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Bacteria in cancer therapy: beyond immunostimulation

Journal of Cancer Metastasis and Treatment 2018年第1期4卷 44-68页

作者： Wheeler Torres Victor Lameda Luis Carlos Olivar carla navarro Jorge Fuenmayor Adrian Perez Andres Mindiola Milagros Rojas Maria Sofia Martinez Manuel Velasco Joselyn Rojas Valmore Bermudez Endocrine and Metabolic Diseases Research Center the University of ZuliaMaracaibo 4001Venezuela Miami Veterans Affairs Medical Center Geriatric Research Education and Clinical Center(GRECC)Miami 33125FLUSA Departme nt of Pharmacology "JM Vargas"Medical SchoolCentral University of VenezuelaCaracas 1050Venezuela Division of Pulmonary and Critical Care Medicine Brigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Advaneed Frontier Studies Research Group(ALEF) Simon Bolivar UniversityCucuta 540006Colombia

Currently,conventional therapies in cancer are improving;chemotherapy,radiotherapy and surgery have increased survival *** therapies have arisen with the same goal;immunotherapy has appeared as a promising option in the fight against cancer stimulating the immune system by inducing innate and adaptive *** responses include release of pro-inflammatory cytokines,making the immune system capable to eliminate or protect against multiple ***,many of these therapies are being used in clinical settings,such as checkpoint inhibitors,monoclonal anti cytotoxic T-Lymphocyte associated protein 4(CTL-4)and programmed death protein 1(PD1),with inspiring results;however,they may decrease immunotolerance,limiting their *** the same time,chemotherapy works by passive transport across the cell membrane,limiting its capacity to penetrate in tumor *** these reasons,bacteria employment represents one of the best candidates for cancer *** can surpass these barriers with their selective colonization which also has an oncolytic effect by increasing proliferation and immunostimulation in the tumor *** strains,such as Mycobacterium bovis,Clostridium,Salmonella typhimirium and Listeria monocytogenes have been studied showing promising results in experimental ***,their application in clinical trials has shown the need to maximize their therapeutic *** engineering and synthetic biology are necessary to prove the scope that this novel approach has against cancer due to implications of cancer therapy and public health.

关键词： Bacterium cancer selective colonization salmonella clostridium listeria

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Impact of dental clearance on total joint arthroplasty: A systematic review

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World Journal of Orthopedics 2019年第12期10卷 416-423页

作者： Christopher Frey Sergio M navarro Terri Blackwell carla Lidner H Del Schutte Jr Department of Orthopedic Surgery Stanford MedicineRedwood CityCA 94063United States Department of Surgery Baylor College of MedicineHoustonTX 77030United States Said School of Business University of Oxford Oxford OX11HPUnited Kingdom Comprehensive Joint Program Charleston Institute for Advanced OrthopedicsCharlestonSC 29464United States Dentistry Orange County Dental SocietyOrangeCA 92868United States

Many orthopedic surgeons require that their patients obtain dental clearance before elective total joint arthroplasty(TJA).However,there is no consensus substantiating the *** this end,a systematic review on the prevalence of dental pathology in TJA patients,risk factors for failing dental screening,and impact of dental evaluations was *** was sourced from PubMed and Scopus *** papers were sourced from the initial search,one study was extracted from the references of the original six manuscripts,and one new publication was retrieved from a second search conducted after the *** prevalence of dental pathology ranged from 8.8%to 29.4%across *** of four papers reported lower than average or improvements in postoperative infection with pre-operative dental evaluations while two found no such *** is insufficient evidence to support universal dental clearance before TJA.

关键词： Total knee arthroplasty Total hip arthroplasty Total joint arthroplasty Periprosthetic joint infection Dental screening

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Non-guided self-learning program for high-proficiency optical diagnosis of diminutive and small colorectal lesions: A single-endoscopist pilot study

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World Journal of Gastroenterology 2019年第10期25卷 1278-1287页

作者： Marco Bustamante-Balén carla Satorres Lorena Puchades Belén navarro Natalia García-Morales Noelia Alonso Marta Ponce Lidia Argüello Vicente Pons-Beltrán Gastrointestinal Endoscopy Research Group Gastrointestinal Endoscopy UnitDigestive Diseases DepartmentLa Fe Polytechnic University Hospital Digestive Diseases Department La Fe Polytechnic University Hospital Gastrointestinal Endoscopy Unit Digestive Diseases DepartmentLa Fe Polytechnic University Hospital

BACKGROUND The implementation of optical diagnosis(OD) of diminutive colorectal lesions in clinical practice has been hampered by differences in performance between community and academic settings. One possible cause is the lack of a standardized learning tool. Since the factors related to better learning are not well described, strong evidence upon which a consistent learning tool could be designed is lacking. We hypothesized that a self-designed learning program may be enough to achieve competency in OD of diminutive lesions of the *** To assess the accuracy of OD of diminutive lesions in real colonoscopies after application of a self-administered learning *** This was a single-endoscopist prospective pilot study, in which an experienced endoscopist followed a self-designed, self-administered learning program in OD of colorectal lesions. An assessment phase divided in two halves with a 6-mo period in between without performance of OD was developed in a populationbased colorectal cancer screening program. The accomplishment of the Preservation and Incorporation of Valuable Endoscopic Innovations criteria and performance measures were calculated overall and in the two halves of the assessment phase, assessing their response to the 6-mo stopping period. The evolution of performance through blocks of 50 lesions was also *** Overall, 152 patients and 522 lesions(≤ 5 mm: 399, and 6-9 mm: 123) were included. The negative predictive value for the OD of adenoma in rectosigmoid lesions diagnosed with high confidence was 91.7% [95% confidence interval(CI):87.3-96.6]. The proportion of agreement on surveillance interval between OD and pathological diagnosis was higher than 95%. Overall accuracy for diminutive lesions diagnosed with high confidence was 89.5%(95%CI: 86.3-92.7). The overall accuracy of OD was similar in the two halves of the assessment phase [90.1(95%CI: 85.6-94.7) vs 88.2(95%CI: 87.9-95.9)]. All the other performance parameters we

关键词： Optical diagnosis Accuracy Learning Polyp Colonoscopy Education

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自体牙断片粘结术-牙周手术、牙髓和充填治疗的综合疗法：病例报告

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中国口腔医学继续教育杂志 2006年第4期9卷 10-13页

作者： Regina Guenka Palma-Dobb Mario Taba carla Moreto Santos Valeria Pontelli navarro 李銶石（译）王嘉德（校）不详北京大学口腔医学院北京海淀区中关村南大街22号 100081

文献报道中，成年人牙外伤发生率不断增长，为了保存牙齿，需要对每个外伤牙进行正确、恰当的专业治疗。本篇报告了2个牙折病例。从病例的情况可以得出结论：临床医生需要掌握多学科知识对患牙进行有效的治疗。

关键词：病例报告充填治疗牙周手术综合疗法粘结术自体牙牙髓保存牙齿

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