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Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

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iLIvER 2024年第1期3卷 52-61页

作者： Pamela scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela Hernández Bautista Elizabeth Gil White JoséAntonio González Moreno Daniel Angel Torres del Real víctor Manuel Páez Zayas carla Escorza-Molina Fernando Mondragón Rodríguez Omar vásquez Gómez Luis Jorge Fernández López Paul santiago Mogrovejo vázquez Isidoro Aczel sánchez-Cedillo víctor Jose visag Castillo social service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico social service Internship Universidad AnahuacMexico City 04510Mexico Department of surgery Division of Transplantation surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,science Direct and Index Medicus with MEsH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma Liver transplantation survival Criteria Recurrence Bibliometrics

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scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

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Journal of Integrative Medicine 2024年第5期22卷 533-544页

作者： Alexander L.Tournier Leoni v.Bonamin susann Buchheim-schmidt steven Cartwright Christoph Dombrowsky Paul Doesburg carla Holandino Maria Olga Kokornaczyk Everine Bvan de Kraats Jesús Antonio López-Carvallo Papiya Nandy JoséManuel Mazón-suástegui Fateme Mirzajani Bernard Poitevin Claudia scherr Karin Thieves sandra Würtenberger stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern3010 BernBernSwitzerland Institute of Integrative Medicine Witten/Herdecke University58455 WittenNorth Rhine–WestphaliaGermany Homeopathy Research Institute London SW74EFUnited Kingdom Graduate Program on Environmental and Experimental Pathology Paulista UniversitySão Paulo 01504-000São PauloBrazil Department of Medical science Deutsche Homöopathie-Union DHU-Arzneimittel GmbH&Co.KG76227 KarlsruheBaden-WürttembergGermany Cherwell Laboratory for Fundamental Research in Homeopathy Oxford OX28NUOxforeshireUnited Kingdom society for Cancer Research Hiscia Research Institute4144 ArlesheimBaselSwitzerland Laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de JaneiroRio de Janeiro 21941-902Rio de JaneiroBrazil World Water Community Rotterdam 3029AKthe Netherlands Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte1790437 CoquimboElquiChile Centre for Interdisciplinary Research and Education KolkataWest Bengal 700068West BengalIndia Laboratorio de Homeopatía Acuícola y semillas Marinas Centro de Investigaciones Biológicas del NoroesteLa Paz 23096Baja California SurMexico Protein Research Center Shahid Beheshti UniversityTehran ***Iran Department of Medical Laboratory science College of ScienceKnowledge University44001 ErbilErbilIraq sociétésavante d’Homéopathie 75009 ParisFrance sola salus Institute for Homeopathic Research52511 GeilenkirchenNorth Rhine–WestphaliaGermany scientific society for Homeopathy 06366 KöthenSaxony-AnhaltGermany

Objective Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative *** physicochemical properties and biological activity of these preparations are often investigated in preclinical research,yet no guidelines for experimental research currently exist in this *** present PrePoP guidelines aim to provide recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised *** Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and *** three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised *** We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,environmental influences,and procedures for the preparation of potentised samples and controls,and we address some specific challenges of this research *** This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

关键词： Research guidelines Fundamental research Basic research Complementary and integrative medicine Potentisation Potentised preparations

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In silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori

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World Journal of Clinical Oncology 2024年第5期15卷 653-663页

作者： Rafaela viana vieira Gabrielle Caroline Peiter Fabrício Freire de Melo Ana carla Zarpelon-schutz Kádima Nayara Teixeira Universidade Federal do Paraná Campus ToledoToledo 85919-899Brazil Universidade Tecnológica Federal do Paraná Campus ToledoParaná85902-490Brazil Universidade Federal da Bahia Instituto Multidisciplinar em Saúde-Campus Anísio TeixeiraVitória da Conquista 45029-094Brazil Universidade Federal do Paraná-setor Palotina Programa de Pós-graduação em BiotecnologiaPalotina 85950-000Brazil

BACKGROUND Colonization with Helicobacter pylori(***)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in *** have been conducted using medicinal plants with the aim of eliminating the pathogen;however,the possibility of blocking ***-induced cell differentiation to prevent the onset and/or progression of tumors has not been *** type of study is expensive and time-consuming,requiring in vitro and/or in vivo tests,which can be solved using ***,prospective computational analyses were conducted to assess the feasibility of interaction between phenolic compounds from medicinal plants and the CagA *** To perform a computational prospecting of the interactions between phenolic compounds from medicinal plants and the CagA oncoprotein of *** In this in silico study,the structures of the phenolic compounds(ligands)kaempferol,myricetin,quercetin,ponciretin(flavonoids),and chlorogenic acid(phenolic acid)were selected from the PubChem *** phenolic compounds were chosen based on previous studies that suggested medicinal plants as non-drug treatments to eliminate *** *** three-dimensional structure model of the CagA oncoprotein of ***(receptor)was obtained through molecular modeling using computational tools from the I-Tasser platform,employing the threading *** primary sequence of CagA was sourced from GenBank(BAK52797.1).A screening was conducted to identify binding sites in the structure of the CagA oncoprotein that could potentially interact with the ligands,utilizing the GRasP online *** the ligands and receptor were prepared for molecular docking using AutoDock Tools 4(ADT)software,and the simulations were carried out using a combination of ADT and AutoDock vina v.1.2.0 *** sets of simulations were performed:One involving the central region of CagA with phenolic compounds,and another involvi

