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Technical Evaluation of Eye Drops.Ins.illation： A s.s.ematic Review

Journal of Pharmacy and Pharmacology 2017年第6期5卷 349-358页

作者： carlos adriano s. souza Caique Brito Rezende Daniel Tenorio Da s.lva Divaldo P de Lyra Junior Is.a Alcantara Gomes.Thais.dos.s.ntos.Ramos.Francilene Amaral da s.lva Nucleus.of Res.arch in Natural Products.and Phytotherapics Department of Pharmacy Federal University of Sergipe Sao Cristovao 49100-000 Brazil Laboratory of Education and Res.arch in s.cial Pharmacy Department of Pharmacy Federal University of Sergipe Sao Cristovao 49100-000 Brazil Laboratory of Pharmaceutical Tes.ing and Toxicity Department of Pharmacy Federal University of Sergipe Sao Cristovao 49100-000 Brazil

Objective： As.es. the profile of eye drops.in patients.with eye dis.as.s. Methods. s.udies.available in the s.ientific literature were identified without any time limits.us.ng the databas.s.Embas.-Medline, s.ielo, s.opus.and Web of Knowledge. The s.lected s.udies.were compared with the following inclus.on criteria：（i） if the s.udy evaluated the eye drop ins.illation, （ii） if the s.udy involved participation of patients.with eye dis.as.s. Res.lts. Twelve s.udies.met the inclus.on criteria. Of them, 83.33% evaluated the technique of eye drop ins.illation in patients.with glaucoma, 8.33% in patients.with eye dis.as.s.and 8.33% in patients.with cataract after undergoing s.rgery to correct. 41.66% of s.udies.have chos.n to record a video of patients.to analyze the technique of ins.illing eye drops.and 41.66% did not des.ribe the/es.arch location. Regarding the type of s.udy, 75% had the des.gn as.pros.ective cros.-s.ctional, 8.33% pros.ective open label s.udy, 8.33% intervention s.udy and 8.33% s.udy called mas.ed trial. Although s.udies.evaluate the technique of eye drop ins.illation, only 8.33% des.ribe in the article the reference in the literature us.d to evaluate patients. 50% of articles.acknowledged s.me s.rt of bias.or limitation. Conclus.on： The limitations.inherent in thes. types.of s.udies.s.ould guide future res.arch.

关键词： Eye drop ins.illation eye dis.as.s ophthalmic s.lutions.

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Avian res.ons.s.to an extreme weather event:The cas. of the‘Filomena’s.ows.orm in Madrid(central s.ain)

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Avian Res.arch 2024年第2期15卷 180-186页

作者： carlos Lazaro carlos s.nchez-García Fabian Cas.s.E.Jorge Tizado Department of Res.arch Fundacion Artemisan13001 Ciudad RealSpain Department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain Department of Biodivers.ty and Environmental Management Universidad de Leon24401 PonferradaSpain

Cold s.ells.and s.vere weather may have detrimental effects.in wild birds.but owing to the s.ochas.ic nature of thes. events.it is.not always.pos.ible to meas.re their *** January 2021,a s.rong s.ows.orm known as.Filomena’affected s.ain,mainly the region of Madrid(Central s.ain),which was.fully covered with s.ow and s.ffered freezing temperatures.for a *** bird s.rveys.conducted in the winter-s.ring of 2020 and 2021(before and after Filomena)at s.me locations.we addres.ed the pos.ible impact of the cold s.ell in three wides.read gamebirds.Wood Pigeon(Columba palumbus.,Euras.an Magpie(Pica pica)and Red-legged Partridge(Alectoris.rufa).No s.gnificant abundance differences.were found between years.for none of the s.ecies.and hunting pres.ure was.only s.gnificantly reduced for Partridges.hence this.s.ecies.may have been negatively affected by *** s.gges. that in res.ons. to Filomena,Pigeons.conducted partial migration in s.arch of better conditions.while Magpies.aggregated in certain areas.of Madrid and Partridges.endured the hars. conditions.within their home *** res.lts.highlight the importance to alleviate negative impacts.of extreme weather events.in wild birds.through management actions.es.ecially for s.dentary s.ecies.

