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Robot-assisted adrenalectomy:Step-by-step technique and surgical outcomes at a high-volume robotic center

Asian Journal of Urology 2023年第4期10卷 475-481页

作者： Federico Piramide carlo andrea bravi Marco Paciotti Luca Sarchi Luigi Nocera Adele Piro Maria Peraire Lores Eleonora Balestrazzi Angelo Mottaran Rui Farinha Hubert Nicolas Pieter De Backer Frederiek D'hondt Peter Schatteman Ruben De Groote Geert De Naeyer Alexandre Mottrie Department of Urology Onze-Lieve-VrouwziekenhuisAalstBelgium ORSI Academy GhentBelgium Department of Oncology Division of UrologyUniversity of TurinSan Luigi Gonzaga HospitalTurinItaly Department of Urology Humanitas Research Hospital-IRCCSRozzanoItaly Department of Urology ASST Santi Paolo e CarloUniversity of MilanMilanItaly Unit of Urology Division of Experimental OncologyUrological Research InstituteIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly Department of Urology Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense ModenaUniversity of Modena and Reggio EmiliaModenaItaly Division of Urology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Urological Department La CitadelleLiègeBelgium

Objective In the last years,robotic surgery was introduced in several different settings with good perioperative ***,its role in the management of adrenal masses is still *** order to provide a contribution to this field,we described our step-by-step technique for robotic adrenalectomy(RA)and related modifications according to the type of adrenal mass *** We retrospectively analyzed 27 consecutive patients who underwent RA at Onze-Lieve-Vrouw hospital(Aalst,Belgium)between January 2009 and October ***,intra-and post-operative,and pathological data were retrieved from our prospectively maintained institutional *** variables are summarized as median and interquartile range(IQR).Categorical variables are reported as frequencies(percentages).Results Twenty-seven patients underwent RA were included in the *** age,body mass index,and Charlson's comorbidity index were 61(IQR:49-71)years,26(IQR:24-29)kg/m^(2),and 2(IQR:0-3),respectively,and 16(59.3%)patients were *** tumor size at computed tomography scan was 6.0(IQR:3.5-8.0)*** operative time and blood loss were 105(IQR:82-120)min and 175(IQR:94-250)mL,*** intraoperative complications were *** postoperative complications rate was 11.1%,with a postoperative transfusion rate of 3.7%.A total of 10(37.0%)patients harbored malignant adrenal *** them,3(11.1%)had adrenocortical carcinoma,6(22.2%)secondary metastasis,and 1(3.7%)malignant pheochromocytoma on final pathological *** 1(10.0%)patient had positive surgical *** We described our step-by-step technique for RA,which can be safely performed even in case of high challenging settings as malignant tumors,pheochromocytoma,and large *** standardization of perioperative protocol should be encouraged to maximize the outcomes of this complex surgical procedure.

关键词： Robotics Adrenalectomy Pheochromocytoma Malignant Surgical technique

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Phase-matching-free parametric oscillators based on two-dimensional semiconductors

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Light(Science & Applications) 2018年第1期7卷 992-1000页

作者： Alessandro Ciattoni andrea Marini carlo Rizza Claudio Conti Consiglio Nazionale Delle Ricerche(CNR-SPIN) Via Vetoio 1067100 L’AquilaItaly Department of Physical and Chemical Sciences University of L’AquilaVia Vetoio 1067100 L’AquilaItaly Institute for Complex Systems(ISC-CNR) Via dei Taurini 1900185 RomeItaly ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860 CastelldefelsBarcelonaSpain Department of Industrial and Information Engineering and Economics University of L’AquilaVia G.Gronchi 18I-67100 L’AquilaItaly Department of Physics University SapienzaPiazzale Aldo Moro 500185 RomeItaly

Optical parametric oscillators are widely used as pulsed and continuous-wave tunable sources for innumerable applications,such as quantum technologies,imaging,and biophysics.A key drawback is material dispersion,which imposes a phase-matching condition that generally entails a complex design and setup,thus hindering tunability and *** we show that the burden of phase-matching is surprisingly absent in parametric microresonators utilizing mono-layer transition-metal dichalcogenides as quadratic nonlinear *** the exact solution of nonlinear Maxwell equations and first-principle calculations of the semiconductor nonlinear response,we devise a novel kind of phase-matching-free miniaturized parametric oscillator operating at conventional pump *** find that different two-dimensional semiconductors yield degenerate and non-degenerate emission at various spectral regions due to doubly resonant mode excitation,which can be tuned by varying the incidence angle of the external pump *** addition,we show that high-frequency electrical modulation can be achieved by doping via electrical gating,which can be used to efficiently shift the threshold for parametric *** results pave the way for the realization of novel ultra-fast tunable micron-sized sources of entangled photons—a key device underpinning any quantum *** miniaturized optical parametric oscillators may also be employed in lab-on-chip technologies for biophysics,detection of environmental pollution and security.

