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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios Carlos Perez Muñoz Juan Cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial(AF),taking rivaroxaban in clinical *** Out of 1433 patients,453(31.6%)were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5±1.3vs.3.0±1.4;P<0.001)and HAS-BLED scores(2.0±1.0vs.1.4±1.0;P<0.001).Overall,the dose of rivaroxaban was adequately prescribed in 83.4%of patients,but more frequently in the younger population(71.1%vs.89.1%;P=0.039).After a mean follow-up of 2.2±0.6 years,annual rates of stroke+systemic embolism+transient ische-mic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03%and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar com-pared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independ-ently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with and higher HAS-BLED score with major ***,Conclusions In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately pre-scribed in the majority of octogenarians.

关键词： patients atrial bleeding

High-throughput study of the anomalous Hall effect

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npj Computational Materials 2023年第1期9卷 767-774页

作者： JakubŽelezný Yuta Yahagi carles Gomez-Olivella Yang Zhang Yan Sun Institute of Physics Czech Academy of SciencesCukrovarnická1016200 Praha 6Czech Republic Department of Applied Physics Tohoku UniversitySendaiMiyagiJapan Department of Physics and Astronomy University of Tennessee KnoxvilleKnoxvilleTN 37996USA Min H.Kao Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996USA Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Despite its long history,the anomalous Hall continues to attract attention due to its complex origins,its connection to topology,and its use as a probe of magnetic *** this work we investigate the anomalous Hall effect in 2871 ferromagnetic materials using an automatic high-throughput calculation *** analyze general properties of the effect,such as its reliance on spin-orbit coupling strength and *** materials with the largest anomalous Hall effect,we find that symmetry-protected band degeneracies in the non-relativistic electronic structure,such as mirror symmetry-protected nodal lines,are typically responsible for the large ***,we examine the dependence of the anomalous Hall effect on magnetization direction and demonstrate deviations from the commonly assumed expression j^(AHE)~M×E.

关键词： effect symmetry protected

Septic Arthritis and Multifocal Osteomyelitis Caused by Capnocytophaga Canimorsus: A Case Report

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Infectious Diseases & Immunity 2023年第3期3卷 136-139页

作者： Saul Levy-Blitchtein Paula Salmeron Dolores Rodriguez-Pardo Pablo Corona carles Amat Mayli Lung-Suarez Microbiology Department Vall d'Hebron University HospitalBarcelonaSpain Department of Infectious Diseases Vall d'Hebron University HospitalBarcelonaSpain Orthopaedic Surgery Department Vall d'Hebron University HospitalBarcelonaSpain

Microbiological diagnosis of chronic osteoarticular infections remains a major challenge,particularly when the clinical presentation is atypical and the pathogen is *** this unique case,Capnocytophaga canimorsus,a microorganism belonging to the oral microbiota of some domestic animals,caused septic arthritis and multifocal osteomyelitis in the long bone of a 43-year-old immunocompetent *** patient was treated with two-stage surgery and local and systemic antibiotic therapy,and had a successful *** should be considered as a possible etiological agent in patients with osteoarticular pathology and a history of exposure to domestic animals.

关键词： Capnocytophaga Case report Osteomyelitis Septic arthritis Osteoarticular infection

Algebraic manipulation detection codes

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Science China Mathematics 2013年第7期56卷 1349-1358页

作者： CRAMER Ronald FEHR Serge PADRó carles Centrum voor Wiskunde en Informatica (CWI) Mathematical Institute Leiden University Division of Mathematical Sciences School of Physical and Mathematical Sciences Nanyang Technological University

Algebraic manipulation detection codes are a cryptographic primitive that was introduced by Cramer et al. (Eurocrypt 2008). It encompasses several methods that were previously used in cheater detection in secret sharing. Since its introduction, a number of additional applications have been found. This paper contains a detailed exposition of the known results about algebraic manipulation detection codes as well as some new results.

关键词：代数运算检测代码操作秘密共享应用程序原语加密

Plasma-enabled healing of graphene nano-platelets layer

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 350-359页

作者： Xiuqi Fang carles Corbella Denis B.Zolotukhin Michael Keidar Department of Mechanical & Aerospace Engineering George Washington UniversityWashingtonDC 20052USA Department of Physics Tomsk State University of Control Systems and RadioelectronicsTomsk 634050Russia

Graphene platelet networks (GPNs) were deposited onto silicon substrates by means of anodic arc discharge ignited between two graphite *** temperature and pressure of helium atmosphere were optimized for the production of the carbon *** samples were modified or destroyed with different methods to mimic typical environments responsible of severe surface *** emulated conditions were performed by four surface treatments,namely thermal oxidation,substrate overheating,exposition to glow discharge,and metal coating due to arc *** the next step,the samples were regenerated on the same substrates with identical deposition *** and re-growth of GPN samples were systematically characterized by scanning electron microscopy and Raman *** full regeneration of the structural and morphological properties of the samples has proven that this healing method by arc plasma is adequate for restoring the functionality of2D nanostructures exposed to harsh environments.