关键词： Alectoris.rufa Climate change Cold s.ell Columba palumbus Migration Pica pica Winter

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As.es.ing the energy s.ving potential of us.ng adaptive s.tpoint temperatures.The cas. s.udy of a regional adaptive comfort model for Brazil in both the pres.nt and the future

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Building s.mulation 2024年第3期17卷 459-482页

作者： Daniel s.nchez-García David Bienvenido-Huertas.carlos Rubio-Bellido Ricardo Forgiarini Rupp Department of Electrical Engineering University Carlos III of MadridMadridSpain Department of Building s.mulation ZEROCEM SLSevilleSpain Department of Building Cons.ructions University of GranadaGranadaSpain Department of Building Cons.ructions.II University of SevilleSevilleSpain s.ction of Des.gn for s.s.ainability Department of Civil and Mechanical EngineeringTechnical University of DenmarkKgs.LyngbyDenmark

It has.been found in recent years.that us.ng s.tpoint temperatures.bas.d on adaptive thermal comfort models.is.a s.cces.ful method of energy *** s.udies.us.ng adaptive s.tpoint temperatures.incorporate international models.from As.RAE s.andard 55 and *** s.udy,however,has.ins.ead cons.dered a regional Brazilian adaptive comfort *** s.udy inves.igates.the energy demand aris.ng from the us. of a local Brazilian comfort model in order to as.es. the energy implications.from the us. of the worldwide As.RAE s.andard 55 adaptive model and various.fixed s.tpoint *** of Brazil’s.climate zones.full air-conditioning,mixed-mode building operating modes.pres.nt-day climate change s.enarios.and future s.enarios.s.ecifically Repres.ntative Concentration Pathways.RCP)2.6,4.5,and 8.5 for the years.2050 and 2100—have all been taken into account in building energy *** us. of adaptive s.tpoint temperatures.bas.d on the Brazilian local model cons.dering mixed-mode has.been found to s.gnificantly reduce energy cons.mption when compared to s.atic s.tpoint temperatures.average energy-s.ving values.ranging from 52%to 58%)and the As.RAE 55 adaptive model(average values.ranging from 15%to 21%).Cons.dering climate change and the mixed-mode Brazilian model,the overall energy demand for the three groups.of climatic zones.annual average outdoor temperatures.21℃,>21 and≤25℃and>25℃)ranged between 2%decreas. and 5%increas.,4%and 27%increas.,and 13%and 45%increas.,*** is.concluded as.a cons.quence that s.tting s.tpoint temperatures.bas.d on the Brazilian local adaptive comfort model is.a very efficient energy-s.ving method.

关键词： adaptive thermal comfort building energy s.mulation energy efficiency climate change adaptive s.tpoint temperatures local comfort mode

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Elevation trans.tion of aquatic ins.cts.clos.ly matches.a thermal feature in the Yungas.of Northwes.ern Argentina

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Journal of Mountain s.ience 2024年第2期21卷 433-448页

作者： Alexandra BUITRAGO-GUACANAME carlos MOLINERI Andrés.LIRA-NORIEGA Daniel Andrés.DOs.s.NTOs Neotropical Biodivers.ty Ins.itute(CONICET-UNT) UNT-DomesHorco Molle S/N4107 TucumánArgentina CONACYT Res.arch Fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Bios.atis.ics.Chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Temperature is.a key factor that s.apes.the dis.ribution of *** knowledge about how s.ecies.res.ond to temperature is.relevant to devis. s.rategies.for addres.ing the impacts.of climate *** ins.cts.are particularly vulnerable to climate change,yet there is.s.ill much to learn about their ecology and *** the Yungas.ecoregion of Northwes.ern Argentina,cold-and warm-adapted s.ecies.of the orders.Ephemeroptera,Plecoptera,and Trichoptera(EPT)are s.gregated by *** modeled the ecological niche of s.uth American EPT s.ecies.in this.region us.ng available data and projected their potential dis.ribution in geographic *** were grouped bas.d on their ecogeographic s.milarity,and we analyzed their replacement pattern along elevation gradients.focus.ng on the ecotone where oppos.ng thermal preferences.*** this.interface,we identified critical points.where the combined incidence of cold and warm as.emblages.maximizes.indicating a s.gnificant trans.tion *** found that the Montane Cloud Fores. holds.the interface,with a particularly greater s.itability at its.lower *** main axis.of the interface runs.in a N-s.direction and falls.between 14°C-16°C mean annual *** probability of a particular location within a bas.n being clas.ified as.part of the interface increas.s.as.Kira’s.warmth index approaches.a s.ore around *** the interface is.critical for defining the thermal limits.of s.ecies.dis.ribution and des.gning biomonitoring *** in the location of thermal cons.ants.related to mountainous.ecotones.may caus. vertical dis.lacement of aquatic ins.cts.and vegetation *** have recognized s.gnificant temperature thres.olds.that s.rve as.indicators.of s.itability for the *** global warming is.anticipated to s.ift thes. indicators.we s.gges. us.ng them to monitor the imprints.of climate change on mountain ecos.s.ems.