关键词： parametric matching degenerate

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The epigenetics of autoimmunity

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Cellular & Molecular Immunology 2011年第3期8卷 226-236页

作者： Francesca Meda Marco Folci andrea Baccarelli carlo Selmi Department of Medicine and Hepatobiliary Immunopathology Unit IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Department of Translational Medicine University of MilanRozzanoMilanItaly Harvard School of Public Health ExposureEpidemiology&Risk ProgramBostonMAUSA

The etiology of autoimmune diseases remains largely *** rates in monozygotic twins are lower than 50% while genome-wide association studies propose numerous significant associations representing only a minority of *** lines of evidence strongly support other complementary mechanisms involved in the regulation of genes expression ultimately causing overt *** in the post-translational modification of histones and DNA methylation are the two major epigenetic mechanisms that may potentially cause a breakdown of immune tolerance and the perpetuation of autoimmune *** recent years,several studies both in clinical settings and experimental models proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and *** specifically,data support the impact of epigenetic changes in systemic lupus erythematosus,rheumatoid arthritis,multiple sclerosis and other autoimmune diseases,in some cases based on mechanistical *** herein discuss what we currently know and what we expect will come in the next ***,epigenetic treatments already being used in oncology may soon prove beneficial also in autoimmune diseases.

关键词： DNA methylation histone modification microRNA tolerance breakdown

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Thermal and chemical analysis of massive use of hot briquetted iron inside basic oxygen furnace

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Journal of Iron and Steel Research International 2017年第9期24卷 901-907页

作者： Cosmo Di Cecca Silvia Barella carlo Mapelli andrea Gruttadauria andrea Francesco Ciuffini Davide Mombelli Enrico Bondi Depatment of Mechanical Engineering Politecnico di MilanoMilano 20156Italy Freelance Milano 20100Italy

The integrated steelmaking cycle based on the blast furnace-basic oxygen furnace（BOF）route plays an important role in the production of plain and ultra-low carbon steel,especially for deep drawing *** steelmaking is based on the conversion of cast iron in steel by impinging oxygen on the metal bath at supersonic *** order to avoid the addition of detrimental chemical elements owing to the introduction of uncontrolled scrap and in order to decrease environmental impact caused by the intensive use of coke for the production of cast iron,HBI（hot briquetted iron）can be used as a source of metal and a fraction of cast *** industrial experimental tests were performed to evaluate the viability of the use of HBI in *** experimental campaign was supported by a thermal prediction model and realized through the estimation of the oxidation ***,the process was thermodynamically analyzed based on oxygen potentials using the off-gas composition and the bath temperature evolution during the conversion as reference data.

关键词： Hot briquetted iron Basic oxygen furnace Thermal analysis Chemical analysis Oxygen potential

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Late-onset hypogonadism： beyond testosterone

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Asian Journal of Andrology 2015年第2期17卷 236-238,I0008页

作者： carlo Foresta Aldo E Calogero Francesco Lombardo andrea Lenzi Alberto Ferlin Department of Medicine and Centre for Human Reproduction Pathology University of Padova Padova 35128 Italy Department of Medical and Pediatric Sciences Section of Endocrinology Andrology and Internal Medicine University of Catania Catania 95123 Italy Department of Experimental Medicine Section of Medical Pathophysiology and Endocrinology Sapienza University of Rome Rome 00185 Italy

