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Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell Line (ZF-L): Cytotoxicity and Oxidative Stress

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Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria Kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus Andrade pereira Lucas Moraes Berneira Claudio Martin pereira de pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean carlos Bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares Kütter Janice Luehring Giongo Rodrigo de Almeida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio Grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (GC-MS) and thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-L hepatic cells showed IC50 values of 12.75 µg/mL, 3.01 µg/mL, 2.67 µg/mL, and 1.61 µg/mL for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays, respectively. The median IC50 of 2.84 µg/mL was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-L cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage

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Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel soares Conceição Rodrigo Menezes Jales Patrick Nunes pereira Luis Otávio Sarian Glauco Baiocchi Sophie Derchain Agnaldo Lopes da Silva Filho Department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil Department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil Department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil Department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil Department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

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The Integration of Circular Economy and Impact Assessment: A Bibliometric Analysis

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Journal of Environmental Science and Engineering(A) 2024年第4期13卷 136-150页

作者： Marina Morhy pereira Marcelo Montaño São carlos School of Engineering University of São PauloSão Carlos-SP 13563-120Brazil

In spite of the proximity between“CE(Circular Economy)”and“sustainability”,it is relevant to consider that a circular strategy is not inherently sustainable or free from significant environmental and social ***,assessing the impacts of CE initiatives and the promotion of circularity in development projects submitted to IA(Impact Assessment)processes are crucial,though the relationship between both fields has not been yet systematically ***,the present paper is focused on the identification of the links between IA and CE,based on the application of bibliometric techniques and Content *** outcomes revealed three thematic clusters in which significant overlaps were found:the 1st revealed LCA(Life Cycle Assessments)as the most used IA technique to assess the impacts of CE strategies,the 2nd encompasses climate change and environmental issues,and the 3rd cluster revealed that the integration of sustainability is the most frequent objective linking IA and CE,though characterized by different *** findings allow concluding that IA fosters the transition to CE by assessing the impacts of circular initiatives and CE strategies can improve IA practice by making it more effective.

关键词： IA CE sustainability bibliometric analysis

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Entropy model to assess sediment resuspension probability and trap efficiency of small dams

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International Journal of Sediment Research 2022年第5期37卷 675-686页

作者： Francisco Jairo soares pereira Antonio Viana da Silva Filho José Wellington Batista Lopes José carlos de Araújo Department of Agricultural Engineering Federal University of Ceará Campus Do Pici Rural Federal University of Pernambuco Federal University of Piauí

In the Brazilian drylands, there are tens of thousands of small dams. Despite their paramount importance to the rural population, they are rarely monitored. Water demand increases with time while, simultaneously, siltation reduces reservoir water capacity and availability. Reservoir siltation models are, therefore, mandatory to manage the numerous ungauged small dams in these *** objective of the current study is to improve sediment trap efficiency(TE) modeling by including resuspension as a key probabilistic process. The Shannon entropy was used to estimate the sediment resuspension probability, which was merged with the Camp model and generated the RETSED entropy model. To validate the RETSED model, an experimental check dam(ECD, 300 m3), located in the Gilbu es desertification site, Brazil, was monitored hourly during one hydrological year(July 2018-July 2019). Measurements show that the annual volumetric decline of the check dam was 12%; and that the average trap efficiency equaled 86%. Only 9.5% of the hourly sediment concentration outflow exceeded the average plus one standard deviation, showing that the reservoir is well mixed; a fact which highlights the relevance of the resuspension process. Three empirical models failed to mimic the experimental results: Churchill(TE = 99%), Brune(TE = 75%), and Maryland(TE = 94%). According to the RETSED entropy model, the resuspension probability during the experiment was 10%and TE = 81%, a value only 6% below the measured one. The Camp model simulated TE = 89%, only 3%higher than the measured value, but confirmed the Camp model’s tendency to overestimate TE due to a disregard of resuspension. The deterministic model showed low sensitivity concerning the hydrodynamic effects, whereas the entropy formulation proved to be more consistent with physical behavior: the resuspension probability clearly increased and trap efficiency decreased with rising reservoir discharge.

