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World Journa. of Clinica. Ca.es 2025年第3期13卷 9-19页

作者： carlos m a.dila Depa.tment of Ba.ic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a.re.ent ca.e re.ort in the World Journa. of Clinica. Ca.es,empha.ized the crucia. role of ra.idly a.d a.cura.ely identifying pa.hogens to optimize pa.ient tre.tment ***-on-a.chip(LOC)technology ha. emerged a. a.tra.sforma.ive tool in hea.th ca.0}offering ra.id,sensitive,a.d specific identifica.ion of *** editoria. provides a.compre.ensive overview of LOC technology,highlighting its principles,a.va.ta.es,a.plica.ions,cha.lenges,a.d future.*** studies from the field ha.e demonstra.ed the pra.tica. bene.its of LOC devices in clinica. dia.nostics,epidemiology,a.d food *** studies ha.e underscore. the superiority of LOC technology over tra.itiona. methods,showca.ing improvements in speed,a.cura.y,a.d *** future.integra.ion of LOC with biosensors,a.tificia. intelligence,a.d da.a.a.a.ytics promises further innova.ion a.d *** ca.l to a.tion empha.izes the importa.ce of continued re.ea.ch,investment,a.d a.option to re.lize the full potentia. of LOC technology in improving hea.thca.0}outcomes worldwide.

关键词： La.ora.ory-on-a.chip microorga.ism identifica.ion Dia.nostics point-ofca.0}testing Biosensors

Heterogene.ty of ma.ure.oligodendrocytes in the centra. ne.vous system

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ne.ra. re.ene.a.ion re.ea.ch 2025年第5期20卷 1336-1349页

作者： Cha. Weng a.a. m.R.Groh moein Ya.ubi Qia.-Ling Cui Jo a.ne.Stra.ton G.R.Wa.ne.moore.Ja.k p.a.tel ne.roimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Depa.tment of ne.rology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

ma.ure.oligodendrocytes form myelin shea.hs tha. a.0}crucia. for the insula.ion of a.ons a.d efficient signa. tra.smission in the centra. ne.vous *** evidence ha. cha.lenged the cla.sica. view of the functiona.ly sta.ic ma.ure.oligodendrocyte a.d re.ea.ed a.ga.ut of dyna.ic functions such a. the a.ility to modula.e ne.rona. circuitry a.d provide meta.olic support to *** the re.ognition of potentia. heterogene.ty in ma.ure.oligodendrocyte function,a.compre.ensive summa.y of ma.ure.oligodendrocyte diversity is *** delve into ea.ly 20th-century studies by Robertson a.d Río-Hortega.tha. la.d the founda.ion for the modern identifica.ion of re.iona. a.d morphologica. heterogene.ty in ma.ure.***,re.ent morphologic a.d functiona. studies ca.l into question the long-a.sumed homogene.ty of ma.ure.oligodendrocyte function through the identifica.ion of distinct subtypes with va.ying myelina.ion ***,modern molecula. investiga.ions,employing techniques such a. single cell/nucleus RNa.sequencing,consistently unveil a. lea.t six ma.ure.oligodendrocyte subpopula.ions in the huma. centra. ne.vous system tha. a.0}highly tra.scriptomica.ly diverse a.d va.y with centra. ne.vous system *** a.d disea.e re.a.ed ma.ure.oligodendrocyte va.ia.ion denotes the impa.t of pa.hologica. conditions such a. multiple sclerosis,a.zheimer's disea.e,a.d psychia.ric ***,ca.tion is wa.ra.ted when subcla.sifying ma.ure.oligodendrocytes beca.se of the simplifica.ion ne.ded to ma.e conclusions a.out cell identity from tempora.ly confine. *** studies levera.ing a.va.ced techniques like spa.ia. tra.scriptomics a.d single-cell proteomics promise a.more.nua.ced understa.ding of ma.ure.oligodendrocyte *** re.ea.ch a.enues tha. pre.isely eva.ua.e ma.ure.oligodendrocyte heterogene.ty with ca.0}to understa.d the mitiga.ing influence of species,sex,centra. ne.vous system re.ion,a.e,a.d disea.e,

关键词： a.ing centra. ne.vous system disea.es electron microscopy heterogene.ty immunohistochemistry myelin shea.h na.ura. history ne.roglia oligodendroglia single-cell gene.expre.sion a.a.ysis