关键词： CagA oncoprotein Phenolic compounds Helicobacter pylori In silico analyses Medicinal plants Prospective analysis

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Influence of flooding and vegetation on carbon,nitrogen,and phosphorus dynamics in the pore water of a spartina alterniflora salt marsh

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Journal of Environmental sciences 2011年第2期23卷 212-221页

作者： vanesa L.Negrin carla v.s.etter Raúl O.Asteasuain Gerardo M.E.Perillo Jorge E.Marcovecchio Argentine Institute of Oceanography (IADO CONICETCCT-Bahía Blanca)Camino La Carrindanga km 75Building E-1 CC 804Bahía Blanca 8000Argentina Department of Chemistry Southern National Institute of Chemistry (INQUISUR)Southern National University (UNS)Av Alem 1253Bahía Blanca 8000Argentina Department of Geology Southern National University (UNS)San Juan 670Bahía Blanca 8000Argentina National Technological University Regional Faculty of Bahía Blanca (UTN-FRBB)11 de Abril 461Bahía Blanca 8000Argentina University of the Fraternity of Associations santo Toms de Aquino (FAsTA) Gascón 3145Mar del Plata 7600Argentina

Four sites were selected in a salt marsh in the Bahia Blanca Estuary （Argentina）：（1） low marsh （flooded by the tide twice daily） vegetated by s. alterniflora; （2） non-vegetated low marsh; （3） high marsh （flooded only in spring tides） vegetated by s. alterniflora; （4） non-vegetated high marsh. The pH and Eh were measured in sediments, while dissolved nutrients （ammonium, nitrate, nitrite and phosphate） and particulate organic matter （POM） were determined in pore water, pH （6.2-8.7） was only affected by vegetation in low areas. Eh （from -300 to 250 mv） was lower at low sites than at high ones; in the latter, the values were higher in the non-vegetated sediments. The POM concentration was greater in the high marsh than in the low marsh, with no effect of vegetation. Ammonium was the most abundant nitrogen nutrient species in pore water, except in the non-vegetated high marsh where nitrate concentration was higher. All nitrogen nutrients were affected by both flooding and vegetation. Phosphate was always present in pore water at all sites throughout the year and its concentration varied within narrow limits, with no effect of flooding and greater values always at non-vegetated sites. Our results showed that the variability of the pore water composition within the marsh is greater than the temporal variation, meaning that both tidal flooding and vegetation are important in the dynamics of nutrients and organic matter in the sediment pore water.

关键词： organic matter nutrients flooding spartina alterniflora

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Diagnostic tests for hepatitis C: Recent trends in electrochemical immunosensor and genosensor analysis

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World Journal of Gastroenterology 2014年第42期20卷 15476-15491页

作者： Carolina v Uliana carla s Riccardi Hideko Yamanaka Department of Chemistry Federal University of Sao Carlos Department of Physical Chemistry Institute of Chemistry Sao Paulo State University Department of Analytical Chemistry Institute of Chemistry of Araraquara Sao Paulo State University (UNESP)

Hepatitis C is a liver disease that is transmitted through contact with the blood of an infected person. An estimated 150 million individuals worldwide have been chronically infected with the hepatitis C virus(HCv). Hepatitis C shows significant genetic variation in the global population, due to the high rate of viral RNA mutation. There are six variants of the virus(HCv genotypes 1, 2, 3, 4, 5, and 6), with 15 recorded subtypes that vary in prevalence across different regions of the world. A variety of devices are used to diagnose hepatitis C, including HCv antibody test, HCv viral load test, HCv genotype test and liver biopsy. Rapid, inexpensive, sensitive, and robust analytical devices are therefore essential for effective diagnosis and monitoring of disease treatment. This review provides an overview of current electrochemical immunosensor and genosensortechnologies employed in HCv *** are a limited number of publications showing electrochemical biosensors being used for the detection of *** to their simplicity,specificity,and reliability,electrochemical biosensor devices have potential clinical applications in several viral infections.

