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Diabetic foot syndrome:Immune-inflammatory features as possible cardiovascular markers in diabetes

World Journal of Orthopedics 2015年第1期6卷 62-76页

作者： Antonino Tuttolomondo carlo maida Antonio Pinto Dipartimento Biomedico di Medicina Interna e Specialistica U.O.C di Medicina Interna e CardioangiologiaUniversità degli Studi di Palermo

Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality. Diabetic foot syndrome(DFS), as defined by the World Health Organization, is an "ulceration of the foot(distally from the ankle and including the ankle) associated with neuropathy and different grades of ischemia and infection". Pathogenic events able to cause diabetic foot ulcers are *** the commonest causes of this pathogenic pathway it's possible to consider peripheral neuropathy, foot deformity, abnormal foot pressures, abnormal joint mobility, trauma, peripheral artery disease. Several studies reported how diabetic patients show a higher mortality rate compared to patients without diabetes and in particular these studies under filled how cardiovascular mortality and morbidity is 2-4 times higher among patients affected by type 2 diabetes mellitus. This higher degree of cardiovascular morbidity has been explained as due to the observed higher prevalence of major cardiovascular risk factor, of asymptomatic findings of cardiovascular diseases, and of prevalence and incidence of cardiovascular and cerebrovascular events in diabetic patients with foot complications. In diabetes a fundamental pathogenic pathway of most of vascular complications has been reported as linked to a complex interplay of inflammatory, metabolic and procoagulant variables. These pathogenetic aspects have a direct interplay with an insulin resistance, subsequent obesity, diabetes, hypertension, prothrombotic state and blood lipid disorder. Involvement of inflammatory markers such as IL-6 plasma levels and resistin in diabetic subjects as reported by Tuttolomondo et al confirmed the pathogenetic issue of the a "adipo-vascular" axis that may contribute to cardiovascular risk in patients with type 2 diabetes. This "adipo-vascular axis" in patients with type 2 diabetes has been reported as characterized by lower plasma l

关键词： Diabetic foot syndrome Inflammation Cytokines Cardiovascular risk Marker

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Management of antiplatelet or anticoagulant therapy in endoscopy: A review of literature

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World Journal of Gastrointestinal Endoscopy 2020年第6期12卷 172-192页

作者： Marcello maida Sandro Sferrazza carlo maida Gaetano Cristian Morreale Alessandro Vitello Giovanni Longo Vincenzo Garofalo Emanuele Sinagra Gastroenterology and Endoscopy Unit S.Elia-Raimondi HospitalCaltanissetta 93100Italy Gastroenterology and Endoscopy Unit Santa Chiara HospitalTrento 38123Italy U.O.C di Medicina Interna con Stroke Care Dipartimento di Promozione della SaluteMaterno-Infantiledi Medicina Interna e Specialistica di Eccellenza“G.D’Alessandro”University of PalermoPalermo 93100Italy Cardiology Unit S.Elia-Raimondi HospitalCaltanissetta 93100Italy Gastroenterology and Endoscopy Unit Istituto San Raffaele GiglioCefalu 90015Italy

Endoscopic procedures hold a basal risk of bleeding that depends on the type of procedure and patients’***,they are often performed in patients taking antiplatelet and anticoagulants agents,increasing the potential risk of intraprocedural and delayed *** if the interruption of antithrombotic therapies is undoubtful effective in reducing the risk of bleeding,the thromboembolic risk that follows their suspension should not be ***,it is fundamental for each endoscopist to be aware of the bleeding risk for every procedure,in order to measure the risk-benefit ratio for each ***,knowledge of the proper management of antithrombotic agents before endoscopy,as well as the adequate timing for their resumption is *** review aims to analyze current evidence from literature assessing,for each procedure,the basal risk of bleeding and the risk of bleeding in patients taking antithrombotic therapy,as well as to review the recommendation of American society for gastrointestinal endoscopy,European society of gastrointestinal endoscopy,British society of gastroenterology,Asian pacific association of gastroenterology and Asian pacific society for digestive endoscopy guidelines for the management of antithrombotic agents in urgent and elective endoscopic procedures.

