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Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel Soares Conceição Rodrigo Menezes Jales Patrick Nunes Pereira Luis Otávio Sarian Glauco Baiocchi Sophie Derchain Agnaldo lopes da Silva Filho Department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil Department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil Department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil Department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil Department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

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Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants

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World Journal of Gastroenterology 2006年第31期12卷 5033-5036页

作者： Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias carlos lopes Rui Medeiros Mário Dinis-Ribeiro Molecular Oncology GroupPortuguese Institute of Oncology of Porto Portugal Oncology DepartmentPortuguese Institute of Oncology of Porto Portugal Gastroenterology DepartmentPortuguese Institute of Oncology of Porto Portugal and ICBAS Abel Salazar Institute for the Biomedical SciencesPortoPortugal and CINTESIS/Faculty of Medicine University of Porto PortoPortugal

AIM： To study the role of an insertion/deletion polymorphism in the pepsinogen C （PGC） gene, an effective marker for terminal differentiation of the stomach mucosa, in the susceptibility to the development of gastric lesions. METHODS： The study was performed with 99 samples of known gastric lesions and 127 samples without evidence of neoplastic disease. PCR was employed and the 6 polymorphic alleles were amplified： Allele 1 （510 bp）, Allele 2 （480 bp）, Allele 3/4 （450/460 bp）, Allele 5 （400 bp） and Allele 6 （310 bp）. RESULTS： Our results revealed that Allele 6 carriers seemed to have protection against the development of any gastric lesion （OR = 0.34; P 〈 0.001）, non-dysplastic lesions associated with gastric adenocarcinoma such as atrophy or intestinal metaplasia （OR = 0.28; P 〈 0.001） or invasive GC （OR = 0.39; P = 0.004）. CONCLUSION： Our study reveals that the Allele 6 carrier status has a protective role in the development of gastric lesions, probably due to its association with higher expression of PGC. Moreover, the frequency of Allele 6 carriers in the control group is far higher than that obtained in Asian populations, which might represent a genetic gap between Caucasian and Asian populations.

关键词： Gastric adenocarcinoma Pepsinogen C Polymorphism

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Friction Material Temperature Distribution and Thermal and Mechanical Contact Stress Analysis

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Engineering（科研） 2014年第13期6卷 1017-1036页

作者： carlos Abilio Passos Travaglia Luiz carlos Rolim lopes PPGEM—Programa de Poacute s Graduç ã o em Engenharia Metalú rgica UFF Volta Redonda Brazil

In brake systems, where the components are exposed to mechanical and thermal loads, the numerical analysis is very helpful. The main function of the brake system is to control or reduce vehicle’s speed by transformation of kinetic and potential energy in thermal energy. Using finite element method and Abaqus application, the present work proposed a model to study the impact of these loads on the performance of a pneumatic S cam drum brake’s friction material. The model included the effects of the rivet process;brake torque and warming in one of the 17 t bus front brake lining. Areas where the stresses vary with considerable amplitudes during temperature increase and brake application were identified. Also, it was possible to compare results of the numerical model to vehicle’s experimental measurements and understand its proximity to real braking events. By the application of the methodology and using the numerical model, proposed in this work, it will be possible to contribute considerably for a more accurate design of the friction material, besides undertake a better selection of the sub-compounds which it is made of.

关键词： Brake System Friction Material Heat Flux Simulation Numerical Analysis

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Endoscopic resection of superficial gastrointestinal tumors

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World Journal of Gastroenterology 2008年第29期14卷 4600-4606页

作者： Giovannini Marc Cesar Vivian lopes Endoscopic Unit Paoli-Calmettes Institute232 Bd St-Marguerite Cedex 13273 France

Therapeutic endoscopy plays a major role in the management of gastrointestinal (GI) neoplasia. Its indications can be generalized into four broad categories; to remove or obliterate neoplastic lesion, to palliate malignant obstruction, or to treat bleeding. Only endoscopic resection allows complete histological staging of the cancer, which is critical as it allows stratification and refinement for further treatment. Although other endoscopic techniques, such as ablation therapy, may also cure early GI cancer, they can not provide a definitive pathological specimen. Early stage lesions reveal low frequency of lymph node metastasis which allows for less invasive treatments and thereby improving the quality of life when compared to surgery. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are now accepted worldwide as treatment modalities for early cancers of the GI tract.

