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Artificial intelligence in the diagnosis and management of colorectal cancer liver metastases

World Journal of Gastroenterology 2022年第1期28卷 108-122页

作者： Gianluca Rompianesi Francesca Pegoraro carlo dl ceresa Roberto Montalti Roberto Ivan Troisi Division of Hepato-Bilio-Pancreatic Minimally Invasive and Robotic SurgeryDepartment of Clinical Medicine and SurgeryFederico II University HospitalNaples 80125Italy Department of Hepato-Pancreato-Biliary Surgery Oxford University Hospitals NHS Foundation TrustOxford OX39ESUnited Kingdom Division of Hepato-Bilio-Pancreatic Minimally Invasive and Robotic SurgeryDepartment of Public HealthFederico II University HospitalNaples 80125Italy

Colorectal cancer(CRC)is the third most common malignancy worldwide,with approximately 50%of patients developing colorectal cancer liver metastasis(CRLM)during the follow-up *** of CRLM is best achieved via a multidisciplinary approach and the diagnostic and therapeutic decision-making process is *** order to optimize patients’survival and quality of life,there are several unsolved challenges which must be *** primarily include a timely diagnosis and the identification of reliable prognostic ***,to allow optimal treatment options,a precision-medicine,personalized approach is *** widespread digitalization of healthcare generates a vast amount of data and together with accessible high-performance computing,artificial intelligence(AI)technologies can be *** increasing diagnostic accuracy,reducing timings and costs,the application of AI could help mitigate the current shortcomings in CRLM *** this review we explore the available evidence of the possible role of AI in all phases of the CRLM natural *** analysis and convolutional neural networks(CNN)which combine computed tomography(CT)images with clinical data have been developed to predict CRLM development in CRC *** models have also proven themselves to perform similarly or better than expert radiologists in detecting CRLM on CT and magnetic resonance scans or identifying them from the noninvasive analysis of patients’exhaled *** application of AI and machine learning(ML)in diagnosing CRLM has also been extended to histopathological examination in order to rapidly and accurately identify CRLM tissue and its different histopathological growth *** and CNN have shown good accuracy in predicting response to chemotherapy,early local tumor progression after ablation treatment,and patient survival after surgical treatment or *** the initial enthusiasm and the accumulating evidence,AI technologies’role i

关键词： Colorectal cancer Liver metastases Artificial intelligence Machine learning Deep learning Neural networks Radiomics

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SIMULATION OF THE THERMODYNAMIC QUANTITIES OF SELF-AVOIDING WALK CHAIN

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Chinese Chemical Letters 1996年第1期7卷 63-66页

作者： Zhao, dl Zhou, XD Huang, Y ACAD SINICA INST CHEMBEIJING 100080PEOPLES R CHINA BEIJING UNIV DEPT PHYSBEIJING 100871PEOPLES R CHINA

A Monte carlo method has been proposed for direct simulating the thermodynamic quantities of a single self-avoiding walk chain with the neighbour interaction on a simple cubic lattice. The simulation data of the conformational entropy of the chain length 16 have been found to be consistent very well with the exact results obtained by the direct counting method.

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Role of nutritional ketosis in the improvement of metabolic parameters following bariatric surgery

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World Journal of Diabetes 2022年第1期13卷 54-64页

作者： Fioralba Pindozzi carlo Socci Massimiliano Bissolati Monica Marchi Elisabetta Devecchi Alessandro Saibene Caterina Conte Unitàdi Chirurgia Generale Provinciale Ospedale del DeltaLagosanto(FE)44023Italy Transplant and Metabolic/Bariatric Surgery Unit IRCCS Ospedale San RaffaeleMilan 20132Italy Department of General Medicine Diabetes and EndocrinologyIRCCS Ospedale San RaffaeleMilan 20132Italy Department of Human Sciences and Promotion of the Quality of Life San Raffaele Open UniversityRome 00166Italy Department of Endocrinology Nutrition and Metabolic DiseasesIRCCS MultiMedicaMilan 20099Italy

BACKGROUND Ketone bodies(KB)might act as potential metabolic modulators besides serving as energy *** metabolic surgery(BMS)offers a unique opportunity to study nutritional ketosis,as acute postoperative caloric restriction leads to increased lipolysis and circulating free fatty *** To characterize the relationship between KB production,weight loss(WL)and metabolic changes following *** For this retrospective study we enrolled male and female subjects aged 18-65 years who underwent BMS at a single *** on demographics,anthropometrics,body composition,laboratory values and urinary KB were *** Thirty-nine patients had data available for analyses[74.4%women,mean age 46.5±9.0 years,median body mass index 41.0(38.5;45.4)kg/m^(2),fat mass 45.2%±6.2%,23.1%had diabetes,43.6%arterial hypertension and 74.4%liver steatosis].At 46.0±13.6 d post-surgery,subjects had lost 12.0%±3.6%of pre-operative ***-nine percent developed *** with nutritional ketosis were significantly younger[42.9(37.6;50.7)years vs 51.9(48.3;59.9)years,P=0.018],and had significantly lower fasting glucose[89.5(82.5;96.3)mg/dl vs 96.0(91.0;105.3)mg/dl,P=0.025]and triglyceride levels[108.0(84.5;152.5)mg/dl vs 152.0(124.0;186.0)mg/dl,P=0.045]vs those with *** 6 mo,percent WL was greater in those with postoperative ketosis(-27.5%±5.1%vs 23.8%±4.3%,P=0.035).Urinary KBs correlated with percent WL at 6 and 12 *** metabolic changes were *** Our data support the hypothesis that subjects with worse metabolic status have reduced ketogenic capacity and,thereby,exhibit a lower WL following BMS.