关键词： Antiplatelet Anticoagulant Endoscopy Management Bleeding Risk

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AC ripple on DC voltage:Experimental and theoretical investigation of the impact on accelerated ageing in electrical insulation

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High Voltage 2024年第4期9卷 902-910页

作者： Giovanni Gardan Gian carlo Montanari Dipartimento di Ingegneria Industriale Universita degli Studi di PadovaPadovaItaly Center for Advanced Power Systems Florida State UniversityTallahasseeFloridaUSA

With the increasing penetration of DC systems into the high voltage and medium voltage power industry,DC voltage is becoming common for distribution/transmission and to supply different typologies of *** allowable extent of AC ripple superimposed to DC,and its effect on insulation ageing,is a long-term discussed *** most harmful phenomenon causing extrinsic ageing acceleration and insulation system premature failure is partial discharges(PD);thus,the risk of incepting PD due to AC ripple could become a primary issue for electrical asset equipment *** this work,the impact of AC sinusoidal ripple on insulation system life and reliability is dealt with,considering both intrinsic and extrinsic ageing but focusing on the latter,that is,the PD *** are performed to assess how the jump voltage(due to AC ripple)and the DC component impact on PD activity in terms of amplitude and repetition *** the first time,the correlation between the magnitude of jump voltage associated with ripple and PD inception is established,shedding a light on the allowable ripple extent which does not impact significantly on ageing and premature insulation *** approach can provide straightforward tools for design specification and ageing inference of insulation systems.

关键词： impact insulation electrical

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Experimental evaluation of mechanical compression of lattice trusses made with Ti6Al4V for aerospace use

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Chinese Journal of Aeronautics 2024年第5期37卷 520-532页

作者： carlo Giovanni FERRO Sara VARETTI Paolo MAGGIORE Department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli AbruzziTorino 10124Italy

Lattice structures are three-dimensional structures composed of repeated geometrical shapes with multiple interconnected nodes,providing high strength-to-weight ratios,customizable properties,and efficient use of materials.A smart use of materials leads to reduced fuel consumption and lower operating costs,making them highly desirable for aircraft ***,the customizable properties of lattice structures allow for tailoring to specific design requirements,leading to improved performance and safety for *** advantages make lattice structures an important focus for research and development in the aviation *** paper presents an experimental evaluation of the mechanical compression properties of lattice trusses made with Ti6Al4V,designed for use in an anti-ice *** truss structures were manufactured using additive manufacturing techniques and tested under compressive loads to determine mechanical *** showed that lattice trusses exhibited high levels of compressive strength,making them suitable for use in applications where mechanical resistance and durability are critical,such as in anti-ice *** also highlight the potential of additive manufacturing techniques for the fabrication of lattice trusses with tailored mechanical *** study provides valuable insights into the mechanical behavior of Ti6Al4V lattice trusses and their potential applications in anti-ice systems,as well as other areas where high strength-to-weight ratios are *** results of this research contribute to the development of lightweight,efficient,and durable anti-ice systems for use in aviation and other industries.

关键词： Additive Manufacturing(AM) Selective Laser Sintering(SLM) Anti ice systems Lattice structures Aircraft on board systems Design of Experiments(DOE)

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When sepsis affects the heart: A case report and literature review

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World Journal of Clinical Cases 2015年第8期3卷 743-750页

作者： Giuseppe Clemente Antonino Tuttolomondo Daniela Colomba Rosaria Pecoraro Chiara Renda Vittoriano Della Corte carlo maida Irene Simonetta Antonio Pinto U.O.C.di Medicina Interna e Cardioangiologia University of Palermo

A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient.

关键词： Sepsis Shock Hypotension Troponin Myocardial dysfunction

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Local recurrence rate as quality indicator in surgery for pancreatic cancer?

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 548-550页

作者： carlo Alberto Pacilio Alessandro Cucchetti Giorgio Ercolani General and Oncologic Surgery Unit Morgagni-Pierantoni HospitalAUSL RomagnaVia Carlo Forlanini 3447121ForlìItaly Department of Medical and Surgical Sciences Alma Mater StudiorumUniversity of BolognaVia Massarenti 940138BolognaItaly

To the Editor: As we all know, even with the current advancements regarding novel chemotherapy regimens, patients affected by pancreatic cancer(PC) have an extremely dismal prognosis(5-year survival rate 12% for all stages in the National Cancer Institute SEER database). Among the patients undergoing surgical treatment, the prognosis is mostly affected by recurrence. PC after surgery has mainly four patterns of recurrence, isolated or variously associated with each other: local, lymph nodal, peritoneal or distant(liver, lung, other sites).

关键词： surgery prognosis cancer

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Introduction to the Special Issue on Recent Developments on Computational Biology-I

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2261-2264页

作者： carlo Cattani Haci Mehmet Baskonus Armando Ciancio Engineering School(DEIM) University of TusciaViterbo01100Italy Department of Mathematics and Science Education Faculty of EducationHarran UniversitySanliurfa63190Turkey Universitàdegli Studi di Messina Dipartimento di Scienze BiomedicheOdontoiatriche e delle Immagini Morfologiche e FunzionaliMessina98122Italy

In modern time,experts started to use interdisciplinary properties with the development of technology and ***,these disciplines provide more sophisticated properties of real-world *** this sense,some models need to be investigated by using revised and modified traditional *** first discipline is the applied sciences such as physics,engineering,mechanics,electricity,biology,economy and mathematical applications[1-5].In this stage,many methods[5-10]are developed and *** uncover the deep properties of problems is to use the main properties of such interdisciplinary ***,works conducted on such mathematical models including non-local operators,partial,ordinary and integer order have introduced a deeper investigation of problems for *** using technological tools,expertsmay observe more realistic and exact results of models.

