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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

History Teacher Training from Decolonial Curriculum Practices to Combat Racism at UniProjeção in the Federal District-A Secondary Publication

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Journal of Contemporary Educational Research 2024年第2期8卷 187-202页

作者： Karoline da silva Ramos Cláudia Pinheiro Nascimento Francisca carla Santos Ferrer Faculty of Philosophy Languages and Human SciencesUniversity of São PauloSão PauloBrazil

This article aims to understand the training process of history undergraduates,to see if there are decolonial curricular practices to combat racism at the Centro Universitário e Faculdade Projeção(UniProjeção)in the Federal District,to understand how coloniality has corroborated the exclusion of different epistemologies and the erasure of different cultures,and how this exclusionary process of coloniality interferes in the training of history *** order to combat this practice,we are looking for alternatives that can break these suppressions carried out by *** this way,we turn to decolonial ideas that aim to break with the logic of *** can conclude that these practices are poorly developed in the institution,so we proposed active problem-based methodology and music as a didactic *** playful educational tools that strengthen the teaching-learning process,they are active agents in the decolonial work of combating racism,and it is essential to train responsible and ethical teachers in the fight against racism and any form of oppression.

关键词： Coloniality Decoloniality Education Curriculum practices Racism

Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira silva Mariana Santos Calmon Cláudio Lima Souza Ana carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

Vulvar Rejuvenation Using High-Intensity Focused Ultrasound (HIFU): Fundamentals and Technique

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Journal of Biosciences and Medicines 2022年第12期10卷 239-252页

作者： Fábio dos Santos Borges Mylana Almeida de Carvalho carla Barreto silva de Cerqueira Tais Andrade Cravo Monteiro Isabelle Maria Almeida e Benevides Adriele Machado Dantas Thiago Gusmão da silva Carolina Barreto Ribeiro Martins dos Santos Estácio de Sá University Rio de Janeiro Brazil IDE Faculty—Institute for Educational Development Salvador Brazil Longevitat Clinic—Advanced Aesthetics Salvador Brazi FAINOR Independent College of the Northeast Vitória da Conquista Brazil UFBA Federal University of Bahia Salvador Brazil

Background: The unaesthetic appearance of the female intimate area (vulva, “mound of venus” and perianal region) is a triggering factor of negative psychological responses, embarrassment, anxiety and insecurity in many women. Using rejuvenating equipment for vaginal structure or for the intimate area as a whole is already widespread in the literature, and High-Intensity Focused Ultrasound (HIFU) has proven to be very effective in the clinical practice of many professionals. This study, therefore, aims to describe the fundamentals and applicability that guide the use of HIFU in vulvar rejuvenation. Materials and Methods: Exploratory research was carried out, presented in a narrative review, to highlight the action of HIFU in female intimate rejuvenation. The review explored scientific articles published and available in the following databases: MEDLINE (Medical Literature Analysis and Retrieval System Online), PubMed (National Library of Medicine), SCIELO (Scientific Electronic Library Online), and LILACS (Latin Literature American and the Caribbean in Health Sciences). In addition, some clinical findings obtained through a retrospective analysis of medical records were added to describe the authors’ clinical experience in the use of Focused Ultrasound (HIFU) for vulvar rejuvenation. Results: We verified that the tissues of female external genitalia respond very well to the stimuli of the focused sound waves of the HIFU, being able to produce immediate and lasting results through isolated applications or in association with intradermotherapy or other therapeutic resources. Conclusion: We conclude that using High Intensity Focused Ultrasound aimed at vulvar rejuvenation is safely indicated and assures excellent aesthetic results at the end of the treatment because similarly to other treatment techniques, the thermal stimuli of HIFU are also able to produce an excellent therapeutic response in the dermal tissue of the female intimate area, promoting intense neocollagen

关键词： Intimate Aesthetics Vulvar Rejuvenation Vaginal Rejuvenation HIFU Focused Ultrasound Micro Focused Ultrasound and Cosmetic Gynecology

Plug-In Vehicle Acceptance and Probable Utilization Behaviour

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Journal of Transportation Technologies 2012年第1期2卷 67-74页

作者： Patrícia Baptista Catarina Rolim carla silva 不详

This paper presents a study undertaken to understand the plug-in vehicle acceptance and probable utilization behaviour in terms of charging habits and utility factor (probability of driving in electrical mode). A survey was designed to be answered via World Wide Web, throughout 3 months and only accessible to Portuguese inhabitants. The survey was composed by biographical and car ownership info, mobility patterns, awareness toward plug-in vehicle technologies, price premium and, finally, potential buyer’s attitudes regarding charging vehicles with electricity from the grid. An explanation of how each vehicle technology works in the case of a regular hybrid (HEV), a plug-in hybrid (PHEV) and a pure electric vehicle (EV) was provided. A total sample of 809 volunteers answered the survey, aged above 18 years old, 50% male and 50% female. The results allowed the estimation of the typical daily driving distance, the Utility Factor curve for plug-in hybrid future users, the charging preferences for future users of pure electric or plug-in hybrid vehicles and the necessary feebates to promote the market penetration of such technologies. Other correlations were also analyzed between driving patterns, type of owned car, price premium and the willingness to buy pure electric and plug-in hybrid vehicles. The main policy implications are that an increase of awareness campaigns is necessary if the government intends to support the plug-in electric vehicle technology widespread and a minimum of 5000 € investment per ton of avoided CO2 will be necessary in a year.

