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The effects of 12 weeks of functional strength training on muscle strength,volume and activity upon exposure to elevated Gz forces in high-performance aircraft personnel

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Military Medical Research 2021年第4期8卷 481-489页

作者： Monika Rausch Frank Weber Sven Kühn carla Ledderhos Christoph Zinner Billy Sperlich Multinational Medical Coordination Centre/European Medical Command Andernacher Strasse 10056070 KoblenzGermany. German Air Force Center of Aerospace Medicine 82256 FuerstenfeldbruckGermany. Department of Radiology Bundeswehr Central Hospital56072 KoblenzGermany. Department of Sport University of Applied Sciences for Police and Administration of Hesse65199 WiesbadenGermany. Integrative&Experimental Exercise Science&Training Institute of Sport ScienceUniversity of Wuerzburg97082 WuerzburgGermany

Background:Technological advancements in modern military and acrobatic jet planes have resulted in extraordinary psychophysiological loads being exerted upon flying personnel,including inducing neck and back *** purpose of this study was to examine the effects of 12 weeks of functional strength training on 1)the volume and strength of the neck and shoulder muscles and 2)muscular activity upon exposure to helmets of different masses and elevated Gz forces in a long-arm centrifuge in high-performance aircraft ***:Eighteen participants underwent 12 weeks of functional strength training(n=12)or the control protocol(n=6)without additional strength ***-and post-intervention tests included evaluations of isometric strength of the head extensor muscles,flexion,and lateral flexion and rotation,as well as magnetic resonance imaging(MRI)to measure the volume of the ***,***,and deep neck ***,during a long-arm centrifuge(+1.4 and+3Gz)protocol,the muscular activity levels of the ***,*** and *** spinae muscles were assessed without a flight helmet,with a helmet,and with a helmet and night vision *** participant’s perception of muscular strain was noted immediately after the long-arm centrifuge ***:The maximal isometric strength in all exercises and muscle volumes increased in the training group but not the control group(P<0.05).Relative muscle activity(%MVC)with a helmet decreased after the intervention in the training but not the control group(P=0.01).Relative muscle activity while wearing a helmet and night vision goggles was higher after intervention in the control group than in the training group(P<0.01).The perceived muscular strain of the neck muscles induced by the long-arm centrifuge did not differ between the ***:Twelve weeks of functional strength training improves the maximal isometric strength and volume of neck and shoulder m

关键词： Fighter pilots Long-arm centrifuge Muscular strain Strength training Neck muscle High-performance aircraft Gz forces

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Predictive value of bleeding risk scores in elderly patients with atrial fibrillation and oral anticoagulation

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老年心脏病学杂志:英文版 2023年第9期20卷 684-692页

作者： Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi Andrea Lizancos-Castro Jose A Parada-Barcia AndréGonzález-García Ana Ledo-Piñeiro Vanesa Noriega-Caro carla Iglesias-Otero AndrésÍñiguez-Romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain

BACKGROUND The predictive value of bleeding risk scores for atrial fibrillation in older patients is not as well *** goal of this study was to evaluate the predictive value of HASBLED,ORBIT and ATRIA for major bleeding(MB)and intracranial hemorrhage(ICH)in patients≥75 years with atrial fibrillation and oral anticoagulation(OAC).METHODS A retrospective unicenter study including patients≥75 years with atrial fibrillation(AF)and OAC.A total of 7613 patients≥75 years with AF and OAC included between 2014 and 2018(registry:NCT04364516).We analyzed the discriminative value of HASBLED,ATRIA and ORBIT scores for bleeding endpoints(major bleeding as primary endpoint and intracerebral hemorrhage as secondary).Cox regression was used to predict major bleeding with each scale and also for searching other variables potentially predictor of major *** discrimination was assessed using Harrell’s *** was assessed with goodness-of-fit test proposed by Gronnesby and *** During a mean follow up of 4.0 years(IQR:2.4–5.7 years),729 patients developed MB(2.61 per 100 patients/year)and 243 patients developed ICH(0.85 per 100 patients/year).Three scores showed a low discrimination for major bleeding,being ORBIT the best(HASBLED C statistic=0.557;ATRIA C statistic=0.568;ORBIT C statistic=0.595)and also a low discrimination for ICH(HASBLED C statistic=0.509;ATRIA C statistic=0.522;ORBIT C statistic=0.526).Among the variables that are part of the scores and other baseline characteristics,after multivariable adjustment only sex(male),dementia,prior admission for bleeding,anemia and liver disease were found as a predictors of *** In older patients under oral anticoagulation with atrial fibrillation,the risk scores HASBLED,ATRIA and ORBIT showed a weak discrimination for major bleeding and intracranial ***,other better alternatives should be evaluated for this purpose.