关键词： graphene platelet networks anodic arc discharge plasma healing scanning electron microscopy Raman spectroscopy

Diabetes in French Guiana,adapting national standards of therapeutic education and care to the amazonian challenge

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World Journal of Diabetes 2021年第2期12卷 98-107页

作者： Nadia Sabbah Gabriel carles Magalie Demar Mathieu Nacher Endocrinology Diabetology Nutrition Centre Hospitalier Andree RosemonCayenne 97300French Guiana Department of Obstetrics and Gynaecology Centre Hospitalier Franck JolySt Laurent Du Maroni 97320French Guiana Department of Laboratory University of French GuianaCayenne 97300French Guiana Department of Medicine COREVIH Centre Hospitalier Andree RosemonCayenne 97300French Guiana

French Guiana is a territory located more than 7000 km from *** is also the largest French territory,with almost 84000 km2 and 90%of it is covered by *** municipalities are isolated due to the scarcity of transportation and the poor road *** population is extremely diverse ethnically and culturally,and includes more than thirty ethnic *** is high because it is one of the richest countries in the area bordering northern Brazil,Suriname,Guyana,and as a result of socio-economic crises in some other countries such as Haiti,and it has permeable natural *** and obesity,are emerging issues,with double the prevalence of Mainland France,whereas infectious diseases,such as HIV,take second *** and educational management are challenging because they require the adaptation of tools and treatments to the multiculturalism and precariousness often encountered in these *** French and European recommendations are unsuited to the needs of the territory and must take into account the epidemiological,sociological and cultural parameters of these populations in order to provide appropriate and graded management of diabetes in the French Amazon.

关键词： French Guiana Diabetes mellitus Ethnicity Consensus workshops Poverty Immigration

Relationship of sperm plasma membrane andacrosomal integrities with sperm morphometry inBos taurus

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Asian Journal of Andrology 2020年第6期22卷 578-582页

作者： Inmaculada Palacin Pilar Santolaria Carlos Alquezar-Baeta carles Soler Miguel A Silvestre Jesus Yaniz BIOFITER Research Group Environmental Sciences Institute(IUCA)Department of Animal Production and Food SciencesUniversity of ZaragozaHuesca 22071Spain Department of Computer Science University of ZaragozaZaragoza 50018Spain Department of Cellular Biology Functional Biology and Physical AnthropologyUniversity of ValenciaBurjassot 46100Spain

To date,sperm morphometric studies have assessed whole sperm populations without considering sperm *** aim of this study was to evaluate the relati on ship of sperm membrane and acrosomal integrity with sperm morphometry in liquid semen samples collected from *** this end,sperm morphometry was performed on cryopreserved semen samples from 16 bulls by a combination of fluorescent dyes,including Hoechst 33343,carboxyfluorescein diacetate,and propidium *** allowed discrimination of different subpopulations on the basis of sperm membrane and acrosomal integrity and analysis of the morphometries of the sperm head,nucleus,and acrosome using a specific plug-in module created on *** integrity was related to sperm morphometry as the heads of spermatozoa with a damaged acrosome were significantly smaller than those with a normal acrosome(P<0.001).In the case of spermatozoa with an intact acrosome,those with a damaged plasma membrane had a larger sperm head and acrosome than spermatozoa with an intact plasma membrane(P<0.001).No significant differences in the sperm head size were observed between sperm subpopulations without an acrosome or in the nuclear sperm morphometry of the different *** was a positive correlation between the sperm motility values of the samples and the morphometric parameters for in tact *** correlations were particularly strong for the morphometric parameters of the sperm *** conclude that there are clear differences in the sperm morphometry depending on the status of the sperm membrane and acrosome and this should be considered when performing this kind of analysis.

关键词： Bos taurus fluoresce nee microscopy image analysis sperm morphometry sperm quality

Updating semen analysis:a subpopulation approach

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Asian Journal of Andrology 2020年第1期22卷 118-119页

作者： Almudena Garcia-Molina Anthony Valverde Daznia Bompart Carina Caldeira Alberto Vendrell carles Soler Proiser R+D S.L. Scientific ParkUniversitat de ValenciaPaterna 46980ValenciaSpain Department of Functional Biology and Physical Anthropology University of ValenciaBurjassot 46100ValenciaSpain Technological Institute of Costa Rica San Carlos CampusSchool of AgronomyAlajuela 223-21001Costa Rica

Dear Editor,Reproductive problems affect 8%-12%of human populations worldwide;40%-50%of all infertility cases are due to the male,and up to 2%of men have suboptimal sperm quality.

关键词： dating cases infertility

Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants

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Molecular Plant 2019年第6期12卷 743-763页

作者： Xuelei Lai Arnaud Stigliani Gilles Vachon Cristel carles Cezary Smaczniak Chloe Zubieta Kerstin Kaufmann Francois Parcy CNRS Univ. Grenoble Alpes CEA INRA BIG-LPCV 38000 Grenoble France Department for Plant Cell and Molecular Biology Institute for Biology Humboldt-Universitat zu Berlin Berlin Germany

Transcription factors (TFs) are key cellular components that control gene expression. They recognize specific DNA sequences, the TF binding sites (TFBSs), and thus are targeted to specific regions of the genome where they can recruit transcriptional co-factors and/or chromatin regulators to fine-tune spatiotemporal gene regulation. Therefore, the identification of TFBSs in genomic sequences and their subsequent quantitative modeling is of crucial importance for understanding and predicting gene expression. Here, we review how TFBSs can be determined experimentally, how the TFBS models can be constructed in silico, and how they can be optimized by taking into account features such as position interdependence within TFBSs, DNA shape, and/or by introducing state-of-the-art computational algorithms such as deep learning methods. In addition, we discuss the integration of context variables into the TFBS modeling, including nucleosome positioning, chromatin states, methylation patterns, 3D genome architectures, and TF cooperative binding, in order to better predict TF binding under cellular contexts. Finally, we explore the possibilities of combining the optimized TFBS model with technological advances, such as targeted TFBS perturbation by CRISPR, to better understand gene regulation, evolution, and plant diversity.

关键词： Transcription factor binding site Gene regulation flower development