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Occupational exposures and colorectal cancers:A quantitative overview of epidemiological evidence

World Journal of Gastroenterology 2014年第35期20卷 12431-12444页

作者： Enrico Oddone carlo modonesi Gemma Gatta Department of Public Health Experimental and Forensic MedicineOccupational Medicine UnitUniversity of Pavia Department of Biosciences Natural History MuseumUniversity of Parma Department of Preventive and Predictive Medicine Evaluative Epidemiology UnitFondazione IRCCS Istituto Nazionale dei Tumori

A traditional belief widespread across the biomedical community was that dietary habits and genetic predisposition were the basic factors causing colorectal *** more recent times,however,a growing evidence has shown that other determinants can be very important in increasing(or reducing) incidence of this *** hypothesis that environmental and occupational risk factors are associated with colorectal cancer is gaining ground,and high risks of colorectal cancer have been reported among workers in some industrial *** aim of this study was to investigate the epidemiologic relationship between colorectal cancer and occupational exposures to several industrial activities,by means of a scientific literature review and *** work pointed out increased risks of colorectal cancer for labourers occupied in industries with a wide use of chemical compounds,such as leather(RR = 1.70,95%CI:1.24-2.34),basic metals(RR = 1.32,95%CI:1.07-1.65),plastic and rubber manufacturing(RR = 1.30,95%CI:0.98-1.71 and RR = 1.27,95%CI:0.92-1.76,respectively),besides workers in the sector of repair and installation of machinery exposed to asbestos(RR = 1.40,95%CI:1.07-1.84).Based on our results,the estimated crude excess risk fraction attributable to occupational exposure ranged from about 11% to about 15%.However,homogeneous pattern of association between colorectal cancer and industrial branches did not emerge from this review.

关键词： Colorectal cancer Occupational exposures Public health Chemical compounds Basic metals Meta analysis

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Thermal and Electrical Modelling of a CPV/T System Varying Its Configuration

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Journal of Thermal Science 2019年第1期28卷 123-132页

作者： RENNO carlo Department of Industrial Engineering University of Salerno

In this paper, the main aim is the performances modelling from the electrical and thermal point of view of a concentrating photovoltaic and thermal(CPV/T) system in order to evaluate the primary energy and economic savings respect to a traditional system, when the same energy loads are satisfied. This study is realized by both varying the CPV/T system configuration and considering two different users. In particular, the point-focus(PF), and linear focus(LF) configurations of the CPV/T system are considered in order to match the residential user and hotel energy loads. The CPV/T system is sized adopting as input data: the Direct Normal Irradiance(DNI) modelled by an artificial neural network and the users' energy demands. In these hypotheses, the performances of the PF and LF systems are evaluated and then compared for the two users located in Southern Italy, in terms of electrical and thermal energy production, cells number, space occupied, energy and economic savings and CO2 emissions avoided. Finally, the PF system shows a lower simple pay-back and a higher primary energy saving, while the space occupied by a LF system results to be lower respect to the PF configuration.

关键词： CPV/T system point-focus configuration linear focus configuration thermal analysis electrical analysis primary energy saving economic analysis

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Reliability based multiobjective optimization for design of structures subject to random vibrations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 15-25页

作者： Giuseppe carlo MARANO Department of Environmental Engineering and Sustainable Development Technical University of Bari viale del Turismo 10-74100 Taranto Italy

Based on a multiobjective approach whose objective function (OF) vector collects stochastic reliability performance and structural cost indices, a structural optimization criterion for mechanical systems subject to random vibrations is presented for supporting engineer’s design. This criterion differs from the most commonly used conventional optimum design criterion for random vibrating structure, which is based on minimizing displacement or acceleration variance of main structure responses, without considering explicitly required performances against failure. The proposed criterion can properly take into account the design-reliability required performances, and it becomes a more efficient support for structural engineering decision making. The multiobjective optimum (MOO) design of a tuned mass damper (TMD) has been developed in a typical seismic design problem, to control structural vibration induced on a multi-storey building structure excited by nonstationary base acceleration random process. A numerical example for a three-storey building is developed and a sensitivity analysis is carried out. The results are shown in a useful manner for TMD design decision support.

