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原子能科学技术 2021年第12期55卷 2237-2250页

作者：韩宁李龙刘新赞刘书焕马勇熊艳丽李炳均张国和 carlo ettore fiorini 陈伟西安交通大学能源与动力工程学院陕西西安710049 河北经贸大学信息技术学院河北石家庄050061 西安交通大学微电子学院陕西西安710049 米兰理工大学电子信息与生物工程系意大利米兰20133 西北核技术研究所陕西西安710024

基于Si CMOS技术的前端读出ASIC主要是根据3D Si PIN阵列热中子探测器的输出信号特性设计的。所设计的读出ASIC的主要电路模块包括电荷灵敏放大器(CSA)、模拟开关设计、具有三级电荷灵敏自动转换的自动增益控制模块(AGC)、相关双采样(C... 详细信息

基于Si CMOS技术的前端读出ASIC主要是根据3D Si PIN阵列热中子探测器的输出信号特性设计的。所设计的读出ASIC的主要电路模块包括电荷灵敏放大器(CSA)、模拟开关设计、具有三级电荷灵敏自动转换的自动增益控制模块(AGC)、相关双采样(CDS)和基准电流源电路。仿真结果表明,前端电路的输入动态范围为10 fC~8.0 pC。根据热中子探测器输出信号特性设计的ASIC的3个增益系数分别为1.9 V/pC、0.39 V/pC和94 mV/pC。所设计的ASIC的积分非线性小于1%。单通道静态功耗约为5.36 mW。零输入探测器电容时的等效噪声电荷为241.6e;。计数率可达1 MHz。

关键词：前端读出电路宽动态范围电荷灵敏前置放大器

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Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca Di Gianfrancesco Angelo Porreca Francesco Del Giudice ettore De Berardinis carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples Federico Il Naples 80126Italy G.E.Palade University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

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Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma:a prospective cohort study

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Frontiers of Medicine 2021年第1期15卷 101-107页

作者： Maura Massimino Marta Podda Lorenza Gandola Emanuele Pignoli ettore Seregni carlo Morosi Filippo Spreafico Andrea Ferrari Emilia Pecori Monica Terenziani Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale dei TumoriMilan 20146Italy Pediatric Radiotherapy Unit Fondazione IRCCS Istituto Nazionale dei TumoriMilan 20146Italy Medical Physics Unit Fondazione IRCCS Istituto Nazionale dei TumoriMilan 20146Italy Department of Nuclear Medicine Fondazione IRCCS Istituto Nazionale dei TumoriMilan 20146Italy Department of Radiology Fondazione IRCCS Istituto Nazionale dei TumoriMilan 20146Italy

Primary hypothyroidism commonly occurs after radiotherapy(RT),and coincides with increased circulating thyroid-stimulating hormone(TSH)*** tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma(HL)in a prospective cohort *** 1998 to 2001,a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL,scheduled for craniospinal irradiation and mediastinum/neck radiotherapy,respectively,underwent thyroid ultrasound and free triiodothyronine(FT3),free thyroxine(FT4),and TSH evaluation at the beginning and end of craniospinal *** 14 days before and up to the end of radiotherapy,patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3μIU/*** follow-up,blood tests and ultrasound were repeated;primary hypothyroidism was considered an increased TSH level greater than normal ***-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels˂0.3μIU/mL and well matched for other *** years on,hypothyroidism-free survival rates differed significantly,being 60%±15%and 15.6%±8.2%in TSH-suppressed ***-TSH suppressed patients,respectively(P=0.001).These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae,but it should be confirmed in a larger cohort.

关键词： iatrogenic primary hypothyroidism late effects of radiotherapy long-term follow-up medulloblastoma Hodgkin lymphoma

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