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Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation

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World Journal of Gastroenterology 2005年第38期11卷 5944-5950页

作者： Pierluigi Toniutto carlo Fabris Claudio Avellini Rosalba Minisini Davide Bitetto Elisabetta Rossi carlo Smirne Mario Pirisi Liver Transplantation Unit Pathology Department of Medical Sciences

AIM: To investigate how weight gain after OLT affects the speed of fibrosis progression (SFP) during recurrent hepatitis C virus (HCV) infection of the ***: Ninety consecutive patients (63 males,median age 53 years; 55 with HCV-related liver disease),transplanted at a single institution, were studied. All were followed for at least 2 years after OLT and had at least one follow-up graft biopsy, performed not earlier than 1 year after the transplant operation. For each biopsy, a single,experienced pathologist gave an estimate of both the staging according to Ishak and the degree of hepatic *** SFP was quantified in fibrosis units/month (FU/mo).The lipid metabolism status of patients was summarized by the plasma triglycerides/cholesterol (T/C) ratio. Body mass index (BMI) was measured before OLT, and 1 and 2 years after ***: In the HCV positive group, the highest SFP was observed in the first post-OLT year. At that time point,a SFP ≤0.100 FU/mo was observed more frequently among recipients who had received their graft from a young donor and had a pre-transplant BMI value ＞26.0 kg/m2. At completion of the first post-transplant year, a BMI value ＞26.5 kg/m2 was associated with a T/C ratio ≤1. The proportion of patients with SFP ＞0.100 FU/mo descended in the following order: female recipients with a high T/C ratio, male recipients with high T/C ratio, and recipients of either gender with low T/C ratio. Hepatic steatosis was observed more frequently in recipients who, in the first post-transplant year, had increased their BMI ≥1.5 kg/m2 in comparison to the pre-transplant value. Hepatic steatosis was inversely associated with the staging ***: Among HCV positive recipients, excessweight gain post-OLT does not represent a factor favoring early liver fibrosis development and might even be protective against it.

关键词： Liver transplantation Hepatitis C infection Liver fibrosis Liver steatosis Body mass index

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Injectable versus oral first-line multiple sclerosis therapies:knows and unknowns from observational studies

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Neural Regeneration Research 2022年第3期17卷 567-568页

作者： Emanuele D’Amico Aurora Zanghì carlo Avolio Department“G.F.Ingrassia” MS CenterUniversity of CataniaCataniaItaly Department of Medical and Surgical Sciences University of Foggia Multiple Sclerosis Center Department of NeurosciencesPoliclinico Riuniti HospitalFoggiaItaly

The approval of oral disease modifying therapies(DMTs) for relapsing-remitting multiple sclerosis(RRMS) has changed considerably the therapeutic scenario and they often represent the first therapeutic choice for patie... 详细信息

关键词： al. therapies sclerosis

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Synaptic alterations as a common phase in neurological and neurodevelopmental diseases: JNK is a key mediator in synaptic changes

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Neural Regeneration Research 2023年第3期18卷 531-532页

作者： Clara Alice Musi carlo Bonadonna Tiziana Borsello Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanoItaly Mario Negri Insitute for Pharmacolgical Research-IRCCS MilanoItaly

Brain synapses play a key role in neuronal communication:this“conversation”is at the basis of all brain activities and synaptic dysfunction leads to brain *** study the modulators of this crucial synaptic function and we here present the evidence supporting the c-Jun N-terminal kinase(JNK)pathway as a pivotal actor in this scenario.

关键词： alterations diseases neurological

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Choice for China:What Role for Vocational Education in Green Growth?

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China & World Economy 2014年第5期22卷 55-75页

作者： carlo Jaeger Beijing Normal University

Green growth cannot succeed without significant changes in the education system and the closely related social division of labor. This paper combines historical evidence and a game-theoretic analysis to study the relation between vocational education and green growth. It is found that a low-vocation and a high-vocation equilibrium can be distinguished in the interplay between education and labor markets, and that a high-vocation equilibrium is better suited for green growth. A t the present stage of development, there are tendencies in both directions in China. Therefore, China has the possibility to successfully implement a green growth strategy by developing a strong vocational education with Chinese characteristics.

