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Commentary on“Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain”

Neural Regeneration Research 2024年第4期19卷 728-728页

作者： Lorenzo Di Cesare Mannelli carla Ghelardini Department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Section of Pharmacology and ToxicologyUniversity of Florence

In pat i e nt s,a s well as in animal mod e l s,hypersensitivity to external stimuli(hyperalgesia and allodynia)or spontaneous pain is often the first,and the most disabling,symptom of neuropathy(davis et al.,2020).The increased activity of sensitive neurons drives pain development,making ion channel modulation a fundamental target for current pharmacotherapy as well as one of the most investigated by the R&D departments of pharmaceutical companies(Bennett et al.,2019).

关键词： companies pain ent

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食物蛋白诱导性小肠结肠炎综合征诊断和治疗国际共识指南

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中华临床免疫和变态反应杂志 2018年第1期12卷 109-123页

作者： Anna Nowak-We.grzyn MirnaChehade Marion E.Groetch Jonathan M.Spergel Robert A.Wood Katrina Allen Dan Atkins Sami Bahna Ashis V.Barad Cecilia Berin Terri Brown Whitehorn A.Wesley Burks Jean-Christoph Caubet Antonella Cianferoni Marisa Conte carla davis Alessandro Fiocchi Kate Grimshaw RNutr Ruchi Gupta Brittany Hofmeister J.B.Hwang Yitzhak Katz George N.Konstantinou Stephanie A.Leonard Jennifer Lightdale Sean McGhee Sami Mehr Stefano MiceliSopo Giovanno Monti Antonella Muraro Stacey Katherine Noel Ichiro Nomura Sally Noone Hugh A.Sampson Fallon Schultz Scott H.Sicherer Cecilia C.Thompson Paul J.Turner Carina Venter A.Amity Westcott-Chavez Matthew Greenhawt 李丽莎钱家鸣杨红不详中国医学科学院北京协和医学院北京协和医院变态(过敏)反应科中国医学科学院北京协和医学院北京协和医院消化内科

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIES）是一种非IgE,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIES 的知晓率却较低；而且有关FPIES 病理生... 详细信息

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIES）是一种非IgE,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIES 的知晓率却较低；而且有关FPIES 病理生理学,诊断和治疗的高质量研究数据缺乏；其临床预后尚不明确。这篇国际共识由美国变态反应、哮喘和免疫学会（AAAAI）食物不良反应委员会和国际FPIES 协会宣传组召集组织国际工作组总结撰写。这是第一部基于临床证据的FPIES 国际指南,有助于提高FPIES 的临床诊治水平。当然未来还需要更多有关FPIES 患病率,病理生理学,诊断标志物和未来治疗方法的研究,以便为FPIES 患者提供更好的医疗服务。这些指南内容将会在获得更多证据后定期更新。

关键词：食物蛋白诱导性小肠结肠炎综合征指南非IgE 介导的食物过敏

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Recommendations for improved tropical cyclone formation and position probabilistic Forecast products

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Tropical Cyclone Research and Review 2023年第4期12卷 241-258页

作者： Jason P.Dunion Chris davis Helen Titley Helen Greatrex Munehiko Yamaguchi John Methven Raghavendra Ashrit Zhuo Wang Hui Yu Anne-Claire Fontan Alan Brammer Matthew Kucas Matthew Ford Philippe Papin Fernando Prates carla Mooney Andrew Kruczkiewicz Paromita Chakraborty Andrew Burton Mark DeMaria Ryan Torn Jonathan L.Vigh CIMAS University of Miamiand Hurricane Research DivisionNOAA/AOMLFloridaUSA NCAR Mesoscale and Microscale Meteorology Laboratory ColoradoUSA UK Met Office ExeterUK Pennsylvania State University PennsylvaniaUSA World Meteorological Organization GenevaSwitzerland University of Reading ReadingUK National Centre for Medium Range Weather Forecasting Ministry of Earth SciencesNoidaIndia University of Illinois at Urbana-Champaign IllinoisUSA Shanghai Typhoon Institute CMAShanghaiChina WMO Tropical Cyclone Programme(TCP)GenevaSwitzerland Cooperative Institute for Research in the Atmosphere/Colorado State University ColoradoUSA Joint Typhoon Warning Center HonoluluUSA MetService New Zealand WellingtonNew Zealand NOAA National Hurricane Center FloridaUSA European Centre for Medium-Range Weather Forecasts ReadingUK Bureau of Meteorology MelbourneAustralia Columbia University New YorkUSA Centre for Climate Research Singapore Meteorological Services SingaporeSingapore CIRA/Colorado State University ColoradoUSA University at Albany-SUNY New YorkUSA Research Applications Laboratory National Center for Atmospheric ResearchColoradoUSA

Prediction of the potentially devastating impact of landfalling tropical cyclones(TCs)relies substantially on numerical prediction systems.Due to the limited predictability of TCs and the need to express forecast confidence and possible scenarios,it is vital to exploit the benefits of dynamic ensemble forecasts in operational TC forecasts and warnings.RSMCs,TCWCs,and other forecast centers value probabilistic guidance for TCs,but the International Workshop on Tropical Cyclones(IWTC-9)found that the“pull-through”of probabilistic information to operational warnings using those forecasts is slow.IWTC-9 recommendations led to the formation of the WMO/WWRP Tropical Cyclone-Probabilistic Forecast Products(TC-PFP)project,which is also endorsed as a WMO Seamless GDPFS Pilot Project.The main goal of TC-PFP is to coordinate across forecast centers to help identify best practice guidance for probabilistic TC forecasts.TC-PFP is being implemented in 3 phases:Phase 1(TC formation and position);Phase 2(TC intensity and structure);and Phase 3(TC related rainfall and storm surge).This article provides a summary of Phase 1 and reviews the current state of the science of probabilistic forecasting of TC formation and position.There is considerable variability in the nature and interpretation of forecast products based on ensemble information,making it challenging to transfer knowledge of best practices across forecast centers.Communication among forecast centers regarding the effectiveness of different approaches would be helpful for conveying best practices.Close collaboration with experts experienced in communicating complex probabilistic TC information and sharing of best practices between centers would help to ensure effective decisions can be made based on TC forecasts.Finally,forecast centers need timely access to ensemble information that has consistent,user-friendly ensemble information.Greater consistency across forecast centers in data accessibility,probabilistic forecast products,and warnings and their communication to u

关键词： Tropical cyclone Probabilistic Formation Position

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