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Efficacy of penile low-intensity shockwave treatment for erectile dysfunction:correlation with the severity of cavernous artery disease

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Asian Journal of Andrology 2021年第5期23卷 462-467页

作者： Nicola Caretta Maurizio De Rocco Ponce Nadia Minicuci ilaria De Santis Pierfrancesco Palego Andrea Garolla carlo Foresta Department of Medicine University of PadovaPadova 35128Italy CNR Neuroscience InstitutePadova 35128Italy Foresta Foundation Onlus for Biomedical Research Padova 35128Italy

We analyzed the efficacy of penile low-intensity extracorporeal shockwave treatment for erectile dysfunction(ED)combined with cavernous artery disease(CAD).ED was evaluated by the International Index of Erectile Function,subdividing patients into mild and moderate/severe *** was assessed using penile color Doppler ***(n=111)with a positive outcome after treatment,based upon the minimal clinically important difference of the International Index of ED,were followed up for 3 months and 6 *** found a significant mean increase in the index of erectile function,with an overall improvement in hemodynamic parameters of the cavernous *** particular,93.9%of the patients with mild ED without CAD responded to treatment and 72.7%resumed normal erectile *** 31.2%of the patients with moderate/severe ED and CAD responded to treatment,and none resumed normal erectile *** patients with mild ED and no CAD maintained the effects of therapy after 3 months,while no patients with moderate/severe ED and CAD maintained the benefits of treatment after 3 ***,patients with mild ED and no CAD have better and longer lasting responses to such treatment,with a higher probability of resuming normal erectile function than patients with moderate/severe ED and CAD.

关键词： cavernous artery disease erectile dysfunction extracorporeal shockwave therapy International Index of Erectile Dysfunction penile color Doppler ultrasound

Red-emitting tetraphenylethylene derivative with aggregation-induced enhanced emission for luminescent solar concentrators:A combined experimental and density functional theory study

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Aggregate 2022年第2期3卷 177-186页

作者： Cosimo Micheletti Qinfan Wang Francesco Ventura Michele Turelli ilaria Ciofini carlo Adamo Andrea Pucci Department of Chemistry and Industrial Chemistry University of PisaPisaItaly École nationale supérieure de chimie de Paris Centre national de la recherche scientifiqueInstitute of Chemistry for Life and Health SciencesPSL Research UniversityParisFrance Institut Universitaire de France ParisFrance

This study examines the use of an aggregation-induced enhanced emission fluorophore(TPE-MRh)to prepare red-emitting luminescent solar concentrators(LSCs)based on poly(methyl methacrylate)(PMMA)and poly(cyclohexyl methacrylate)(PCMA).TPE-MRh is a tetraphenylethylene(TPE)derivative bearing two dimethylamino push groups and a 3-methyl-rhodanine pull moiety,with absorption maxima at around 500 nm and fluorescence peak at 700 nm that strongly increases in ***-MRh displays a typical crystallizationinduced enhanced emission that has been rationalized by modeling the compound behavior in solution and solid-state via density functional theory calculations with the inclusion of the ***-MRh dispersed into 5×5 cm2 polymer films with a thickness of 25±5μm has revealed a partial fluorescence quenching with fluorophore *** yields(QYs)below 10%for the 2 wt.%of doping have been addressed to the formation of less emissive micro-sized clusters of *** slabs with the same surface size but 3 mm of thickness and 200 ppm of TPE-MRh have provided QY of 36.5%thanks to the attenuation of the detrimental effects of fluorophore *** feature is reflected in the LSCs performance,with devices achieving the largest power collected by the photovoltaic cell.

关键词： aggregation-induced enhanced emission density functional theory luminescent solar concentrators poly(methyl methacrylate) tetraphenylethylene core

Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

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World Journal of Clinical Pediatrics 2025年第1期14卷 69-77页

作者： Valentina Giorgio ilaria Venezia Licia Pensabene Elisa Blasi Donato Rigante Paolo Mariotti Giuseppe Stella Gaia Margiotta Giovanna Quatrale Giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani Pediatric Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Child Neuropsychiatry Unit ASST Santi Paolo e CarloSan Paolo HospitalMilan 20142Italy Child Neuropsychiatry Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medical and Surgical Sciences Pediatric UnitUniversity Magna GraeciaCatanzaro 88100Italy Unit of Psychiatry Fondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario"A.Gemelli"IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in *** To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without *** One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy *** filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of *** Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关键词： Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients

Hepatitis B virus recurrence after liver transplantation: An old tale or a clear and present danger?

