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Replacement of Cereal with Low Starch Fibrous By-Products on Nutrients Utilization and Methane Emissions in Dairy Goats

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Open Journal of Animal Sciences 2015年第2期5卷 198-209页

作者： carla Ibanez Vicente Javier Moya Haritz Arriaga Diana maria Lopez Pilar Merino Carlos Fernandez Research Group ACUMA Animal Science DepartmentPolytechnic University of ValenciaValenciaSpain Institute for Animal Science and Technology Universitat Politecnica de ValenciaValenciaSpain Neiker-Tecnalia Basque Institute for Agricultural Research and DevelopmentBizkaiaSpain

Feeding systems for dairy ruminants need to ensure high intake of energy to achieve maximum milk production potential. This might be accomplished by raising the dietary concentration of cereal grain. Increasing the concentration of starch in diets can lead to undesirable ruminal fermentation, and to prevent it, the partial replacement of cereal grain with low starch by-product feeds is recommended. The purpose of the present study was to compare the effect of fed two mixed diets to dairy goats differing in the type of carbohydrate (starch vs. easily degradable fiber). Energy and nitrogen balance, short chain fatty acids in rumen liquor and milk performance in dairy goats during mid lactation were determined. Enteric methane (CH4) emissions and CH4 production from manure were determined as well. Ten multiparous Muciano-Granadina goats were assigned to two isoenergetic and isoproteic diets (19.1 MJ/kg dry matter (DM) and 18.1% of CP, DM basis) in a crossover design. One group was fed a mixed ration with 21.9% of starch (HS diet) and the other (LS diet) with 7.0% of starch. HS diet had 36% of barley (as source of starch) and it was replaced with soy hulls and corn gluten feed in LS diet (as potentially digestible fiber). No differences were observed for dry matter intake in both diets (2.05 kg/d, on average). A significant increase of ruminal acetic acid was found for low starch diet (66.4 and 56.6 mol/100 mol for LS and HS diet, respectively). No significant effect was found among diets for enteric CH4 emissions (28.5 g/d, on average). Manure derived maximum potential yield was (Bo) higher in HS diet, with 5.9 L CH4/kg OM vs. 0.28 L CH4/kg OM for LS diet, probably associated with the low ADF digestibility. Differences among diets were found for milk production (2.4 vs. 2.2 kg/d for HS and LS, respectively), and greater milk fat was observed with LS diet compared with HS (6.4% vs. 5.5%, respectively).

关键词： Goats Starch Enteric Methane Manure CH_(4)0. Potential Production

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High prevalence of occult hepatitis C infection in predialysis patients

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World Journal of Hepatology 2019年第1期11卷 109-118页

作者： Luís Henrique Bezerra Cavalcanti Sette Edmundo Pessoa de Almeida Lopes Nathália Campello Guedes dos Anjos Lucila maria Valente Sávio Augusto vieira de Oliveira Norma Lucena-Silva Nephrology-Department of Clinical Medicine Federal University of Pernambuco Gastroenterology-Department of Clinical Medicine Federal University of Pernambuco Laboratory of Immunogenetics of the Aggeu Magalh?es Institute - Fiocruz Pernambuco

BACKGROUND Occult hepatitis C virus(HCV) infection(OCI) may be associated with extrahepatic diseases and it is known that the patients with chronic kidney disease(CKD) who are on hemodialysis(HD) present a higher prevalence of this type of infection than the general population, with a worse clinical ***, there are no data in the literature to assess the presence of OCI in patients prior to the initiation of renal replacement therapy(RRT). Therefore, this study aimed to evaluate the occurrence and epidemiological aspects of OCI in patients with Predialysis CKD. We hypothesize that this infection could occur before RRT *** To research the status in predialysis patients when HD patients have high prevalence of *** A cross-sectional study was conducted between 2015 and 2017. Adults with creatinine clearance < 60 mL/min·1.73 m^2(predialysis patients) were recruited to the study. Pregnant and postpartum women, patients with glomerulopathies,and patients showing positivity for serological markers of hepatitis B virus(HBV), HCV or human immunodeficiency virus infection were excluded. Patients were diagnosed with OCI according to test results of anti-HCV antibody negativity and HCV RNA positivity in either ultracentrifuged serum or, if serumnegative, in peripheral blood mononuclear *** Among the 91 total patients included in the study, the prevalence of OCI was 16.5%. Among these 15 total OCI patients, 1 was diagnosed by 14 ultracentrifuged serum results and 14 were diagnosed by peripheral blood mononuclear cell results. Compared to the non-OCI group, the OCI patients presented higher frequency of older age(P = 0.002), patients with CKD of mixed etiology(P = 0.019), and patients with markers of previous HBV infection(i.e.,combined positivity for anti-hepatitis B core protein antibody and anti-hepatitis B surface protein antibody)(P = 0.001).CONCLUSION Among predialysis patients, OCI involved the elderly, patients with CKD of mixed eti

