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Lithosphere density structure beneath the eastern margin of the Tibetan Plateau and its surrounding areas derived from GOCE gradients data

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Geodesy and Geodynamics 2017年第3期8卷 147-154页

作者： Honglei Li Jian Fang carla Braitenberg State Key Laboratory of Geodesy and Earth's Dynamics Institute of Geodesy and Geophysics Chinese Academy of Sciences Wuhan 430077 China University of Chinese Academy of Sciences No. 19A Yuquan Road Beijing 100049 China Department of Mathematics and Geosciences University of Trieste Trieste Italy

A three-dimensional density model of the crust and uppermost mantle is determined by the inversion of a set of GOCE gravity and gradients residual anomalies beneath the eastern margin of the Tibetan Plateau and its surrounding areas. In our work, we choose five independent gravity gradients （Txx, Tzz, Txy, Txz, Tyz） to perform density inversion. Objective function is given based on Tikhonov regularization theory. Seismic S-wave velocities play the role of initial constraint for the inversion based on a relationship between density and S-wave velocity. Damped Least Square method is used during the inversion. The final density results offer some insights into understanding the underlying geodynamic processes：（1） Low densities in the margin of the Tibet, along with low wave velocity and resistivity results, yield conversions from soft and weak Tibet to the hard and rigid cratons. （2）The lowest densities are found in the boundary of the plateau, instead of the whole Tibet indicates that the effects of extrusion stress environment in the margin affect the changes of the substance there. The substances and environments conditioning for the earthquake preparations and strong deformation in this transitional zone. （3） Evident low-D anomaly in the upper and middle crust in the Lasha terrane and Songpan-Ganzi terrane illustrated the eastward sub-ducted of southeastern Tibet, which could be accounts for the frequent volcano and earthouakes there.

关键词： Eastern Tibet Plateau Gravity gradient inversion Least square Density construction

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Unpaired sex chromosomes in metaphase I human spermatocytes locally modify autosomal bivalents positioning

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Asian Journal of Andrology 2018年第6期20卷 626-628页

作者： carla Mayans Joan Blanco Oliver Valero Francesca Vidal Zaida Sarrate Genetics of Male Fertility Group Unitat de Biologia Cel.lularDepartament de Biologia Cel.lularFisiologia i ImmunologiaFacultat de BiocienciesUniversitat Autbnoma de BarcelonaBellaterra（Cerdanyola del Vall~s）08193Spain Servei d＇Estadistica Aplicada Universitat AutOnoma de BarcelonaBetlaterra（Cerdanyola del Valles）08193Spain.

Dear Editor, In interphase nuclei, chromosomes occupy specific localizations called chromosome territories （CTs）. Distribution of CTs has been related to chromosome size and gene density and is known to influence gene expression.~ This pattern of organization appears to be a widespread nuclear feature, both in somatic and germ ceils.

关键词： ABNORMALITIES

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The effects of 12 weeks of functional strength training on muscle strength,volume and activity upon exposure to elevated Gz forces in high-performance aircraft personnel

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Military Medical Research 2021年第4期8卷 481-489页

作者： Monika Rausch Frank Weber Sven Kühn carla Ledderhos Christoph Zinner Billy Sperlich Multinational Medical Coordination Centre/European Medical Command Andernacher Strasse 10056070 KoblenzGermany. German Air Force Center of Aerospace Medicine 82256 FuerstenfeldbruckGermany. Department of Radiology Bundeswehr Central Hospital56072 KoblenzGermany. Department of Sport University of Applied Sciences for Police and Administration of Hesse65199 WiesbadenGermany. Integrative&Experimental Exercise Science&Training Institute of Sport ScienceUniversity of Wuerzburg97082 WuerzburgGermany

Background:Technological advancements in modern military and acrobatic jet planes have resulted in extraordinary psychophysiological loads being exerted upon flying personnel,including inducing neck and back *** purpose of this study was to examine the effects of 12 weeks of functional strength training on 1)the volume and strength of the neck and shoulder muscles and 2)muscular activity upon exposure to helmets of different masses and elevated Gz forces in a long-arm centrifuge in high-performance aircraft ***:Eighteen participants underwent 12 weeks of functional strength training(n=12)or the control protocol(n=6)without additional strength ***-and post-intervention tests included evaluations of isometric strength of the head extensor muscles,flexion,and lateral flexion and rotation,as well as magnetic resonance imaging(MRI)to measure the volume of the ***,***,and deep neck ***,during a long-arm centrifuge(+1.4 and+3Gz)protocol,the muscular activity levels of the ***,*** and *** spinae muscles were assessed without a flight helmet,with a helmet,and with a helmet and night vision *** participant’s perception of muscular strain was noted immediately after the long-arm centrifuge ***:The maximal isometric strength in all exercises and muscle volumes increased in the training group but not the control group(P<0.05).Relative muscle activity(%MVC)with a helmet decreased after the intervention in the training but not the control group(P=0.01).Relative muscle activity while wearing a helmet and night vision goggles was higher after intervention in the control group than in the training group(P<0.01).The perceived muscular strain of the neck muscles induced by the long-arm centrifuge did not differ between the ***:Twelve weeks of functional strength training improves the maximal isometric strength and volume of neck and shoulder m