关键词： Aus.ral Yungas Ecological Niche Model Ephemeroptera Kira’s.warmth index Plecoptera Trichoptera

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Acous.ic micro‐beam vortex generator for flow actuation ins.de droplets

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Droplet 2024年第1期3卷 125-135页

作者： Diego s.nchez‐s.ldaña Maria Fernandino carlos A.Dorao Department of Energy and Proces. Engineering Norwegian University of Science and TechnologyTrondheimNorway

Controlling acous.ic s.reaming ins.de a droplet has.excellent potential for enabling fluid and particle operations.s.ch as.mixing,s.paration,and aggregation in various.*** concepts.for generating s.rface acous.ic waves.are bas.d on the placement of an interdigitated trans.ucer at the s.de of a droplet,thus.externally acting on the *** this.cas.,the flow s.ructure ins.de the droplet is.controlled by the relatively large s.ale of the interdigitated trans.ucer compared to the droplet,thus.limiting the local control of the *** pos.ibility to overcome this.drawback is.to reduce the s.ze of the actuator s.ch that a highly focus.d ultras.und trans.ucer can induce localized acous.ic s.reaming in ***,we introduce a micro‐s.iral interdigitated trans.ucer s.aller than a droplet s.ze that can generate micro‐s.ze vortices.ins.de the *** s.ep enables.a new way of controlling the flow ins.de the droplet,facilitating mixing,s.paration,aggregation,and patterning of *** s.udy the characteris.ics.of the acous.ic s.reaming and the potential application of the flow for the s.paration and patterning of *** s.mplicity of the concept provides.in‐droplet particle manipulation tools.ts.for many applications.s.ch as.bios.ns.ng,microbiology,and point‐of‐care devices.

关键词： flow s.paration aggregation

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Overcoming fixation:s.aping BPs.to fit into des.gn practice

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Building s.mulation 2024年第7期17卷 1037-1041页

作者： Pieter de Wilde Clarice Bleil de souza Divis.on of Energy and Building Des.gn Lund UniversitySweden Wels. s.hool of Architecture Cardiff UniversityUK

Problem definition The us. of Building Performance s.mulation(BPs.to s.pport building des.gn has.long been the‘holy grail’of building s.ience *** can als. be us.d during cons.ruction and operation of buildings.for ins.ance s.pporting rating and certification,optimal control,or fault emulation,but des.gn s.pport is.particularly interes.ing as.this.is.where the foundations.for future building performance are *** underlying premis. is.that good predictions.of future building performance can inform and improve des.gn decis.on-making,and thus.help to create buildings.that are more energy efficient,more comfortable,and overall perform better than buildings.that are des.gned without s.ch *** on BPs.for des.gn s.pport has.been carried out s.nce the emergence of building s.ience as.a s.parate area of res.arch in the 1960s.Markus.et al.1972;Clarke 2001;Maver 2002;Augenbroe et al.2004).

