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Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

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iLIVER 2024年第1期3卷 52-61页

作者： Pamela Scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela Hernández Bautista Elizabeth Gil White JoséAntonio González Moreno Daniel Angel Torres del Real Víctor Manuel Páez Zayas carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez Gómez Luis Jorge Fernández López Paul Santiago Mogrovejo Vázquez Isidoro Aczel Sánchez-Cedillo Víctor Jose Visag Castillo Social Service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico Social Service Internship Universidad AnahuacMexico City 04510Mexico Department of Surgery Division of Transplantation Surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,Science Direct and Index Medicus with MESH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma Liver transplantation Survival Criteria Recurrence Bibliometrics

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Thermal transport and phase transitions of zirconia by on-the-fly machine-learned interatomic potentials

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npj Computational Materials 2021年第1期7卷 1426-1434页

作者： carla Verdi Ferenc Karsai Peitao Liu Ryosuke Jinnouchi Georg Kresse University of Vienna Faculty of PhysicsComputational Materials PhysicsKolingasse 14-161090 ViennaAustria VASP Software GmbH Sensengasse 81090 ViennaAustria Toyota Central R&D Labs. Inc.Aichi 480-1192Japan

Machine-learned interatomic potentials enable realistic finite temperature calculations of complex materials properties with firstprinciples *** is not yet clear,however,how accurately they describe anharmonic properties,which are crucial for predicting the lattice thermal conductivity and phase transitions in solids and,thus,shape their technological *** we employ a recently developed on-the-fly learning technique based on molecular dynamics and Bayesian inference in order to generate an interatomic potential capable to describe the thermodynamic properties of zirconia,an important transition metal *** machine-learned potential accurately captures the temperature-induced phase transitions below the melting *** further showcase the predictive power of the potential by calculating the heat transport on the basis of Green–Kubo theory,which allows to account for anharmonic effects to all *** study indicates that machine-learned potentials trained on the fly offer a routine solution for accurate and efficient simulations of the thermodynamic properties of a vast class of anharmonic materials.

关键词： materials transitions harmonic

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Resource requirements of an edge-based digital twin service:an experimental study

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Virtual Reality & Intelligent Hardware 2022年第6期4卷 506-520页

作者： Federico MUNGARI Milan GROSHEV carla Fabiana CHIASSERINI Department of Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Departamento de Ingenieria Telematica Universidad Carlos III de MadridMadrid 28911Spain

Digital Twin(DT)is a pivotal application under the industrial digital transformation envisaged by the fourth industrial revolution(Industry 4.0).DT defines intelligent and real-time faithful reflections of physical entities such as industrial robots,thus allowing their remote *** on the latest advances in Information and Communication Technologies(ICT),namely Network Function Virtualization(NFV)and Edge-computing,DT can be deployed as an on-demand service in the factories close proximity and offered leveraging radio access ***,with the purpose of achieving the well-known scalability,flexibility,availability and performance guarantees benefits foreseen by the latest ICT,it is steadily required to experimentally profile and assess DT as a Service(DTaaS)***,the dependencies between the resources claimed by the service and the relative demand and work loads require to be *** this work,an Edge-based Digital Twin solution for remote control of robotic arms is deployed in an experimental testbed where,in compliance with the NFV paradigm,the service has been segmented in virtual network *** research has primarily the objective to evaluate the entanglement among overall service performance and VNFs resource requirements,and the number of robots consuming the service *** profiles show the most critical DT features to be the inverse kinematics and trajectory ***,the same analysis has been carried out as a function of the industrial processes,namely based on the commands imposed on the robots,and particularly of their ion-level,resulting in a novel trade-off between computing and time resources requirements and trajectory *** derived results provide crucial insights for the design of network service scaling and resource orchestration fra-meworks dealing with DTaaS ***,we empirically prove LTE shortage to accommodate the minimum DT latency requirements.

