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Patency and agile capsules

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World Journal of Gastroenterology 2008年第34期14卷 5269-5273页

作者： ngel Caunedo-lvarez Javier Romero-Vazquez Juan M Herrerias-Gutierrez Gastroenterology Service "Virgen Macarena" University Hospital

Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.

关键词： Capsule endoscopy Patency capsule Agile capsule Small bowel strictures

Topology of nuclear reaction networks of interest for astrophysics

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Science China(Physics,Mechanics & Astronomy) 2020年第11期63卷 10-11页

作者： carlos ABertulani Department of Physics and Astronomy Texas A&M University-CommerceCommerce TX 75429USA

Our understanding of the observed elemental abundance in the universe,stemming from nuclear reactions during the big bang or from nucleosynthesis within stellar environments,requires theoretical analyses based on multidimensional nucleosynthesis calculations involving hundreds of nuclei connected via thousands of nuclear *** to recently,full nucleosynthesis network calculations remained computationally expensive and prohibitive.

关键词： nucleosynthesis universe environments

Identification and functional characterization of fish IL‑17 receptors suggest important roles in the response to nodavirus infection

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Marine Life Science & Technology 2024年第2期6卷 252-265页

作者： Carmen González‑Fernández Miguel A.García‑Álvarez Alberto Cuesta Department of Cell Biology and Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain Laboratoire d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a lymphocyte T helper(Th)subpopulation relevant in the control and regulation of the immune response characterized by the production of interleukin(IL)-*** crucial cytokine family acts through their binding to the IL-17 receptors(IL-17R),having up to six *** the biology of fish Th17 is well-recognized,the molecular and functional characterization of IL-17 and IL-17R has been ***,our aim was to identify and characterize the IL-17R repertory and regulation in the two main Mediterranean cultured fish species,the gilthead seabream(Sparus aurata)and the European sea bass(Dicentrarchus labrax).Our in silico results showed the clear identification of six members in each fish species,from IL-17RA to IL-17RE-like,with well-conserved gene structure and protein domains with their human *** of them showed wide and constitutive transcription in naïve tissues but with highest levels in mucosal tissues,namely skin,gill or *** leucocytes,T mitogens showed the strongest up-regulation in most of the il17 receptors though il17ra resulted in inhibition by most ***,in vivo nodavirus infection resulted in alterations on the transcription of il17 *** nodavirus infection led to some increments in the il17ra,il17rb,il17rc and il17rd transcripts in the susceptible European sea bass,many down-regulations were observed in the resistant gilthead *** data identify the presence and conservation of six coding IL-17R in gilthead seabream and European sea bass as well as their differential regulation in vitro and upon nodavirus infection.

关键词： Th17 cells IL-17 receptors Immunity Teleost fish Nodavirus(NNV) Aquaculture

Autoimmune hepatitis:Towards a personalized treatment

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World Journal of Hepatology 2024年第11期16卷 1225-1242页

作者： Alejandro Costaguta Guillermo Costaguta FernandoÁlvarez Department of Hepatology and Liver Transplant Unit Sanatorio de Niños de RosarioRosario 2000Santa FeArgentina Department of Gastroenterology Hepatologyand NutritionCHU Sainte-JustineMontreal H3T 1C5QuebecCanada of Pediatrics CHU Sainte-JustineMontreal H3T 1C5QuebecCanada

Autoimmune hepatitis is an uncommon condition that affects both adults and children and is characterized by chronic and recurrent inflammatory activity in the *** inflammation is accompanied by elevated IgG and autoantibody ***,treatment consists of steroids with the addition of azathioprine,which results in remission in approximately 80%of *** significant advancements in our understanding of the immune system over the past two decades,few modifications have been made to treatment algorithms,which have remained largely unchanged since they were first proposed more than 40 years *** review summarized the various treatment options currently available as well as our experiences using *** steroids are the standard treatment for induction therapy,other medications may be *** A,a calcineurin inhibitor that decreases T cell activation,has proven effective for induction of remission,but its long-term side effects limit its appeal for ***,a drug belonging to the same family,has been used in patients with refractory diseases with fewer side *** and everolimus have interesting effects on regulatory T cell populations and may become viable options in the *** mofetil is not effective for induction but is a valid alternative for patients who are intolerant to azathioprine.B celldepleting drugs,such as rituximab and belimumab,have been successfully used in refractory cases and are useful in both the short and long *** promising treatments include anti-tumor necrosis factors,Janus kinases inhibitors,and chimeric antigen receptor T cell *** growing armamentarium allows us to imagine a more tailored approach to the treatment of autoimmune hepatitis in the near future.

