of MedicineHospital das ClínicasCuritibaBrazil Department of Urology Hospital Médica SurMexico CityMexico Department of Urology Hospital Yalgado Ouedraogo OuagadougaKadiogoBurkina Faso Department of Urology Hospital Das Clínicas da Universidade de Sao PauloSao PauloBrazil Department of Urology AIIMSBhubaneshwarIndia Department of Urology Hospital Municipal Dr.Moysés Deutsch(M'Boi Mirim)Sao PauloBrazil Department of Urology Azienda Ospedaliero-Universitaria Ospedali Riuniti di AnconaPolytechnic University of Le Marche RegionAnconaItaly Department of Minim

Background:Emphysematous pyelonephritis(EPN)is a necrotizing infection of the kidney and the surrounding tissues associated with considerable *** aimed to formulate a score that classifies the risk of mortality in patients with EPN at hospital *** and methods:Patients diagnosed with EPN between 2013 and 2020 were retrospectively *** from 15 centers(70%)were used to develop the scoring system,and data from 7 centers(30%)were used to validate *** and mułtivariable logistic regression analyses were performed to identify independent factors related to *** operating characteristic curve analysis was performed to construct the sconng system and calculate the risk of mortality.A standardized regression coefficient was used to quantify the discriminating power of each factor to convert the individual coefficients into *** area under the curve was used to quantify the scoring system *** 8-point scoring system for the mortality risk was created(range,0-7).Results:In total,570 patients were included(400 in the test group and 170 in the validation group).Independent predictors of mortality in the multivariable logistic regression were included in the scoring system:quick Sepsis-related Organ Failure Assessment score≥2(2 points),anemia,paranephric gas extension,leukocyte count>22,000/pL,thrombocytopenia,and hyperglycemia(1 point each).The mortality rate was<5%for scores≤3,83.3%for scores 6,and 100%for scores *** area under the Curve was 0.90(95%confidence interval,0.84-0.95)for test and 0.91(95%confidence interval,0.84-0.97)for the validation ***:Our score predicts the risk of mortality in patients with EPN at presentation and may help clinicians identify patients at a higher risk of death.

关键词： Emphysematous pyelonephritis Mortality Prognosis

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(P<0.02)and those from the Visayas(P<0.003).Based on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

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秘鲁第三代华裔的价值观与土生性质

江苏师范大学学报（哲学社会科学版） 2016年第2期42卷 16-23页

作者： [秘]帕德利西亚·卡斯特罗·奥万多蓝博(译) 朱伦(校) 太平洋大学秘鲁中国研究中心秘鲁利马江苏师范大学外国语学院

本研究所指的秘鲁华裔群体包括第三代(或第四代)土生者,以及1980年以后在秘鲁出生的土生者。由于受时空影响,土生者与其中国之根(祖辈或曾祖辈)的联系几近断裂,但中国遗产在他们身上不仅得到了继承,甚至还得到了加强。这主要有两个因素... 详细信息

本研究所指的秘鲁华裔群体包括第三代(或第四代)土生者,以及1980年以后在秘鲁出生的土生者。由于受时空影响,土生者与其中国之根(祖辈或曾祖辈)的联系几近断裂,但中国遗产在他们身上不仅得到了继承,甚至还得到了加强。这主要有两个因素所致:其一是外部因素,即与中国在世界上的崛起有关,是中国正在发展和中国话语复兴的结果;其二是内部因素,与华人概念在秘鲁社会的演化有关。内外两种因素相结合,强化了华裔的"土生性质"。在秘鲁华裔家庭中,中国价值观延续了160多年,历经时空而不变并得到历次华人移民潮的巩固。基于对家庭的回忆,土生年轻人赞同他们从家庭获得的对自己成长具有决定性作用的一些价值观,源自他们的中国人遗传。在第三代和第四代土生者的观念中,传承自中国的因素主要有教育、金钱和家庭观念。这些中国遗产在土生者身上根深蒂固,而其他中国传统和联系则大部分不复存在。"土生性质"中较为明显的特征还有:对中国血统感到自豪;对当代中国特别关注;主动与中国和中国文化重建联系等。

关键词：秘鲁华人土生者价值观中餐

气候正义的跨地域性对国际气候变化机制的贡献

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人权法学 2023年第2期2卷 121-136,153,154页

作者： [巴西]道格拉斯·德·卡斯特罗 [巴西]阿拉纳·科斯塔李清宇(译) 兰州大学法学院美国安布拉大学

在科技的不确定与未知性盛行的风险社会中,国际气候变化机制的监管效力面临着严峻挑战。鉴于此,国际社会已多次召开会议以应对气候变化带来的生存危机。但是,由于该监管机制将国际与国内两方面割裂开来,使得机制应对危机的力度不够,有... 详细信息

在科技的不确定与未知性盛行的风险社会中,国际气候变化机制的监管效力面临着严峻挑战。鉴于此,国际社会已多次召开会议以应对气候变化带来的生存危机。但是,由于该监管机制将国际与国内两方面割裂开来,使得机制应对危机的力度不够,有效性存在巨大的缺陷。国际与国内间的管制空白催生了气候正义跨地域假想的出现,也使得相关思潮、共同价值观及世界观不断涌现,进一步激发学者探求跨地域性合作及通过传统的制定国际法以解决问题。本文将气候正义与提升国际气候变化机制监管有效性中的因果关系作为假设前提进行研究,指出法律是跨地域流动监管体系中的一个重要组成部分。

关键词：气候变化气候正义跨地域

作者回复：提上唇肌切断术及上唇复位：矫正露龈笑的联合方法

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中国美容整形外科杂志 2014年第6期25卷 I0013-I0013页

作者： Luis Henrique Ishida Nivaldo Alonso Luiz C. Ishida Marcus castro Ferriera 圣保罗大学整形外科中心巴两圣保罗

我们带着极大的兴趣阅读了Polo医师关于我们提上唇肌切开术联合上唇重新定位矫治露龈笑一文的评论。我们同样阅读了他在此领域报道过的论文，并祝贺他所取得的成果。

关键词：露龈笑上唇切断术合方矫正复位唇肌作者

木质砌体外墙技术的新运用——卡马拉组学院的Arcus中心

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设计家 2015年第1期 92-95页

作者： Jeanne Gang Mark Schendel Todd Zima Margaret Cavenagh Claire Halpin with John castro Juan de la Mora Ana Flor Ortiz (RA) Jay Hoffman Wei-Ju Lai Lindsey Moyer Jeana Ripple Schuyler Smith Rolf Temesvari John Wolters Iwan Baan Steve Hall Hedrich Blessing GANG建筑事务所 Studio Gang Architects

从历史上看,寻求社会公义的集会,包括许多对这个国家来说最重要的人权集会常常发生在最非正式的场合,例如在某个教堂的地下室,在某个起居室,甚或只是围在厨房里的圆桌旁集会就形成了。想要设计一栋能够促进公开讨论并向所有人都开放的建... 详细信息

从历史上看,寻求社会公义的集会,包括许多对这个国家来说最重要的人权集会常常发生在最非正式的场合,例如在某个教堂的地下室,在某个起居室,甚或只是围在厨房里的圆桌旁集会就形成了。想要设计一栋能够促进公开讨论并向所有人都开放的建筑,从各个方面来说都是一个前所未有的挑战。设计Arcus中心的目的便是将社会公义的话题从地下室带入公共意识。

关键词：卡马拉公共意识 Arcus 公义弧形墙学校园社会公正人的生命内凹可达性