关键词： Digital twin Edge NFV Testbed Performance evaluation

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Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies

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Neural Regeneration Research 2017年第3期12卷 403-404页

作者： Lorenzo Di Cesare Mannelli carla Ghelardini Department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly

Neuropathic pain originates from damages to the somatosensory nervous system（IASP-International Association for the Study of Pain-taxonomy）.Lesions（traumas,compression,iatrogenic and pharmacological causes）or dise... 详细信息

关键词： Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies EFSA

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Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: Old question new insights

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World Journal of Gastroenterology 2014年第28期20卷 9439-9450页

作者： Carlos Sostres carla Jerusalen Gargallo Angel Lanas Service Department of Digestive Diseases University Hospital Lozano Blesa Digestive Diseases Department Aragon Health Sciences Institute CIBERehd University of Zaragoza (Zaragoza)

Previous reports clearly demonstrated that Helicobacter pylori(***)infection,nonsteroidal anti-inflammatory drugs(NSAID)or low dose aspirin(ASA)use significantly and independently increased the risk for the development of peptic ulcer ***,the presence of *** infection associated with low dose ASA and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important *** NSAID intake in the presence of *** infection may further increase the risk of peptic ulcer carried by the presence of only one risk factor is still a matter of *** on the interaction between the two risk factors yielded conflicting data and no consensus has been reached in the last *** addition,the interaction between *** infection and low-dose ASA remains even more *** real clinical practice,we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk *** huge variety of possible combinations greatly hinder the decision making process of physicians.

关键词： Nonsteroidal anti-inflammatory drugs Low dose aspirin Helicobacter pylori infection Helicobacter pylori eradication Peptic ulcer disease

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On the wavelet analysis of cutting forces for chatter identification in milling

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Advances in Manufacturing 2017年第2期5卷 130-142页

作者： Cesar Giovanni Cabrera Anna carla Araujo Daniel Alves Castello Department of Mechanical Engineering UniversidadeFederal do Rio de Janeiro Rio de Janeiro Brazil

Chatter vibrations in machining operations affect surface finishing and tool behaviour, particularly in the end-milling of aluminum parts for the aerospace industry. This paper presents a methodological approach to identify chatter vibrations during manufacturing processes. It relies on wavelet analyses of cutting force signals during milling operations. The cutting-force signal is first decomposed into an approximation/trend sub-signal and detailed subsignals, and it is then re-composed using modified subsignals to reduce measurement noise and strengthen the reference peak forces. The reconstruction of the cuttingforce signal is performed using a wavelet denoising pro- cedure based on a hard-thresholding method. Four experimental configurations were set with specific cutting parameters using a workpiece specifically designed to allow experiments with varying depths of cut. The experimental results indicate that resultant force peaks （after applying the threshold to the detailed sub-signals） are related to the presence of chatter, based on the increased correlation of such peaks and the surface roughness profiles, thereby reinforcing the applicability of the proposed method. The results can be used to control the online occurrence of chatter in end-milling processes, as the method does not depend on the knowledge of cutting geometry nor dynamic parameters.

关键词： Cutting force End milling Chatter Waveletfilter

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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva Tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

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Timing of breeding as a determinant of nest success of the vulnerable Chestnut Seedeater(Sporophila cinnamomea)in grasslands of southern South America

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Avian Research 2023年第1期14卷 126-135页

作者： Jonas Rafael Rodrigues Rosoni carla Suertegaray fontana Caio JoséCarlos Programa de Pós-Graduacão em Biologia Animal Departamento de ZoologiaUniversidade Federal do Rio Grande do SulUFRGSAvenida Bento Gonçalves950091501-970Porto AlegreRio Grande do SulBrazil Laboratório de Ornitologia Museu de Ciências e TecnologiaPrograma de Pós-Graduacão em Ecologia e Evolucão da BiodiversidadePontifícia Universidade Católica do Rio Grande do SulPUCRSAvenida Ipiranga668190619-900Porto AlegreRio Grande do SulBrazil Departamen to de Ecologia Universidade Federal do Rio Grande do SulUFRGSAvenida Bento Gonçalves950091501-970Porto AlegreRio Grandedo SulBrazil