关键词： Novel therapies Immunosuppressors Treatment tailoring Personalization Special populations

A novel semantic segmentation approach based on U-Net,WU-Net,and U-Net++deep learning for predicting areas sensitive to pluvial flood at tropical area

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International Journal of Digital Earth 2023年第1期16卷 3661-3679页

作者： Laura Melgar-García Francisco Martínez-álvarez Dieu Tien Bui Alicia Troncoso Data Science&Big Data Lab Pablo de Olavide UniversitySevilleSpain GIS Group Department of Business and ITUniversity of South-Eastern NorwayGullbringvegen 36B?i Telemark3800Norway

Floods remain one of the most devastating weather-induced disastersworldwide, resulting in numerous fatalities each year and severelyimpacting socio-economic development and the ***, the ability to predict flood-prone areas in advance is crucialfor effective risk management. The objective of this research is to assessand compare three convolutional neural networks, U-Net, WU-Net, andU-Net++, for spatial prediction of pluvial flood with a case study at atropical area in the north of Vietnam. They are relative new convolutionalgorithms developed based on U-shaped architectures. For this task, ageospatial database with 796 historical flood locations and 12 floodindicators was prepared. For training the models, the binary crossentropywas employed as the loss function, while the Adaptive momentestimation (ADAM) algorithm was used for the optimization of themodel parameters, whereas, F1-score and classification accuracy (Acc)were used to assess the performance of the models. The results unequivocally highlight the high performance of the three models,achieving an impressive accuracy rate of 96.01%. The flood susceptibility maps derived from this research possess considerable utility for local authorities, providing valuable insights and informationto enhance decision-making processes and facilitate the implementation of effective risk management strategies.

关键词： Flash-flood assessment convolutional networks climate change GIS

Theranostic of orthotopic gliomas by core-shell structured nanoplatforms

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Light(Science & Applications) 2022年第6期11卷 1034-1035页

作者： Luis D.carlos Phantom-G CICECO-Aveiro Institute of MaterialsPhysics DepartmentUniversity of Aveiro3810-193 AveiroPortugal

Smart designed core-shell nanostructures formed by a YVO_(4)∶Nd^(3+) nanoparticle as the core,the sonosensitizer hematoporphyrinmonomethyl ether as the carrier,and MnO_(2) nanosheets as the shell demonstrate bimodal ... 详细信息

关键词： modal glioma orthotopic

Impact of seismic design on tunnels in rock-Case histories

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Underground Space 2017年第2期2卷 106-114页

作者： carlos A.Jaramillo COWI North America 1300 Clay Street7th FloorOaklandCA 94612USA

The tunnel industry has considered that tunnels,especially tunnels in rock,are naturally resistant to earthquake action,including faulting,shaking,deflection and ground *** the number of case histories of tunnels subject to earthquake action has increased,the industry has started to recognize that,although tunnels in rock have good resistance against earthquakes generating peak ground accelerations(PGA)lower than 0.5 g,it is important to include the dynamic forces and displacements generated by seismic ground motions in the design process to obtain a more reliable *** additional earthquake forces impact the final design,potentially requiring changes to the ground support and additional reinforcement of the concrete lining,as illustrated by case histories presented in this paper.

