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Evaluating rehabilitation interventionsin Parkinson's disease with functional MRI:a promising neuroprotective strategy

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Neural Regeneration Research 2015年第5期10卷 702-703页

作者： carlo augusto mallio Bruno Beomonte Zobel carlo Cosimo Quattrocchi Departmental Faculty of Medicine and Surgery Unit of Diagnostic ImagingUniversità Campus Bio-Medico di Roma

Parkinson＇s disease （PD） is a progressive neurodegenerative disorder affecting approximately 10 million people world- wide （Planetta et al., 2014; Zigmond and Smeyne, 2014）. The principal clinical features of PD are bradykinesia, rigidity, tremor at rest and postural instability （Planetta et al., 2014）. It is known that both PD itself and the use of anti-parkinson drugs are associated with several non-motor symptoms such as cognitive impairment, neuropsychiatric disturbances and sleep, autonomic, and sensory disorders （Park and Stacy, 2009; Foster et al., 2014）. The histopathological hallmark of PD is the reduction of dopaminergic cells in the substantia nigra pars compacta, causing dopamine deficiency in spe- cific nuclei of the basal ganglia such as the dorsal striatum （Fearnley and Lees, 1991; Planetta et al., 2014）. The disrup- tion of the dopaminergic system has long been regarded as the major cause of PD; however, it has been shown that a widespread involvement of several non-dopaminergic path- ways also contribute to the clinical manifestations of PD （Park et al., 2014）.

关键词： MRI Evaluating rehabilitation interventionsin Parkinson’s disease with functional MRI

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Decreased cross-sectional muscle area in male patients with clear cell renal cell carcinoma and peritumoral collateral vessels

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World Journal of Radiology 2022年第4期14卷 82-90页

作者： Federico Greco Bruno Beomonte Zobel carlo augusto mallio UnitàOperativa Complessa Diagnostica per Immagini Territoriale Aziendale Cittadella della Salute Azienda Sanitaria Locale di LecceLecce 73100Italy Unit of Diagnostic Imaging UniversitàCampus Bio-Medico di RomaRome 00128Italy

BACKGROUND Sarcopenia is the loss of skeletal muscle mass(SMM)and is a sign of cancer *** with advanced renal cell carcinoma(RCC)may show *** To evaluate the amount of SMM in male clear cell RCC(ccRCC)patients with and without collateral *** In this study,we included a total of 124 male Caucasian patients divided into two groups:ccRCCa group without collateral vessels(n=54)and ccRCCp group with collateral vessels(n=70).Total abdominal muscle area(TAMA)was measured in both groups using a computed tomography imaging-based *** measures were also corrected for age in order to rule out age-related *** There was a statistically significant difference between the two groups in terms of TAMA(P<0.05)driven by a reduction in patients with peritumoral collateral *** result was confirmed by repeating the analysis with values corrected for age(P<0.05),indicating no age effect on our *** This study showed a decreased TAMA in ccRCC patients with peritumoral collateral *** presence of peritumoral collateral vessels adjacent to ccRCC might be a fine diagnostic clue to sarcopenia.

关键词： Cancer cachexia Body composition Clear cell renal cell carcinoma Collateral vessels Kidney cancer Sarcopenia

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