关键词： China green growth vocational education

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miRNAs in precancerous lesions of the gastrointestinal tract

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World Journal of Gastroenterology 2011年第48期17卷 5231-5239页

作者： Matteo Fassan carlo M Croce Massimo Rugge Department of Medical Diagnostic Sciences and Special Therapies Surgical Pathology and Cytopathology Unit University of Padova Department of Oncological and Surgical Sciences General Oncology Unit University of Padova Comprehensive Cancer Center Ohio State University Istituto Oncologico del Veneto-IOV-IRCCS

In spite of the well-established understanding of the phenotypic lesions occurring in the shift from native epithelia to invasive （adeno） carcinoma, the molecular b/ping of the precancerous changes in the gastrointes- tinal tract remains unreliable. In recent years, no biomarkers have aroused as much interest as the miRNAs, a class of non-coding RNA molecules that function as endogenous silencers of numerous target genes. Aberrant miRNA expression is a hallmark of human disease, including cancer. Unlike most mRNAs, miRNAs are both long-living in vivo and very stable in vitro. Such charac- teristics allow their testing in paraffin-embedded tissue samples, which is essential in the biological profiling of small （phenotypically characterized） preneoplastic lesions of the gastrointestinal tract （as well as in other fields of human pathology）. The upcoming challenge lies in the reliable identification of disease-specific targets of dysregulated miRNAs, to enable miRNA testing in the clinical management of the secondary prevention of gastrointestinal cancer.

关键词： miRNA Dysplasia Barrett's esophagus Atro-phic gastritis Inflammatory bowel disease

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Electromagnetic chirality induced by graphene inclusions in multilayered metamaterials

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Photonics Research 2014年第5期2卷 121-125页

作者： carlo Rizza Elia Palange Alessandro Ciattoni Dipartimento di Scienza e Alta Tecnologia Universitàdell’Insubriavia Valleggio 1122100 ComoItaly Consiglio Nazionale delle Ricerche CNR-SPIN67100 Coppito L’AquilaItaly Dipartimento di Scienze fisiche e chimiche Universitàdi L’Aquilavia Vetoio67100 Coppito L’AquilaItaly

We theoretically investigate the electromagnetic response of a novel class of multilayered metamaterials obtained by alternating graphene sheets and dielectric layers,the whole structure not exhibiting a plane of reflection symmetry along the stacking *** show that the electromagnetic response of the structure is characterized by a magneto-electric coupling described by an effective chiral *** the intrinsic tunability of graphene–light coupling,we prove that one can tune both the dielectric and the chiral electromagnetic response by varying the graphene chemical potential through external voltage gating.

关键词： parameter. dielectric chiral

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Estimation of the Lyman-α signal of the EFILE diagnostic under static or radiofrequency electric field in vacuum

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Plasma Science and Technology 2018年第7期20卷 1-6页

作者： carlo POGGI Theo GUILLAUME Fabrice DOVEIL Laurence CHIERIGIER-KOVACIC Consorzio RFX Corso Stati UnitiI-35127 PadovaItaly Aix-Marseille Universite CNRSPIIM UMR 7345F-13397 Marseille Cedex 20France

The electric field induced Lyman-a emission diagnostic aims to provide a non intrusive and precise measurement of the electric field in plasma, using a beam of hydrogen atoms prepared in the metastable 2s state. The metastable particles are obtained by means of a proton beam extracted from a hydrogen plasma source, and neutralised by interaction with vaporised caesium. When a 2s atom enters a region where an electric field is present, it undergoes a transition to the 2p state （Stark mixing）. It then quickly decays to the ground level, emitting Lyman-a radiation, which is collected by a photomultiplier. The 2s → 2p transition rate is proportional to the square of the magnitude of the electric field, and depends on the field oscillation frequency （with peaks around l GHz）. By measuring the intensity of the Lyman-a radiation emitted by the beam it is possible to determine the magnitude of the field in a defined region. In this work, an analysis of the behaviour of the diagnostic under static or radiofrequency electric field is presented. Electric field simulations obtained with a finite element solver of Maxwell equations, combined with theoretical calculations of the Stark mixing transition rate, are used to develop a model for the interpretation of photomultiplier data. This method shows good agreement with experimental results for the static field case, and allows to measure the field magnitude for the oscillating case.

