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Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice

World Journal of Gastroenterology 2006年第40期12卷 6464-6472页

作者： Alfredo Santana carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio salas Marek W Radomski Enrique Quintero Gastroenterology Department and Research Unit Hospital Universitario de Canarias Tenerife Spain Reumathology Department Hospital Universitario de Canrias Tenerife Spain Pathology Department Hospital Mutua de Terrassa Barcelona Spain Institute of Molecular Medicine University of Texas Houston-Texas United States

AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in ***: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation.

关键词： Matrix metalloproteinases MMP-9-deficient Dextran sodium sulphate Inflammatory bowel disease Experimental colitis

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Biogeographical informativeness of Y-STR haplotypes

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Science Bulletin 2019年第19期64卷 1381-1384页

作者： Jacobo Pardo-Seco Alberto Gómez-Carballa Xabier Bello Federico Martinón-Torres Antonio salas Unidade de Xenética Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstitutode Investigaciones Sanitarias(IDIS)Hospital Clínico Universitario de Santiago(SERGAS)GaliciaSpain Grupo de Investigación en Genética VacunasInfecciones y Pediatría(GENVIP)Universidade de Santiago de Compostelaand Hospital Clínico Universitario de Santiago(SERGAS)GaliciaSpain

Research on biogeographical ancestry(BGA)is becoming of growing interest in forensic genetics and in the biomedical literature(1)Thus,for instance,the need to predict ethnicity of an unknown suspect based on DNA profiles found at the crime scene is of maximum interest in criminalistics[2],and several autosomal SNP panels have been designed and tested for BGA investigations[3,4].Most of these panels aim at discriminating three main continental groups(sub-Saharan Africans,Europeans,and Asians)by way of testing a number of ancestry informative markers(AIMs)that run from a few dozens to a few hundred[5](see more background in Supplementary data online).

关键词： BGA STR Biogeographical informativeness of Y-STR haplotypes

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Diversity and host assemblage of avian haemosporidians in different terrestrial ecoregions of Peru

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Current Zoology 2022年第1期68卷 27-40页

作者： Luz GARCIA-LONGORIA Jaime MURIEL Sergio MAGALLANES Zaira Hellen VILLA-GALARCE Leonila RICOPA Wilson Giancarlo INGA-DIAZ Esteban FONG Daniel VECCO Cesar GUERRA-SALDANA Teresa salas-RENGIFO Wendy FLORES-SAAVEDRA Kathya ESPINOZA carlos MENDOZA Blanca SALDANA Manuel GONZALEZ-BLAZQUEZ Henry GONZALES-PINEDO Charlene LUJAN-VEGA carlos Alberto Del AGUILA Yessica VILCA-HERRERA carlos Alberto PINEDA Carmen REATEGUI Jorge Manuel CARDENAS-CALLIRGOS JoseAlberto IANNACONE Jorge Luis MENDOZA Ravinder NMSEHGAL Alfonso MARZAL Departamento de Anatomia Biologia Celular y ZoologiaUniversidad de ExtremaduraBadajoz E-506071Spain Molecular Ecology and Evolution Lab Department of BiologyLund UniversitySolvegatan 37SE-22362 LundSweden Instituto Pirenaico de Ecologıa-IPE(CSIC) Avda.Nuestra Senora de la Victoria 16Jaca 22700Spain DIRESA Direccion Regional de SaludLoreto 16001Peru Departamento Academico de Microbiologia y Parasitologia.Facultad de Ciencias Biologicas Universidad Nacional de la Amazonia PeruanaIquitos 16001Peru Facultad de Ciencias Agropecuarias Universidad Alas PeruanasLima 15823Peru EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Peru Observatorio de Aves Loreto(LBO) Distrito de San JuanLoreto 16008Peru Centro Urku de Estudios Amazonicos Tarapoto 22200Peru Servicio Nacional de Areas Naturales Protegidas por el Estado 15036Peru Sanidad Animal-Facultad de Zootecnia Universidad Nacional Agraria La MolinaLima 15012Peru Laboratorio de Microbiologia Facultad de Medicina Veterinaria y ZootecniaUniversidad CientUfica del SurLima 15067Peru Laboratorio de Analisis Clinico Moraleslab SAC MoralesSan Martin 22201Peru Asociacion Ecosistemas Andinos(ECOAN) Cuzco 08002Peru Pharmacology and Toxicology Graduate Group University of CaliforniaDavisDA 95616USA Global Health Initiative Wabash CollegeCrawfordsvilleIN 47933USA Facultad de Ciencias Biologicas Universidad Nacional Mayor de San MarcosLima 15081Peru Facultad de Medicina Veterinaria Universidad Nacional Hermilio ValdizanHuanuco10160Peru Asociacion Peruana de Helmintologia e Invertebrados Afines Lima 15054Peru Laboratorio de Ecologia y Biodiversidad Animal Universidad Nacional Federico VillarrealEl AgustinoLima 15007Peru Laboratorio de Invertebrados Universidad Ricardo Palma-Santiago de SurcoLima 15537Peru Department of Biology San Francisco State UniversitySan FranciscoCA 94132USA

