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Commentary on“Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain”

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Neural Regeneration Research 2024年第4期19卷 728-728页

作者： Lorenzo Di Cesare Mannelli Carla Ghelardini Department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Section of Pharmacology and ToxicologyUniversity of Florence

In pat i e nt s,a s well as in animal mod e l s,hypersensitivity to external stimuli(hyperalgesia and allodynia)or spontaneous pain is often the first,and the most disabling,symptom of neuropathy(Davis et al.,2020).The increased activity of sensitive neurons drives pain development,making ion channel modulation a fundamental target for current pharmacotherapy as well as one of the most investigated by the R&D departments of pharmaceutical companies(Bennett et al.,2019).

关键词： companies pain ent

Investigating epithelial-neuronal signaling contribution in visceral pain through colon organoid-dorsal root ganglion neuron co-cultures

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Neural Regeneration Research 2024年第6期19卷 1199-1200页

作者： Francesco Margiotia Lorenzo Di Cesare Mannelli Antonino Morabito Carla Ghelardini Elena Lucarini Department of Neuroscience Psychology Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section University of Florence Department of Neuroscience Psychology Drug Research and Child Health-NEUROFARBA University of Florence 3. Meyer Children's Hospital IRCCS

Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs), affecting about 20% of the global population(Grundy et al., 2019). Current pain therapies are poorly effective on visceral pain of intestinal origin and present several side effects, hence the need to identify novel molecular and cellular targets for drug development. The pathophysiology of visceral-abdominal pain,

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Mesenchymal stem cells, implications for pain therapy

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Neural Regeneration Research 2019年第11期14卷 1915-1916页

作者： Elena Trallori Carla Ghelardini Lorenzo Di Cesare Mannelli Dipartimento di Neuroscienze Psicologia Area del Farmaco e Salute del Bambino-Neurofarba-Sezione di Farmacologia e Tossicologia Università degli Studi di Firenze

History and biology of mesenchymal stem cell (MSC): MSCs were firstly described around 1970s by Friedenstein and his collaborators as a subpopulation of colony forming, clonogenic, plastic adherent stromal bone marrow derived cells, with the capacity to regenerate other tissues (Murphy et al., 2013). Caplan (1991) proposed that these mesenchymal cells were “stem” because of their ability to differentiate to any lineage of mesodermal cells. The richest sources of MSCs are bone marrow and adipose tissue, but they can also be isolated from synovial fluid, periosteum, fetal organs, placenta, umbilical cord blood and amniotic fluid (Murphy et al., 2013;Sherman et al., 2015).

关键词： mesenchymal stem cell (MSC) implications pain therapy

Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies

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Neural Regeneration Research 2017年第3期12卷 403-404页

作者： Lorenzo Di Cesare Mannelli Carla Ghelardini Department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly

Neuropathic pain originates from damages to the somatosensory nervous system（IASP-International Association for the Study of Pain-taxonomy）.Lesions（traumas,compression,iatrogenic and pharmacological causes）or dise... 详细信息

关键词： Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies EFSA

Treatment with acetyl-L-carnitine exerts a neuroprotective effect in the sciatic nerve following loose ligation:a functional and microanatomical study

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Neural Regeneration Research 2018年第4期13卷 692-698页

作者： Daniele Tomassoni Lorenzo Di Cesare Mannelli Vincenzo Bramanti Carla Ghelardini Francesco Amenta Alessandra Pacini School of Bioscience and Veterinary Medicine University of Camerino Department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Pharmacology and Toxicology SectionUniversity of Florence Department of Biomedical and Biotechnological Sciences University of Catania Section of Human Anatomy School of Medicinal and Health Products SciencesUniversity of Camerino Department of Experimental and Clinical Medicine-DMSC-Section of Anatomy and Histology University of Florence

Peripheral neuropathies are chronic painful syndromes characterized by allodynia,hyperalgesia and altered nerve functionality.Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathies.Aimed to improve the therapeutic possibilities,this study investigated the hypersensitivity and the neuromorphological alterations related to the loose ligation of the sciatic nerve in rats.Effects elicited by treatment with acetyl-L-carnitine（ALCAR） in comparison to gabapentin were assessed.Axonal injury,reduction of myelin deposition and accumulation of inflammatory cells were detected in damaged nerve.A decrease of phosphorylated 200-k Da neurofilament（NFP） immunoreactivity and a redistribution in small clusters of myelin basic like-protein（MBP） were observed in ipsilateral nerves.Treatment with ALCAR（100 mg/kg intraperitoneally-i.p.） and gabapentin（70 mg/kg i.p.） administered bis in die for 14 days induced a significant pain relieving effect.ALCAR,but not gabapentin,significantly countered neuromorphological changes and increased axonal NFP immunoreactivity.These findings indicate that both ALCAR and gabapentin significantly decreased the hypersensitivity related to neuropathic lesions.The observation of the positive ALCAR effect on axonal and myelin sheath alterations in damaged nerve supports its use as neurorestorative agent against neuropathies through mechanism（s） consistent to those focused in this study.

关键词： peripheral nerve chronic constriction injury neurorestoration morphology neurofilament myelin basic protein neural regeneration