关键词： Fighter pilots Long-arm centrifuge Muscular strain Strength training Neck muscle High-performance aircraft Gz forces

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Subcostal artery bleeding after endoscopic combined intrarenal surgery: Signs and treatment

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Asian Journal of Urology 2022年第1期9卷 101-102页

作者： Davide Campobasso Roberto Menozzi carla Marcato Antonio Frattini Urology Unit Civil Hospital of GuastallaAzienda USL-IRCCS di Reggio EmiliaParmaItaly Interventional Neuroradiology Unit University Hospital of ParmaParmaItaly Department of Radiology University Hospital of ParmaParmaItaly

Percutaneous nephrolithotomy is the first option in renal stones>2 *** of the most serious complications of this procedure is postoperative bleeding[1].Various risk factors(multiple punctures,position,access size,stone volume,operative time,and non-papillary puncture)were considered in the literature with no clear conclusions[[1],[2]].

关键词： bleeding puncture operative

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Alzheimer’s disease risk after COVID-19:a view from the perspective of the infectious hypothesis of neurodegeneration

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Neural Regeneration Research 2023年第7期18卷 1404-1410页

作者： Eugenia Olivera Albany Sáez Lila Carniglia carla Caruso Mercedes Lasaga Daniela Durand Instituto de Investigaciones Biomédicas INBIOMED UBA-CONICET Facultad de MedicinaUniversidad de Buenos AiresArgentina

In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term *** wondered how SARS-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the *** also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.

关键词： Alzheimer amyloid beta antimicrobial cognitive decline COVID-19 infectious hypothesis long-term sequelae neurodegeneration neuroinflammation neurological symptoms neurotropism SARS-CoV-2

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Tetrahydrohyperforin:a neuroprotective modified natural compound against Alzheimer's disease

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Neural Regeneration Research 2015年第4期10卷 552-554页

作者： carla Montecinos-Oliva Andreas Schüller Nibaldo C.Inestrosa Centro de Envejecimientoy Regeneración (CARE) Departamento de Biología Celulary Molecular Facultad de Ciencias Biológicas Pontificia Universidad Católica de ChileSantiagoChile Departamento de Genética Moleculary Microbiología Facultad de Ciencias BiológicasPontificia Universidad Católica de Chile Center for the Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia Centro de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de MagallanesPunta ArenasChile (Inestrosa NC) Centro UC Síndrome de Down Pontificia Universidad Católica de ChileSantiagoChile

According to the World Health Organization （WHO）, a total of 35.6 million cases of dementia were estimated in 2010, with close to 7.7 million new cases each year. In 2008, WHO declared dementia a priority condition. 90% of all dementia cases are considered to be Alzheimer＇s disease （AD）. Therefore, great effort was made to understand the etiology of the disease and stop or slow down AD progression.

关键词： TRPC PS APP Tetrahydrohyperforin CREB SKF Hyp

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Post hoc validation of a tool that accurately predicts the outcome of endoscopic therapy in Bouveret syndrome

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Gastroenterology Report 2022年第1期10卷 298-304页

作者： carla Swift John Ong Man Zhou Benjamin Stokell Yasseen Al-Naeeb Department of Gastroenterology Norwich University HospitalNorwichUK Department of Engineering University of CambridgeCambridgeUK Department of Medicine National University of SingaporeSingapore GKT School of Medical Education King’s College LondonLondonUK Statistical Laboratory Centre for Mathematical SciencesUniversity of CambridgeCambridgeUK Department of Gastroenterology Bedford HospitalBedfordUK

Background Bouveret syndrome is characterized by gallstone impaction in the upper gastrointestinal tract causing gastric outlet *** Bouveret syndrome,endoscopic gallstone removal can avert the need for ***,in cases in which endoscopic therapy is unlikely to succeed,endoscopic attempts delay definitive treatment and compound patient *** previously developed a model that predicts endoscopic outcomes from data derived through a systematic *** tool uses gallstone length,site of impaction,and the number of planned methods of lithotripsy to predict the likelihood of endoscopic success with an accuracy of 81.0%.This study aimed to evaluate our tool performance in an independent,non-training data set and assess endoscopic and surgical *** Systematic searches of the PubMed,Scopus,and Cochrane databases were performed for articles published between 16 April 2018 and 1 June *** data reported after our previous study were harvested and inputted into the tool to evaluate their ability to accurately predict outcomes when compared with actual *** Newly collated data in fields of interest showed no significant statistical differences compared with previous training data *** therapy was successful in 41.9%of *** of ≤4 cm had a higher chance of successful endoscopic intervention(odds ratio 6.7,95%confidence interval 1.7–25.8,P<0.01).Complications of surgery were reported in 29.5%;there was one fatality *** hoc evaluation of our predictive tool demonstrated an AUROC score of *** We have demonstrated in an independent data set that the tool can be used to accurately predict outcomes of endoscopic *** in whom endoscopic therapy is most likely to fail should be offered an early surgical opinion.