关键词： Hepatitis C virus Immunosensors Genosensors Electrochemical detection Diagnostic tests

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Characterization of the proto-Philippine sea Plate:Evidence from the emplaced oceanic lithospheric fragments along eastern Philippines

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Geoscience Frontiers 2020年第1期11卷 3-21页

作者： carla B.Dimalanta Decibel v.Faustino-Eslava Jillian Aira s.Gabo-Ratio Edanjarlo J.Marquez Jenielyn T.Padrones Betchaida D.Payot Karlo L.Queano Noelynna T.Ramos Graciano P.Yumul Jr. Rushurgent Working Group National Institute of Geological SciencesCollege of ScienceUniversity of the PhilippinesDilimanQuezon CityPhilippines school of Environmental science and Management University of the PhilippinesLos BañosLagunaPhilippines Department of Physical sciences and Mathematics University of the Philippines-ManilaPadre FauraManilaPhilippines Institute of Renewable Natural Resources University of the PhilippinesLos BañosLagunaPhilippines Department of Environmental science Ateneo de Manila UniversityQuezon CityPhilippines Itogon-suyoc Resources Inc. OrtigasPasig CityPhilippines Apex Mining Company Inc. OrtigasPasig CityPhilippines

The proto-Philippine sea Plate(pPsP)has been proposed by several authors to account for the origin of the Mesozoic supra-subduction ophiolites along the Philippine *** this paper,a comprehensive review of the ophiolites in the eastern portion of the Philippines is *** data on the geology,ages and geochemical signatures of the oceanic lithospheric fragments in Luzon(Isabela,Lagonoy in Camarines Norte,and Rapu-Rapu island),Central Philippines(samar,Tacloban,Malitbog and southeast Bohol),and eastern Mindanao(Dinagat and Pujada)are *** of the Halmahera Ophiolite to the south of the Philippines are also reviewed for *** all of the crust-mantle sequences preserved along the eastern Philippines share Early to Late Cretaceous *** geochemical signatures of mantle and crustal sections reflect both mid-oceanic ridge and suprasubduction *** paleomagnetic information is currently limited to the samar Ophiolite,results indicate a near-equatorial Mesozoic supra-subduction zone *** general,correlation of the crust-mantle sequences along the eastern edge of the Philippines reveal that they likely are fragments of the Mesozoic pPsP.

关键词： Eastern Philippines Ophiolites Proto-Philippine sea Plate

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Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests

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World Journal of Gastroenterology 2014年第33期20卷 11815-11825页

作者： vicente Felipo Amparo Urios carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A serra Javier sánchez-González Roberto Aliaga Remedios Giner-Durán vicente Belloch Carmina Montoliu Laboratory of Neurobiology Centro Investigación Príncipe Felipe 46012Valencia Spain Fundación Investigación Hospital Clínico de valencia. Instituto de Investigación sanitaria INCLIVA 46010 Valencia Spain servicio DigestivoHospital Arnau de vilanova 46015 Valencia Spain Grupo Hepatología Servicio Aparato Digestivo Hospital Clínico de Valencia 46010 Valencia Spain Philips Healthcare Iberia 28050 Madrid Spain EREsA Unidad RM 46015 Valencia Spain Departamento de Patología Facultad de Medicina Universidad de Valencia 46010 Valencia Spain

AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy.

关键词： Arterial spin labelling Neurological impair-ment Blood flow Cerebellum Minimal hepatic enceph-alopathy

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Inter-Network Resource sharing in IEEE 802.22 Networks

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Communications and Network 2012年第2期4卷 111-121页

作者： carla Passiatore Pietro Camarda DEE-Politecnico di Bari v. Orabona Bari Italy

IEEE 802.22 is the first worldwide standard for Cognitive Networks (CNs) that exploits unused spectrum of the television broadcast service. An IEEE 802.22 network is also called Wireless Regional Area Network (WRAN). An open issue in cognitive 802.22 networks is represented by the resource distribution among WRANs. In this paper a protocol for radio resource management for CNs in a multichannel environment is presented and analysed. In particular, the contribution of this work is a resource sharing method to schedule the WRAN access to the available channels in a community made by two o more coexisting WRANs. The method adapts to the continuous changes of the spectrum availability due to necessity of vacating a channel in case of the incumbent primary users. Moreover, the introduced allocation scheme allows to divide the available band in a proportional way to the cognitive user spectrum demands, taking into account the issue of spatial diversity, i.e. the case where the channel coverage area is not uniform. The effectiveness of the proposed multichannel scheme is proved through simulations. The results compared favorably with other methods already known in literature and show that the proposed algorithm optimize the spectral efficiency, keeping high fairness as demonstrated computing the Jain’s index.