关键词： Structural optimization Multiobjective optimization (MOO) Random vibration Tuned mass damper (TMD)

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Multi-Scale Compliant Foot Designs and Fabrication for Use with a Spider-Inspired Climbing Robot

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Journal of Bionic Engineering 2008年第3期5卷 189-196页

作者： Dan Sameoto carlo Menon MENRVA Group School of Engineering Science Simon Fraser University Burnaby BC V5A 1S6 Canada

Climbing robots are of potential use for surveillance, inspection and exploration in different environments. In particular, the use of climbing robots for space exploration can allow scientists to explore environments too challenging for traditional wheeled designs. To adhere to surfaces, biomimetic dry adhesives based on gecko feet have been proposed. These biomimetic dry adhesives work by using multi-scale compliant mechanisms to make intimate contact with different surfaces and adhere by using Van der Waals forces. Fabrication of these adhesives has frequently been challenging however, due to the difficulty in combining macro, micro and nanoscale compliance. We present an all polymer foot design for use with a hexapod climbing robot and a fabrication method to improve reliability and yield. A high strength, low-modulus silicone, TC-5005, is used to form the foot base and microscale fibres in one piece by using a two part mold. A macroscale foot design is produced using a 3D printer to produce a base mold, while lithographic definition of microscale fibres in a thick photoresist forms the ＇hairs＇ of the polymer foot. The adhesion of the silicone fibres by themselves or attached to the macro foot is examined to determine best strategies for placement and removal of feet to maximize adhesion. Results demonstrate the successful integration of micro and macro compliant feet for use in climbing on a variety of surfaces.

关键词： biomimetics dry adhesive gecko climbing robot MEMS silicone

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Enhanced Compliant Adhesive Design and Fabrication with Dual-Level Hierarchical Structure

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Journal of Bionic Engineering 2010年第3期7卷 228-234页

作者： Dan Sameoto carlo Menon Department of Mechanical Engineering University of Alberta MENRVA Lab School of Engineering ScienceSimon Fraser University

Synthetic dry adhesives inspired by the nano-and micro-scale hairs found on the feet of geckos and some spiders have beendeveloped for almost a decade. Elastomeric single level micro-scale mushroom shaped fibres are currently able to function evenbetter than natural dry adhesives on smooth surfaces under normal loading. However, the adhesion of these single level syntheticdry adhesives on rough surfaces is still not optimal because of the reduced contact surface area. In nature, contact area ismaximized by hierarchically structuring different scales of fibres capable of conforming surface roughness. In this paper, weadapt the nature’s solution arid propose a novel dual-level hierarchical adhesive design using Polydimethylsiloxane (PDMS),which is tested under peel loading at different orientations. A negative macro-scale mold is manufactured by using a laser cutterto define holes in a Poly(methyl methacrylate) (PMMA) plate. After casting PDMS macro-scale fibres by using the obtainedPMMA mold, a previously prepared micro-fibre adhesive is bonded to the macro-scale fibre substrate. Once the bondingpolymer is cured, the micro-fibre adhesive is cut to form macro scale mushroom caps. Each macro-fibre of the resulting hierarchicaladhesive is able to conform to loads applied in different directions. The dual-level structure enhances the peel strengthon smooth surfaces compared to a single-level dry adhesive, but also weakens the shear strength of the adhesive for a given areain contact. The adhesive appears to be very performance sensitive to the specific size of the fibre tips, and experiments indicatethat designing hierarchical structures is not as simple as placing multiple scales of fibres on top of one another, but can requiresignificant design optimization to enhance the contact mechanics and adhesion strength.

关键词： biomimetics dry adhesive hierarchical dual-level adhesive silicone polymer

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Probabilistic seismic response and reliability assessment of isolated bridges

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Earthquake Engineering and Engineering Vibration 2005年第1期4卷 95-106页

作者： Giuseppe carlo Marano Department of Environmental Engineering and Sustainable Development Technical University of BariTarantoItalyAssistantProfessor

Bridge seismic isolation strategy is based on the reduction of shear forcestransmitted from the superstructure to the piers by two means: shifting natural period andearthquake input energy reduction by dissipation concentrated in protection devices. In this paper,a stochastic analysis of a simple isolated bridge model for different bridge and device parametersis conducted to assess the efficiency of this seismic protection strategy. To achieve this aim, asimple nonlinear softening constitutive law is adopted to model a wide range of isolation devices,characterized by only three essential mechanical parameters. As a consequence of the random natureof seismic motion, a probabilistic analysis is carried out and the time modulated Kanai-Tajimistochastic process is adopted to represent the seismic action. The response covariance in the statespace is obtained by solving the Lyapunov equation for a stochastic linearized system. After asensitivity analysis, the failure probability referred to extreme displacement and the mean value ofdissipated energy are assessed by using the introduced stochastic indices of seismic bridgeprotection efficiency. A parametric analysis for protective devices with different mechanicalparameters is developed for a proper selection of parameters of isolation devices under differentsituations.