关键词： Superficial gastrointestinal cancers Endoscopic mucosal resection Endoscopic submucosaldissection Lymph node spreading Esophagus Stomach Colorectal

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Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model

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World Journal of Gastroenterology 2020年第43期26卷 6782-6794页

作者： Denise Sayuri Calheiros Silveira Luciana Chain Veronez Luis carlos lopes-Junior Elen Anatriello Mariangela Ottoboni Brunaldi Gabriela Pereira-da-Silva Department of Biochemistry and Immunology University of São Paulo at Ribeirão Preto Medical SchoolRibeirão Preto 14049-900SPBrazil Health Sciences Center Federal University of Espírito Santo-UFESVitória 29043-900ESBrazil Institute of Science and Technology Federal University of São PauloUNIFESPSão Josédos Campos 12231-280SPBrazil Department of Pathology and Forensic Medicine University of São PauloRibeirao Preto 14040-902SPBrazil Department of Maternal-Infant Nursing and Public Health University of São Paulo at Ribeirão Preto College of NursingRibeirão Preto 14040-902SPBrazil

BACKGROUND Colitis-associated cancer(CAC)accounts for 2%-3%of colorectal cancer(CRC)cases preceded by inflammatory bowel diseases(IBD)such as Crohn's disease and ulcerative *** microbiota has been reported to play a central role in the pathogenesis of IBD and ***,numerous prebiotics and probiotics have being investigated as antitumor agents due to their capacity to modulate inflammatory *** studies have indicated that lactic acid bacteria could be successfully used in managing sporadic CRC,however little is known about their role in *** To investigate the effect of the probiotic Lactobacillus bulgaricus(***)during the development of an experimental model of colitis associated colon cancer(CAC).METHODS C57BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg),followed by three cycles of sodium dextran sulphate diluted in water(5%w/v).Probiotic group received daily *** inflammation was determined by scoring clinical *** levels were determined from colon and/or tumor samples by ELISA BD OptEIATM *** level of significance was set at P<*** were generated and statistical analysis performed using the software GraphPad Prism *** *** treatment inhibited of total tumor volume and mean size of *** addition,the probiotic also attenuated the clinical signs of intestinal inflammation inducing a decrease in intestinal and tumor levels of IL-6,TNF-α,IL-17,IL-23 and IL-1β.CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on *** regulates the inflammatory response and preventing CAC.

关键词： Lactobacillus bulgaricus Colitis-associated cancer Colorectal cancer Carcinogenesis Probiotics Inflammation

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Influence of physical and chemical factors during foraging and culture of the symbiont fungus in Atta sexdens rubropilosa （Hymenoptera： Formicidae）

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Insect Science 2007年第4期14卷 295-300页

作者： SANDRA S. VERZA LUIZ C. FORTI JULIANE F. S. lopes ROBERTO S.CAMARGO carlos A. O. MATOS Departamento de Zoologia Instituto de Biociencias Laboratrio de Insetos Sociais-Praga Departamento de Produ~~o Vegetal-Def-esa Fitossanitaria Faculdade de Ciencias Agronomicas UNESP-Sao Paulo State University Fazenda Experimental LageadoBotucatu SP Comportamento e Biologia Animal Instituto de Ciencias Biologicas UFJF-Universidade Federal de Juiz de ForaCampus Universitario Martelos Juiz de Fora MG Campus Experimental de Itapeva UNESP Itapeva SP Brazil

The aim of this paper is to investigate the influence of physical and chemical factors on transport and use of substrate for Atta sexdens rubropilosa workers. Three types of rectangular fragments were used to study the physical influence factors： filter paper with paraffin, filter paper without paraffin and polyester film. To study the chemical factors, some fragments were impregnated with organic extract of orange albedo, others were soaked with soybean oil and for the remaining ones nothing was applied. The fonowing parameters were evaluated：（i） attractiveness of substrate for transport and number of loading workers per treatment; （ii） foraged material incorporation; （iii） rejection by numbers of fragments deposited in the garbage or beside the fungus garden. All the polyester film fragments carried out to the fungus garden were subsequently rejected. We verified that chemical factors of the substrate were more quickly detected by the workers, whereas physical factors were used as a criterion in the decision-making to reject or accept the substrate collected.

关键词： Atta sexdens rubropilosa attractiveness behavior leaf-cutting ants substraterejection substrate selection

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Cyst fluid glucose: An alternative to carcinoembryonic antigen for pancreatic mucinous cysts

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World Journal of Gastroenterology 2019年第19期25卷 2271-2278页

作者： César Vivian lopes Department of Gastroenterology and Digestive Endoscopy Santa Casa Hospital