关键词： Pure Electric Vehicles Plug-In Hybrid Vehicles Utility Factor Frequency Period of Recharging

Antihyperglycemic effect of Passiflora glandulosa cav. fruit rinds flour in streptozotocin-induced diabetic mice

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 510-517页

作者： Erlandia Alves Magalhaes Queiroz Raquel Teixeira Terceiro Paim Sandra Machado Lira Jose Ytalo Gomes da silva carla Laine silva Lima Marcelo Oliveira Holanda Stephen Rathinaraj Benjamin Icaro Gusmao Pinto Vieira Maria Izabel Florindo Guedes Biotechnology and Molecular Biology Laboratory State University of CearaFortaleza Ceara Brazil Technological Development Park(PADETEC) Federal University of CearaPici Campus Fortaleza Ceara Brazil

Objective:To investigate the effect of administration of Passiflora glandulosa(***) fruit rinds flour on streptozotocin(STZ)-induced diabetic ***:The preliminary phytochemical screening and parameters such as centesimal composition and brine shrimp toxicity were *** in vivo study Swiss female mice were divided into four groups:NC-normal control;DC-diabetic control animals receiving saline;MET-diabetic animals receiving metformin(200 mg/kg);PFRF-diabetic animals receiving *** fruit rinds flour(200 mg/kg).All of them were treated for 28 *** was used in a single dose of 120 mg/kg to establish diabetic *** weight,water and food intake,fasting blood glucose were *** analysis of pancreas and liver were performed to evaluate STZ-induced tissue ***:Phytochemical screening showed the presence of flavanones and *** *** fruit rinds flour was non-toxic by the brine shrimp *** fruit rinds flour also reduced the loss of body weight and significantly decreased food intake in the diabetic ***,a significant reduction in blood glucose was observed for 15 d and this was maintained on 21 d and 28 d when compared with diabetic ***,the *** fruit rinds flour has a favourable effect on the histopathological changes of the pancreas in STZ induced ***:It is concluded that *** fruit rinds flour is a natural product that contains potent antioxidant compounds and presents good prospects for the improvement of diabetic mellitus by reducing serum glucose levels.

关键词： Diabetes mellitus Passiflora Blood glucose Histology Streptozotocin Mice

Intervention in the Loneliness of the Elderly What Strategies, Challenges and Rewards？

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Journal of Health Science 2015年第2期3卷 71-80页

作者： Manuela Dias carla silva Ricardo Dias Helena Oliveira Primary Care Unit of Terceira Island-Angra do Herolsmo Health Center Angra do Heroismo Terceira Azores 9701-869 Portugal Terceira Island Hospital Angra do Herolsmo Terceira Azores 9700-049 Portugal University of the Azores College of Nursing S. Miguel Azores 9504-538 Portugal

A descriptive study about the use of pillboxes by older adults

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Health 2013年第12期5卷 103-109页

作者： Frank Roger Defanti e Souza carla da silva Santana Bio-Engineering Inter-Unit Program University of Sao PauloSao CarlosBrazil

The goal of this research was to observe which features, according to the users’ point of view, might influence the use of pillboxes. Older adults were surveyed in order to test different pillboxes and report their observations about their difficulties. Both the individuals and the pillboxes themselves have characteristics that might influence successful use, such as difficulty remembering medication names and lack of hand strength and the complexity of the pillboxes’ alarm system and opening mechanism. Pillboxes can be effective in helping older adults take their medication provided they are designed according to both dosage prescription and the user’s functional capacity.

关键词： Aging Medication Adherence Self-Help Devices

Evaluation of Novel 3D Architectures Based on Knitting Technologies for Engineering Biological Tissues

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Journal of Donghua University(English Edition) 2013年第5期30卷 421-426页

作者： RIBEIRO Viviana Pinto RIBEIRO Ana Soares silva carla Joana DURES Nelson Feio BONIFCIO Graa CORRELO Vitor Manuel MARQUES Alexandra Pinto SOUSA Rui Amandi OLIVEIRA Ana Leite REIS Rui Luís 3B's Research G roup-Biomaterials Biodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine ICVS /3B's-PT G overnment Associated Laboratory University of Minho CeNTI Centre for Nanotechnology and Smart MaterialsV. N. CITEVE Technological Centre for Textile and Clothing IndustryV. N. CBQF-School of Biotechnology Portuguese Catholic University

Textile-based technologies are considered as potential routes for the production of 3D porous architectures for tissue engineering( TE) applications. We describe the use of two polymers,namely polybutylene succinate( PBS) and silk fibroin(SF) to produce fiber-based finely tuned porous architectures by weft and warp knittings. The obtained knitted constructs are described in terms of their morphology, mechanical properties,swelling ability,degradation behaviour,and cytotoxicity. Each type of polymer fibers allows for the processing of a very reproducible intra-architectural scaffold geometry,with distinct characteristics in terms of the surface physicochemistry,mechanical performance,and degradation capability,which has an impact on the resulting cell behaviour at the surface of the respective biotextiles. Preliminary cytotoxicity screening shows that both materials can support cell adhesion and proliferation. Furthermore, different surface modifications were performed( acid /alkaline treatment, UV radiation,and plasma) for modulating cell behavior. An increase of cell-material interactions were observed,indicating the important role of materials surface in the first hours of culturing. Human adipose-derived stem cells( hASCs) became an emerging possibility for regenerative medicine and tissue replacement therapies. The potential of the recently developed silk-based biotextile structures to promote hASCs adhesion,proliferation,and differentiation is also evaluated. The obtained results validate the developed constructs as viable matrices for TE applications. Given the processing efficacy and versatility of the knitting technology, and the interesting structural and surface properties of the proposed polymer fibers,it is foreseen that our developed systems can be attractive for the functional engineering of tissues such as bone,skin,ligaments or cartilage and also for develop more complex systems for further industrialization of TE products.

关键词： textile-based technologies silk polybutylene succinate(PBS) surface modifications human adipose-derived stem cells(hASCs) tissue engineering(TE)