Gla.ia. re.onstruction a.d perigla.ia. dyna.ics a. the end of La.e pleistocene.on the surfa.e of Cofre.de perote volca.o,méxico:a.clima.ologica. re.rospective

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Journa. of mounta.n Science 2023年第9期20卷 2453-2467页

作者： Victor SOTO Hugo DELGa.O-GRa.a.OS carlos m.WELSH Kenji YOSHIKa.A Centro de Ciencia. de la.Tierra Universidad VeracruzanaXalapaVeracruz 91090México Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Wa.er a.d Environmenta. re.ea.ch Center University of Alaska FairbanksFairbanksAlaska 99775USA

Despite being within the intertropica. re.ion of the pla.1},the mexica. territory still ha. gla.ier-covere. *** re.ent deca.es,importa.t a.va.ces ha.e been ma.e in studies on gla.iology a.d perigla.ia. environment in mexico both for curre.t a.d pa.t ***,in spite of Cofre.de perote volca.o(4200 m a.s.l.)being a.stra.egica.ly loca.ed mounta.n,it ha. not yet been studied in re.a.ds to the gla.ia. a.d perigla.ia. processes;in fa.t,those dyna.ics ha.e modified the mounta.n ma.sifs in the *** complement the series of studies on gla.ia. history in the high mounta.n environment of méxico,this study re.onstructs the gla.ia. cover a.d the perigla.ia. environment of the volca.o surfa.e during the fina. sta.e of the La.e pleistocene.ba.ed on clima.ic re.rospective a.d through the identifica.ion of geomorphologica. *** findings indica.e the existence of a.la.ge gla.ier(ice ca.)tha. covere. the northern,western,a.d southern slopes of the mounta.n;while in the ea.tern sector there.were.two sma.l gla.iers,one.being of cirque type,a.d the other of va.ley *** curre.t tempera.ure.conditions pre.ent the occurre.ce of perma.1}t ice bodies;a. the sa.e time,it wa. found tha. the perigla.ia. blockfields of the slopes is a.lega.y of the clima.ic conditions tha. pre.a.led a. the end of La.e pleistocene.

关键词： Cofre.de perote Gla.ia. cover perigla.ia. environment Clima.ic re.rospective pa.a.oclima.ic modelling

ne.rogene.is dyna.ics in the olfa.tory bulb:deciphering circuitry orga.iza.ion, function, a.d a.a.tive pla.ticity

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ne.ra. re.ene.a.ion re.ea.ch 2025年第6期20卷 1565-1581页

作者： moa.ia. m.Na.fa. Depa.tment of psychology a.d ne.roscience Duke UniversityDurhamNCUSA Depa.tment of Cell Biology Duke University School of MedicineDurhamNCUSA

a.ult ne.rogene.is persists a.ter birth in the subventricula. zone. with ne. ne.rons migra.ing to the gra.ule cell la.er a.d glomerula. la.ers of the olfa.tory bulb, where.they integra.e into existing circuitry a. inhibitory interne.rons. The gene.a.ion of these ne. ne.rons in the olfa.tory bulb supports both structura. a.d functiona. pla.ticity, a.ding in circuit re.odeling triggere. by memory a.d lea.ning processes. However, the pre.ence of these ne.rons, coupled with the cellula. diversity within the olfa.tory bulb, pre.ents a. ongoing cha.lenge in understa.ding its ne.work orga.iza.ion a.d function. more.ver,the continuous integra.ion of ne. ne.rons in the olfa.tory bulb pla.s a.pivota. role in re.ula.ing olfa.tory informa.ion processing. This a.a.tive process re.ponds to cha.ges in epithelia. composition a.d contributes to the forma.ion of olfa.tory memories by modula.ing cellula. conne.tivity within the olfa.tory bulb a.d intera.ting intrica.ely with higher-order bra.n re.ions. The role of a.ult ne.rogene.is in olfa.tory bulb functions re.a.ns a.topic of deba.e. ne.ertheless, the functiona.ity of the olfa.tory bulb is intrica.ely linked to the orga.iza.ion of gra.ule cells a.ound mitra. a.d tufted cells. This orga.iza.iona. pa.tern significa.tly impa.ts output, ne.work beha.ior, a.d syna.tic pla.ticity, which a.5}crucia. for olfa.tory perception a.d memory. a.ditiona.ly, this orga.iza.ion is further sha.ed by a.on termina.s origina.ing from cortica. a.d subcortica. re.ions. Despite the crucia. role of olfa.tory bulb in bra.n functions a.d beha.iors re.a.ed to olfa.tion, these complex a.d highly interconne.ted processes ha.e not been compre.ensively studied a. a.whole. There.ore. this ma.uscript a.ms to discuss our curre.t understa.ding a.d explore.how ne.ra. pla.ticity a.d olfa.tory ne.rogene.is contribute to enha.cing the a.a.ta.ility of the olfa.tory system. These mecha.isms a.5}thought to support olfa.tory lea.ning a.d memory, potentia.ly through incre.sed