Characterizing the diversity and structure of host–parasite communities is crucial to understandingtheir eco-evolutionary *** and related haemosporidian parasites are responsible forfitness loss and mortality in bird species ***,despite exhibiting the greatest ornithologicalbiodiversity,avian haemosporidians from Neotropical regions are quite ***,we analyze the genetic diversity of bird haemosporidian parasites(Plasmodium andHaemoproteus)in 1,336 individuals belonging to 206 bird species to explore for differences in diversityof parasite lineages and bird species across 5 well-differentiated Peruvian *** 70 different haemosporidian lineages infecting 74 bird *** showed that 25 out ofthe 70 haplotypes had not been previously ***,we also identified 81 new host–parasite interactions representing new host records for these haemosporidian *** outcomesrevealed that the effective diversity(as well as the richness,abundance,and Shannon–Weaver index)for both birds and parasite lineages was higher in Amazon basin ***,we also showed that ecoregions with greater diversity of bird species also had highparasite richness,hence suggesting that host community is crucial in explaining parasite *** parasites were found in ecoregions with lower bird diversity,implying that the abundanceand richness of hosts may shape the exploitation strategy followed by haemosporidian *** outcomes reveal that Neotropical region is a major reservoir of unidentified *** studies analyzing host distribution and specificity of these parasites inthe tropics will provide important knowledge about phylogenetic relationships,phylogeography,and patterns of evolution and distribution of haemosporidian parasites.

关键词： Amazonia avian malaria generalist parasite habitat specificity Haemoproteus Plasmodium specialist parasite

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Temperature changes in the root ecosystem affect plant functionality

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Plant Communications 2023年第3期4卷 197-214页

作者： Mary Paz González-García carlos M.Conesa Alberto Lozano-Enguita Victoria Baca-González Bárbara Simancas Sara Navarro-Neila María Sánchez-Bermúdez Isai salas-González Elena Caro Gabriel Castrillo Juan C.del Pozo Centro de Biotecnología y Genómica de Plantas(UPM-INIA/CSIC) Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agrariay Alimentaria-CSIC(INIA/CSIC)Campus Montegancedo28223 Pozuelo de Alarcón(Madrid)Spain Departamento de Biotecnología-Biología Vegetal Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de Madrid(UPM)28040 MadridSpain Undergraduate Program in Genomic Sciences Center for Genomics SciencesUniversidad Nacional Autonóma de MéxicoAv.Universidad s/n.Col.ChamilpaCuernavaca 62210MorelosMéxico Future Food Beacon of Excellence&School of Biosciences University of NottinghamSutton BoningtonUK