关键词： Erosion Check dam Sedimentation Ungauged basins Camp model

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Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de Lima Thaís Cristine pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

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Behavior of wood basic density according to environmental variables

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Journal of Forestry Research 2022年第2期33卷 497-505页

作者： Gabriel Marcos Vieira Oliveira JoséMárcio de Mello carlos Rogério de Mello JoséRoberto soares Scolforo Eder pereira Miguel Thiago Campos Monteiro Brazil Institute of Agricultural and Forestry Defense of Espírito Santo(IDAF) Av.Lourival Lugon Moulinnº300CentroJerônimo MonteiroES CEP:29.550-000Brazil Department of Forestry Sciences Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Engineering Department Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Forestry Engineering Department Faculdade de TecnologiaUniversity of Brasilia-UnBCampus Universitário Darcy RibeiroCaixa Postal 4357Asa Norte-BrasíliaDF CEP:70910-900Brazil Department of Forestry Engineering and Technology Universidade Federal do Paraná-UFPRAv.Pref.Lothário Meissner632Jardim BotânicoCuritibaPR CEP:80.210-170Brazil

The relationships between climate conditions and wood density in tropical forests are still poorly *** quantify spatial dependence of wood density in the state of Minas Gerais(MG,Brazil),map spatial distribution of density,and correlate density with climate variables,we extracted data from the Forest Inventory of Minas Gerais for 1988 trees scaled throughout the territory and measured wood density of discs removed from the *** variables were extracted from the database of the Ecological-Economic Zoning of Minas *** spatial analysis,tree densities were measured at 44 georeferenced sampling *** data were subjected to exploratory analysis,variography,cross-validation,model selection,and ordinary *** relationships between wood density and environmental variables were calculated using dispersion matrices,linear correlation,and *** density proved to be highly spatially dependent,reaching a correlation of 96%,and was highly continuous over a distance of 228 *** distribution of wood density followed a continuous gradient of 514-659 kg m^(−3),enabling corre-lation with environment *** was correlated with mean annual precipitation(−0.57),temperature(0.63),and evapotranspiration(0.83).Geostatistical methods proved useful in predicting wood density in native tropical forests with different climate *** results confirmed the sensitivity of wood density to climate change,which could affect future carbon stock in forests.

关键词： Biomass Climate variables Geostatistics Hardwood Forest inventory Minas Gerais

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System Reliability Analysis of an Offshore Jacket Platform

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Journal of Ocean University of China 2020年第1期19卷 47-59页

作者： ZHAO Yuliang DONG Sheng JIANG Fengyuan GUEDES soares carlos College of Engineering Ocean University of ChinaQingdao 266100China Centre for Marine Technology and Ocean Engineering(CENTEC Instituto Superior TécnicoLisboa 1049-001Portugal

This study investigates strategies for solving the system reliability of large three-dimensional jacket *** structural systems normally fail as a result of a series of different components *** failure characteristics are investigated under various environmental conditions and direction ***β-unzipping technique is adopted to determine critical failure components,and the entire system is simplified as a series-parallel system to approximately evaluate the structural system ***,this approach needs excessive computational effort for searching failure components and failure *** on a trained artificial neural network(ANN),which can be used to approximate the implicit limit-state function of a complicated structure,a new alternative procedure is proposed to improve the efficiency of the system reliability analysis *** failure probability is calculated through Monte Carlo simulation(MCS)with Latin hypercube sampling(LHS).The features and applicability of the above procedure are discussed and compared using an example jacket platform located in Chengdao Oilfield,Bohai Sea,*** study provides a reference for the evaluation of the system reliability of jacket structures.

关键词： system reliability jacket platform β-unzipping technique artificial neural network latin hypercube sampling response surface

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Joint Return Value Estimation of Significant Wave Heights and Wind Speeds with Bivariate Copulas

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中国海洋大学学报:英文版 2023年第5期22卷 1181-1192页

作者： TAO Shanshan DONG Sheng LIN Yifan GUEDES soares carlos College of Engineering Ocean University of ChinaQingdao 266100China Huadian Heavy Industries Co. Ltd.Beijing 100070China Instituto Superior Técnico Universidade de LisboaLisboa 1049-001Portugal

The joint design criteria of significant wave heights and wind speeds are quite important for the structural reliability of fixed offshore ***,the design method that regards different ocean environmental variables as independent is *** the present study,we introduce a bivariate sample consisting of the maximum wave heights and concomitant wind speeds of the threshold by using the peak-over-threshold and declustering *** selecting the appropriate bivariate copulas and univariate distributions and blocking the sample into years,the bivariate compound distribution of annual extreme wave heights and concomitant wind speeds is *** joint design criteria,namely,the joint probability density method and the conditional probability method,are applied to obtain the joint return values of significant wave heights and wind *** show that(28.5±0.5)m s^(-1)is the frequently obtained wind speed based on the Atlantic dataset,and these joint design values are more appropriate than those calculated by univariate analysis in the fatigue design.