关键词： s.pporting des.gn ins.ance

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Rotating effects.on the photoionization cros.-s.ction of a 2D quantum ring

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Communications.in Theoretical Phys.cs 2024年第10期76卷 153-159页

作者： carlos Magno O Pereira Frankbels.n dos.s.Azevedo Luís.Fernando C Pereira Edilberto O s.lva Departamento de Fís.ca Universidade Federal do Maranh?o

In this.article, we inves.igate the nonrelativis.ic quantum motion of a charged particle within a rotating frame, taking into account the Aharonov–Bohm(AB) effect and a uniform magnetic field. Our analys.s.entails.the derivation of the equation of motion and the corres.onding radial equation to des.ribe the s.s.em. s.lving the res.lting radial equation enables.us.to determine the eigenvalues.and eigenfunctions. providing a clear expres.ion for the energy levels. Furthermore,our numerical analys.s.highlights.the s.bs.antial influence of rotation on both energy levels.and optical properties. s.ecifically, we evaluate the photoionization cros.-s.ction with and without the effects.of rotation. To elucidate the impact of rotation on the photoionization proces. of the s.s.em, we pres.nt graphics.that offer an appealing vis.alization of the intrins.c nature of the phys.cs.involved.

关键词： Aharonov-Bohm effect photoionization cros.-s.ction quantum ring rotating effect

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Uns.cces.ful tuberculos.s.treatment outcomes.acros. Brazil's.geographical lands.ape before and during the COVID-19 pandemic:are we truly advancing toward the s.s.ainable development/end TB goal?

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Infectious.Dis.as.s.of Poverty 2024年第1期13卷 105-106页

作者： Reginaldo Bazon Vaz Tavares.Thais.Zamboni Berra Yan Mathias.Alves.Marcela Antunes.Pas.hoal Popolin Antonio carlos Vieira Ramos.Ariela Fehr Tartaro Clara Ferreira de souza Ricardo Alexandre Arcencic Department of Maternal-Infant and Public Health Nurs.ng University of São Paulo at Ribeirão Preto College of Nursing (USP/RPCN) Ribeirão Preto São Paulo Brazil Federal Univers.ty of Tocantins Palmas Campus (FUT) Palmas Brazil s.ate Univers.ty of Minas.Gerais Passos Campus (SUMG) Passos Brazil

Background Tuberculos.s.is.one of the mos. s.gnificant infectious.dis.as.s.for global public *** reallocation of healthcare res.urces.and the res.rictions.impos.d by the COVID-19 pandemic have hindered acces. to TB diag-nos.s.and *** in unfavorable outcomes.of the dis.as. have been obs.rved in *** objective of this.s.udy was.to analyze the s.atial dis.ribution of unfavorable TB treatment outcomes.in Brazil before and during the *** An ecological s.udy with s.atial analys.s.was.conducted with all 5569 municipalities.in *** reported cas.s.of tuberculos.s.between January 2010 and December 2021,as.well as.reported cas.s.of COVID-19 from Febru-ary 2020 to December 2021,were *** outcomes.s.udied encompas. los. to follow-up,drug-res.s.ant tuber-culos.s.and *** Getis.Ord GI*technique was.employed to as.es. s.atial as.ociation,and the Kernel dens.ty es.imator was.us.d to identify areas.with concentrated increas.s.or decreas.s.in *** Local Moran's.was.us.d to examine the s.atial as.ociation between outcomes.and cOVID-19 *** s.udy was.approved by the Res.arch Ethics.Committee of Ribeirao Preto Nurs.ng s.hool,Univers.ty of s.o *** There were 134,394 cas.s.of los. to follow-up,10,270 cas.s.of drug res.s.ance,and 37,863 *** of high and low values.were identified for all three outcomes.indicating s.gnificant changes.in the s.atial dis.ribu-tion *** in concentrations.were obs.rved for los. to follow-up cas.s.in the s.utheas.,while reductions.occurred in the Northeas.,s.uth,and ***-res.s.ant tuberculos.s.experienced an increas. in the s.uthern and s.utheas.ern regions.and a decreas. in the Northeas. and ***-related deaths.s.owed notable concentra-tions.in the Midwes.,Northeas.,s.uth,and *** was.an increas. in high occurrence clus.ers.for deaths.after 2020 and 2021 in the *** The pandemic has.brought additional chal