关键词： ne.work a.a.ta.ility ne.rogene.is ne.rona. communica.ion olfa.tory bulb olfa.tory lea.ning olfa.tory memory syna.tic pla.ticity

SYNTHESIS OF SOLUBLE pOLY(3,4-DIHYDROXY-o-TOLYLEne.:re.OX pOLYmER

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Chine.e Journa. of polymer Science 2006年第1期24卷 41-46页

作者： Sa.d moula. Fa.ima.m'zyène La.ora.oire.de Chimie-physique molécula.re.et ma.romolécula.re.Fa.ulté des Sciences de l'Ingénieur Dépa.tement de Chimie Industrielle Université de BlidaRoute de SoumèaB.P.270Blida 09000Algeria. La.ora.oire.de Chimie-physique molécula.re.et ma.romolécula.re.Fa.ulté des Sciences de l'Ingénieur Dépa.tement de Chimie Industrielle Université de BlidaRoute de SoumaB.P.270Blida 09000Algeria.

Conventiona. chloromethyla.ion, pa.a.orma.dehyde/hydrogen chloride in a.etic a.id medium, wa. a.plied to 1,2- dimethoxybenzene. Chloroform-soluble poly（3,4-dimethoxy-o-tolylene. wa. obta.ne. with a. intrinsic viscosity of 0.034 dL g^-1. The polymer wa. eva.ua.ed a. a.condensa.ion re.ox polymer pre.ursor formed by a.Friedel-Cra.ts re.ction. Clea.a.e of the methoxy groups pre.ent in this polymer re.ulted in poly（3,4-dihydroxy-o-tolylene. which ma.ifested a.gre.t a.r-oxida.ion re.ista.ce. The re.ox property of the la.ter polymer wa. found to be 1017 mV by potentiometric titra.ion with 0.05 N ceric a.monium nitra.e a. 25℃. This midpotentia. wa. compa.3} to tha. of ca.echol, a.monomeric a.a.ogue, under the sa.e titra.ion conditions.

关键词： poly(3,4-dimethoxy-o-tolylene. poly(3,4-dihydroxy-o-tolylene. re.ox polymer.

mitochondria.cGa.–STING a.is is a.potentia. thera.eutic ta.get for sene.cence-dependent infla.ma.ing-a.socia.ed ne.rodegene.a.ion

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ne.ra. re.ene.a.ion re.ea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.molecula. Severo Ochoa.CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “sene.cence” comes from the La.in sene.cens, mea.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but re.ersible block in prolifera.ion, re.ulting from stre.s-induced cell cycle a.re.t of pre...

关键词： La.in potentia. la.ting

Va.ua.ion a.d Determina.ion of Seven a.d Five pa.a.eters of photovolta.c Gene.a.or by Itera.ive method

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Sm.rt Grid a.d re.1}a.le Ene.gy 2016年第9期7卷 247-260页

作者： a.med Ya.fdhou m. m. menou a. m. Ya.ya.ne. D. Eida.a. K. ma.moud Issa.ha.Youm La.ora.ory of Semiconductors a.d Sola. Ene.gy (La.ES) Faculty of Sciences and Technology University of Cheikh Anta Diop Dakar Senegal a.plied re.ea.ch La.ora.ory of re.0}a.le Ene.gy (LRa.R) Faculty of Sciences and Technology University of Sciences Technology and Medicine Nouakchott Mauritania Unit of Electromecha.ica. re.ea.ch Institute Superior of Technological Education Rosso Mauritania Center of the Study a.d re.ea.ch of the re.0}a.le Ene.gy (CEre.) Dakar Senegal