关键词： Tunnel Tunnels Seismic design Earthquake impact Tunnel lining Ground support

Mass-Stiffness Templates for Cubic Structural Elements Dedicated to Professor Karl Stark Pister for his 95th birthday

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Computer Modeling in Engineering & Sciences 2021年第12期129卷 1209-1241页

作者： carlos A.Felippa Department of Aerospace Engineering Sciences and Aerospace Mechanics Research Center University of Colorado at BoulderBoulderCO 80309-0429USA

1 This paper considers Lagrangian finite elements for structural dynamics constructed with cubic displacement shape *** method of templates is used to investigate the construction of accurate mass-stiffness *** method introduces free parameters that can be adjusted to customize elements according to accuracy and rank-sufficiency ***-and two-dimensional Lagrangian cubic elements with only translational degrees of freedom(DOF)carry two additional nodes on each side,herein called side nodes or *** usually placed at the third-points,the SN location may be adjusted within geometric *** adjustment effect is studied in detail using symbolic computations for a bar *** best SN location is taken to be that producing accurate approximation to the lowest natural frequencies of the continuum *** is investigated through Fourier analysis of the propagation of plane waves over a regular infinite lattice of bar *** is placed on the acoustic branch of the frequency-vs.-wavenumber dispersion *** is found that dispersion results using the fully integrated consistent mass matrix(CMM)are independent of the SN location whereas its lowfrequency accuracy order is O(κ8),whereκis the dimensionless wave *** the diagonally lumped mass matrix(DLMM)constructed through the HRZ scheme,two optimal SN locations are identified,both away from third-points and of accuracy order O(κ8).That with the smallest error coefficient corresponds to the Lobatto 4-point integration rule.A special linear combination of CMM and DLMM with nodes at the Lobatto points yields an accuracy of O(κ10)without any increase in the computational effort over *** effect of reduced integration(RI)on both mass and stiffness matrices is also *** is shown that singular mass matrices can be constructed with 2-and 3-point RI rules that display the same optimal accuracy of the exactly integrated case,at the cost of introducing spurious modes

关键词： Structural dynamics Lagrangian elements finite elements cubic shape functions bar plane stress mass stiffness vibration wave propagation Fourier analysis dispersion templates

Unveiling plant defense arsenal: metabolic strategies in Brassica oleracea during black rot disease

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Horticulture Research 2023年第11期10卷 120-130页

作者： Carmen Vega-Álvarez Pilar Soengas Thomas Roitsch Rosaura Abilleira Pablo Velasco Marta Francisco Group of Genetics Breeding and Biochemistry of BrassicasMisión Biológica de Galicia(CSIC)ES-36143PontevedraSpain Department of Plant and Environmental Sciences Copenhagen Plant Science CentreUniversity of CopenhagenDK-2630TaastrupDenmark

Alterations in plant metabolism play a key role in the complex plant-pathogen ***,there is still a lack of knowledge about the connection between changes in primary and specialized metabolism and the plant defense against diseases that impact ***,we aim to study the metabolic reprograming in Brassica oleracea plants upon infection by Xanthomonas campestris ***(Xcc).To accomplish this,we utilized a combination of untargeted and targeted metabolomics,through UPLC-Q-TOF-MS/MS and 1H-NMR,in two crop lines differing in resistance thatwere evaluated at two-and four-week intervals following inoculation(T1 and T2,respectively).Besides,to depict the physiological status of the plant during infection,enzymatic activities related to the carbohydrate pathway and oxidative stress were *** results revealed different temporal dynamics in the responses of the susceptible *** crops *** *** line suppresses carbohydrate metabolism contributing to limit nutrient supplies to the bacterium and prioritizes the induction of defensive compounds such as indolic glucosinolates,salicylic acid,phenylpropanoids and phytoalexins precursors at early infection *** contrast,the susceptible line invests in carbohydratemetabolism,including enzymatic activities related to the hexoses turnover,and activates defense signaling related to reactive oxygen ***,each line triggers a different metabolic strategy that will affect how the plant overcomes the disease in terms of resistance and *** work provides first insights of a fine-tuned metabolic regulation during Xcc infection in *** that will contribute to develop new strategies for plant disease management.

关键词： metabolic metabolism black