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Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies

World Journal of Gastroenterology 2007年第30期13卷 4035-4041页

作者： Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio carlo clerici Christoph A Maurer Gieri Cathomas Elisabetta Antonelli Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine University of Perugia Italy 2nd Pathology Department Spedali Civili Brescia Italy Department of Surgery Liestal Hospital Switzerland Department of Pathology Liestal Hospital Switzerland

The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies.

关键词： Enteric glia Glial cells Gastrointestinal motility

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Blood extracellular vesicles (EVs) of central nervous system origin: a window into the brain

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Neural Regeneration Research 2020年第1期15卷 55-56页

作者： Cristina Agliardi Mario clerici IRCCS Fondazione Don carlo Gnocchi MilanoItaly(Agliardi CClerici M) Department of Pathophisiology and Transplantation University of MilanMilanoItaly(Clerici M)

Extracellular vesicles(EVs)are heterogeneous nano-sized vesicles of endocytic origin shed into blood and other body fluids such as urine,saliva,seminal fluid,ascites,amniotic liquid,synovial fluid,breast milk and cerebrospinal fluid(CSF)by quite all cell *** actively contribute to intercellular communication as they carry bioactive molecules that are selectively incorporated by the originating cell and are delivered to recipient cells over long and short distances(Simons and Raposo,2009).EVs can be divided into three main groups according to their size and cellular origin:1)exosomes(40–120 nm),that have an endocytic origin and are formed by inward budding of the limiting membrane of multivescicular bodies,which fuse with the plasma membrane and release exosomes into the extracellular space;2)microvesicles(50–1000 nm),budding directly off the plasma membrane;3)apoptotic bodies(>1000 nm),which are released during *** originating via distinct processes,different subtypes of EVs carry different proteins within their membrane and luminal compartments that reflect the phenotype of the tissue of origin.

关键词： Blood urine origin

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Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles

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Neural Regeneration Research 2022年第7期17卷 1503-1504页

作者： Cristina Agliardi Franca R.Guerini Mario Meloni Mario clerici IRCCS Fondazione Don carlo Gnocchi MilanItaly Department of Pathophysiology and Transplantation University of MilanMilanItaly

The prevalence of Parkinson’s disease(PD)is rapidly increasing,and more than 12 million people are expected to suffer from PD by *** is a highly invalidating neurodegenerative condition that arises from the progressive degeneration of dopaminergic neurons in the substantia nigra pars *** main cause for such degeneration is the formation of cytoplasmic inclusions known as Lewy bodies.

关键词： degeneration Alpha prevalence

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Can the detection of IgA anti-Mycoplasma pneumoniae added to IgM increase diagnostic accuracy in patients with infections of the lower respiratory airways?

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World Journal of Clinical Infectious Diseases 2016年第4期6卷 67-72页

作者： Massimo De Paschale Teresa Cerulli Debora Cagnin Alessia Paganini Maria Teresa Manco Luisa Belvisi Cristina Morazzoni Laura Marinoni carlo Agrappi Paola Mirri Pierangelo clerici Microbiology Unit ASST-Ovest Milanese Hospital of Legnano

AIM To evaluate the increase in diagnostic yield, by using IgA in addition to IgM, instead of IgM alone, in relation to the age of the *** The study considered 1067 blood samples from patients with clinical signs of lower respiratory tract infections, tested for anti-Mycoplasma IgG, IgM and IgA *** The increase in diagnostic yield with IgA, compared to IgM detection alone was of 3.5% with statistically significant differences between age groups(0.8% for those equal/under 50 years of age and 4.3% for those over 50).CONCLUSION Our findings demonstrate that IgA detection lead to a twofold increase in the number of diagnoses among the older age groups, but it did not result in relevant increase among the younger age groups.

关键词： Community-acquired infections Diagnostic yield Elderly patients IgA Mycoplasma pneumoniae

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