The breeding traits of Sporophila seedeaters have been relatively well studied in recent years;nevertheless,a group of ten species in the genus,known as southern capuchinos,remain *** is the case with Chestnut Seedeater(Sporophila cinnamomea),a species vulnerable to extinction,which breeds in the grasslands of southeast South America and,after reproduction,migrates towards the Cerrado region in central ***,we investigated breeding ecology and calculated average clutch size,productivity,the sex ratio of nestlings,and estimated nest *** we tested(1)whether there is a relationship between the number of active nests and environmental variables,(2)whether the nestling sex ratio deviates from the 1:1 ratio,(3)whether clutch size varies between breeding seasons,and(4)whether the nest success is related to starting date,nest age,plant support,nest height from the ground,and clutch *** two breeding seasons(October-March 2018-2020),we monitored 98 *** generated survival models with five interacting covariates to assess the survival of the *** recorded the entire breeding period for Chestnut Seedeater,which was estimated to be 4.6 months,similar to other migratory *** size did not differ between breeding *** sex ratio of nestlings was not significantly different from the 1:1 *** success was 31%,and predation was the leading cause of unsuccessful nests(83%).The daily survival rate was 0.95±*** main predictor of nest survival was the covariate starting *** findings,added to other aspects of the species’natural history described here,may help illuminate the ecology and behavior of Chestnut Seedeater and other southern endangered capuchinos,and grassland-dependent species of South America.

关键词： Brood parasitism Clutch size Neotropical grassl ands Nest age Nest predation Nest survival

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Redox behavior of gold supported on ceria and ceria-zirconia based catalysts

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Journal of Rare Earths 2009年第2期27卷 196-203页

作者： Michela Vicario Jordi Llorca Marta Boaro carla de Leitenburg Alessandro Trovarelli Dipartimento di Scienze e Tecnologie Chimiche Università di UdineVia del Cotonificio 10833100 UdineItaly Institut de Tècniques Energètiques Universitat Politècnica de CatalunyaDiagonal 647ed. ETSEIB08028 BarcelonaSpain

A series of gold-based catalysts were prepared by deposition precipitation or incipient wetness impregnation on CexZ1-xO2 solid solutions （0.28≤x≤1.00）. The morphological and structural characterization of these catalysts were carried out with X-ray diffraction, trans- mission electron microscopy （TEM） analysis and physical adsorption technique, and their redox properties were studied by temperature programmed reduction using both H2 and CO as probe molecules. Two cycles of oxidation/reduction were carried out in order to evaluate the effects of redox aging and gold sintering on the oxygen exchange capability. As observed with other noble metals, gold enhanced and promoted the ceria reduction at lower temperatures. Reduction by CO was shown to be dependent on the fine dispersion of gold and to be nega- tively affected by the ageing process more than reduction with hydrogen. This might have implications in reactions like water gas shift and CO-PROX which involve CO as a main reactant.

关键词： gold ceria zirconia catalysis reduction behaviour nanoparticles temperature programmed reduction X-ray diffraction rare earths

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Earthquake distribution and lithospheric rheology beneath the Northwestern Andes, Colombia

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Geodesy and Geodynamics 2021年第1期12卷 1-10页

作者： carla Lagardère Carlos A.Vargas Department of Geosciences Universidad Nacional de ColombiaBogotaColombia Ecole nationale superieure en environnement georessources et ingenierie du developpement durable(ENSEGID)BordeauxFrance

The rheological behavior of the lithosphere beneath the Northwestern(NW)Andes(Colombian)remains uncertain under a complex geological ***,we analyze the earthquake distribution and the stress drop on the western and the eastern of the transition area between the Upper Magdalena Valley(UMV)and the Middle Magdalena Valley(MMV),a zone related to a plate tectonic transition from steeper to flatter subduction style slabs(Nazca and Caribbean plates).Our results consistently explain the tectonic and geodynamic context of the study area supported in two rheological profiles,which reveal the brittle/ductile transition of the lithospheric crust and mantle and allow to constrain the lithospheric rheological *** subduction phenomenon of the Nazca Plate under the South American Plate is observed in the western *** the eastern region,we find a remarkable aseismic zone under the Eastern Cordillera below 20-km-deep,which made more difficultan accurate estimation of the crust/mantle *** seismic particularity leads us to support the hypothesis of a delamination process due to the tectonic overload generated by the Eastern Cordillera,and that promotes thermal *** results also suggest that the earthquake dataset correlated with rheological estimations may offer a consistent interpretation of the mechanical behavior of the lithosphere.

关键词： Lithosphere rheology Seismicity Northwestern Andes Delamination process

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