Climate change is increasing the frequency of extreme heat events that aggravate its negative impact on plant development and agricultural *** experiments designed to study plant adaption to heat stress apply homogeneous high temperatures to both shoot and ***,this treatment does not mimic the conditions in natural fields,where roots grow in a dark environment with a descending temperature *** high temperatures severely decrease cell division in the root meristem,compromising root growth,while increasing the division of quiescent center cells,likely in an attempt to maintain the stem cell niche under such harsh ***,we engineered the TGRooZ,a device that generates a temperature gradient for in vitro or greenhouse growth *** root systems of plants exposed to high shoot temperatures but cultivated in theTGRooZ grow efficiently and maintain their functionality to sustain proper shoot growth and ***,gene expression and rhizosphere or root microbiomecomposition are significantly less affected in TGRooZ-grown roots than in high-temperature-grown roots,correlating with higher root *** data indicate that use of the TGRooZ in heat-stress studies can improve our knowledge of plant response to high temperatures,demonstrating its applicability from laboratory studies to the field.

关键词： heat stress root temperature gradient nutrition gene expression microbiome

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Lid scrubbing with a gel combining natural extracts for dry eye treatment

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1053-1059页

作者： Blanca Diaz-Vega carlos Rodriguez-Fabuel Sofia Vitores-Mate carlos Carpena-Torres Gran Visión Oftalmología Madrid 28026Spain e-Health Vision Department of OphthalmologyMadrid 28232Spain Gran Óptica Madrid Department of Dry EyeMadrid 28026Spain Ocupharm Research Group Department of Optometry and VisionFaculty of Optics and OptometryComplutense University of MadridMadrid 28037Spain

AIM:To evaluate the effect of lid scrubbing using a gel combining different natural extracts on ocular signs and symptoms of dry eye ***:A retrospective study was performed on 19 dry eye patients(51.1±16.0y).Non-invasive tear break-up time,tear meniscus height,meibomian gland loss,lipid layer thickness,conjunctival redness,corneal staining,ocular surface disease index(OSDI),and ocular pain intensity were measured before(baseline),1wk,and 2mo after lid scrubbing with a gel containing different natural extracts(okra extract,aloe vera leaf juice,hydrolysed soy protein,caffeine,citrus unshiu peel extract,and raspberry seed oil).RESULTS:Compared with the baseline,there was a statistically significant improvement in both first(P=0.048)and average(P=0.026)non-invasive tear break-up time 2mo after treatment,as well as in corneal staining(P=0.043,0.012),OSDI(P<0.001),and ocular pain intensity(P<0.001)after 1wk and *** addition,there was no correlation between ocular signs and ***:The lid scrubbing with a gel combining different natural extracts show beneficial effects on tear film stability,corneal damage,and ocular symptoms,which is the reason why this therapeutic procedure is proposed as an alternative for dry eye ***,it is not possible to attribute this beneficial effect solely to the presence of the natural extracts in the gel,primarily due to the absence of a negative control group.

关键词： lid hygiene natural extracts okra aloe vera soy dry eye

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Standing-wave spectrometry in silicon nano-waveguides using reflection-based near-field scanning optical microscopy

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Chinese Physics B 2019年第1期28卷 306-312页

作者： Yi-Zhi Sun Wei Ding Bin-Bin Wang Rafael salas-Montiel Sylvain Blaize Renaud Bachelot Zhong-Wei Fan Li-Shuang Feng School of Instrumentation Science and Opto-Electronics Engineering Beihang University Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Laboratoire de Nanotechnologie et d’Instrumentation Optique(LNIO)ICD CNRS UMR 6281 Universitéde Technologie de Troyes Academy of Opto-Electronics Chinese Academy of Science

Utilizing reflection-based near-field scanning optical microscopy(NSOM) to image and analyze standing-wave patterns, we present a characterization technique potentially suitable for complex photonic integrated circuits. By raster scanning along the axis of a straight nano-waveguide in tapping mode and sweeping wavelength, detailed information of propagating waves in that waveguide has been extracted from analyses in both space and wavelength domains. Our technique needs no special steps for phase stabilization, thus allowing long-duration and environment-insensitive measurements. As a proof-of-concept test, in a silicon single-mode waveguide with a few of etched holes, the locations and reflection strengths of the inner defects have been quantified. The measurement uncertainty of the reflection amplitude is less than 25% at current stage. Our technique paves the way for non-destructively diagnosing photonic circuits on a chip with sub-wavelength spatial resolution and detailed information extraction.