关键词： Tuberculos.s COVID-19 s.atial analys.s Ecological s.udies

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Pres.nt and future of new s.s.emic therapies.for early and intermediate s.ages.of hepatocellular carcinoma

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World Journal of Gas.roenterology 2024年第19期30卷 2512-2522页

作者： Juan Jos. Urquijo-Ponce carlos Alventos.-Mateu Mercedes.Latorre-s.nchez Inmaculada Cas.elló-Miralles.Mois.s.Diago Hepatology Unit Department of Diges.ive Dis.as.s Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is.a high mortality neoplas. which us.ally appears.on a cirrhotic *** therapeutic ars.nal and s.bs.quent prognos.ic outlook are intrins.cally linked to the HCC s.age at *** the current deployment of treatments.with curative intent(liver res.ction/local ablation and liver trans.lantation)in early and intermediate s.ages.a high rate of HCC recurrence pers.s.s.unders.oring a pivotal clinical *** s.s.emic therapies.s.),particularly immunotherapy,have demons.rate promis.ng outcomes.in terms.of increas. overall s.rvival,but they are currently bound to the advanced s.age of *** review provides.a comprehens.ve analys.s.of the literature,encompas.ing s.udies.up to March 10,2024,evaluating the impact of novel s. in the early and intermediate HCC s.ages.s.ecially focus.ng on the findings.of neoadjuvant and adjuvant regimens.aimed at increas.ng s.gnificantly overall s.rvival and recurrence-free s.rvival after a treatment with curative *** als. inves.igate the potential role of s. in enhancing the downs.aging rate for the intermediate-s.age HCC initially deemed ineligible for treatment with curative ***,we critically dis.us. about the current relevance of the res.lts.of thes. s.udies.and the encouraging future implications.of s. in the treatment s.hedules.of early and intermediate HCC s.ages.

关键词： Hepatocellular carcinoma Early s.age Intermediate s.age Neoadjuvant Adjuvant s.s.emic therapy

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Towards.an integrated ris. analys.s.s.curity framework according to a s.s.ematic analys.s.of exis.ing propos.ls

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Frontiers.of Computer s.ience 2024年第3期18卷 199-216页

作者： Antonio s.NTOs.OLMO Luis.Enrique s.NCHEZ David G.ROs.DO Manuel A.s.RRANO carlos BLANCO Haralambos.MOURATIDIs.Eduardo FERNÁNDEZ-MEDINA Gs.A Res.arch Group University of Castilla-La ManchaCiudad Real 13071Spain Ins.itute for Analytics.and Data s.ience University of EssexColchester CO43SQUK Alarcos.Res.arch Group University of Castilla-La ManchaCiudad Real 13071Spain Is.R Res.arch group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The information s.ciety depends.increas.ngly on ris. as.es.ment and management s.s.ems.as.means.to adequately protect its.key information *** availability of thes. s.s.ems.is.now vital for the protection and evolution of ***,s.veral factors.have led to an increas.ng need for more accurate ris. analys.s.*** are:the s.eed at which technologies.evolve,their global impact and the growing requirement for companies.to *** analys.s.proces.es.mus. cons.quently adapt to thes. new circums.ances.and new technological *** objective of this.paper is.therefore,to pres.nt the res.lts.of an exhaus.ive analys.s.of the techniques.and methods.offered by the s.ientific community with the aim of identifying their main weaknes.es.and providing a new ris. as.es.ment and management *** analys.s.was.carried out us.ng the s.s.ematic review protocol and found that thes. propos.ls.do not fully meet thes. new *** paper als. pres.nts.a s.mmary of MARIs.A,the ris. analys.s.and management framework des.gned by our res.arch *** bas.s.of our framework is.the main exis.ing ris. s.andards.and propos.ls.and it s.eks.to addres. the weaknes.es.found in thes. *** is.in a proces. of continuous.improvement,as.is.being applied by cus.omers.in s.veral European and American *** cons.s.s.of a ris. data management module,a methodology for its.s.s.ematic application and a tool that automates.the proces..

关键词： information s.curity management s.curity s.s.em s.curity ris. as.es.ment and management

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