关键词： joint design wave height wind speed compound distribution copula

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Competition among rare earth elements on sorption onto six seaweeds

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Journal of Rare Earths 2021年第6期39卷 734-741,I0005页

作者： Joāo Pinto Marcelo Costa Bruno Henriques Josésoares Mariana Dias Thainara Viana Nicole Ferreira carlos Vale JoséPinheiro-Torres Eduarda pereira Department of Chemistry University of Aveiro3810-193 AveiroPortugal CESAM Department of ChemistryUniversity of Aveiro3810-193 AveiroPortugal LAQV-REQUIMTE Department of Chemistry&Central Laboratory of AnalysisUniversity of Aveiro3810-193 AveiroPortugal CIIMAR一Interdisciplinary Centre of Marine and Environmental Research MatosinhosPortugal N9VE-Nature Ocean and ValueLdaPortoPortugal Central Laboratory of Analysis University of Aveiro3810-193 AveiroPortugal

Sorption has been proposed as a promising approach towards a sustainable water decontamination and recently to the recycling of rare earth elements(REE).Although living seaweed have been shown to be capable of removing REE from contaminated solutions,no studies have yet compared the effects of REE competition on sorption onto different groups of *** effects were analysed in the present study by exposing six living seaweeds(Ulva lactuca,Ulva intestinalis,Fucus spiralis,Fucus vesiculosus,Gracilaria *** Osmundea pinnatifida)(3 g/L,fresh weight) to mono-element and multi-element solutions of Y,La,Ce,Pr,Nd,Eu,Gd,Tb and Dy(1 μmol/L).Results show a preference towards light REE in mono-element solutions,which is reduced when in competition with other *** competitive effect is less pronounced in heavy REE indicating that these are still able to bind to the macroalgae despite the presence of competing *** to water content(%),seaweed specific surface area(cm^(2)/g) shows to be an important factor in the sorption of REE,since larger surface area is associated with higher removal and larger competitive effect.

关键词： Bioaccumulation Wastewater e-waste Recovery Removal Marine macroalgae

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Spudcan Penetration Simulation Using the Coupled Eulerian-Lagrangian Method with Thermo-Mechanical Coupled Analysis

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Journal of Ocean University of China 2019年第2期18卷 317-327页

作者： YIN Qilin DONG Sheng JIANG Fengyuan GUEDES soares carlos College of Engineering Ocean University of China Centre for Marine Technology and Ocean Engineering (CENTEC) Instituto Superior Técnico

A novel modeling technique based on the coupled Eulerian-Lagrangian(CEL) method is provided to solve the geotechnical problems with large deformations. The technique is intended to solve the update problem of soil mechanical properties during spudcan penetration in normally consolidated clay soil. In the CEL model, the normal method of assigning an increasing shear strength profile with depth(NA) is defective due to its Eulerian framework. In this paper, a new technique is proposed to update soil material properties by introducing thermo-mechanical coupled analysis(TMCA) to the CEL models. During establishment of the CEL models, the optimal penetration velocity and minimum mesh size are determined through parametric studies. Reasonability and accuracy are then verified through comparison of the preliminary results with the soil flow configuration and penetration resistance(Fv) of a centrifuge test, and the results of the proposed method are compared with those of the remeshing and interpolation technique with small strain(RITSS) method. To achieve a CEL model with satisfactory accuracy, the NA and TMCA methods implemented in the CEL models and the RITSS method are first adopted in weightless soil. Comparison of the findings with those obtained in previous studies shows that the TMCA method can update material properties and predict Fv. The TMCA method is then applied to soils with self-weight and different shear strength profiles. Results show that the proposed method is capable of accurately modeling the large deformation problem of spudcan penetration in non-homogeneous clay.

关键词： thermo-mechanical coupled analysis non-homogeneous clay spudcan penetration CEL RITSS

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