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World Journal of Gastroenterology 2020年第18期26卷 2166-2176页

作者： ilaria Lenci Martina Milana Giuseppe Grassi Tommaso M Manzia carlo Gazia Giuseppe Tisone Roberta Angelico Leonardo Baiocchi Hepatology and Liver Transplant Unit University of Tor VergataRome 00133Italy Hepato-Pancreato-Biliary and Transplant Department of SurgeryUniversity of Rome Tor VergataRome 00133Italy

Hepatitis B virus(HBV) recurrence after liver transplantation(LT) has been described more than 50 years ago. Similarly, to other clinical conditions, in which impairment of host immune defense favors viral replication, early reports described in details recurrence and reactivation of HBV in liver transplant recipients. The evidence of a possible, severe, clinical evolution of HBV reappearance in a significant percentage of these patients, allowed to consider,for some years, HBV positivity a contraindication for LT. Moving from the old to the new millennium this picture has changed dramatically. Several studies contributed to establish efficient prophylactic protocols for HBV recurrence and with the advent of more potent anti-viral drugs an increased control of infection was achieved in transplanted patients as well as in the general immunecompetent HBV population. Success obtained in the last decade led some authors to the conclusion that HBV is now to consider just as a "mere nuisance".However, with regard to HBV and LT, outstanding issues are still on the table:(1)A standard HBV prophylaxis protocol after transplant has not yet been clearly defined;(2) The evidence of HBV resistant strains to the most potent antiviral agents is claiming for a new generation of drugs;and(3) The possibility of prophylaxis withdrawal in some patients has been demonstrated, but reliable methods for their selection are still lacking. The evolution of LT for HBV is examined in detail in this review together with the description of the strategies adopted to prevent HBV recurrence and their pros and cons.

关键词： Liver transplant Hepatitis B virus Viral recurrence Prophylaxis Minimization Antiviral drug

Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis

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World Journal of Hepatology 2019年第6期11卷 489-512页

作者： Daniela Campion ilaria Giovo Paola Ponzo Giorgio M Saracco Federico Balzola carlo Alessandria Division of Gastroenterology and Hepatology Città della Salute e della Scienza di Torino Hospital University of Turin

Hepatic encephalopathy(HE)is a common and serious neuropsychiatric complication of cirrhosis,acute liver failure,and porto-systemic *** largely contributes to the morbidity of patients with liver disease,severely affecting the quality of life of both patients and their relatives and being associated with poor *** presentation is largely variable,manifesting with a broad spectrum of cognitive abnormalities ranging from subtle cognitive impairment to *** pathogenesis of HE is complex and has historically been linked with ***,in the last years,it has become evident that the interplay of multiple actors,such as intestinal dysbiosis,gut hyperpermeability,and neuroinflammation,is of crucial importance in its ***,HE can be considered a result of a dysregulated gut-liverbrain axis function,where cognitive impairment can be reversed or prevented by the beneficial effects induced by“gut-centric”therapies,such as non-absorbable disaccharides,non-absorbable antibiotics,probiotics,prebiotics,and fecal microbiota *** this context dietary modifications,by modulating the intestinal milieu,can also provide significant benefit to cirrhotic patients with *** review will provide a comprehensive insight into the mechanisms responsible for gut-liver-brain axis dysregulation leading to HE in ***,it will explore the currently available therapies and the most promising future treatments for the management of patients with HE,with a special focus on the dietary approach.

关键词： Cirrhosis Hepatic encephalopathy Diet therapy Gut microbiota Leaky gut Hyperammonemia Prebiotics Probiotics Gluten-casein free diet Gut microbiota transplantation

Measurement of body composition as a surrogate evaluation of energy balance in obese patients

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World Journal of Methodology 2015年第1期5卷 1-9页

作者： carlo Maria Rotella ilaria Dicembrini Section of Endocrinology Department of Biomedical Experimental and Clinical Sciences University of Florence Medical School Obesity Agency Diabetes Agency Careggi University Hospital Diabetes Agency Careggi University Hospital