关键词： properties. integer operators

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Witness for resolution: post-conflict quadratic affiliation in semi-free ranging pigs

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Current Zoology 2024年第2期70卷 233-243页

作者： Ivan Norscia Edoardo Collarini carlo Robino Elena Chierto Giada Cordoni Department of Life Sciences and Systems Biology University of TorinoVia Accademia Albertina 1310123 TorinoItaly Department of Public Health Sciences and Pediatric s University of TorinoC.So Galileo Galilei 2210126 TorinoItaly

In social mammals,post-conflict resolution can involve the reunion of former opponents(reconciliation),spontaneous/solicited post-conflict affliation of a third party with either opponent(triadic contacts),and affiliation between other individuals(hereafter bystanders;quadratic contacts).Quadratic contacts-possibly informing complex cognitive abilities-have been neglected in post-conflict *** investi-gated quadratic affliation in semi-free ranging pigs Sus scrofa,at the ethical farm Parva-Domus(Cavagnolo,Italy).Kinship was *** collected behavioral data on adult pigs(n=104)via video recordings(43 h)followed by video *** and anxiety behaviors between bystanders were collected under post-conflict(PC;following a conflict between non-bystanders)and matched-control(MC;no conflict)*** affiliation was present in pigs,as bystanders affliated more in PC than MC,and such affiliation was followed by a decrease in the anxiety behaviors of both the interacting ***,quadratic contacts may be partly aimed at reducing one's own anxiety(intrinsic regulation).Quadratic affiliation was highest between closely related bystanders,which suggests that such affiliation may be most effective when close kin is *** affiliation was lowest after reconciliation and spontaneous triadic *** suggests that direct peacemaking between opponents and spontaneous triadic contacts with close kin may most likely replace quadratic ***,pigs can be influenced by the negative events that affect other pigs-but not themselves-and their response may be modulated by social *** non-random quadratic affiliation may point toward the presence of elements of social appraisal abilities inpigs.

关键词： anxiety reduction emotional regulation reconciliation social appraisal triadic contacts.

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Parallel pathways:A chronicle of evolution in rectal and breast cancer surgery

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1091-1096页

作者： Antonio Pesce NicolòFabbri Diletta Iovino carlo Vittorio Feo Unit of General Surgery University of FerraraAzienda USL of FerraraFerrara 44023LagosantoItaly

In this editorial,we have analyzed the historical evolution of rectal and breast cancer surgery,focusing on the progressive reduction of demolitive approaches and the increasing use of more conservative strategies,accompanied by a growing emphasis on perioperative treatments aimed at enhancing surgical *** of these changes have been made possible due to an increased awareness and understanding of oncological diseases and improved perioperative treatments.

关键词： Rectal cancer History Breast surgery Demolitive treatment Conservative surgery

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Tax enforcement activities:Evidence on the impact of a threat-of-audit letter

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Economic and Political Studies 2024年第2期12卷 188-206页

作者： carlo V.Fiorio Alessandro Santoro Department of Economics Management and Quantitative Methods(DEMM)University of MilanMilanItaly The Research Institute for the Evaluation of Public Policies Bruno Kessler Foundation(FBK-IRVAPP)TrentoItaly Dondena Centre MilanItaly Department of Economics Management and Statistics(DEMS)University of Milan-BicoccaMilanItaly Centre for European Studies(CefES) University of Milan-BicoccaMilanItaly

As part of their ordinary enforcement activities,tax authorities around the world use letters and other forms of personalised communications to elicit tax compliance at a low *** literature shows that the impact of a threat-of-audit letter(TAL)depends critically on the credibility of the letter which,in turn,depends on the information disclosed to the *** study a TAL that is credible because it also uses third-party information to target a form of cost manipulation but,at the same time,incentivises alternative forms of cost manipulation by not targeting *** find that the direct impact on the targeted cost manipulation is stronger than the strategic increase in other costs,and therefore the overall effect of the TAL on taxable income is *** approach can be applied to any letter or enforcement action that reveals information to taxpayers and thus prompts their strategic *** observing the taxpayers’responses along all relevant dimensions,the tax authority can evaluate the impact of the strategy and also obtain valuable information to target future enforcement activities.

关键词： Tax compliance by businesses threat-of-audit letter difference-indifferences small business taxation

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