关键词： near-field scanning optical microscopes integrated optics interferometry

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Impact of radiative cooling on the energy performance of courtyards in Mediterranean climate

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Building Simulation 2024年第9期17卷 1491-1513页

作者： carlos-Antonio Domínguez-Torres Antonio Domínguez-Delgado Escuela Técnica Superior de Arquitectura Universidad de SevillaAv.de Reina Mercedes241012 SevillaSpain Department of Applied Mathematics 1 Escuela Técnica Superior de ArquitecturaUniversidad de SevillaAv.de Reina Mercedes241012 SevillaSpain

Radiative cooling has proven to be a useful tool to address the problems of lack of comfort and excessive energy consumption in situations of high temperatures,overheating and heat ***,incorporating courtyards in warm climate zones has been found to be highly beneficial in addressing similar ***,there is interest in analyzing the combined effects of both:radiative cooling and *** paper presents an analysis of the impact of the application of radiative cooling on a courtyard using a comprehensive simulation approach that includes a CFD model for the thermodynamic airflow in the adjacent roofs and inside the courtyard,equations for the transient heat conduction through roofs,walls and courtyard slabs,and a hybrid raytracing-radiosity model for the evaluation of the solar radiation reaching the building surfaces and its reflections,both of specular and diffuse origin,and for the calculation of the thermal radiation exchange,especially with the *** results show that in the hot season,the courtyard with radiative cooling always provides lower temperatures than the initial courtyard does,with a temperature range of 18.33℃to 33.78℃,compared to a range of 19.32℃to 38.00℃in the initial courtyard,and producing a greater difference with outdoor temperatures that can reach 12℃versus 8℃for the reference *** addition,it was found that the courtyard with radiative cooling is able to significantly reduce the observed nighttime overheating by providing lower temperatures than the outdoor temperatures in the 50%of the nights *** was also found that the thermal loads to achieve indoor thermal comfort in the spaces adjacent to the courtyard were reduced by 63.46%to 69.85%.

关键词： radiative cooling passive cooling CFD three-dimensional modeling energy saving thermal comfort

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Less is more:dimensionality reduction as a general strategy for more precise luminescence thermometry

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Light(Science & Applications) 2022年第9期11卷 2127-2139页

作者： ERVING XIMENDES RICCARDO MARIN LUIS DIAS carlos DANIEL JAQUE NanoBIG Departamento de Fisica de MaterialesFacultad de CienciasUniversidad Autónoma de MadridC/Francisco Tomás y Valiente 7Madrid 28049Spain NanoBIG Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Ctra.Colmenar km.9.100Madrid 28034Spain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of AveiroAveiro 3810-193Portugal

Thermal resolution(also referred to as temperature uncertainty)establishes the minimum discernible temperature change sensed by luminescent thermometers and is a key figure of merit to rank *** has been done to minimize its value via probe optimization and correction of readout artifacts,but little effort was put into a better exploitation of calibration *** this context,this work aims at providing a new perspective on the definition of luminescence-based thermometric parameters using dimensionality reduction techniques that emerged in the last *** application of linear(Principal Component Analysis)and non-linear(t-distributed Stochastic Neighbor Embedding)transformations to the calibration datasets obtained from rare-earth nanoparticles and semiconductor nanocrystals resulted in an improvement in thermal resolution compared to the more classical intensity-based and ratiometric ***,in turn,enabled precise monitoring of temperature changes smaller than 0.1℃.The methods here presented allow choosing superior thermometric parameters compared to the more classical ones,pushing the performance of luminescent thermometers close to the experimentally achievable limits.