关键词： Bouveret syndrome Bouveret’s syndrome gallstone duodenal obstruction gastric outlet obstruction gallstone ileus

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Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn's disease, cause or epiphenomenon?

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World Journal of Gastroenterology 2014年第36期20卷 13060-13070页

作者： Elisa Liverani Eleonora Scaioli carla Cardamone Paola Dal Monte Andrea Belluzzi Gastroenterology Division Department of Medical and Surgical Sciences Sant’Orsola-Malpighi University Hospital 40138 Bologna Italy Diagnostic and Speciality Medicine Department of Experimental Microbiology Unit Sant’Orsola-Malpighi University Hospital 40138 Bologna Italy

The origin of inflammatory bowel disease is unknown. Attempts have been made to isolate a microorganism that could explain the onset of inflammation, but no pathological agent has ever been identified. Johne’s disease is a granulomatous chronic enteritis of cattle and sheep caused by Mycobacterium avium subspecies paratuberculosis (MAP) and shows some analogies with Crohn’s disease (CD). Several studies have tried to clarify if MAP has a role in the etiology of CD. The present article provides an overview of the evidence in favor and against the “MAP-hypothesis”, analyzing the methods commonly adopted to detect MAP and the role of antimycobacterial therapy in patients with inflammatory bowel disease. Studies were identified through the electronic database, MEDLINE, and were selected based on their relevance to the objective of the review. The presence of MAP was investigated using multiple diagnostic methods for MAP detection and in different tissue samples from patients affected by CD or ulcerative colitis and in healthy controls. On the basis of their studies, several authors support a close relationship between MAP and CD. Although increasing evidence of MAP detection in CD patients is unquestionable, a clear etiological link still needs to be proven.

关键词： Mycobacterium avium paratuberculosis Crohn’ s disease Inflammatory bowel disease Johne’ s disease Mycobacterial protein tyrosine phosphatase

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Cancer stem cell plasticity and tumor hierarchy

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World Journal of Stem Cells 2015年第1期7卷 27-36页

作者： Marina carla Cabrera Robert E Hollingsworth Elaine M Hurt MedImmune LLC Department of Oncology ResearchGaithersburg MD 20878 United States

The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer.

关键词： Cancer stem cells Stem cell Plasticity Tumor hierarchy Microenvironment Immune-mediatedtherapies Epithelial-to-mesenchymal transition

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Deep brain stimulation for autism spectrum disorder

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World Journal of Psychiatry 2023年第5期13卷 174-181页

作者： Stefano Marini Lucia D'Agostino carla Ciamarra Alessandro Gentile Department of Mental Health National Health ServiceTermoli 86039Italy

Deep brain stimulation(DBS)is a medical treatment that aims to obtain therapeutic effects by applying chronic electrical impulses in specific brain structures and neurological *** the years,DBS has been studied for the treatment of many psychiatric *** research on the use of DBS in people with autism has focused this interest mainly on treatment-resistant obsessive-compulsive disorder,drug-resistant epilepsy,self-injurious behaviors(SIB),and aggressive behaviors toward the *** spectrum disorder(ASD)includes a group of developmental disabilities characterized by patterns of delay and deviance in the development of social,communicative,and cognitive skills and the presence of repetitive and stereotyped behaviors as well as restricted *** with autism often have numerous medical and psychiatric comorbidities that worsen the quality of life of patients and their ***-compulsive symptoms can be found in up to 81.3%of people with *** are often severe,refractory to treatment,and particularly difficult to *** has a high prevalence in severely retarded individuals and is often associated with *** treatment of both autism and SIB presents a therapeutic *** describe the current state of the art regarding the efficacy of DBS in people with ASD,a literature search was conducted for relevant studies using the PubMed *** studies have been considered in this *** to date,DBS has been used for the stimulation of the nucleus accumbens,globus pallidus internus,anterior limb of the internal capsule,ventral anterior limb of the internal capsule,basolateral amygdala,ventral capsule and ventral striatum,medial forebrain bundle,and posterior *** the total sample of 16 patients,4 were adolescents,and 12 were *** patients had symptoms resistant to multiple drug *** patients taken into consideration by the studies showed clinical improvements as evidenced

关键词： stimulation capsule epilepsy

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