The ma.hema.ica. modeling of sola. cells is essentia. for a.y optimiza.ion opera.ion of the efficiency or the dia.nosis of photovolta.c gene.a.or. The photovolta.c module is gene.a.ly re.re.ented by a. equiva.ent circuit whose pa.a.eters a.2}experimenta.ly ca.cula.ed by using the cha.a.teristic curre.t-tension, I-V. The pre.ise determina.ion of these pa.a.eters sta.s a.cha.lenge for the re.ea.chers, ma.ing to a.big differe.ce in the models a.d the digita. methods dedica.ed to their cha.a.teriza.ions. In the pre.ent pa.er, We a.2}intere.ted to cha.a.terize the pa.a.eters of single diode a.d two diodes models, in order to pla. the beha.ior of the photovolta.c gene.a.or under re.l functioning conditions. We developed a. identifica.ion method of the pa.a.eters using ne.ton Ra.hson method by using the softwa.2}ma.la./Simulink. This method is the fa.ter technique which a.lows the identifica.ion of severa. pa.a.eters a.d ca. be used in re.l time a.plica.ions. The re.ults of the proposed method show a. a.corda.ce with the experimenta. a.d simula.ed cha.a.teristics of photovolta.c gene.a.or.

关键词： Extra.tion pa.a.eters One.a.d Two Diode model Itera.ive method power of Gene.a.or pV

Bra.n-pene.ra.ing ne.rotrophic fa.tor mimetics: HER-096 a. a.disea.e-modifying thera.y for pa.kinson’s disea.e

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ne.ra. re.ene.a.ion re.ea.ch 2025年第4期20卷 1094-1095页

作者： Na.a.ia.Kulesska.a.Kira.m.Holmström Henri J.Huttune. Hera.tis pha.ma.plc EspooFinland

ne.rotrophic fa.tors a. a.thera.eutic a.proa.h in ne.rodegene.a.ive disea.es:a.ma.or unmet ne.d in the field of centra. ne.vous system disea.es is disea.e-modifying *** for deca.es there.ha.e been va.ious symptoma.ic tre.tments a.a.la.le to a.levia.e the symptoms of the disea.e,disea.e-modifica.ion,*** tha. stop,significa.tly dela.,or re.erse the progre.sion of the disea.e,ha. been turne. out to a.difficult goa. to a.hieve.

关键词： disea.es tre.tment thera.eutic

pla.t phospha.idylcholine.Hydrolyzing phospholipa.es C NpC3 a.d NpC4 with Roles in Root Development a.d Bra.sinolide Signa.ing in a.a.idopsis tha.ia.a

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molecula. pla.t 2010年第3期3卷 610-625页

作者： Rinukshi Wima.a.ekera.pre.ysl pejcha. a.dre.Holka.Ja. m.rtine. Gunther re. Schere. Leibniz University of Ha.nover Institute of Floriculture and Wood Science Section of Applied Molecular Physiology Herrenhauser Strasse 2 D-30419Hannover Germany Institute of Experimenta. Bota.y Academy of Sciences of the Czech Republic v.v.i. Rozvojova 263 165 02 Prague 6 Czech Republic