关键词： Obesity Ketone bodies Bariatric surgery Weight loss Glucose metabolism Lipid metabolism

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The Long Magenstrasse with pyloroplasty as functional gastric bypass: 6-years experience, 308 operations

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Health 2010年第8期2卷 935-940页

作者： carlo Vassallo Giovanni Berbiglia Matteo Carena Centro Multidisciplinare per la cura dell"Obesita Istituto di Cura "Citta di Pavia" Unita operativa di Chirurgia Generale IIa Centro Multidisciplinare per la cura dell"Obesita Istituto di Cura "Citta di Pavia"

Background: The Long Magenstrasse with py-loroplasty as functional Gastric Bypass (briefly LMGBP) procedure for morbid obesity may re- duce the incidence of side effects associated with gastric restrictive and malabsorptive sur- gery, particularly on quality of life and long-term nutritional insufficiency. In follow-up to pre- liminary findings in 34 patients, we report the results of an additional 274 LMGBPs performed over the past 3 years. Methods: Between October 2003 and 2009, 308 patients were treated with the LMGBP. 149 patients underwent open procedures;74, hand-assisted laparoscopic surgery (HALS);and 85 were operated laparo-scopically. 17% had ≥ 125 mg/dl glycemia, 43% sleep apnea, 38% hyperlipidemia, 12% hyperuricemia, and 58% arterial hypertension under treatment. Results: The mean BMI of 256 pre-operatively normoglycemic patients at 1 year was 29 (range 26-31);27 (25-30) in 45 patients at 3 years;and 27.5 (26-30) in 12 patients at 5 years. Mean BMI of 53 preoperatively hyperglycemic patients (≥ 125 mg/dl) at 1 year (21 patients) was 32 (29-34), and at 3 years (9 patients), 32.5 (30- 33). 15 patients with preoperative type 2 diabetes under oral treatment required no therapy 3-6 months after surgery. Patients reported considerable appetite reduction with rapid satiety but maintained good nutrition with no supplementation. There was no mortality. Conclusions: Safe and effective sustained weight loss, positive metabolic changes, and appetite diminution with rapid satiety were seen after LMGBP.

关键词： Morbid Obesity Bariatric Surgery Partial Vagotomy Pyloroplasty Magenstrasse and Mill Gastric Bypass

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Arterioureteral fistula:An unusual cause of haematuria 10 years after the implantation of a synthetic iliac-femoral stent

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Asian Journal of Urology 2023年第4期10卷 563-564页

作者： Luca Ongaro Michele Rizzo Francesco Claps Ottavia Runti Andrea Piasentin carlo Trombetta Giovanni Liguori Department of Urology Cattinara HospitalASUGIUniversity of TriesteTriesteItaly

Dear Editor,The patient had a history of intermittent self-resolving episodes of gross haematuria and was referred to our department for a massive *** presentation,haemoglobin was 8.6 g/dl and creatinine was 1.37 mg/*** was hemodynamically stable,but suffered an important anemization in the subsequent days requiring multiple blood *** his medical history,it was reported that he had type II diabetes mellitus and the implantation of a right iliac-femoral stent 10 years before.

关键词： iliac femoral transfusion

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Ecological Costs Applied in the Bleaching of Cotton： A Study for an Optimized Process

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Journal of Chemistry and Chemical Engineering 2013年第7期7卷 633-636页

作者： Rosa Jorge Marcos Tambourgi Elias Basile Santana Jose carlo Curvelo Carmo Renee Simoes Argolo Arafjo Mauricio de Campos College of Chemistry Engineering State University of Campinas Sao Paulo 03008-020 Brazil Post Graduation Department College of Technology Antoine Skaf Sao Paulo 03008-202 Brazil Production Engineering Post Graduation Program Nine o f July University Sao Paulo 5001-100 Brazil Textile and Fashion Post Graduation Program Sao Paulo University S6o Paulo 03828-000 Brazil

The aim of this paper was to study three variables in hydrogen peroxide bleaching of cotton fabrics： the amount of hydrogen peroxide （H2O2）, peroxide stabilizer （Na2SiO3） and the process temperature. The factorial planning of two levels and three factors was done in order to obtain an optimized recipe for subsequent comparison with commons recipes used in industry. Were evaluated the brightness （dl）, energy consumption （dQ）, H2O2 residual （Rox）, processing time and ecological costs.

关键词： Cotton bleaching factorial planning ecological costs.

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