关键词： Occult hepatitis infection Chronic hepatitis C Chronic kidney disease Hemodialysis Hepatitis C virus-RNA Peripheral blood mononuclear cells

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Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis

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World Journal of Experimental Medicine 2017年第1期7卷 11-24页

作者： Pedro Xavier-Elsas Daniela Masid-de-Brito Bruno Marques vieira maria Ignez C Gaspar-Elsas Department Immu-nology Instituto de Microbiologia Paulo de GóesUniversidade Federal do Rio de Janeiro Department Pediatrics Instituto Nacional de Saúde da Mulherda Crian?a e do Adolescente Fernandes FigueiraFIOCRUZ

Granulopoiesis in murine bone-marrow is regulated by both intrinsic and extrinsic factors(including hormones, drugs, inflammatory mediators and cytokines). Eosinophils, a minor subpopulation of circulating leukocytes, which remains better understood in its contributions to tissue injury in allergic disease than in its presumably beneficial actions in host defense, provide a striking example of joint regulation of granulopoiesis within murine bone-marrow by all of these classes of extrinsic factors. We first described the upregulation of eosinopoiesis in bone-marrow of allergen-sensitized mice following airway allergen challenge. Over the last decade, we were able to show a critical role for endogenous glucocorticoid hormones and cytokines in mediating this phenomenon through modification of cytokine effects, thereby supporting a positive association between stress hormones and allergic reactions. We have further shown that cysteinylleukotrienes(Cys LT), a major proinflammatory class of lipid mediators, generated through the 5-lipoxygenase pathway, upregulate bone-marrow eosinopoiesis in vivo and in vitro. Cys LT mediate the positive effects of drugs(indomethacin and aspirin) and of proallergic cytokines(eotaxin/CCL11 and interleukin-13) on in vitro eosinopoiesis. While these actions of endogenous GC and Cys LT might seem unrelated and even antagonistic, we demonstrated a critical partnership of these mediators in vivo, shedding light on mechanisms linking stress to allergy: GC are required for Cys LT-mediated upregulation of bone-marrow eosinopoiesis in vivo, but also attenuate subsequent ex vivo responses to Cys LT. GC and Cys LT therefore work together to induce eosinophilia, but through subtle regulatory mechanisms also limit the magnitude of subsequent bone-marrow responses to allergen.

关键词： Bone marrow Leukotriene Eosinophil Stress Glucocorticoid

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Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

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World Journal of Hepatology 2020年第4期12卷 137-148页

作者： Cliviany Borges da Silva Diego Alves vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene maria de Magalh?es Queiroz Gifone Aguiar Rocha maria Marta Sarquis Soares Juliana maria Trindade Bezerra Luciana Diniz Silva Sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Medical undergraduate student Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Department of Internal Medicine Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Division of Endocrinology Department of Internal MedicineFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Epidemiology of Infectious and Parasitic Diseases Laboratory Department of ParasitologyInstitute of Biological SciencesUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes *** the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune *** serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C *** To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same *** between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC *** Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively *** 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes ***,biochemical,histological and radiological methods were used for the diagnosis of the liver ***-6 polymorphism was evaluated by Taqman SNP genotyping *** data were analysed by logistic regression *** Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,*** frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C *** identification of potential inflammatory mediato

关键词： Chronic Hepatitis C Type 2 diabetes mellitus Interleukin 6-174G/Cgenepromoter single nucleotide polymorphism Blood hypertension Healthy control subjects

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Evaluation of the Efficacy of 99.9% Pure Silver Trilaminate Cups in the Prevention and Treatment of Nipple Pain and Fissures

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Open Journal of Nursing 2023年第10期13卷 686-698页

作者： Monica Pilloni Pierina Zedda carla Orrù Elena Fassina maria Carmela Forte Rossana Mazzulla Brunella Celestino maria Francesca Marotto Manuela Neri Gian Benedetto Melis Anna maria Paoletti University Hospital of Cagliari (UHC) Cagliari Italy Department of Surgical Sciences University of Cagliari Cagliari Italy Maternal and Child Family Counselling Quartu Sant’Elena Cagliari Italy Caruso’s Medical Office Cusago Italy Hospital of Castrovillari Cosenza Italy Hospital of Cosenza Cosenza Italy Maternal and Child Family Counselling Argentano Cosenza Italy Company of National Importance and High Specialization (CNIHS) Giovanni Brotzu Cagliari Italy Women’s Wellness Foundation Cagliari Italy

Breastfeeding is drastically decreasing over time and nipple trauma constitutes one of the most significant reasons for its discontinuation. In this context, this study aimed at evaluating the effectiveness and tolerability of a topical treatment device, namely Silver Cap® (Depofarma S.P.A.), when used to prevent pain and nipple fissure formation. The medical device consists in a silver trilaminate cup to be placed on the nipple, providing physical protection and creating a moist environment. The study involved 187 women: 38 started to apply the device prior to lactation (PL group) and 149 during lactation (DL group). Aiming to collect safety and performance data, both groups were provided with questionnaires during 6 consecutive visits (120 days of follow-up). At last visit, absence of painful symptoms was reported by the 98.8% and the 100% of women in DL and PL groups, respectively. Moreover, no nipple fissures were observed and no adverse events directly correlated to use of the device were reported. According to these findings, it can be concluded that Silver Cap® is a safe and effective device for nipple pain and fissure prevention. .