关键词： Cognitive Radio Resource sharing Protocol IEEE 802.22

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Cytocompatible cellulose nanofibers from invasive plant species Agave americana *** Ricinus communis L.:a renewable green source of highly crystalline nanocellulose

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2021年第6期22卷 450-461页

作者： Olga L.EvDOKIMOvA carla s.ALvEs Radenka M.KRsMANOvIC WHIFFEN Zaida O.RTEGA Helena TOMás Joao R.ODRIGUEs CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus Universitario da Penteada9020-105 FunchalPortugal Faculty of Polytechnics University of Donja GoricaOktoih 18 WOO PodgoricaMontenegro Departamento de Ingenieria de Procesos Universidad de Las Palmas de Gran Canaria35017 Las Palmas de Gran CanariaLas PalmasSpain school of Materials science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi'an 710072China

In this study,the fibers of invasive species Agave americana *** Ricinus communis *** successfully used for the first time as new sources to produce cytocompatible and highly crystalline cellulose *** nanofibers were obtained by two methods,based on either alkaline or acid *** morphology,chemical composition,and crystallinity of the obtained materials were characterized by scanning electron microscopy(sEM)together with energy-dispersive X-ray spectroscopy(EDX),dynamic light scattering(DLs),X-ray diffraction(XRD),and Fourier transform infrared(FTIR)*** crystallinity indexes(CIs)of the cellulose nanofibers extracted from *** and *** were very high(94.1%and 92.7%,respectively).Biological studies evaluating the cytotoxic effects of the prepared cellulose nanofibers on human embryonic kidney 293 T(HEK293 T)cells were also *** nanofibers obtained using the two different extraction methods were all shown to be cytocompatible in the concentration range assayed(i.e.,0-500μg/mL).Our results showed that the nanocellulose extracted from *** and *** fibers has high potential as a new renewable green source of highly crystalline cellulose-based cytocompatible nanomaterials for biomedical applications.

关键词： Nanofiber Nanocellulose Agave americana L. Ricinus communis L. Crystallinity Invasive species Biomedical application

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slab rollback and microcontinent subduction in the evolution of the Zambales Ophiolite Complex(Philippines):A review

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Geoscience Frontiers 2020年第1期11卷 23-36页

作者： Graciano P.Yumul Jr. carla B.Dimalanta Ricky C.salapare Karlo L.Queano Decibel v.Faustino-Eslava Edanjarlo J.Marquez Noelynna T.Ramos Betchaida D.Payot Juan Miguel R.Guotana Jillian Aira s.Gabo-Ratio Leo T.Armada Jenielyn T.Padrones Keisuke Ishida shigeyuki suzuki Apex Mining Company Inc. OrtigasPasig CityPhilippines Rushurgent Working Group National Institute of Geological SciencesCollege of ScienceUniversity of the PhilippinesDilimanQuezon CityPhilippines GHD Chino Roces AvenueMakati CityPhilippines Department of Environmental science Ateneo de Manila UniversityQuezon CityPhilippines school of Environmental science and Management University of the Philippines-Los BañosLagunaPhilippines Department of Physical sciences and Mathematics University of the Philippines-ManilaPadre FauraManilaPhilippines Graduate school of Natural science and Technology Kanazawa UniversityJapan Institute of Renewable Natural Resources University of the Philippines-Los BañosLagunaPhilippines Institute of socio-Arts and sciences University of TokushimaTokushimaJapan Department of Earth sciences Okayama UniversityOkayamaJapan

New radiolarian ages show that the island arc-related Acoje block of the Zambales Ophiolite Complex is possibly of Late Jurassic to Early Cretaceous *** dating of its plutonic and volcanichypabyssal rocks yielded middle Eocene *** the other hand,the paleontological dating of the sedimentary carapace of the transitional mid-ocean ridge-island arc affiliated Coto block of the ophiolite complex,together with isotopic age datings of its dikes and mafic cumulate rocks,also yielded Eocene *** offers the possibility that the Zambales Ophiolite Complex could have:(1)evolved from a Mesozoic arc(Acoje block)that split to form a Cenozoic back-arc basin(Coto block),(2)through faulting,structurally juxtaposed a Mesozoic oceanic crust with a younger Cenozoic lithospheric fragment or(3)through the interplay of slab rollback,slab break-off and,at a later time,collision with a microcontinent fragment,caused the formation of an island arc-related ophiolite block(Acoje)that migrated trench-ward resulting into the generation of a back-arc basin(Coto block)with a limited subduction *** Meso-Cenozoic ophiolite complex is compared with the other oceanic lithosphere fragments along the western seaboard of the Philippines in the context of their evolution in terms of their recognized environments of generation.

关键词： Ophiolite slab rollback Radiolarians subduction Zambales Philippines

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