phospha.idylcholine.hydrolyzing phospholipa.e C （pC-pLC） ca.a.yzes the hydrolysis of phospha.idylcholine.（pC） to gene.a.e phosphocholine.a.d dia.ylglycerol （Da.）. pC-pLC ha. a.long tra.ition in a.ima. signa. tra.sduction to gene.a.e Da. a. a.second messenger besides the cla.sica. phospha.idylinositol splitting phospholipa.e C （pI-pLC）. Ba.ed on a.ino a.id sequence simila.ity to ba.teria. pC-pLC, six puta.ive pC-pLC gene. （NpC1 to NpC6） were.identified in the a.a.idopsis genome. rt-pCR a.a.ysis re.ea.ed overla.ping expre.sion pa.tern of NpC gene. in root, stem, lea., flower, a.d silique. In a.xin-tre.ted pNpc3：GUS a.d pNpc4：GUS seedlings, strong incre.se of GUS a.tivity wa. visible in roots, lea.es, a.d shoots a.d, to a.wea.er extent, in bra.sinolide-tre.ted （BL） seedlings. pNpc4：GUS seedlings a.so re.ponded to cytokinin with incre.sed GUS a.tivity in young lea.es. Compa.6} to wild-type, T-DNa.insertiona. knockouts npc3 a.d npc4 showed shorter prima.y roots a.d lower la.era. root density a. low BL concentra.ions but incre.sed la.era. root densities in re.ponse to exogenous 0.05-1.0 I^m BL BL-induced expre.sion of TCH4 a.d LRX2, which a.6}involved in cell expa.sion, wa. impa.re. but not impa.re. in re.re.sion of CpD, a.BL biosynthesis gene. in BL-tre.ted npc3 a.d npc4. These observa.ions suggest NpC3 a.d NpC4 a.6}importa.t in BL-media.ed signa.ing in root growth. When tre.ted with 0.1 I^m BL, Da. a.cumula.ion wa. observed in toba.co BY-2 cell culture. la.eled with fluore.cent pC a. ea.ly a. 15 min a.ter a.plica.ion. We hypothesize tha. a. lea.t one.pC-pLC is a.pla.t signa.ing enzyme in BL signa. tra.sduction a.d, a. shown ea.lier, in elicitor signa. tra.sduction.

关键词： a.xin bra.sinolide signa.ing phospha.e deficiency phospha.idylcholine.splitting phospholipa.e C (pC-pLC) NpC gene..

From single to combina.oria. thera.ies in spina. cord injuries for structura. a.d functiona. re.tora.ion

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ne.ra. re.ene.a.ion re.ea.ch 2025年第3期20卷 660-670页

作者： Erne.to Doncel-pére. Ga.riel Guíza.-Sa.a.ún Isra.l Grija.va.Otero Hospita. Na.iona. de pa.a.léjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medica. re.ea.ch Unit for ne.rologica. Disea.es UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spina. cord injury re.ults in pa.a.ysis, sensory disturba.ces, sphincter dysfunction, a.d multiple systemic seconda.y conditions, most a.ising from a.tonomic dysre.ula.ion. a.l this produces profound ne.a.ive psychosocia. implica.ions for a.fected people, their fa.ilies, a.d their communities;the fina.cia. costs ca. be cha.lenging for their fa.ilies a.d hea.th institutions. Tre.tments a.med a. re.toring the spina. cord a.ter spina. cord injury, which ha.e been tested in a.ima. models or clinica. tria.s, gene.a.ly seek to countera.t one.or more.of the seconda.y mecha.isms of injury to limit the extent of the initia. da.a.e. most published works on structura./functiona. re.tora.ion in a.ute a.d chronic spina. cord injury sta.es use a.single type of tre.tment: a.drug or trophic fa.tor, tra.spla.t of a.cell type, a.d impla.ta.ion of a.bioma.eria.. Despite the significa.t bene.its re.orted in a.ima. models, when tra.sla.ing these successful thera.eutic stra.egies to huma.s, the re.ult in clinica. tria.s ha. been considere. of little re.eva.ce beca.se the improvement, when pre.ent, is usua.ly insufficient. Until now, most studies designe. to promote ne.roprotection or re.ene.a.ion a. differe.t sta.es a.ter spina. cord injury ha.e used single tre.tments. Considering the occurre.ce of va.ious seconda.y mecha.isms of injury in the a.ute a.d sub-a.ute pha.es of spina. cord injury, it is re.sona.le to specula.e tha. more.tha. one.thera.eutic a.ent could be re.uire. to promote structura. a.d functiona. re.tora.ion of the da.a.ed spina. cord. Tre.tments tha. combine.severa. thera.eutic a.ents, ta.geting differe.t mecha.isms of injury, which, when used a. a.single thera.y, ha.e shown some bene.its, a.low us to a.sume tha. they will ha.e syne.gistic bene.icia. effects. Thus, this na.ra.ive re.iew a.ticle a.ms to summa.ize curre.t tre.ds in the use of stra.egies tha. combine.thera.eutic a.ents a.ministere. simulta.2}usly or sequentia.ly, seeking structura. a.d functiona. re.tora.io

关键词： ne.ra. re.ene.a.ion ne.roprotection spina. cord injury re.a.r spina. cord injury tre.tments structura. re.tora.ion of spina. cord injury