关键词： precise dimensionality luminescence

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PtRu nanoparticles supported on noble carbons for ethanol electrooxidation

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Journal of Energy Chemistry 2022年第3期31卷 168-180,I0006页

作者： Alberto Rodríguez-Gómez Enrico Lepre Luz Sánchez-Silva Nieves López-salas Ana Raquel de la Osa Faculty of Chemical Sciences and Technologies University of Castilla-La ManchaEnrique Costa Novella Building.Avda.Camilo Jose Cela1213071 Ciudad RealSpain Colloid Chemistry Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 114476 PotsdamGermany

In this work,three cytosine derived nitrogen doped carbonaceous materials(noble carbons,NCs)with different atomic C/N ratios and porous networks have been synthesized and used as supports for Pt Ru electrocatalysts in the ethanol oxidation reaction(EOR)for clean hydrogen ***,the metal phase and the carbon support play critical roles in the electrocatalysts final *** NPs size distribution was obtained over supports with low atomic C/N ratios(i.e.,4 and 6)and defined porosity(i.e.,1701 m^(2)g^(-1)for Pt Ru/CNZ and 1834 m^(2)g^(-1)for Pt Ru/CLZ,respectively).In contrast,a lower C/N ratio and poor porous network(i.e.,65 m^(2)g^(-1),Pt Ru/CLK)led to the largest particle size and fostered an increase of the alloying degree between Pt and Ru NPs(i.e.,3%for C/N~6 and 28%for C/N~3).Electrochemical active surface area was found to increase with decreasing NPs size and the alloy extent,due to a higher availability of Pt active *** degradation tests showed that Pt Ru/NCs outperform similar to Pt Ru NPs on commercial carbon pointing at the stabilizing effect of *** Ru/CNZ exhibited the best electrochemical performance(i.e.,69.1 m A mgPt-1),outperforming Pt Ru/CLZ and Pt Ru/CLK by3-and 9-fold,respectively,due to a suitable compromise between particle sizes,degree of alloy,textural properties and elemental *** anodes were scaled-up to a proton exchange membrane cell and Pt Ru/CNZ was proved to provide the best electrocatalytic activity(262 m A cm^(-2)and low energy requirements),matching the values obtained by the state of the art of EOR electrocatalysts.

关键词： Noble carbon Cytosine H2 production Ethanol electrooxidation PtRu anode PEM cell

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Repurposing drugs to target nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2019年第15期25卷 1783-1796页

作者： Silvia Sookoian carlos J Pirola Department of Clinical and Molecular Hepatology National Scientific and Technical Research Council (CONICET) University of Buenos Aires Institute of Medical Research (IDIM) Department of Molecular Genetics and Biology of Complex Diseases National Scientific and Technical Research Council (CONICET) University of Buenos Aires Institute of Medical Research (IDIM)

Nonalcoholic fatty liver disease(NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack of approved pharmacological interventions for the treatment of nonalcoholic steatohepatitis(NASH) and NASH-fibrosis-the severe histological forms. Over the past decade,tremendous advances have been made in NAFLD research, resulting in the discovery of disease mechanisms and novel therapeutic targets. Hence, a large number of pharmacological agents are currently being tested for safety and efficacy. These drugs are in the initial pharmacological phases(phase 1 and 2),which involve testing tolerability, therapeutic action, and pharmacological *** is thus reasonable to assume that the next generation of NASH drugs will not be available for clinical use for foreseeable future. The expected delay can be mitigated by drug repurposing or repositioning, which essentially relies on identifying and developing new uses for existing drugs. Here, we propose a drug candidate selection method based on the integration of molecular pathways of disease pathogenesis into network analysis tools that use OMICs data as well as multiples sources, including text mining from the medical literature.

关键词： Drug discovery Drug repositioning Fibrosis Genetics Treatment Systems biology

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