关键词： patients bleeding fibrillation

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Tetrahydrohyperforin:a neuroprotective modified natural compound against Alzheimer's disease

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Neural Regeneration Research 2015年第4期10卷 552-554页

作者： carla Montecinos-Oliva Andreas Schüller Nibaldo C.Inestrosa Centro de Envejecimientoy Regeneración (CARE) Departamento de Biología Celulary Molecular Facultad de Ciencias Biológicas Pontificia Universidad Católica de ChileSantiagoChile Departamento de Genética Moleculary Microbiología Facultad de Ciencias BiológicasPontificia Universidad Católica de Chile Center for the Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia Centro de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de MagallanesPunta ArenasChile (Inestrosa NC) Centro UC Síndrome de Down Pontificia Universidad Católica de ChileSantiagoChile

According to the World Health Organization （WHO）, a total of 35.6 million cases of dementia were estimated in 2010, with close to 7.7 million new cases each year. In 2008, WHO declared dementia a priority condition. 90% of all dementia cases are considered to be Alzheimer＇s disease （AD）. Therefore, great effort was made to understand the etiology of the disease and stop or slow down AD progression.

关键词： TRPC PS APP Tetrahydrohyperforin CREB SKF Hyp

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Editorial note for the geodesy and geodynamics journal special issue contemporary research in geodynamics and earth tides-Selection from the 19th international symposium on geodynamics and earth tides,2021,Wuhan,China

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Geodesy and Geodynamics 2023年第1期14卷 1-3页

作者： Heping Sun carla Braitenberg Wei Feng Jean-Paul Boy S everine Rosat Chengli Huang Olivier Francis Cheinway Hwang Jacques Hinderer State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyCASWuhan 430077PR China University of Trieste Department of Mathematics and GeosciencesVia Weiss 1Trieste 34100Italy School of Geospatial Engineering and Science Sun Yat-sen UniversityZhuhai 519082PR China Institut de Physique du Globe de Strasbourg UMR 7516Universitede Strasbourg/EOSTCNRS5 rue DescartesStrasbourg 67084France Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030PR China University of Luxembourg(UL) L-1359Luxembourg National Chiao Tung University Taiwan 86PR China

This volume aims at providing a platform for sharing valuable topics discussed at the 19th International Symposium on Geodynamics and Earth Tides,23-26 June 2021,Wuhan,*** complete overview of all nineteen Symposia is... 详细信息

关键词： China tides Earth

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Suggestions on gut-eye cross-talk:about the chalazion

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1566-1566页

作者： carla Enrica Gallenga Marco Mura Pier Enrico Gallenga Department of Medical Sciences University of FerraraFerrara 44124Italy Eye Unit UOC University Hospital Arcispedale Sant’AnnaFerrara 44124Italy Department of Traslational Medicine and for Romagna University of FerraraFerrara 44124Italy Department of Ophthalmology Pescara 65100Italy

Dear Editor,We have studied with interest the publication"Effectiveness of oral probiotics supplementation in the treatment of adult small chalazion"by Filippelli et al[1].The conclusion of this work is exciting:the dialogue between gut and eye(brain)is now under the magnification lens and it deserves to continue the relationship studies,previously started by Filippelli et al[2]also on children.

关键词： conclusion gut exciting

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Cancer stem cell plasticity and tumor hierarchy

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World Journal of Stem Cells 2015年第1期7卷 27-36页

作者： Marina carla Cabrera Robert E Hollingsworth Elaine M Hurt MedImmune LLC Department of Oncology ResearchGaithersburg MD 20878 United States

The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer.

关键词： Cancer stem cells Stem cell Plasticity Tumor hierarchy Microenvironment Immune-mediatedtherapies Epithelial-to-mesenchymal transition

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The modifying influence of HLA classⅡDQB1^(*)06:02 on the Streptococcus and clinical phenotype correlation among anti-Ro+mothers of children with neonatal lupus

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Genes & Diseases 2023年第4期10卷 1169-1171页

作者： Robert M.Clancy carla J.Guthridge Miranda C.Marion Joel Guthridge Timothy D.Howard Peter M.Izmirly Mala Masson Jill P.Buyon Judith A.James Carl D.Langefeld Department of Medicine Division of RheumatologyNYU Grossman School of MedicineNew YorkNY 10016USA Arthritis and Clinical Immunology Oklahoma Medical Research FoundationOklahoma CityOK 73104USA Department of Biostatistics and Data Science Wake Forest School of MedicineWinstone SalemNC 27101USA Center for Precision Medicine Wake Forest School of MedicineWinstoneSalemNC 27101USA Department of Biochemistry Wake Forest School of MedicineWinstoneSalemNC 27101USA

The genus Streptococcus,a gram-positive bacterium,con-tains species associated with immune activation at morbid outcomes,including scarlet fever,endocarditis,meningitis,and rheumatic *** both stool and saliva,there is a pos-itive correlation between Streptococcus abundance and Sjogren’s syndrome(SS)and systemic lupus erythematosus(SLE).