Late-onset hypogonadism is defined as a combination of low testosterone （T） levels and typical symptoms and signs. A major area of uncertainty is whether T concentrations are always really sufficient to fully reflect Leydig cell （dys）function. Mild testicular alteration could be diagnosed only by additional biochemical markers, such as luteinizing hormone （LH） and 25-hydroxyvitamin D levels. These markers help in identifying the so-called ＂subclinical＂ hypogonadism （normal T, high LH levels）. Patients with hypogonadism have frequently low levels of 25-hydroxyvitamin D due to impairment of the hydroxylating enzyme CYP2R1 in the testis. However, no data have been published dealing with the best treatment option （cholecalciferol - the Vitamin D precursor, or calcidiol - 25-hydroxylated form of Vitamin D） in these patients. We studied 66 patients with classic hypogonadism （total T [TT] 〈12 nmol I-~, LH 〉 8 IU 1-1）（n = 26） and subclinical hypogonadism （TT 〉 12 nmol I-＊, LH 〉 8 IU I-~）（n = 40） and low 25-hydroxyvitamin D （〈50 nmol I-1）. Subjects received cholecalciferol （5000 IU per week）（n = 20） or calcidiol （4000 IU per week）（n -- 46）, and 25-hydroxyvitamin D and parathyroid hormone （PTH） were evaluated after 3 months of therapy. Supplementation with calcidiol significantly increased 25-hydroxyvitamin D and significantly decreased PI＂H levels in both groups of men with hypogonadism （primary, n = 16 and subclinical, n = 30）, whereas supplementation with cholecalciferol did not modify their levels. This study shows for the first time that the administration of the 25-hydroxylated form of Vitamin D （calcidiol）, and not the administration of the precursor cholecalciferol, restores 25-hydroxyvitamin D levels in subjects with hypogonadism.

关键词： insulin-like factor 3 late-onset hypogonadism male hypogonadism testosterone Vitamin D

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Orchestrating stem cell fate: Novel tools for regenerative medicine

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World Journal of Stem Cells 2019年第8期11卷 464-475页

作者： Sara Cruciani Sara Santaniello andrea Montella carlo Ventura Margherita Maioli Department of Biomedical Sciences University of Sassari Sassari 07100 Italy Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems – Eldor Lab Innovation Accelerator Consiglio Nazionale delle Ricerche Bologna 40129 Italy Operative Unit of Clinical Genetics and Developmental Biology Sassari 07100 Italy Istituto di Ricerca Genetica e Biomedica Consiglio Nazionale delle Ricerche Cagliari 09042 Italy Center for Developmental Biology and Reprogramming-CEDEBIOR Department of Biomedical Sciences University of Sassari Sassari 07100 Italy

Mesenchymal stem cells are undifferentiated cells able to acquire different phenotypes under specific stimuli. In vitro manipulation of these cells is focused on understanding stem cell behavior, proliferation and pluripotency. Latest advances in the field of stem cells concern epigenetics and its role in maintaining self-renewal and differentiation capabilities. Chemical and physical stimuli can modulate cell commitment, acting on gene expression of Oct-4, Sox-2 and Nanog, the main stemness markers, and tissue-lineage specific genes. This activation or repression is related to the activity of chromatin-remodeling factors and epigenetic regulators, new targets of many cell therapies. The aim of this review is to afford a view of the current state of in vitro and in vivo stem cell applications, highlighting the strategies used to influence stem cell commitment for current and future cell therapies. Identifying the molecular mechanisms controlling stem cell fate could open up novel strategies for tissue repairing processes and other clinical applications.

关键词： Stem cells Epigenetics Self-renewal In vitro differentiation Physical stimuli Stem cell fate Clinical practice Cell transplantation

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Raman spectra and vibrational analysis of CsPbI3:A fast and reliable technique to identify lead halide perovskite polymorphs

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Journal of Materiomics 2021年第1期7卷 127-135页

作者： Jessica Satta Claudio Melis carlo Maria Carbonaro andrea Pinna Manuel Salado Daniel Salazar Pier carlo Ricci Department of Physics University of CagliariS.p.No.8 Km 0.70009042MonserratoCAItaly Department of Mechanical Chemical and Materials EngineeringCINSAINSTMUniversity of CagliariVia Marengo 2CagliariI-09123Italy BCMaterials Basque Center for MaterialsApplications and NanostructuresUPV/EHU Science Park48940LeioaSpain

A major issue in the development of Lead halide perovskites is the assessment of the crystal structure of the samples,due to their typically limited time-stability,and the understanding of the role of external factors that can induce a crystal phase transformation(such as humidity,intense light flux,temperature,etc.).In this perspective,it is of utmost importance to have at disposal a fast and reliable experimental tool able to give an immediate indication of the polymorph of the sample with the possibility to integrate in-situ measurements for constant *** this paper we propose Raman spectroscopy as the ideal technique to solve this *** vibrational analysis of CsPbI3 in the a-phase and 5-phase and of the Cs4PbI6 secondary phase is reported and all the vibrational modes are assigned by comparing experimental spectra of the phases to Raman modes calculated within the DFT ***,the mechanism of laser induced phase degradation was studied using in-situ Raman measurements providing new insights on the secondary phase generated during the process.

