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Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: A case report and a review of literature

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World Journal of Gastroenterology 2006年第32期12卷 5234-5236页

作者： Chiara Riviello Ilaria Tanini Greta Cipriani Pietro Pantaleo carlo nozzoli Alberto Poma Viligiardi Riccardo Andrea Valeri Second Division of General and Vascular Surgery Careggi Hospital FlorenceItaly Department of Internal Medicine Oncologic Day-Hospital University of Florence Italy Second Division of Internal Medicine Careggi Hospital FlorenceItaly

Renal cell carcinoma （RCC） is the most common renal tumor, accounting for 2%-3% of all malignancies. Though RCC is known to spread hematogenously, isolated RCC metastasis to the stomach is a rare event. In this article, we describe the clinical course of a patient who developed a pancreatic recurrence of RCC and 1 year later a gastric recurrence of RCC treated 10 years ago with a resection and interleukin-2 （IL-2）. Accumulating evidence indicates that metastatic involvement of the pancreas and stomach should be suspected in any patient with a history of RCC who presents with gastrointestinal symptoms even 10 years after RCC resection and immunotherapy.

关键词： Renal cell carcinoma Stomach metastasis Interleukin-2 treatment

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Acute heart failure in the elderly:setting related differences in clinical features and management

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Journal of Geriatric Cardiology 2021年第6期18卷 407-415页

作者： Francesco Orso Alessandra Pratesi Andrea Herbst Anna Chiara Baroncini Francesca Bacci Gabriele Ciuti Andrea Berni Camilla Tozzetti carlo nozzoli Alberto Moggi Pignone Loredana Poggesi Luciano Gabbani Mauro Di Bari Francesco Fattirolli Massimo Milli Andrea Ungar NiccolòMarchionni Samuele Baldasseroni Heart Failure Clinic Division of Geriatric Medicine and Intensive Care UnitAzienda Ospedaliero-Universitaria CareggiFlorenceItaly Department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Divisions of Internal Medicine 1 Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Divisions of Internal Medicine 4 Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Divisions of Internal Medicine 3 Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Division of Medical-Geriatric Department Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Department of Cardiothoracovascular Medicine Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Division of Cardiology Santa Maria Nuova HospitalFlorenceItaly

BACKGROUND Administrative data show that acute heart failure(HF)patients are older than those enrolled in clinical registries and frequently admitted to non-cardiological settings of *** purpose of this study was to describe clinical characteristics of old patients hospitalised for acute HF in Cardiology,Internal Medicine or Geriatrics *** Data came from ATHENA(AcuTe Heart failurE in advaNced Age)registry which included elderly patients(≥65 years)admitted to the above mentioned settings of care from December 1,2014 to December 1,*** We enrolled 396 patients,15.4%assigned to Cardiology,69.7%to Internal Medicine,and 14.9%to a Geriatrics *** age was 83.5±7.6 years(51.8%of patients≥85 years)and was higher in patients admitted to Geriatrics(P<0.001);more than half were *** treatments did not differ significantly among settings of care(in a context of a low prescription rate of renin-angiotensin-aldosterone system inhibitors)whereas significant differences were observed in comorbidity patterns and management guidelines recommendation adherence for decongestion evaluation with comparison of weight and N-terminal pro-B-type natriuretic peptide levels on admission and at discharge(both P=0.035 and P<0.001),echocardiographic evaluation(P<0.001)and follow-up visits planning(P<0.001),all higher in *** in-hospital length of stay was 9±5.9 days,significantly higher in Geriatrics(13.7±6.5 days)and Cardiology(9.9±6.7 days)compared to Internal Medicine(8±5.2 days),P<***-hospital mortality was 9.3%,resulting higher in Geriatrics(18.6%)and Cardiology(16.4%)than Internal Medicine(5.8%),P=*** In elderly patients hospitalised for acute HF,clinical characteristics and management differ significantly according to the setting of admission.

关键词： admitted clinical acute

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