关键词： electric field measurement electromagnetic simulations Stark effect plasma diagnostics

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Optimal Gait for Bioinspired Climbing Robots Using Dry Adhesion： A Quasi-Static Investigation

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Journal of Bionic Engineering 2013年第1期10卷 1-11页

作者： Paolo Boscariol Michael A. Henrey Yasong Li carlo Menon MENRVA Research Group School of Engineering Science Simon Fraser University Burnaby BC V5A 1S6 Canada

Legged robots relying on dry adhesives for vertical climbing are required to preload their feet against the wall to increase contact surface area and consequently maximize adhesion force. Preloading a foot causes a redistribution of forces in the entire robot, including contact forces between the other feet and the wall. An inappropriate redistribution of these forces can cause irreparable detachment of the robot from the vertical surface. This paper investigates an optimal preloading and detaching strategy that minimizes energy consumption, while retaining safety, during locomotion on vertical surfaces. The gait of a six-legged robot is planned using a quasi-static model that takes into account both the structure of the robot and the character- istics of the adhesive material. The latter was modelled from experimental data collected for this paper. A constrained optimi- zation routine is used, and its output is a sequence of optimal posture and motor torque set-points.

关键词： climbing robot dry adhesive gait planning legged robots preloading

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A Biomimetic Climbing Robot Based on the Gecko

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Journal of Bionic Engineering 2006年第3期3卷 115-125页

作者： carlo Menon Metin Sitti Carnegie Mellon University Pittsburgh Pennsylvania 15213-389 USA

The excellent climbing performance of the gecko is inspiring engineers and researchers for the design of artificial systems aimed at moving on vertical surfaces. Climbing robots could perform many useful tasks such as surveillance, inspection, repair, cleaning, and exploration. This paper presents and discusses the design, fabrication, and evaluation of two climbing robots which mimic the gait of the gecko. The first robot is designed considering macro-scale operations on Earth and in space. The second robot, whose motion is controlled using shape memory alloy actuators, is designed to be easily scaled down for micro-scale applications. Proposed bionic systems can climb up 65 degree slopes at a speed of 20 mm·s^-1.

关键词： gecko robotics biomimetics climbing space memory alloy

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Large Eddy Simulation of the By-pass Transition Process under Different Inlet Turbulence Conditions

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Journal of Thermal Science 2021年第6期30卷 2112-2121页

作者： BARSI Dario COSTA carlo LENGANI Davide SIMONI Daniele UBALDI Marina DIME-University of Genova Via Montallegro 11-16145 GenovaItaly

The transition process of the boundary layer developing over a flat plate with elevated inlet Free Stream Turbulence Intensity(FSTI)has been studied by means of Large Eddy Simulation(LES).To this purpose,four cases with different inflow disturbances have been tested varying the magnitude and the length scale of *** has been performed by using the finite-volume ANSYS Fluent *** computational domain,which was constituted by a rectangular domain with a zero thickness plate,was based on an ERCOFTAC test case in order to provide a validation with a well-known set of data by comparing the boundary layer integral parameters and mean and fluctuating streamwise velocity *** four cases were discussed within the paper by looking at classical statistical properties as well as advanced post-processing *** was shown that the decrease in the free stream turbulence level postpones the transition location,whereas the variation of the integral length scale has a very low influence on the distribution of the time-mean flow *** Orthogonal Decomposition(POD)has been applied to the instantaneous LES flow fields in order to provide a statistical representation of the structures responsible for transition and their response to free-stream turbulence intensity and length *** presence of vortical filaments parallel to the wall,typically referred as boundary layer streaks,is clearly identified;their characteristic dimensions and how they change as a function of FSTI properties were analyzed within the paper.

关键词： by-pass transition Large Eddy Simulation(LES) Proper Orthogonal Decomposition(POD) boundary layer streaks

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