检索结果-南通市图书馆

Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine pereira Soraya S Smaili Maria Cristina Marcucci carlos Rocha Oliveira Gustavo JS pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Leading for Sustainability in the Brazilian Construction Industry

引用

Open Journal of Civil Engineering 2016年第5期6卷 737-748页

作者： Alexandre Jose Vianna Barbosa de Araujo Ubiratan Rohan Robson Rosa Branco Christine Kowal Chinelli carlos alberto pereira soares Graduate Program in Civil Engineering Fluminense Federal University Niterói Brazil

This article analyzes the major stakeholders in the Brazilian construction industry from the viewpoint of the companies in this sector, as well as how these organizations relate to their stakeholders with regard to the topic of sustainability in the construction. The study was based on the principle that the relationship with stakeholders is one of the foundations for the inception and continuity of activities toward sustainability. The findings of which show that the construction companies start the sustainability implementation process without the involvement of external stakeholders. This survey points out the difficulty faced by Brazilian construction companies in relating to their stakeholders. There is the perception that the customers and other actors do not value sustainability-oriented activities, but, at the same time, the relationship of the companies with these stakeholders is limited to disclosure of information. This characteristic of the industry reveals a need for sustainability projects that take into consideration, since their formulation, the stakeholders’ perceptions. The importance of this article lies in the recognition that, although the topic of sustainability is discussed at all levels, studies that examine how specific construction industries have been dealing with it are still rare.

关键词： Construction Industry Sustainability Environmental Challenges Stakeholders

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health Vigilance and Risk Factors for Cervical Cancer: A Study in the State of Maranhão, Brazil

引用

Open Journal of Epidemiology 2024年第1期14卷 75-89页

作者： José Márcio soares Leite carlos Tomaz School of Medicine CEUMA University S&#227o Luís Brazil Master’s Program in Environment CEUMA University S&#227o Luís Brazil

The purpose of this cross-sectional study was to investigate the importance of health vigilance in the prevention of cervical cancer. The sample consisted of 536 women. To identify which risk factors were associated with cervical cancer or with an increase in the mortality rate of this kind of cancer, a logistic regression model was used. The Odds Ratios (OR) and their respective 95% confidence intervals were also calculated. Most of them were at the age of highest incidence of cervical cancer (21 - 59 years old), had an unstable conjugal situation, minimal educational level (78.7%), low income (58.3%), consumed alcoholic beverages (56.4%), had a history of smoking (57.0%) and possessed limited knowledge about the prevention. These results are discussed in terms of a predictive model for cervical cancer that considers the importance of public health vigilance in the screening and precocious diagnosis.

关键词： Cancer Cervix Uteri Public Health Surveillance Epidemiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Barriers and Challenges to the Sustainability Requirements Implementation in Public Procurement of Engineering Works and Services

引用

Open Journal of Civil Engineering 2017年第1期7卷 1-13页

作者： Clézio Thadeu de Souza Dutra Ubiratan Rohan Robson Rosa Branco Christine Kowal Chinelli Alexandre Jose Vianna Barbosa de Araujo carlos alberto pereira soares Graduate Program in Civil Engineering Fluminense Federal University Niterói Brazil

The environmental damage arising from the construction and engineering services was responsible for the appearance of several norms and resolutions regulating and directing the sector’s performance. In this article, we research how professionals with experience in public bids assess the difficulty degree of the implementation of those requirements and how they assess the environmental legislation regarding the protection and conservation of the environment, impact on costs, deadlines and the solution to environmental problems. The results show that industry professionals consider as “high” the level of difficulty to implement the addressed sustainability requirements, and that the Brazilian environmental legislation does not comply with its environmental protection role, increases the possibility of delays and costs of projects and services and hampers the emergence of solutions that could solve environmental problems.

关键词： Environmental Sustainability Requirements Environmental Protection Sustainable Procurement Construction and Engineering Services

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Gas Power Plants in the System Security Role—The Situation and Solutions in Brazil

引用

Energy and Power Engineering 2024年第4期16卷 151-178页

作者： Ciro Galvão Hirdan Katarina de Medeiros Costa Eduardo Guedes pereira Edmilson Moutinho dos Santos Dorel soares Ramos Polytechnic School (EP) University of S&#227o Paulo S&#227o Paulo Brazil Institute of Energy and Environment (IEE) University of S&#227o Paulo S&#227o Paulo Brazil

This study aims to apply a methodology to analyze the regulatory obstacles for the development of thermal power plants in a country. The study uses Brazil as an application case, although mostly of the findings can be useful to other countries. It also discusses other policies and actions by the government that may contribute to the growth of natural gas-fired power plants. Using deductive and comparative research methods, the first part of this method focuses on the stage of thermoelectric power generation in Brazil. The subsequent sections present the role of the integration of gas and electricity sectors, the main obstacles to the expansion of natural-gas power generation, how the country has deal with the expansion of natural-gas power generation, as well as how other obstacles has been faced. In raising the research question, when comparing the research results of selected countries, it should be noticed the impact that the experience and lessons elsewhere have had on policies formulation on Brazil. Our conclusions pointed out that adequate policies for the natural gas-electricity Brazilian market integration make advisable the unification of electricity and natural gas agencies. We recommended developing a mathematical model to support decision-making on natural gas and electricity integration.