In clinical practice obesity is primarily diagnosed through the body mass index. In order to characterize patients affected by obesity the use of traditional anthropometric measures appears misleading. Beyond the body mass index, there are overwhelming evidences towards the relevance of a more detailed description of the individual phenotype by characterizing the main body componentsas free-fat mass, muscle mass, and fat mass. Among the numerous techniques actually available, bioelectrical impedance analysis seems to be the most suitable in a clinical setting because it is simple, inexpensive, noninvasive, and highly reproducible. To date, there is no consensus concerning the use of one preferred equation for the resting energy expenditure in overweight and/or obese population. Energy restriction alone is an effective strategy to achieve an early and significant weight loss, however it results in a reduction of both fat and lean mass therefore promoting or aggravating an unfavourable body composition(as sarcobesity) in terms of mortality and comorbidities. Therefore the implementation of daily levels of physical activity should be simultaneously promoted. The major role of muscle mass in the energy balance has been recently established by the rising prevalence of the combination of two condition as sarcopenia and obesity. Physical exercise stimulates energy expenditure, thereby directly improving energy balance, and also promotes adaptations such as fiber type, mitochondrial biogenesis, improvement of insulin resistance, and release of myokines, which may influence different tissues, including muscle.

关键词： Obesity Body composition Bioelectrical impedance analysis Energy expenditure Sarcobesity

The surprising‘Coeliac Chinese box’from Italy

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Gastroenterology Report 2021年第5期9卷 478-479,I0003页

作者： Chiara Maria Trovato Monica Montuori Annalisa Morelli Elena Lionetti Giulia Naspi-Catassi ilaria Laudadio Francesco Valitutti carlo Catassi Maternal and Child Health Department Pediatric Gastroenterology and Liver UnitSapienza—University of RomeRomeItaly Department of Pediatrics Marche Polytechnic UniversityAnconaItaly Department of Molecular Medicine Sapienza-University of RomeRomeItaly Pediatric Unit AOU San Giovanni di Dio e Ruggi di AragonaSalernoItaly European Biomedical Research Institute of Salerno SalernoItaly Mucosal Immunology and Biology Research Center Division of Pediatric Gastroenterology and NutritionMassachusetts General HospitalBostonMassachusettsUSA

Background Coeliac disease(CD)-an autoimmune systemic disorder elicited by gluten in genetically predisposed individuals-can be considered a major public-health *** prevalence is increasing in areas such as Asian *** global seroprevalence of CD is 1.4%,the highest being in Europe and Oceania,and very low in Southern America;however,few data are available for Asian countries,especially for China[1].

关键词：乳糜泻 Asian 令人

Moving forward in the treatment of cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1939-1955页

作者： Tommaso M Manzia Alessandro Parente ilaria Lenci Bruno Sensi Martina Milana carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi Hepato-Pancreato-Biliary and Transplant Department of SurgeryUniversity of Rome Tor VergataRome 00133Italy The Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152THUnited Kingdom Hepatology Unit University of Tor VergataRome 00133Italy

Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still *** fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this *** incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical *** efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA *** within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA *** analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for *** findings are expected to significantly improve the management of this malignancy in the near *** this changing scenario our review focuses on the current and future strategies for CCA *** systemic and surgical treatments are discussed in *** results of the main studies in this field are reported,together with the ongoing *** current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome.

关键词： Cholangiocarcinoma Treatment Genetic aberration Immunotherapy Liver resection Liver transplantation

De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature

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World Journal of Gastroenterology 2019年第35期25卷 5356-5375页

作者： Tommaso Maria Manzia Roberta Angelico carlo Gazia ilaria Lenci Martina Milana Oludamilola T Ademoyero Domiziana Pedini Luca Toti Marco Spada Giuseppe Tisone Leonardo Baiocchi HPB and Transplant Unit Department of Surgery University of Rome Tor Vergata Rome 00133 Italy Division of Abdominal Transplantation and HPB Surgery Bambino Gesù Children's Hospital IRCCS Rome 00165 Italy Wake Forest Institute for Regenerative Medicine Winston-Salem NC 27101 United States Hepatology and Liver Transplant Unit University of Tor Vergata Rome 00133 Italy

BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood *** Emerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences

关键词： Pediatric liver transplant Immunosuppression weaning Clinical operational tolerance Adult liver transplant Graft rejection Immune system De novo malignancies Immunosuppression minimization Cancer