关键词： lupus mother fever Streptococcus

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Effect of Lepidium meyenii(maca)roots on spermatogenesis of male rats

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Asian Journal of Andrology 2001年第3期3卷 231-233页

作者： Gustavo F.Gonzales Ana Ruiz carla Gonzales León Villegas Amanda Cordova Department of Physiological Sciences Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura.Universidad Peruana Cayetano Heredia.Postal Office 1843.LimaPeru

Aim:To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii(maca)on spermatogenesis in adult male ***;Male rats received an aqueous extract of the root(66.7 mg in onemL)twice a day for 14 consecutive ***:Treatment with Lepidium meyenii resulted in an increase in theweights of testis and epididymis but not the seminal vesicle *** length and frequency of stages IX-XIV seminif-erous tubules,where mitosis occurred,were increased and stages I-VI were reduced in rats treated with ***;The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initialstages(IX-XIV).

关键词： spermatogenesis Lepidium meyenii maca transillumination

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Dietary analysis of Homonota darwini (Squamata:Gekkonidae) in Northern Patagonia

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Current Zoology 2010年第4期56卷 406-410页

作者： Marcelo E.KUN carla PIANTONI John D.KRENZ Nora R.IBARGüENGOYTíA Departamento de Zoología Centro Regional Universitario Bariloche Universidad del Comahue Unidad Postal Universidad del Comahue Smithsonian Institution NHB MRC 163 Department of Biological Sciences Minnesota State University Departamento de Zoologia Centro Regional Universitario Bariloche Universidad del Comahue Unidad Postal Universidad del Comahue Instituto de Investigación en Diversidad y Medio Ambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Our study investigated the diet of the southernmost gecko in the world, Homonota darwini. Fifty-three specimenswere captured during spring and summer in four locations in Patagonia, Argentina. The stomach contents of the specimens wereidentified, and we found that prey consisted of six main groups: Coleoptera, Hymenoptera, Homoptera and Araneae, and theadults and larvae of moth Lepidoptera. Lepidoptera was the major dietary component. The presence of ants and moths as commonprey suggests an ambush feeding strategy. In spring, females consumed more ants than males although no other dietary differencesbetween males and females were evident. We found nine geckos with empty stomachs and six parasitized by *** of empty stomachs corroborates previous observations of other nocturnal geckos and non-gecko lizards. Reduced foragingsuccess of nocturnal lizards could be due to difficulty in prey detection due to dim light, reduced or erratic activity of insectprey at night, or shorter activity times of geckos relative to diurnal success. Sex and season were not associated with the incidenceof empty stomachs. Principal component analysis showed that four food alternatives correlated with season. The constraint ofnocturnality, coupled with low night-time temperatures restricting feeding to only a few hours after sunset, appear to have causeda generality of diet which may limit energy acquisition. We conclude that H. darwini is an arthropod generalist and likely an ambushforager, as are many other nocturnal

关键词：壁虎科膳食鳞翅目幼虫胃内容物塔食用蚂蚁夜间活动捕食昆虫

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Neuroprotection induced by NMDA preconditioning as a strategy to understand brain tolerance mechanism

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Neural Regeneration Research 2015年第4期10卷 542-543页

作者： Leandra C.Constantino Samuel Vandresen-Filho carla I.Tasca Departamento de Bioquímica Centro de Ciências BiológicasUniversidade Federal de Santa CatarinaUFSCCampus Trindade88040-900 FlorianópolisSCBrazil Departamento de Ciências Básicas em Saúde Faculdade de MedicinaUniversidade Federal de Mato GrossoCuiabáMTBrasil

Excitotoxicity refers to toxicity caused by abnormal concentrations of glutamate in the synaptic cleft that may lead to neuronal death. Since its description, the phenomenon of glutamatergic excitotoxicity has been implicated in the physiopathology of a wide range of neurological and psychiatric disorders, from acute brain damage such as traumatic brain injury, ischemia as well as chronic condi- tions like epilepsy, depression and neurodegenerative pathologies such as Huntington＇s, Parkinson＇s and Alzheimer＇s diseases. Exces- sive stimulation of glutamatergic receptors, mainly N-methyl-D-as- partate （NMDA） receptors （NMDAR）, can have numerous adverse effects on the cell viability, including increased nitric oxide release （NO）, activation of proteases, increased production of reactive oxygen （ROS） and nitrogen （RNS） species and massive influx of calcium ions （Ca2＋）, resulting in cell death. Thus, the use of strategies that modulate the excitotoxic cell damage represents a perspective for the treatment of diseases such as Parkinson＇s and Alzheimer＇s diseases, ischemia, traumatic brain injury （TBI） and seizures.

关键词： NMDA Neuroprotection induced by NMDA preconditioning as a strategy to understand brain tolerance mechanism

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