关键词： Silver Cap Breastfeeding Breast Pain Nipple Fissures

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Nitrogen and Phosphorus Fertilization Promotes Aerial Part Development and Affect Nutrient Uptake by Carobinha of the Brazilian Cerrado

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American Journal of Plant Sciences 2017年第13期8卷 3377-3398页

作者： Willian vieira Goncalves maria do Carmo vieira Thiago de Oliveira Carnevali Néstor A.Heredia Zarate Heldo Denir Vhaldor Rosa Aran Katia Cristina Silva Mineli Agrarian Science Faculty Federal University of Grande Dourados—UFGDUniversity CityDouradosBrazil Federal University of Para—UFPA Sao SebastiaoBrazil Biological and Environmental Sciences Faculty UFGDDouradosBrazil

Producing Brazilian Cerrado plants, especially ones endangered, is essential for your maintenance. In this way, fertilization is furthermore uncertain. Here, we demonstrate the impact of soil addition of nitrogen (N, 4.20, 18.90, 31.50, 44.10 and 59.85 mg·dm-3) and phosphorus (P, 9.56, 57.38, 95.62, 133.86 and 181.67 mg·dm-3) fertilizers levels on the development and on nutrients uptake by Jacaranda decurrens subsp. symmetrifoliolata (carobinha), species of the Brazilian Cerrado, in a long term pot trial. The N and P addition together increased plant height and N concentration in roots. N and P also increased the P concentration and content on the roots in young plants, but in the older plants, isolated effect of both was stronger than their combined action. The N addition promoted branching, production of dry leaves and dry xylopodium, contents of K, Ca and P on the leaves, and N content on the roots. However, the N reduced xylopodium diameter, leaf area, and Mg contents in the young plants, but increased them in the older plants. The P addition increased stem diameter and dry biomass, P concentration and N content on the leaves, Ca content on the roots and also reduced N concentration on the leaves. However, the P addition increased Mg concentration on the roots in the young plants and reduced it in the older plants. In general, N levels ranging between 25.69 - 38.85 mg·dm-3 and P levels between 84.39 - 109.23 mg·dm-3 promote more effectively the plant development. Thus, N and P fertilization can promote the aerial development of plant and a differential allocation of nutrients between the carobinha tissues.

关键词： Jacaranda decurrens Sub sp.symmetrifoliolata Bignoniaceae Nitrogen Management Phosphorus Management

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Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests

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World Journal of Gastroenterology 2014年第33期20卷 11815-11825页

作者： Vicente Felipo Amparo Urios carla Giménez-Garzó Omar Cauli maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu Laboratory of Neurobiology Centro Investigación Príncipe Felipe 46012Valencia Spain Fundación Investigación Hospital Clínico de Valencia. Instituto de Investigación Sanitaria INCLIVA 46010 Valencia Spain Servicio DigestivoHospital Arnau de Vilanova 46015 Valencia Spain Grupo Hepatología Servicio Aparato Digestivo Hospital Clínico de Valencia 46010 Valencia Spain Philips Healthcare Iberia 28050 Madrid Spain ERESA Unidad RM 46015 Valencia Spain Departamento de Patología Facultad de Medicina Universidad de Valencia 46010 Valencia Spain

AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy.

关键词： Arterial spin labelling Neurological impair-ment Blood flow Cerebellum Minimal hepatic enceph-alopathy

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意大利语

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2012年

作者： (意) carla Larese Riga Chiara maria Dal Martello

本书共分三部分, 第一部分为DVD视频材料“旅行”的相关练习 ; 第二部分为正文部分, 所涉及的主题有: 初次见面、城市、人与性格等 ; 第三部分为附录, 包含了“动词时态”、“前置词与动词不定式的连用”、“动词变位表”和“总词汇表”。

ISBN: (纸本)9787894200129;9787513521024;9787880957075

关键词：意大利语

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Signaling Networks Controlling HCC Onset and Progression: Influence of Microenvironment and Implications for Cancer Gene Therapy

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Journal of Cancer Therapy 2013年第2期4卷 353-358页