关键词： Component Formatting Style Styling Insert

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Participatory Technique Supporting Environmental Management: A Systematic and Bibliometric Review

引用

Journal of Environmental Protection 2024年第7期15卷 781-795页

作者： Barbara Rentes Barbosa Fabiana Da Silva soares Luiz carlos De Faria Kaline De Mello Roberta Averna Valente Department of Environmental Science Federal University of Sao Carlos Sorocaba Brazil Research Institute for the Environment and Livelihoods Charles Darwin University Darwin Australia

The increasing need to manage natural resources sustainably, driven by population growth, requires the simultaneous use of Participatory Techniques (PT) and landscape planning for structured decision-making. We conducted a bibliometric and systematic review to provide an overview of PT usage, identifying evolution in scientific production. We considered the number of publications and citations, prominent journals, and highly cited articles on scientific papers published in the Web of Science database between 1993 and 2023. A total of 415 articles related to PT were identified. After content evaluation, 19 critical articles were selected that underpin the growing combined use of models and indices with PT, enhancing the robustness and credibility of decision-making processes.

关键词： Participation Landscape Planning Decision-Making Process Stakeholders Sustainable Management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A New Approach to the Ordered Classification of Critical Factors in the Degradation Processes of River Basins

引用

Journal of Environmental Science and Engineering(B) 2019年第6期8卷 258-267页

作者： Antonio Cunha Nunes Fernando B.Mainier Robson Rosa Branco carlos alberto pereira soares Escola de Engenharia Universidade Federal FluminenseNiteroiRio de JaneiroBrazil

The aim of this paper is to present through information collected via qualitative analysis in order to provide an alternative perspective to classify critical factors and their correlations in the processes of degradation of river basins in countries in development in an ordered *** study was started with a bibliographical review for gathering relevant information about the main factors,which was submitted to specialists and related professionals via survey developed in a format of answers on Likert scale,with the analyses of data from the respondents as well as their contribution within sample assembly exploratory factorial analysis and the charge factor item from the questionnaire with usage of polychoric correlation matrix with which it is proposed to establish the ordering of the factors relevance as well as their correlations through parametric statistical analysis with the usage of a generalized model of partial credit which belongs to the family of the models for polyatomic gradual answers to the item response theory(IRT)and the applying of cluster analysis(ICLUST)with the usage of both alpha and omega coefficient for the estimation of the variables group,with the R *** a result,the present study aims to establish a comprehension of the main factors for the ordering of the actions and attention of public and private sectors towards the preservation of urban river basins.

关键词： Degradation river basins critical factors society an environment psychometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell Line (ZF-L): Cytotoxicity and Oxidative Stress

引用

Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria Kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus Andrade pereira Lucas Moraes Berneira Claudio Martin pereira de pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean carlos Bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares Kütter Janice Luehring Giongo Rodrigo de Almeida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio Grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (GC-MS) and thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-L hepatic cells showed IC50 values of 12.75 µg/mL, 3.01 µg/mL, 2.67 µg/mL, and 1.61 µg/mL for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays, respectively. The median IC50 of 2.84 µg/mL was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-L cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

引用

Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel soares Conceição Rodrigo Menezes Jales Patrick Nunes pereira Luis Otávio Sarian Glauco Baiocchi Sophie Derchain Agnaldo Lopes da Silva Filho Department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil Department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil Department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil Department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil Department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Integration of Circular Economy and Impact Assessment: A Bibliometric Analysis

引用

Journal of Environmental Science and Engineering(A) 2024年第4期13卷 136-150页

作者： Marina Morhy pereira Marcelo Montaño São carlos School of Engineering University of São PauloSão Carlos-SP 13563-120Brazil

In spite of the proximity between“CE(Circular Economy)”and“sustainability”,it is relevant to consider that a circular strategy is not inherently sustainable or free from significant environmental and social ***,assessing the impacts of CE initiatives and the promotion of circularity in development projects submitted to IA(Impact Assessment)processes are crucial,though the relationship between both fields has not been yet systematically ***,the present paper is focused on the identification of the links between IA and CE,based on the application of bibliometric techniques and Content *** outcomes revealed three thematic clusters in which significant overlaps were found:the 1st revealed LCA(Life Cycle Assessments)as the most used IA technique to assess the impacts of CE strategies,the 2nd encompasses climate change and environmental issues,and the 3rd cluster revealed that the integration of sustainability is the most frequent objective linking IA and CE,though characterized by different *** findings allow concluding that IA fosters the transition to CE by assessing the impacts of circular initiatives and CE strategies can improve IA practice by making it more effective.

关键词： IA CE sustainability bibliometric analysis.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：