关键词： bridge seismic isolation stochastic analysis nonlinear softeningconstitutive law reliability assessment

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Asymmetric Atlantic continental margins

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Geoscience Frontiers 2021年第5期12卷 298-308页

作者： Adriano Vangone carlo Doglioni Dipartimento di Scienze della Terra Sapienza UniversityRomeItaly Istituto Nazionale di Geofisica e Vulcanologia RomeItaly

We analyze the gross crustal structure of the Atlantic Ocean passive continental margins from north to the south,comparing eleven sections of the conjugate *** a general result,the western margins show a sharper continental-ocean transition with respect to the eastern margins that rather show a wider stretched and thinner *** Moho is in average about 5.7±1dipping toward the interior of the continent on the western side,whereas it is about 2.7±1in the eastern ***,the stretched continental crust is on average 244 km wide on the western side,whereas it is up to about 439 km on the eastern side of the *** systematic asymmetry reflects the early stages of the diachronous Mesozoic to Cenozoic continental rifting,which is inferred as the result of a polarized westward motion of both western and eastern plates,being Greenland,Northern and Southern Americas plates moving westward faster with respect to Scandinavia,Europe and Africa,relative to the underlying mantle.

关键词： Passive continental margin Asymmetric rift Moho dip Continental-ocean transition Westward drift of the lithosphere

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Risk,Rationality,and Resilience

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International Journal of Disaster Risk Science 2010年第1期1卷 10-16页

作者： carlo Jaeger Potsdam Institute for Climate Impact Research(PIK) 14473 PotsdamGermany

Improving our ability to cope with large risks is one of the key challenges for humankind in this century. This article outlines a research program in this perspective. Starting with a concrete example of a relatively small disaster, it questions simplistic ideas of rationality. It then proposes a fresh look at the concepts of probability and utility in the context of socioecological systems. This leads first to an emphasis on the problem of equilibrium selection, and then to a distinction between three kinds of resilience that matter both for theory and practice of risk management. They can be investigated by paying attention to the transitions into and out of actual disasters.

关键词： Resilience management. disaster

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AC ripple on DC voltage:Experimental and theoretical investigation of the impact on accelerated ageing in electrical insulation

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High Voltage 2024年第4期9卷 902-910页

作者： Giovanni Gardan Gian carlo Montanari Dipartimento di Ingegneria Industriale Universita degli Studi di PadovaPadovaItaly Center for Advanced Power Systems Florida State UniversityTallahasseeFloridaUSA

With the increasing penetration of DC systems into the high voltage and medium voltage power industry,DC voltage is becoming common for distribution/transmission and to supply different typologies of *** allowable extent of AC ripple superimposed to DC,and its effect on insulation ageing,is a long-term discussed *** most harmful phenomenon causing extrinsic ageing acceleration and insulation system premature failure is partial discharges(PD);thus,the risk of incepting PD due to AC ripple could become a primary issue for electrical asset equipment *** this work,the impact of AC sinusoidal ripple on insulation system life and reliability is dealt with,considering both intrinsic and extrinsic ageing but focusing on the latter,that is,the PD *** are performed to assess how the jump voltage(due to AC ripple)and the DC component impact on PD activity in terms of amplitude and repetition *** the first time,the correlation between the magnitude of jump voltage associated with ripple and PD inception is established,shedding a light on the allowable ripple extent which does not impact significantly on ageing and premature insulation *** approach can provide straightforward tools for design specification and ageing inference of insulation systems.

关键词： impact insulation electrical

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DEM Numerical Simulation of Abrasive Wear Characteristics of a Bioinspired Ridged Surface

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Journal of Bionic Engineering 2010年第2期7卷 175-181页

作者： Mohammad Almagzoub Mohammad carlo Menon Key Laboratory of Bionic Engineering Jilin University College of Biological and Agricultural Engineering Jilin University MENRVA Group Simon Fraser University

This paper presents numerical investigations into a ridged surface whose design is inspired by the geometry of a Farrer’*** objective of the performed research is to assess if the proposed Bioinspired Ridged Surface (BRS) can potentiallyimprove wear resistance of soil-engaging components used in agricultural machinery and to validate numerical simulationsperformed using software based on the Discrete Element Method (DEM).The wear performance of the BRS is experimentallydetermined and also compared with a conventional flat *** size of soil particles and relative velocities between theabrasive sand and the testing surfaces are *** results show that the numerical simulations are in agreement withthe experimental results and support the hypothesis that abrasive wear is greatly reduced by substituting a conventional flatsurface with the BRS.

关键词： bioinspired ridged surface abrasive wear numerical simulation Discrete Element Method (DEM)

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