关键词： Raman spectroscopy CsPb13 Inorganic lead halide perovskites Phase transformation

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Upper aerodigestive tract disorders and gastro-oesophageal reflux disease

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World Journal of Clinical Cases 2015年第2期3卷 102-111页

作者： andrea Ciorba Chiara Bianchini Michele Zuolo carlo Vittorio Feo ENT Department University of Ferrara S.Anna University Hospital Department of Surgery University of Ferrara

A wide variety of symptoms and diseases of the upper aerodigestive tract are associated to gastro-oesophageal reflux disease(GORD). These disorders comprise a large variety of conditions such as asthma, chronic otitis media and sinusitis, chronic cough, and laryngeal disorders including paroxysmal laryngospasm. Laryngopharyngeal reflux disease is an extraoesophageal variant of GORD that can affect the larynx and pharynx. Despite numerous research efforts, the diagnosis of laryngopharyngeal reflux often remains elusive,unproven and controversial, and its treatment is then still empiric. Aim of this paper is to review the current literature on upper aerodigestive tract disorders in relation to pathologic gastro-oesophageal reflux, focusing in particular on the pathophysiology base and results of the surgical treatment of GORD.

关键词： Clinical management Gastro-oesophageal reflux Extraoesophageal disease Upper aerodigestive tract disorders Etiopathogenesis Therapy

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Transphyseal separation of the distal humerus in newborns

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Chinese Journal of Traumatology 2017年第3期20卷 183-186页

作者： Cosimo Gigante Sunil Gurpur Kini carlo Origo andrea Volpin Unit of Paediatric Orthopaedics Azienda Ospedaliera di Pndova. 35128. Padova. Italy Department of Orthopaedics Manipal Hospitals Bangalore India Department of Paediatric Orthopaedics Hospital C Arrigo Alessandria Italy

Obstetric traumatic separation of the distal humeral epiphysis is a very uncommon injury, which pre- sents a diagnostic challenge. These case serials reviewed the functional outcomes of 5 patients who had sustained a fracture-separation of the distal humeral epiphysis at birth. The diagnosis was made at a mean time of 40.8 h after delivery. All the patients were treated with gentle close manipulation, reduction under fluoroscopy and above-elbow cast application. After discharge, the patients were fol- lowed up for a mean of 30 months. Clinico-radiological results were excellent in four patients. One case necessitated closed reduction and percutaneous K-wire fixation at one week follow-up due to failed reduction. Cubitusvarus deformity was the only complication noted in I case. Good functional outcome can be expected in newborns with fracture-separation of the distal humeral epiphysis wherein the physis is anatomically reduced.

关键词： Infant, newborn Humerus Separation of epiphysis

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Short and long-term outcomes of laparoscopic colectomy in obese patients

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World Journal of Gastroenterology 2013年第42期19卷 7405-7411页

作者： andrea Vignali Paola De Nardi Luca Ghirardelli Saverio Di Palo carlo Staudacher Department of Surgery San Raffaele Scientific InstituteUniversity Vita Salute20132 MilanItaly

AIM:To investigate the impact of laparoscopic colectomy on short and long-term outcomes in obese patients with colorectal ***:A total of 98 obese(body mass index>30kg/m2)patients who underwent laparoscopic(LPS)right or left colectomy over a 10 year period were identified from a prospective institutionally approved database and manually matched to obese patients who underwent open *** were selected to match for body mass index,site of primary disease,American Society of Anesthesiologists score,and year of surgery(±3 year).The parameters analyzed included age,gender,comorbid conditions,American Society of Anaesthesiologists class,diagnosis,procedure,and duration of operation,operative blood loss,and amount of homologous blood *** rate,intra and postoperative complications as were as reoperation rate,30 d and long-term morbidity rate were also *** continuous variables,the Student’s t test was used for normally distributed data the Mann-Whitney U test for nonnormally distributed *** Pearson’sχ2tests,or the Fisher exact test as appropriate,were used for ***:Conversion to open surgery was necessary in 13 of 98 patients(13.3%).In the LPS group,operative time was 29 min longer and blood loss was 78 mL lower when compared to open colectomy(P=0.03,P=0.0001,respectively).Overall morbidity,anastomotic leak and readmission rate did not significantly differ between the two groups.A trend toward a reduction of wound complications was observed in the LPS when compared to open group(P=0.09).In the LPS group,an earlier recovery of bowel function(P=0.001)and a shorter length of stay(P=0.03)were *** a median follow-up of 62(range 12-132)mo 23patients in the LPS group and 38 in the open group experienced long-term complications(LPS vs open,P=0.03).Incisional hernia resulted to be the most frequent long-term complication with a significantly higher occurrence in the open group when compared to the lapa

关键词： Obesity Colon cancer Laparoscopy Right colectomy Left colectomy Colorectal disease

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