Pancreatic cystic lesions(PCLs) have been increasingly recognized in clinical practice. Although inflammatory cysts(pseudocysts) are the most common PCLs detected by cross-sectional imaging modalities in symptomatic patients in a setting of acute or chronic pancreatitis, incidental pancreatic cysts with no symptoms or history of pancreatitis are usually neoplastic cysts. For these lesions,it is imperative to identify mucinous cysts(intraductal papillary mucinous neoplasms and mucinous cystic neoplasms) due to the risk of their progression to malignancy. However, no single imaging modality alone is sufficient for a definitive diagnosis of all PCLs. The cyst fluid obtained by endoscopic ultrasound-guided fine needle aspiration provides additional information for the differential diagnosis of PCLs. Current recommendations suggest sending cyst fluid for cytology evaluation and measurement of carcinoembryonic antigen(CEA) levels. Unfortunately, the sensitivity of cytology is greatly limited, and cyst fluid CEA has demonstrated insufficient accuracy as a predictor of mucinous cysts. More recently, cyst fluid glucose has emerged as an alternative to CEA for distinguishing between mucinous and nonmucinous lesions. Herein, the clinical utility of cyst fluid glucose and CEA for the differential diagnosis of PCLs was evaluated.

关键词： Carcinoembryonic antigen Differential diagnosis Fine-needle biopsy Glucose Pancreatic cyst Tumor marker

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Smart Transformer/Large Flexible Transformer

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CES Transactions on Electrical Machines and Systems 2020年第4期4卷 264-274页

作者： Rongwu Zhu Markus Andresen Marius Langwasser Marco Liserre Joao Pecas lopes carlos Moreira Justino Rodrigues Mario Couto Chair of Power Electronics Kiel UniversityGermany

Solid-state transformer-based smart transformer(ST)can provide the dc connectivity and advanced services to improve the grid performance and to increase the penetration of the power electronics interfaced resources(e.g.,distributed generators and electric vehicle charging stations)in modern electricity distribution *** the ST is a new and effective paradigm of the electricity grid evolution to well understand the ST,this paper systematically presents the basic architecture and the typical control schemes of the ST and then the advanced services that ST can provide to improve the electricity grids performances in terms of the power flow control,power quality improvement,active damping and active contribution to improve distribution grid resilience by means of enabling autonomous microgrids operation as well as launching a restoration procedure following a general blackout.

关键词： Smart Transformer voltage control power quality active distribution grid black start

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Influence of PVD-duplex-treated, Bionic Surface Structures on the Wetting Behavior for Sheet-Bulk Metal Forming Tools

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Journal of Bionic Engineering 2017年第3期14卷 520-531页

作者： Wolfgang Tiilmann Dominic Stangier Nelson Filipe lopes Dias Institute of Materials Engineering TU Dortmund 44227 Dortmund Germany Leonhard-Euler-Strafle 2

Bionic surface structures, inspired by the flora, were developed for Sheet-Bulk Metal Forming （SBMF） in order to locally control the friction condition by adjusting the wetting behavior. Five bionic structures were micromilled on ASP 2023 in annealed as well as hardened and tempered conditions. Subsequently, the structured surfaces were plasma-nitrided and coated with a CrA1N thin film. The influence of the treatment method on the structural geometry was investigated with the aid of a scanning electron microscope and 3D-profilometer. The wetting behaviors of water and deep drawing oil （Berufluid ST6007） on bionic surfaces were evaluated using contact angle measurements. The resulting micro-milled structures exhibit an almost identical shape as their bionic models. However, the roughness of the structured surfaces is influenced by the microstructure. The combination of plasma-nitriding and Physical Vapor Deposition （PVD） leads to an increase in roughness. All bionic struc- tures possess higher contact angles than that of the unstructured surfaces when wetted by water. This can be explained by the fact that the structural elevations block the spreading. When the bionic surfaces are wetted by deep drawing oil, the lubricant spreads in the structural cavities, leading to smaller contact angles. Furthermore, the anisotropy of the structure has an influence on the wetting behavior.

关键词： bionic structures sheet-bulk metal forming CrA1N PVD-duplex treatment wetting behavior

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Biliary stone causing afferent loop syndrome and pancreatitis

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World Journal of Gastroenterology 2006年第38期12卷 6229-6231页

作者： André Roncon Dias Roberto Iglesias lopes Department of General Surgery Hospital das Clínicas Faculdade de Medicina da Universidade de So Paulo So Paulo Brazil

We report the case of an 84-year-old female who had a partial gastrectomy with Billroth-Ⅱ anastomosis 24 years ago for a benign peptic ulcer who now presented an acute pancreatitis secondary to an afferent loop syndrome. The syndrome was caused by a gallstone that migrated through a cholecystoenteric fistula. This is the first description in the literature of a biliary stone causing afferent loop syndrome.

关键词： Afferent loop syndrome Biliary stone Acute pancreatitis Gallstone ileus

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