作者： Alessandra Marchetti carla Cicchini Laura Santangelo Angela maria Cozzolino Viviana Costa Marco Tripodi Laura Amicone Pasteur Institute—Cenci Bolognetti Foundation Department of Cellular Biotechnologies and Hematology Sapienza University Rome Italy

Hepatocarcinogenesis, as other epithelial malignancies, has been proved to be a multistep process that, starting from mutagenic events, allows the transformed liver cell to evolve towards a more aggressive phenotype, characterized by the acquisition of migratory/invasive and stem-cell-like properties. Hepatocellular carcinoma(HCC)can originate from both mature hepatocytes and liver precursor/stem cells. Whatever its origin, a common feature of advanced-stage HCC is the reduction or lack of expression of master genes of epithelial/hepatocyte differentiation, i.e. members of the liver enriched transcription factors(LEFTs)family like HNF4α, and conversely an increased expression of epithelial-to-mesenchymal transition(EMT)master genes, i.e. the transcriptional repressors belonging to the Snail family. Recently, it has emerged as members of these families are capable to directly repress each other and to regulate in opposite manner target genes involved in stemness and in hepatocyte differentiation, thus influencing cell outcome between epithelial/differentiated/poor aggressive and mesenchymal/undifferentiated/aggressive phenotype. Consequently, the restoration of LEFT functions in invasive HCC could represent an important goal for anti-cancer therapies. However, any strategy based on gene transfer needs to take in account the influence of micro-environmental factors in HCC tumor niche, like TGFb, responsible for shifting the described balance in tumor cell towards the acquisition of stem-cell like properties and invasiveness, through Snail/EMT induction and LEFTs downregulation. The presence of this cytokine, indeed, was shown to override both anti-EMT and tumor suppressor activity of the ectopically expressed HNF4α protein. In this review, the rationale to propose implementation of HCC gene therapy will be discussed.

关键词： HNF4 Snail TGFβ microRNA EMT Cancer Stem Cell

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Chemical and microbiological characterization of tinctures and microcapsules loaded with Brazilian red propolis extract

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Journal of Pharmaceutical Analysis 2017年第5期7卷 280-287页

作者： Erika Tayse da Cruz Almeida maria Cristina Delgado da Silva José Marcos dos Santos Oliveira Regianne Umeko Kamiya Rodolfo Elleson dos Santos Arruda Danilo Abreu vieira Valdemir da Costa Silva Pierre Barnabé Escodro Irinaldo Diniz Basílio-Júnior Ticiano Gomes do Nascimento Laboratório de Controle de Qualidade e Análise de Fármacos Medicamentos e AlimentosCurso de FarmáciaEscola de Enfermagem e FarmáciaUniversidade Federal de AlagoasCampus A.C.SimõesBR 104 Norte-Km 97MaceióAL.CEP:57072-970Brazil Laboratório de Controle de Qualidade Microbiológico de Alimentos Faculdade de NutriçãoUniversidade Federal de AlagoasCampus A.C.SimõesBR 104 Norte/Km 97MaceióAL.CEP:57072-970Brazil

The aim of this study was to characterize tinctures and microcapsules loaded with an ethanol extract of red propolis through chemical, physicochemical and microbiological assays in order to establish quality control tools for nutraceutical preparations of red propolis. The markers(isoflavonoids, chalcones, pterocarpans,flavones, phenolic acids, terpenes and guttiferones) present in the tinctures A and B were identified and confirmed using LC/ESI/FTMS/Orbitrap. Four compositions(A, B, C and D) were prepared to contain B tincture of the red propolis with some pharmaceutical excipients and submitted to two drying processes, i. ***-drying and freeze-drying to obtain microcapsules loaded with the red propolis extract. The tinctures and microcapsules of the red propolis were submitted to the total flavonoid content and antioxidant activity *** antibacterial activity and minimum inhibitory concentration(MIC) were tested using Staphylococcus aureus ATCC 25293 and Pseudomonas aeruginosa ATCC 27853 strains. The tinctures and microcapsules presented high flavonoid quantities from 20.50 to 40.79 mg/100 mg of the microcapsules. The antioxidant activity and IC50 were determined for the tinctures A and B(IC50: 6.95 μg/m L and 7.48 μg/m L), the spray-dried microcapsules(IC50: 8.89–15.63 μg/m L) and the freeze-dried microcapsules(IC50: 11.83–23.36 μg/m L). The tinctures and microcapsules were proved to be bioactive against gram-positive and gram-negative bacteria with inhibition halos superior to 10 mm at concentration of 200 μg/m L and MIC values of 135.87–271.74 μg/m L using gram-positive strain and 271.74–543.48 μg/m L using gram-negative strain. The tinctures and microcapsules of the red propolis have a potential application for nutraceutical products.

关键词： Red propolis Tinctures Microcapsules Isoflavonoids LC/ESI/FTMS/Orbitrap Antioxidant activity Antibacterial activity

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